UK-Japan collaboration on microbial systems biology

Lead Research Organisation: University of Surrey
Department Name: Microbial & Cellular Sciences

Abstract

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Description The award led to collaborative research between Japan and the UK on microbial systems biology, which has helped to promote the internationalization of UK research and also to obtain a recent MRC grant in collaboration with Japanese partners to investigate antibiotic persistence mechanisms in bacteria.
Exploitation Route We developed a new in silico metabolic model for E. coli that can be used for biotechnology and research.
Sectors Healthcare

Pharmaceuticals and Medical Biotechnology
 
Description The project was prtomote UK-Japan collaboration in biotechnology. The collaborative contact led to extensive contacts: https://sites.google.com/site/ukjapansystemsbiologyworkgroup/members and an MRC collaborative grant as well as publication of a book on systems biology
First Year Of Impact 2017
Sector Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology
Impact Types Cultural

Societal
 
Description Intracellular metabolism of Mycobacterium tuberculosis
Amount £405,329 (GBP)
Funding ID 088677/Z/09/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2009 
End 07/2015
 
Description Japan Partnering Award - Microbial Systems Biology
Amount £51,126 (GBP)
Funding ID BB/G530284/ 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 03/2009 
End 09/2014
 
Description MRC AMED - Systematic analysis of persistence mechanisms by high-throughput bar-seq and single cell analyses.
Amount £72,547 (GBP)
Funding ID MR/T028998/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 11/2019 
End 11/2022
 
Description collaboration with Kyushu Institute of Technology 
Organisation Kyushu Institute of Technology
Department Department of Bioscience and Bioinformatics
Country Japan 
Sector Academic/University 
PI Contribution We collaborated on a project to construct a kinetic model of central metabolism of E. coli.
Collaborator Contribution They generated data and led the construction project
Impact 16. T. B. Asmawaty, A. Mannan, A. Kierzek, J McFadden and Shimizu, K. (2010) Modeling and simulation of the main metabolism in Escherichia coli and its several single-gene knockout mutants with experimental verification. Microbial Cell Factories 9:88.
Start Year 2008
 
Description collaboration with colleagues at Institute of Bio and Geo Sciences, Jülich, Germany 
Organisation Julich Research Centre
Country Germany 
Sector Academic/University 
PI Contribution Our team have provided data that the Juelich team have analyzed. We have also collaborated to generate new systems-based analytical tools for metabolomics.
Collaborator Contribution Our partners, principally Dr katherina Noh and professor Wolfgang Wiechert,
Impact Beste, J.V., Nöh, K., Niedenführ, S., Mendum, T.A., Hawkins, N. D., Ward, J.L., Beale, M.H., Wiechert, W., McFadden, J. Systems level 13C-flux spectral analysis of the metabolic interactions between host cell and pathogen reveals a mixed diet for intracellular Mycobacterium tuberculosis. Chemistry and Biology 20: 1012-21. 2013. D Beste, B. Bonde, N. Hawkins, M. H. Beale, S Noack, K. Noh, N. J. Kruger, R. G. Ratcliffe, and J McFadden. (2011) 13C Metabolic Flux Analysis identifies an unusual route for pyruvate dissimilation in mycobacteria which requires isocitrate lyase and carbon dioxide fixation. Plos Pathog. 7(7): e1002091.
Start Year 2007