Decarboxylative fluorination and trifluoromethylation of benzoic acids
Lead Research Organisation:
University of Manchester
Department Name: Chemistry
Abstract
Objective:
This project will investigate the development of novel catalytic methods capable of transforming benzoic acids and heteroaromatic carboxylic acids into the corresponding decarboxofluorinated products.
Approach:
The student will examine the use of transition metal catalysts to mediate the 'activation' of the carboxyl C-C bond, resulting in a decarboxylative process. Subsequently, this process shall be coupled with a C-F bond forming step.
Novelty:
There are no broad methods available to carry out this transformation. Benzoic acids are extremely readily available, and fluorinated motifs are common in drugs and other biologically active molecules.
This project will investigate the development of novel catalytic methods capable of transforming benzoic acids and heteroaromatic carboxylic acids into the corresponding decarboxofluorinated products.
Approach:
The student will examine the use of transition metal catalysts to mediate the 'activation' of the carboxyl C-C bond, resulting in a decarboxylative process. Subsequently, this process shall be coupled with a C-F bond forming step.
Novelty:
There are no broad methods available to carry out this transformation. Benzoic acids are extremely readily available, and fluorinated motifs are common in drugs and other biologically active molecules.
People |
ORCID iD |
| Igor Larrosa (Primary Supervisor) | |
| Eleanor Bowen (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| EP/T517823/1 | 01/10/2020 | 30/09/2025 | |||
| 2481226 | Studentship | EP/T517823/1 | 01/10/2020 | 17/02/2021 | Eleanor Bowen |