Food Entrainment of the Human Circadian Timing System
Lead Research Organisation:
University of Surrey
Department Name: Biochemistry & Physiology
Abstract
Most living organisms possess internal clocks that regulate daily (circadian) rhythms in many key biological functions (e.g. hormone secretion, sleep time, metabolism). The circadian timing system in mammals, including humans, consists of a 'master' clock within a part of the brain called the hypothalamus and many 'peripheral' clocks found throughout the body. There is increasing evidence to show that abnormal timing of these clocks leads to defects in normal biology. The effects of this abnormal timing can be short lived (e.g. in jet lag) or present over a number of years (e.g. in shift workers). In the second scenario, the long term effects of abnormal rhythms is thought to be a causative factor in many industrial accidents and can lead to increased incidence of major contributors to ill health, such as heart and metabolic diseases. In order for our internal clocks to be matched to external changes in the environment, they are synchronised by various environmental time cues. Although it is known that light is the main synchroniser of the 'master' clock in the brain, the synchronisation of peripheral clocks is poorly understood. Evidence from animal studies suggests that the time of feeding is an important signal for peripheral clocks. However, these animal experiments have not been performed in humans because; 1) very few places in the world can perform well controlled human circadian experiments, and 2) it is difficult to obtain multiple samples of human tissue other than blood. At the University of Surrey, we have the benefit of excellent human biology facilities, experts in circadian rhythms, and experts in nutritional science. Moreover, in our recent research, we have optimised a method for taking multiple samples of fat from human volunteers. We therefore propose to conduct a set of extremely important and timely experiments to discover whether the time of feeding can regulate human clocks. The results of the work will have important implications for scientists and the public. Scientists will learn crucial new information about the basic biology of body clocks. If food is found to be able to regulate circadian timing then this would identify novel treatment strategies that may lead to novel dietary interventions to reduce the burden of shift work and jet lag on health and performance. There has been a lot of public and media interest in both body clocks and nutrition over recent years and so this research is likely to be of broad interest. In particular, we hope to discover new scientific findings that will underpin non-drug treatment for sufferers of circadian disorders including air travellers, shift workers and the totally blind.
Technical Summary
The mammalian circadian timing system consists of a master clock in the hypothalamic suprachiasmatic nuclei (SCN) and many other peripheral clocks throughout the body. Light is thought to be the predominant time cue (zeitgeber) for entrainment of the SCN, which is then thought to synchronise the peripheral clocks via as yet poorly defined mechanisms. One of the primary candidates for entrainment of peripheral clocks is timed feeding. It has long been known in animal experiments that temporal restriction of food availability induces various circadian changes, e.g. food anticipatory activity. Moreover, molecular studies indicate that temporal food restriction has a profound effect on the phase of peripheral clocks. However, there are very few data investigating the effect of timed feeding in humans. In this study, we will conduct two key experiments; firstly the construction of a phase response curve to food, and secondly a meal shift protocol. These experiments will for the first time test the hypothesis that timed feeding entrains human circadian clocks and will study a combination of endocrine and molecular markers of both central (SCN) and peripheral clocks. Furthermore, the second experiment will compare the relative ability of light and food to entrain central and peripheral clocks. Our ability to measure human peripheral clocks is demonstrated by our published data on leukocyte gene expression and our recent unpublished study that has pioneered the use of serial adipose biopsies in circadian biology. These experiments will provide a timely and high impact addition to the fields of chronobiology and nutrition/metabolism. Moreover, they will have clear relevance for sufferers of circadian disorders including air travellers, shift workers and the totally blind.
Planned Impact
This project will provide impact in many key areas identified by the BBSRC; 1. Scientific advancement and supporting excellent research in the science base. The understanding of circadian physiology and its underpinning molecular biology has been an area of major development in the biosciences. It is now appreciated that circadian rhythms interact with many essential biological processes and circadian dysregulation is believed to be an important contributor to multiple disease states. One important area of circadian manipulation that is still poorly understood is how timed feeding regulates human circadian physiology. The combination of the University of Surrey's state-of-the-art facilities and our recent technical developments now permit us to undertake these key experiments. This project will therefore provide major scientific advances that will be at the cutting edge of circadian and nutritional biology. 2. Knowledge and knowledge economy. In addition to its detrimental effect on health, circadian dysregulation in shift workers is thought to reduce performance and may be an important contributor to industrial accidents. By investigating putative mechanisms to reset human circadian rhythms, our study will provide novel knowledge that has the potential to improve worker performance and therefore produce great economic benefit. 3. Training and delivering highly skilled people. We have proposed a named postdoctoral researcher in this application to maximise the efficiency of the project. Although the individual concerned has some of the key skills required to complete the work (e.g. subject recruitment, conducting human trials, data analysis), she will greatly expand her theoretical understanding of circadian biology and also learn a great deal of new practical skills. She will therefore mature into a highly trained researcher who will be able to continue her career in either academic or industrial research. 4. Policy development. The new scientific understanding that will derive from this work has great potential in the development of policy surrounding lifestyle and occupational health. For example, demonstration of the ability of timed feeding to reduce internal circadian desynchrony could inform future research and policy relating to the minimisation of the risks associated with shift work. 5. Public engagement, public health and societal issues. It is anticipated that the current application will also be of great interest to the media and public, so providing opportunity for public engagement. All of the applicants already have experience of public engagement, ranging from newspaper interviews to television appearances, and would be extremely willing to continue this work. As well as providing an interesting scientific story, the research also relates to public health and contemporary societal issues, including nutrition and energy balance. 6. International development. As many of the issues mentioned above (e.g. shift work, energy balance, and scientific advancement) are relevant internationally, the research should have wide-reaching impact both within and outside the UK.
Publications
Loizides-Mangold U
(2017)
Lipidomics reveals diurnal lipid oscillations in human skeletal muscle persisting in cellular myotubes cultured in vitro.
in Proceedings of the National Academy of Sciences of the United States of America
Kantermann T
(2012)
Noisy and individual, but doable: shift-work research in humans.
in Progress in brain research
Johnston JD
Physiological links between circadian rhythms, metabolism and nutrition.
in n/a
Johnston JD
(2014)
Physiological links between circadian rhythms, metabolism and nutrition.
in Experimental physiology
Johnston JD
(2014)
Physiological responses to food intake throughout the day.
in Nutrition research reviews
Johnston JD
(2016)
Circadian Rhythms, Metabolism, and Chrononutrition in Rodents and Humans.
in Advances in nutrition (Bethesda, Md.)
Johnston JD
(2012)
Adipose circadian rhythms: translating cellular and animal studies to human physiology.
in Molecular and cellular endocrinology
Flanagan A
(2020)
Dietary Patterns of Nurses on Rotational Shifts Are Marked by Redistribution of Energy into the Nightshift.
in Nutrients
Flanagan A
(2021)
Chrono-nutrition: From molecular and neuronal mechanisms to human epidemiology and timed feeding patterns.
in Journal of neurochemistry
Christou S
(2019)
Circadian regulation in human white adipose tissue revealed by transcriptome and metabolic network analysis.
in Scientific reports
Description | What were the most significant achievements from the grant? 1. Novel scientific findings. We've provided detailed analysis of the effects of feeding time on multiple aspects of human physiology including; hormone rhythms, gene expression in different tissues, subjective appetite/behavioural scores. These data should be published during 2015 and are anticipated to make a major contribution to the literature. **UPDATE** We demonstrated in a 2017 Current Biology paper that meal timing is a powerful signal that sets daily rhythms of blood sugar control. **UPDATE 2** Major new outputs (2017 PNAS, 2018 eLife) reporting rhythms of human muscle transcriptome/lipidome, via international collaboration, and (2019 Scientific Reports) reporting circadian transcriptome in human adipose tissue. 2. Development of novel collaborations with industrial and academic colleagues. I have been involved in a series of meetings with colleagues at Kellogg and multiple universities. This has lead to a collaborative experiment with one of the academic partners and consultancy work with Kellogg. I am actively pursuing further links with these individuals. 3. Experience of research management. Although I had previously run smaller human trials and been a co-Investigator on large human studies, this was the first large human study on which I've been PI. The process has been challenging and also rewarding, as I have learnt a huge amount and the experience gained will greatly help me to run future projects. 4. New technical skills in the laboratory. Completion of the project required successful implementation of experimental methods that were new to me and other members of the team. These included measurements that were not included in the original grant proposal, e.g. temperature, interstitial glucose and subjective questionnaire data. 5. Follow-on funding. The project has directly enabled me to obtain a new funded PhD studentship and explore funding links with industrial partners. I anticipate that publication of the data will also greatly assist future funding applications. 6. Production of software to aid diet design. At the start of the study, we produced new software to enable design of controlled diets tailored to individual needs in a long-term residential study. This software has already been used by two other Surrey studies and will be made freely available as an attachment to a publication. To what extent were the grant objectives met? The main objectives of the grant were; 1. Construct a Phase Response Curve (PRC) to timed feeding in humans. 2. Investigate the effect of a 6-hour shift in meal times on central and peripheral circadian rhythms. Laboratory work for both objectives is now complete and we are completing final data analysis before publication of the resulting papers. I have deliberately delayed publication in a strategic move to ensure that the core papers from the grant are as comprehensive as possible and thus achieve greatest scientific impact. In addition to the main objectives described above, we have produced many other data and/or outputs that will be made available in the near future. These include the diet design software mentioned above, detailed physiological characterisation of an 'ultradian routine' protocol, addition of data sets not described in the original grant proposal (see 'new technical skills in the laboratory' above) and the ability to extend other aspects of the project via the associated PhD studentship. |
Exploitation Route | How might the findings be taken forward and by whom? The scientific field linking circadian rhythms and sleep physiology with metabolism and nutrition is an extremely active and topical area of international research. The scientific outputs of this study will therefore be of immense interest to many research groups around the world. This interest will in part be stimulated by recent presentations by me and members of the research team, in addition to future presentations that I have been invited to give at major conferences in e.g. Boston and Edinburgh. The timeliness of the work also makes it very popular with the media and I will ensure that media coverage of forthcoming outputs is maximised via our University's Media Relations team and other vehicles, such as the Science Media Centre. Finally, the work is demonstrably of great interest to the food industry, as demonstrated by my existing links with Kellogg and possible future links with Nestle and smaller research institutions. I will explore these industrial opportunities with existing contacts and also by collaboration with nutritional scientists at Surrey and potentially elsewhere. |
Sectors | Agriculture Food and Drink Education Healthcare Pharmaceuticals and Medical Biotechnology |
Description | My research into the concept of timed feeding (chrononutrition) resulted in a major contribution to a recent BBC television programme, Trust Me I'm A Doctor (series 4, episode 2) and BBC iWonder web page. As a result of a major publication in 2017, I was interviewed by multiple national and international (e.g. from USA, Canada, Brazil, Spain) media agencies. The work was reported by 43 different news agencies, according to Altmetric (overall Altmetric score > 500). I have also been invited to speak at a meeting of the UK 'Nutritionists in Industry' group. **UPDATE** I have also written a related article for The Conversation that has been read over 500,000 times. |
First Year Of Impact | 2017 |
Sector | Agriculture, Food and Drink,Education,Culture, Heritage, Museums and Collections,Other |
Impact Types | Cultural Societal |
Description | Nutrition Society of India (Mumbai Chapter): podcast and live video stream on "You are when you eat: Role of Chrononutrition in Metabolic Health" |
Geographic Reach | Asia |
Policy Influence Type | Influenced training of practitioners or researchers |
Impact | Live talk/podcast/video stream to the Nutrition Society of India (Mumbai Chapter); attended by hundreds of nutritionists/dieticians; followed by a lengthy discussion/Q&A session in which I provided specific information and guidance to local practitioners, including how they could conduct field research/interventions on a limited budget |
URL | https://www.youtube.com/watch?v=41WTaEZ8SHg |
Description | Anticipation of meal time in humans |
Amount | £810,048 (GBP) |
Funding ID | BB/S01814X/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2019 |
End | 08/2023 |
Description | PhD studentship |
Amount | £80,000 (GBP) |
Funding ID | BB/J014451/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2012 |
End | 09/2016 |
Description | Population and systems medicine |
Amount | £787,221 (GBP) |
Funding ID | MR/P012205/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 04/2017 |
End | 04/2020 |
Title | Adipose biopsy |
Description | Working with the medical team at the Surrey Clinical Research Centre, we modified existing biopsy procedures to enable multiple (up to 16 in a month) biopsies to be taken from the upper gluteal region of an individual. The method produces much less bruising than common needle punch methods and involves small incisions per biopsy to reduce chances of scarring and speed up healing. |
Type Of Material | Model of mechanisms or symptoms - human |
Provided To Others? | No |
Impact | The novel ability to take repeated serial biopsies from an individual and thus derive temporal profiles of molecular state of a human metabolic tissue. |
Title | Effect of timed meals |
Description | Dataset of hormone and metabolite data before and after a 5-h shift in the timing of the meal schedule |
Type Of Material | Database/Collection of data |
Year Produced | 2017 |
Provided To Others? | Yes |
Impact | Shifting the timing of the mean schedule by 5 h resulted in a mismatch between the central SCN-clock driven rhythms and the peripheral clock driven rhythms. These highly controlled laboratory data from healthy volunteers form the foundation on which to assess the effect of meals, both the timing and content, on metabolite rhythms. |
Title | Human adipose transcriptome |
Description | Novel transcriptomic data set from serial biopsies of human adipose tissue collected during a highly specialised circadian biology protocol. |
Type Of Material | Database/Collection of data |
Provided To Others? | No |
Impact | None yet. A manuscript is under publication and the data will be made freely available immediately after publication. |
URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE87761 |
Description | Collaboration with Dr James Betts |
Organisation | University of Bath |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Intellectual input into experimental design and conduct; endocrine assays; input into molecular assays |
Collaborator Contribution | conduct of the experiment; molecular assays |
Impact | none yet, although there may be industrial input to expand upon the initially planned analyses |
Start Year | 2014 |
Description | Collaboration with Nestle and University of Geneva |
Organisation | Nestlé (Global) |
Department | Société des Produits Nestlé SA |
Country | Switzerland |
Sector | Private |
PI Contribution | Scientific expertise; provision of valuable tissue samples |
Collaborator Contribution | Analytical expertise and man-power; specialist laboratory analysis |
Impact | 1. Publication by Loizides-Mangold et al (2017) in PNAS. Collaboration also involved University of Bath (Dr James Betts). 2. Invited seminar at Nestle. |
Start Year | 2015 |
Description | Collaboration with Nestle and University of Geneva |
Organisation | University of Geneva |
Country | Switzerland |
Sector | Academic/University |
PI Contribution | Scientific expertise; provision of valuable tissue samples |
Collaborator Contribution | Analytical expertise and man-power; specialist laboratory analysis |
Impact | 1. Publication by Loizides-Mangold et al (2017) in PNAS. Collaboration also involved University of Bath (Dr James Betts). 2. Invited seminar at Nestle. |
Start Year | 2015 |
Description | Engagement with Kellogg |
Organisation | Kellogg's |
Country | United States |
Sector | Private |
PI Contribution | consultancy work in the area of circadian control of metabolism |
Collaborator Contribution | payment for consultancy work; ongoing discussions to identify possible areas of future research that would likely be funded in whole by the company |
Impact | consultancy report |
Start Year | 2012 |
Description | Engagement with Nestle and University of Bath |
Organisation | Nestlé (Global) |
Department | Société des Produits Nestlé SA |
Country | Switzerland |
Sector | Private |
PI Contribution | I provided the major intellectual contribution to the design of a collaborative study run at Bath. Some sample analysis was also conducted at Surrey. Together with the Bath lead investigator, I am providing intellectual input to the analysis of samples that have been shipped to Nestle for -omic analyses. |
Collaborator Contribution | University of Bath ran our joint study and performed some sample analysis. Nestle are conducting large scale -omic analyses that are fully funded by the company. |
Impact | No outputs are yet available, although conference abstracts have recently been submitted and at least 1 major publication should be published in 2016. It is hoped that opportunities for industry funded research will emerge in the near future. The collaboration is multi-disciplinary involving; human physiology, transcriptomics, lipidomics and bioinformatics. |
Start Year | 2014 |
Description | Engagement with Nestle and University of Bath |
Organisation | University of Bath |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | I provided the major intellectual contribution to the design of a collaborative study run at Bath. Some sample analysis was also conducted at Surrey. Together with the Bath lead investigator, I am providing intellectual input to the analysis of samples that have been shipped to Nestle for -omic analyses. |
Collaborator Contribution | University of Bath ran our joint study and performed some sample analysis. Nestle are conducting large scale -omic analyses that are fully funded by the company. |
Impact | No outputs are yet available, although conference abstracts have recently been submitted and at least 1 major publication should be published in 2016. It is hoped that opportunities for industry funded research will emerge in the near future. The collaboration is multi-disciplinary involving; human physiology, transcriptomics, lipidomics and bioinformatics. |
Start Year | 2014 |
Title | Adipose biopsies |
Description | Bespoke forceps were designed by the lead clinical at the Surrey Clinical Research Centre for the purpose of taking repeated adipose biopsies (see section on new research methods for detail) |
Type | Therapeutic Intervention - Medical Devices |
Current Stage Of Development | Refinement. Clinical |
Year Development Stage Completed | 2012 |
Development Status | Closed |
Impact | n/a |
Title | Diet design software |
Description | Software/macro in Excel to enable design of controlled diets for long-term residential laboratory studies. NB We have explored the possibility of filing IP on this product. However, our IP team don't consider there to be a significantly large market available to warrant commercialisation. We will therefore make the resource freely available as downloadable content associated with a forthcoming research paper. |
Type Of Technology | Software |
Year Produced | 2012 |
Impact | It has already been used by two other large studies at the Surrey Clinical Research Centre, including BBSRC grant BB/I019405/1. |
Description | BBC Food web article |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Response to a media request for expert opinion on meal timing |
Year(s) Of Engagement Activity | 2022 |
URL | https://www.bbc.co.uk/food/articles/eating_times |
Description | BBC News website |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Provision of information to the public; possible increase in study volunteers due to increased exposure of the research area The story has been mentioned by journalists who've subsequently contacted me and so has presumably increased the interest in me as a potential science communicator, in addition to the work itself. |
Year(s) Of Engagement Activity | 2011 |
URL | http://www.bbc.co.uk/news/uk-england-surrey-14716475 |
Description | BBC Radio Surrey interview |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | REsponse to a media request to do a live radio interview about meal timing |
Year(s) Of Engagement Activity | 2021 |
Description | BBC Television: Trust Me I'm A Doctor (series 4, episode 2) |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Based on my expertise from BBSRC-funded research on the subject of timed feeding, I was asked to run a 'big experiment' and two smaller demonstration experiments for the BBC's Trust Me I'm A Doctor television programme. The programme (series 4, episode 2) was first aired on BBC2 in January 2016. The build-up work spanned the previous 12 months. I have received a number of emails from members of the public as a result of the work, and will use the data as the basis for a research paper and 1-2 research grant applications. |
Year(s) Of Engagement Activity | 2015,2016 |
URL | http://www.bbc.co.uk/programmes/articles/zBx3JZJCKfNBrWgT0Qyj93/the-big-experiment-could-i-lose-fat-... |
Description | BBC iWonder website |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Two of my PhD students (one of whom is BBSRC-funded) and I worked with the BBC to develop an interactive web site relating to my BBSRC-funded research in timed feeding. |
Year(s) Of Engagement Activity | 2015,2016 |
URL | http://www.bbc.co.uk/guides/zyd34j6 |
Description | BDA webinar |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | A live webinar for the British Dietetics Association (BDA) to cover aspects of chrono-nutrition and timed eating. There were questions afterwards and the BDA organisers were very happy with the response of their members. |
Year(s) Of Engagement Activity | 2022 |
URL | https://www.bda.uk.com/events/webinars.html |
Description | Interview for BBC Radio Surrey |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Interview based upon results of Current Biology paper |
Year(s) Of Engagement Activity | 2017 |
Description | Interview for national/international science broadcaster (Naked Scientists) |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Interview for Naked Scientists radio programme and podcast |
Year(s) Of Engagement Activity | 2017 |
Description | Open days - University of Surrey |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | Yes |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Students and parents were extremely appreciative of the opportunity to talk to an academic member of staff about undergraduate study, professional training etc There was very good feedback on the value of the events |
Year(s) Of Engagement Activity | 2008,2009,2010,2011,2012,2013,2014,2015,2016 |
Description | Press release for 2017 Current Biology paper |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Over 40 international and national news outlets picked up the story and the overall Altmetric score is > 500. |
Year(s) Of Engagement Activity | 2017 |
URL | https://www.surrey.ac.uk/mediacentre/press/2018/delaying-meals-impacts-sugar-levels-body |
Description | Press release for 2019 Scientific Reports paper |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Over 10 international news outlets have currently picked up the story, with an overall Altmetric score currently at > 130 (within 1 week of publication). |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.surrey.ac.uk/news/fat-cells-work-different-shifts-throughout-day |
Description | Radio interview for Talk Radio Europe |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Interview about recent Current Biology paper |
Year(s) Of Engagement Activity | 2017 |
Description | Telegraph interview - jet lag |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Provision of expert opinion about a topical media story No obvious impacts to me personally |
Year(s) Of Engagement Activity | 2013 |
URL | http://www.telegraph.co.uk/science/science-news/10409645/Brain-chemical-helps-beat-jet-lag.html |
Description | Video interview - Kellogg/NutSoc |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Strengthening of working relationship with Kellogg; discussion was generated at the meeting where the interview took place |
Year(s) Of Engagement Activity | 2012 |
URL | https://www.youtube.com/watch?v=K-7aPvtKs14 |
Description | Written article for The Conversation |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Written article based on 2017 Current Biology research paper. Over 500,000 reads logged. |
Year(s) Of Engagement Activity | 2017 |
URL | https://theconversation.com/changing-your-meal-times-could-help-you-beat-jet-lag-and-shift-work-7906... |
Description | You and your hormones podcast |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Response to a request to provide expert opinion on the subject of meal timing in a highly regarded professional podcast series |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.yourhormones.info/resources/digital-library/podcasts/does-when-i-eat-affect-my-weight/ |