Exploiting microbial genomics and synthetic biology for discovery of novel antibiotics
Lead Research Organisation:
University of Warwick
Department Name: Chemistry
Abstract
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Publications
Wang W
(2016)
Development of a Synthetic Oxytetracycline-Inducible Expression System for Streptomycetes Using de Novo Characterized Genetic Parts.
in ACS synthetic biology
Wang K
(2024)
Discovery and Biosynthesis of Streptolateritic Acids A-D: Acyclic Pentacarboxylic Acids from Streptomyces sp. FXJ1.172 with Promising Activity against Potato Common Scab.
in Journal of agricultural and food chemistry
Sidda JD
(2016)
Overproduction and identification of butyrolactones SCB1-8 in the antibiotic production superhost Streptomyces M1152.
in Organic & biomolecular chemistry
Rutledge PJ
(2015)
Discovery of microbial natural products by activation of silent biosynthetic gene clusters.
in Nature reviews. Microbiology
| Description | We have discovered novel natural products from Streptomyces species and developed novel synthetic biology tools for use in this genus |
| Exploitation Route | The novel natural products can be screened for biological activity. This may result in the discovery of novel leads for antibiotics, anticancer agents or agrochemicals. The novel synthetic biology tools can be used by others to refactor biosynthetic pathways and create novel gene expression systems. |
| Sectors | Agriculture Food and Drink Chemicals Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |
| Description | We have sent some of the compounds we have discovered to Syngenta for biological testing |
| First Year Of Impact | 2015 |
| Sector | Agriculture, Food and Drink |