Identification of regulatory genomic networks underlying skin ageing
Lead Research Organisation:
King's College London
Department Name: Genetics and Molecular Medicine
Abstract
Deciphering which mRNA or epigenetic changes with age contribute to ageing rather than are a
consequence of ageing is extremely difficult. However, DNA sequence variants that associate with ageing
traits are likely to be causal, because genetic variants do not change with age. How genetic variants
precisely affect regulation of nearby genes and potential downstream targets needs further study. Hence,
unravelling the complex network of epigenetic and expression pathways associated with ageing-related
genetic variation is useful in determining how causal gene variants influence age-related processes in cells.
consequence of ageing is extremely difficult. However, DNA sequence variants that associate with ageing
traits are likely to be causal, because genetic variants do not change with age. How genetic variants
precisely affect regulation of nearby genes and potential downstream targets needs further study. Hence,
unravelling the complex network of epigenetic and expression pathways associated with ageing-related
genetic variation is useful in determining how causal gene variants influence age-related processes in cells.
People |
ORCID iD |
| Jordana Bell (Primary Supervisor) | |
| Christopher Shore (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/V509656/1 | 01/02/2021 | 31/01/2025 | |||
| 2512524 | Studentship | BB/V509656/1 | 01/02/2021 | 31/01/2025 | Christopher Shore |