Synthetic Biology for Biotechnology of Fine Chemicals - SynBioTech
Lead Research Organisation:
The University of Manchester
Department Name: Chemistry
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Karuppiah V
(2017)
Structural Basis of Catalysis in the Bacterial Monoterpene Synthases Linalool Synthase and 1,8-Cineole Synthase.
in ACS catalysis
Toogood H
(2015)
Enzymatic Menthol Production: One-Pot Approach Using Engineered Escherichia coli
in ACS Synthetic Biology
Carbonell P
(2016)
SYNBIOCHEM-a SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals.
in Biochemical Society transactions
Amer M
(2020)
Renewable and tuneable bio-LPG blends derived from amino acids.
in Biotechnology for biofuels
Leferink NGH
(2016)
A 'Plug and Play' Platform for the Production of Diverse Monoterpene Hydrocarbon Scaffolds in Escherichia coli.
in ChemistrySelect
Breitling R
(2016)
Synthetic Biology of Natural Products.
in Cold Spring Harbor perspectives in biology
Breitling R
(2015)
Synthetic biology advances for pharmaceutical production.
in Current opinion in biotechnology
Zebec Z
(2016)
Towards synthesis of monoterpenes and derivatives using synthetic biology
in Current Opinion in Chemical Biology
Amer M
(2020)
Low carbon strategies for sustainable bio-alkane gas production and renewable energy
in Energy & Environmental Science
Cummings M
(2014)
Steps towards the synthetic biology of polyketide biosynthesis.
in FEMS microbiology letters
| Description | This was a travel award, so there are no scientific findings, but new collaborations were formed with the partnering groups. Prof. George Chen was appointed as a part time staff member at the University of Manchester; Prof. Scrutton took up a visiting professorship at Tsinghua in 2016. Both gave lectures to staff/students at respective centres. Prof Chen lectured at ESOF held in Manchester 2016 |
| Exploitation Route | This grant award opened up wider interactions between Manchester, Tsinghua and other Chinese institutions (e.g. Tianjin). Prof. Scrutton was also made adjunct professor at Beijing Chemical Technology University to further develop SynBio programmes in China. |
| Sectors | Chemicals Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology Other |
| Description | Technology transfer is assisting with commercial development programmes in the UK with SYNBIOCHEM spin out companies. |
| First Year Of Impact | 2016 |
| Sector | Manufacturing, including Industrial Biotechology |
| Description | GSK |
| Organisation | GlaxoSmithKline (GSK) |
| Country | Global |
| Sector | Private |
| PI Contribution | Provided expertise, research time and equipment. |
| Collaborator Contribution | Provided expertise and funding. |
| Impact | Synthetic biology methods for production of fine chemicals. |
| Start Year | 2011 |
| Description | Manchester Tsignhua PhD Partnership |
| Organisation | Tsinghua University China |
| Country | China |
| Sector | Academic/University |
| PI Contribution | SYNBIOCHEM developed collaborations with Tsinghua which led to the development of a 2+2 dual degree PhD programme in synthetic and systems biology with applicants spending years at Manchester and Beijing. From early collaborations and the signing of a memorandum of understanding the scheme is funded jointly between the 2 institutions. |
| Collaborator Contribution | Tsinghua collaborator George Guoqiang Chen signed a memorandum of understanding which developed into a strong relationship and co-funding of the PhD scheme. |
| Impact | The first set of PhD students started the course in September 2020 |
| Start Year | 2018 |