Sphingolipidomic analysis.

Lead Research Organisation: University of Edinburgh
Department Name: Sch of Chemistry


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Description We used this UK USA travel grant to build our collaboration with Prof. Teresa Dunn and explore the inhibition of SPT by the inhibitor myriocin. This resulted in the determination of the structure of the SPT:myriocin complex which was published in a high impact paper in JACS 2013. It also led to the award of the BBSRC grant BB/M003493/1
Exploitation Route The structure of the SPT:myriocin complex will help in the development of novel therapeutic agents.
Sectors Pharmaceuticals and Medical Biotechnology

Description We have been invited to Boston to meet the Deater family who are affected by a mutation in the SPT enzyme we work on.Our work may help devise a therapy.
First Year Of Impact 2015
Sector Pharmaceuticals and Medical Biotechnology
Impact Types Societal

Description SPT purification 
Organisation Manchester University NHS Foundation Trust
Department Biochemistry
Country United Kingdom 
Sector Hospitals 
PI Contribution We are helping to determine the structure of the human SPT enzyme
Collaborator Contribution They have provided SPT expressing yeast cells
Impact Purified SPT enzyme
Start Year 2015
Description Deater meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Patients, carers and/or patient groups
Results and Impact We work on the enzyme SPT. A small number of people are affected by a hereditary diseases - HSAN1. A family affected the Deater family invited us to a meeting in Boston in April 2017 to discuss our research and hear the results of a NIH-funded clinical trial.
Year(s) Of Engagement Activity 2017
URL http://www.deaterfoundation.org/