OpenPlant

Lead Research Organisation: University of Cambridge
Department Name: Plant Sciences

Abstract

An essential concept in Synthetic Biology is that genetic systems can be constructed using standardised, interchangeable parts. For example, functional DNA sequences such as promoters, ribosome binding sites and coding sequences can be used to develop synthetic gene systems that can be used to reprogram living systems in a systematic way. The prospect of large-scale reprogramming of living systems, will require access to relatively large numbers of components. This is in contrast to existing GM products that contain one or a few components. There is growing requirement for libraries of well characterized routine components that can be shared for the construction of a variety of systems, where small companies would be ensured freedom to operate. This is essential to foster the kind of innovation seen at the emergence of other new technologies such as microelectronics and software development.

Accordingly, a substantial part of the Synthetic Biology field has promoted open standards and sharing of data and resources, inspired by the open source software movement. The educational community has embraced the open source principle, and DNA parts are widely and freely distributed internationally as part of educational efforts like the iGEM community, and grows year-on-year. The BioBricks Foundation is a non-profit organisation which has roots in the academic community, and which has promoted a legal framework which would allow protection of Synthetic Biology applications and key activities, but which would facilitate sharing of parts.

Plant biotechnology is a good example of a field where current IP practices have led to a restriction of exchange and innovation, and this model is threatening to predominate in plant synthetic biology. For examples, one just has to look at restrictive licensing of basic technologies like transformation, selection markers and useful genes. We believe that the field needs to explore new "two-tier" intellectual property models that will protect investment in applications, while promote sharing of DNA components and freedom-to-operate for small companies in commercial applications of Synthetic Biology. As the speed and scale of biological assembly increases, this becomes more pressing.

As part of the OpenPlant initiative, we will establish open-source DNA registries across the UK for sharing information, and to join an international web of registries with plant specific parts. The technology is inherently low cost, renewable and has obvious applications for new sustainable technologies.

Technical Summary

Foundational technologies: As part of the OpenPlant initiative, we will (i) establish open-source DNA registries for sharing information, and join an international web of registries with the first plant specific parts. (ii) We will develop a major new plant chassis for Synthetic Biology, (iii) develop new DNA parts for the control and quantitative imaging of genetic circuits in plants, and (iv) genome-scale engineering in plants. (v) Software tools will be further improved for automated DNA assembly, modeling of synthetic gene circuits and cellular morphogenesis

Trait Engineering: The development of new foundational tools and parts will directly contribute to the engineering of new traits in plants, such as (i) altered photosynthesis and leaf structure, (ii) carbohydrate content, (iii) metabolic pathways, (iv) new forms of symbiosis and nitrogen fixation and (v) high level production of biomolecules by virus engines.

Open technologies for innovation: Current IP practices and restrictive licensing threaten to restrict innovation as the scale of DNA systems increases. We believe that the field needs to explore new "two-tier" intellectual property models that will protect investment in applications, while promote sharing of DNA components and freedom-to-operate for small companies in commercial applications of Synthetic Biology. We will create new forums and opportunities for open innovation in plant synthetic biology.

We will sponsor discussions in Cambridge on the potential impact of Synthetic Biology on sustainable practices in agriculture, bioproduction, land use and environmental conservation. This will bring together a wide range of engineers, scientists and policy developers to explore new technologies and possible models for sustainable agriculture, bioproduction and land use.

Planned Impact

A significant barrier to the ability of Synthetic Biology to have commercial impact in the UK is social acceptance of genetic modification. OpenPlant will engage with this issue scientifically by the development of precision gene technologies that can introduce desirable traits without the introduction of transgenes and by supporting research on traits such as nitrogen use that can significantly impact bioproduction. It will also engage through discourse on sustainable agriculture and land use and engagement with a variety of groups including conservationists, social scientists and policy developers.

The restrictive licensing of powerful technologies as well as the prohibitive cost of protecting IP for smaller enterprises threatens to impede the pace of research in plant synthetic biology. The OpenPlant centre aims to promote entrepreneurial activities though a framework that allows the exploration of open technologies and fixed-cost, non-exclusive licenses that can ensure that parts, techniques, libraries and materials have are available to facilitate both scientific exchange and commercial innovation.

Publications

10 25 50
publication icon
Delmans M (2018) µCube: A Framework for 3D Printable Optomechanics in Journal of Open Hardware

publication icon
Salmon M (2016) A conserved amino acid residue critical for product and substrate specificity in plant triterpene synthases. in Proceedings of the National Academy of Sciences of the United States of America

publication icon
Duncan S (2016) A method for detecting single mRNA molecules in . in Plant methods

publication icon
Delaux PM (2015) Algal ancestor of land plants was preadapted for symbiosis. in Proceedings of the National Academy of Sciences of the United States of America

publication icon
Boobier S (2017) Can human experts predict solubility better than computers? in Journal of cheminformatics

publication icon
Martins BMC (2018) Cell size control driven by the circadian clock and environment in cyanobacteria. in Proceedings of the National Academy of Sciences of the United States of America

publication icon
Rudge TJ (2016) Characterization of Intrinsic Properties of Promoters. in ACS synthetic biology

publication icon
Volpi E Silva N (2017) CRISPR-based tools for plant genome engineering in Emerging Topics in Life Sciences

publication icon
Hems ES (2018) CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins. in Chemical communications (Cambridge, England)

publication icon
Vazquez-Vilar M (2018) DNA assembly standards: Setting the low-level programming code for plant biotechnology. in Plant science : an international journal of experimental plant biology

 
Title Anxiety and Awe, a collection of poems by Norwich Scientists and Writers 
Description The 2015 NRP-UEA iGEM team worked with the Science and Writing Trust (SAW), to hold a workshop for established poets at the amazing Dragon Hall, a beautiful medieval building and home to the Norwich Writers Centre. At the workshop, we talked about our project, iGEM and bioengineering with established and published poets. We conducted writing exercises guided by the published poet, Esther Morgan in which we expressed our emotions, concerns and awe of science. This workshop resulted in a collaborative collection of poems by writers and scientists. The collection is published on our website (http://2015.igem.org/Team:NRP-UEA-Norwich/WritersWorkshop) and was presented at the iGEM Giant Jamboree, where it gained us a nomination for best communication. 
Type Of Art Creative Writing 
Year Produced 2015 
Impact The collection is published on our website (http://2015.igem.org/Team:NRP-UEA-Norwich/WritersWorkshop) and was presented at the iGEM Giant Jamboree, where it gained us a nomination for best communication. 
URL http://2015.igem.org/Team:NRP-UEA-Norwich/WritersWorkshop
 
Title Glowing oat seedlings 
Description Young oat seedling roots glow under UV due to the accumulation of the antimicrobial triterpene avenacins. Oats naturally produce avenacins exclusively within the root tip epidermal cells, which protects them from soil pathogens. Image supplied by researchers in the Osbourn laboratory at the John Innes Centre on the Norwich Research Park. 
Type Of Art Image 
Year Produced 2016 
Impact Image placed on the Norwich Research Park image library, for free sharing and dissemination. 
URL http://images.norwichresearchpark.ac.uk/imagedetails.aspx?imgid=229
 
Title Image of Nicotiana benthamiana 
Description Nicotiana benthamiana, a relative of the tobacco plant, is commonly used in plant research. Here, the leaf is used as a host organism to produce components of avenacin, a fluorescent antimicrobial produced by oat roots, which protects the roots from soil pathogens. A cluster of genes - the Sad genes - have been identified in oat as the instructions used to produce avenacin. The blue spots indicate the presence of parts of the avenacin compound introduced by inserting some of the Sad genes into the host plant. The other spots are controls to test the expression system. Image supplied by Aymeric Leveau, Osbourn laboratory. 
Type Of Art Image 
Year Produced 2015 
Impact Image placed on the Norwich Research Park Image Library, for free sharing and dissemination. 
URL http://images.norwichresearchpark.ac.uk/imagedetails.aspx?imgid=103
 
Title Nicotiana, biofoundry. 
Description An artistic interpretation inspired by plant systems for bioproduction of natural products developed with artist and designer, Karen Ingram. 
Type Of Art Artwork 
Year Produced 2018 
Impact Published as part of 'Convergent Visions' Faesthetic #15 produced in partnership with SXSW for the SXSW Art Program 2018. Presented at SXSW Interactive 2018. 
URL http://think.faesthetic.com/archives/9687
 
Title OpenMTA Video 
Description A video describing the open material transfer agreement produced by the Biobricks Foundation in collaboration and featuring interviews with OpenPlant group leaders and others. 
Type Of Art Film/Video/Animation 
Year Produced 2016 
Impact The OpenMTA has not yet been officially launched so there are so far only 71 views on youtube. 
URL https://www.youtube.com/watch?v=zt6b8_mY-i4
 
Description Key Findings

2014-2015
• Refurbishment and equipping of new OpenPlant laboratories in Cambridge and Norwich.
• Establishment of a common genetic syntax for exchange of DNA parts for plants, extensible to all eukaryotes (Patron et al., 2015; RFC106).
• Drafting of an Open Materials Transfer Agreement, a simple, standardized legal tool to enable sharing of materials and associated data on a more open basis.
• Implementation of a "single-click" OSX-installable version of the JBEIR-ICE open source DNA registry and DNA manipulation software.
• Development of routine methods for transformation and gene editing in Marchantia polymorpha.
• Development of Marchantia paleacea as a new system for engineering actinomycorrhizal associations.
• Generation of draft genome and transcriptome maps for M. polymorpha and M. paleacea.
• Characterisation of miR1157 and miR1162 precursors for use as synthetic gene regulators in Chlamydomonas reinhardtii.
• Refactoring and use of the HyperTrans system for rapid testing of DNA circuits for terpene synthesis in Nicotiana benthamiana.

2015-2016
• Commissioned advanced imaging/robotics equipment at the Cambridge OpenPlant lab.
• Completion of genome sequence and transcript map of the Cam-1 (male) and Cam-2 (female) isolates of Marchantia polymorpha. Data will be included in forthcoming publication of genome.
• High resolution map of the time course of gene expression during sporeling germination and chloroplast differentiation.
• Construction of MarpoDB, a genecentric database for mining and describing DNA parts from Marchantia (http://marpodb.io)
• Official acceptance of the common syntax for plant DNA parts as a new standard (Phytobricks) in the iGEM 2016 competition, and introduction of an award for plant work.
• Development of Phytobrick and UNS standards for efficient hierarchical assembly of DNA circuits.
• Expansion of a Chlamydomonas DNA toolkit for target gene expression and assay of miRNA-dependent gene silencing.
• Development of a suite of Cas9 variants and toolkit for targeted mutagenesis and gene deletion in multiple plant species.
• Construction of series of vectors for fine tuning of protein expression using HyperTrans system
• Methods for mining plant genomes for biosynthetic gene clusters
• Design and synthesis of an artificial protein scaffold library, built to the Phytobrick standard and verified by BiFC.
• Production of cell-specific epitope tags for identifying DNA motifs that drive gene expression in photosynthetic tissues in Arabidopsis.
• Publication of a novel reporter for chloroplast transformation, and identification of transit peptides for chloroplast localisation of nuclear encoded products in Marchantia.
• Identification of a large repertoire of carbohydrate active enzymes in Euglena gracilis.
• Transformation of gene editing constructs into potato, to create digestion-resistant starches, and preliminary screening of transformed plantlets.
• Gram-scale production of triterpenes for analysis and assay, using the HyperTrans system.
• Production of the plant-derived iridoid alkaloid strictosidine in yeast.
• Generation of a trichome-specific protein database for enzyme discovery.
• Asteraceae P450 proteins as a toolkit for targeted modification of sesquiterpenes.
• Development of the HyperTrans system for use in tomato.
• Screening tomato introgression lines for regulators of monoterpene biosynthesis.
• Yeast one-hybrid analysis for the identification of transcription factors that regulate triterpene metabolic gene clusters.
• Characterisation of gene targets for AtMYB12 and SIMYB12 in tomato, for enhancing phenylpropanoid metabolism and high levels of resveratrol and genistin production.
• Construction of a synthetic gene cluster for dhurrin biosynthesis in Arabidopsis roots.
• Construction and distribution of HyperTrans DNA vectors that are compatible with the Phytobrick standard.
• Testing of the HyperTrans system in Marchantia and BY2 cells.
• Consultation on the design of the Norwich Research Park LeafSystems high throughput production facility, due for completion in Q2 2017.

2016-2017
• Consolidation of the Phytobrick standard for Type IIS based DNA parts for plants, including acceptance as first standard for eukaryotic DNA parts, and introduction of the Plant Prize in iGEM 2016.
• Design, domestication and synthesis of the first 500 DNA parts for Marchantia (Susana Sauret-Gueto, Haseloff lab).
• Establishment of the Loop assembly technique first presented at the iGEM2016 Jamboree (Bernardo Pollak & Fernan Federici, Haseloff lab).
• Automation of Loop assembly at 500nL scale using Labcyte acoustic focusing and Hamilton robots at Earlham Institute (Patron lab, A. Hall lab & Haseloff lab).
• Established an automated assembly and transient expression workflow for assessing Cas9-mediated targeted mutagenesis using plant protoplasts and Illumina MiSeq sequencing (Oleg Raitskin, Patron Lab).
• Validated an expanded molecular toolkit in the plant common syntax of Cpf1- and Cas9- variants showing improved specificity in plant protoplasts (Raitskin, Patron Lab).
• Established methods for direct delivery of a ribonuclease complex (Cas9:YFP recombinant protein & guide RNA) for induction of targeted mutagenesis in protoplasts of N. tabacum, N. benthamiana & S. tuberosum (Raitskin, Patron Lab).
• Developed S. elongatus constructs for examining the circadian clock and its outputs at the single cell level, and published frequency doubling model of the clock in Molecular Systems Biology (Bruno Martins, Locke lab).
• Circadian clock model made available in SBML format (Martins, Locke lab).
• Validated the use of fluorescent protein based reporter for evaluating miRNA mediated gene silencing in Chlamydomonas (Francisco Navarro, Baulcombe lab).
• Optimised miRNA abundance, extent of sequence complementarity and target sites for gene silencing in Chlamydomonas (Navarro, Baulcombe lab).
• Constructing synthetic genetic circuits with miRNA mediated incoherent feed-forward loop to confer robust levels of gene expression (Navarro, Baulcombe lab).
• Constructing DNA parts, in accordance with the common syntax, to contribute to a Chlamydomonas MoClo toolkit (Baulcombe and Smith labs).
• Synthesis of a panel of codon optimised fluorescent reporters spanning the visual spectrum, including five variants of the fluorescent reporters: iRFP670, mCardinal, mPlum, mCerulean, mNeptune, mRaspberry, mTurquoise, mWasabi, eBFP, Sirius and TagCFP, all modified for chloroplast expression (Ajioka lab).
• The Marchantia chloroplast genome has been re-annotated. Missing ORFs have been identified, partial annotations have been completed and likely promoter sites identified throughout the chloroplast genome using BPROM (Ajioka lab).
• CRISPR-Cas9 mediated gene KO to produce "giant chloroplast" phenotypes in Marchantia, (Male, Pollak, Sauret-Gueto, Silvestri in Haseloff lab).
• Established reproducible colonisation of several liverwort species (Marchantia spp., Lunularia cruciata) with Glomeromycota fungi (Funnelliformis mossae, Rhizophagus irregularis) in custom vermiculite system and detection using staining and high resolution confocal fluorescence microscopy (Philip Carella, Schornack lab).
• Established constructs for secretion system pathway and tonoplast labelling and have confirmed functionality in M. polymorpha (Carella, Schornack lab).
• Enhancer trap screen underway in Haseloff lab (Tomaselli, Sauret-Gueto & Silvestri.
• In planta cytometry techniques developed in Marchantia gemma (Pollak & Delmans, Haseloff lab).
• Developed clearing techniques for image reconstruction of Marchantia air chambers (Marta Tomaselli, Haseloff lab) .
• Built ubiquitin-tagged rapid-turnover fluorescent markers for imaging dynamic genetic responses (Lukas Mueller, Webb-Haseloff labs).
• New synthetic version of the 5' UTR used in HyperTrans system has been shown to be twice as effective as the original HT sequence (Hadrian Peyret, Lomonossoff lab).
• Developed a new vector system (pEFF) which combines the high translational benefits of the CPMV-HT system with the replication ability of potato virus X, in collaboration with the Centre for Bioengineering at the Russian Academy of Sciences (Lomonossoff lab).
• Characterised promoter elements that drive specific expression in leaves, and a negative regulator that represses expression in mesophyll and veinal cells (Hibberd lab).
• Compiled a list of transcription factors preferentially expressed in bundle sheath cells of Arabidopsis, including cognate TF for above-mentioned promoter element (Hibberd lab).
• Heterologous xylan arabinosyltransferases have been cloned in Arabidopsis lines using common syntax rules (Henry Temple & Louis Wilson, Dupree lab).
• Testing the enzymatic activities of arabinosyltransferases using N. benthamiana transient expression with the HyperTrans vector system (Temple & Wilson, Dupree lab).
• Exploring artificial in vitro metabolic cycles driving production of glucose-based oligosaccharides from cheap and readily available sucrose by using sucrose phosphorylase and glucan phosphorylases (Field lab).
• Applying and testing the genome editing tools and technologies developed in the Patron lab to generate potatoes that contain digestion-resistant starches with potential nutritional benefits (Aytug Tuncel, Smith lab, JIC).
• Developed methods to transform and engineer protoplasts directly isolated from potato leaves (Tuncel & Raitskin, Smith and Patron labs).
• Mined transcriptome of Euglena gracilis for metabolic carbohydrate metabolism and natural product biochemistry and released in the CAZy database (Field lab).
• Collaborated with Medema lab (Wageningen) to release plantiSMASH, a customised algorithm for mining plant genomes for biosynthetic gene clusters (Kautsar et al. 2017; Osbourn lab).
• Improved agro-infiltration methodology for production of triterpenes using the HyperTrans transient plant expression system, leading to gram-scale production of the triterpene scaffold, ß-amyrin (Reed et al., 2017; Osbourn lab).
• Identified genes that modulate stereochemistry of the iridoid ring system, with potential for compounds with important agrichemical activity (Benjamin Lichman, O'Connor lab.
• Blocking turnover of L-DOPA production in beetroot to enable low-tech plant sourced bioproduction for Parkinson's treatment (Noam Chayut, Martin lab)
• Engineered enzymes from the Asteraceae family into yeast to generate oxygenated sesquiterpenes (Nguyen et al., 2016; Don Nguyen, ex O'Maille lab).
• Investigating three-dimensional positioning of biosynthetic gene clusters in the A. thaliana genome using Hi-C mapping and FISH analysis (Hans Nützmann, Osbourn lab)
• Yeast-one-hybrid assays have been used to identify a candidate transcription factor for a biosynthetic gene cluster from oat (the avenacin cluster; Osbourn lab).
• Nine promoters have been isolated from the oat avenacin cluster that retain root-specific expression patterns in a wide range of plants (Aymeric Leveau, Osbourn lab).
• Three of these oat promoters have been used to drive the expression of a 3 gene pathway for a plant defence compound (dhurrin) from sorghum in Arabidopsis roots (Osbourn lab).
• Produced synthetic virus-like particles (VLPs) to enable the structure of particles of potato leafroll virus to be solved to near atomic resolution (Lomonossoff lab).

2017-2018
• Publication of quantitative microscale work showing intercellular adhesion promotes clonal mixing in growing bacterial populations.
• Development of microfluidic vessels for quantitative observation of cyanobacteria.
• Droplet-based microfluidic analysis and screening of single plant cells.
• Construction of an improved generation of Loop Assembly-compatible transformation vectors for plants.
• Establishment of efficient chloroplast transformation techniques in Marchantia.
• Use of multispectral markers with in planta cytometry, to allow segmentation of cell geometries and quantitative assignment of biological parameters on a cell-by-cell basis.
• Publication of the genome sequence and transcriptome datasets for Marchantia.
• Publication of revision 4.0 of MarpoDB
• Synthesis of an almost complete collection (350/398) of proximal promoters for transcription factors in Marchantia.
• Collection of single-cell transcriptomic data from germinating gemma.
• Launch of the OpenMTA license with a published commentary in Nature Biotechnology 36:923-927, 2018.
• Screening of cell and tissue type specific expression lines from enhancer trap transformants.
• Development of a novel system for "resetting" Marchantia development by surgically dissecting gemma.
• Miniaturisation and automation of efficient DNA Loop Assembly reactions using nanolitre scale handling.
• Integration of Benchling as a free web-based solution for online lab notebooks, sequence editor and inventory handler.
• Use of Benchling as a DNA registry and for protocol sharing across OpenPlant.
• Construction of optimised genetic circuits as reporters for circadian clock output.
• Identification of a number of putative electrically regulated promoters in cyanobacteria.
• Characterisation of improved biophotovoltaic vessels and chassis strains.
• Construction and publication of a MoClo kit, consisting in a set of Golden Gate-domesticated DNA parts, for the green alga Chlamydomonas reinhardtii.
• High-throughput workflow to analyse conditional behavior of riboswitches in vivo.
• MoClo parts for transformation of the chloroplast genome of C. reinhardtii.
• Establishment of protocols to allow chloroplast transformation by electroporation in Chlamydomonas.
• Regulation of chloroplast gene expression via TPR/PPR proteins encoded by the nucleus in Chlamydomonas.
• Sequencing and reannotation of the chloroplast genome from the Cambridge isolates of M. polymorpha.
• Construction of a new generation of Loop Assembly vectors for plastid transformation in Marchantia.
• Optimisation of biolistic delivery protocols for high efficiency plastid transformation in Marchantia.
• Generation of ftsz1 and ftsz2 mutant plant lines that produce fewer and larger plastids per cell.
• Development of techniques and novel vector systems for RNA-guided Cas9-mediated targeted mutagenesis and gene deletion in plant species (Nicotiana, Arabidopsis, Marchantia).
• Automated construct assembly and delivery to plant protoplasts to enable rapid quantitative assessments of the efficiency and specificity of gene editing.
• Development of software-based 3-parameter measurement techniques for quantifying gene expression in cell suspensions to minimise extrinsic noise
• Publication of a computational framework for automated analysis of microplate reader data.
• Construction of models for the coupling of the cyanobacterial clock and control of period and cell growth.
• Development of software-based classification schemes for description of gene expression at the cellular scale in Marchantia gemmae.
• Maintenance and upgrades for the CellModeller software package, to include cell-cell adhesion and cell shape.
• Publication of algorithms for whole colony-scale segmentation from confocal microscopy datasets of growing microbes.
• Identification and functional characterisation of DNA parts for natural product synthesis.
• Employment of genomic neighbourhood associations to identify triterpene-scaffolding genes with tailoring cytochrome P450s and acyltransferases.
• Improvement of agro-infiltration methodology for gram-scale production of triterpenes using the HyperTrans transient plant expression system.
• Publication of the improved infiltration protocol in text and video format.
• In silico identification of new CYP450s with different oxidizing specificities.
• Identification of new building blocks for biosynthesis of iridoids.
• Discovery of neofunctionalisation of a short chain alcohol dehydrogenase (SDR) with a non-redox role in controlling the stereochemical course of ring cyclization during iridoid synthesis.
• Blocked the turnover of L-DOPA in beetroot, using CRISPR/Cas9-mediated genome editing, to enable low-tech accessible production in a plant system.
• Development of a novel suspension culture production system that produces exceptionally high levels of anthocyanins.
• Over-expression of the Rosea1 and Delila transcription factors to produce multiply-acylated blue anthocyanins.
• Activation of the anthocyanin biosynthetic pathway in cultures of Arabidopsis thaliana to produce diacylated cyanidin with a blue colour at neutral pH.
• Identification and characterisation of transcription factors for control of natural product production.
• Use of protocols for chromosome conformation capture and FISH analysis to investigate the three-dimensional positioning of biosynthetic gene clusters in the nucleus of Arabidopsis thaliana.
• Identification of candidate transcription factors that regulate promoters of metabolic gene clusters including central pathway clusters and the avenacin pathway .
• Use of a truncated version of the bHLH transcription factor Delila along with Rosea1 to fine-tune anthocyanin production for increased yield.
• Testing of nine promoters from the oat avenacin cluster to demonstrate retention of characteristic expression patterns when introduced into diverse plant species as promoter-reporter constructs.
• Three promoters from the oat avenacin cluster were used to successfully drive the expression of a three-gene pathway for a plant defence compound (dhurrin) from sorghum in Arabidopsis thaliana roots.
• Development of robust methods for co-cultivation of Marchantia spp. with Glomeromycota fungi and visualisation of colonization.
• Development of a high-throughput transformation system for Marchantia paleacea, with marker systems for labelling the secretory system and tonoplast.
• Establishment of reproducible colonisation of several liverwort species (Marchantia spp., Lunularia cruciata) with Glomeromycota fungi (Funnelliformis mossae, Rhizophagus irregularis).
• Measurement of the Marchantia transcriptome in response to filamentous pathogen colonisation to identify a set of genes strongly upregulated during defense.
• Identification of the MYB14 transcription factor that produces a red pigment in cells, useful for sector analysis.
• Production of a draft genome sequence for M. paleacea using paired end libraries and illumina sequencing.
• The three main symbiosis TFs in (IPD3, NSP1 and NSP2) in M. paleacea were tested in complementation assays in Medicago mutants.
• Integration of Marchantia as a model system in the Bill and Melinda Gates Foundation Engineering Nitrogen Symbiosis for Africa project, which was recently awarded Phase 2 funding.
• Analysis of transcriptome data to indicate that a Marchantia syntaxin (SYP13B) whose legume ortholog is implicated in nitrogen fixing symbiosis may also play a role in intracellular colonisation by an oomycete pathogen.
• Development of new Hyper-Trans vectors to enable fine-tuning of protein expression levels by making changes in the 5'- and 3'-UTRs of the CPMV-HT system
• Construction of modified components of the CPMV-HT system that are compatible with the OpenPlant plant common syntax.
• Development of a new synthetic version of the 5' UTR used in the HT system, which is twice as effective as the original.
• Two new vectors (pHRE and pHREAC) have been finalised and are ready for distribution.
• In collaboration with the Centre for Bioengineering at the Russian Academy of Sciences (CB-RAS), a new vector system (pEFF) has been developed a new which combines the high translational benefits of the CPMV-HT system with the replication ability of potato virus X (PVX).
• The CPMV-HT system has been translated to the BY2 cell pack system, and is also being used in tomatoes and tested in Marchantia.
• Successful expression of a protein from Theileria parva (causal agent of East Coast Fever, a veterinary disease in Sub-Saharan Africa) which has been difficult to express in other systems.
Exploitation Route The key findings of the OpenPlant initiative have been in the areas of open technologies fro plant synthetic biology, and interdisciplinary exchange and responsible innovation for improvement of sustainable agriculture and conservation. These are enabling:

1. The latest generation of cell-free expression systems provide DNA programmable outputs from GMO-free components lyophilised on paper. This allows sophisticated experiments in low resource settings - simple to run, no requirement for refrigeration, no need for autoclaving. We have assembled a team of top scientists, educators and international development specialists in order to develop modular, open curriculum materials.
2. We have had expressions of interest from Australia and South Africa to adopt the Biomaker Challenge and explore open curriculum development. We are planning to introduce cell-free programmable systems in 2018, as well as DIY instrumentation, and document projects at www.hackster.io/biomaker to reach a much wider audience (>300,000).
3. OpenPlant Forum provides a forum for technical exchange with a theme of engineering for bioproduction in plants, and we continue to provide new tools for mis-expression and DNA editing of transcription networks in plants. This is in line with our interest in identifying a wider range of regulatory genes that can be used as effectors for reprogramming plant development and metabolism. We are taking a systematic approach to analysis of all transcription factors (398) in Marchantia polymorpha.
4. Chloroplasts are major sites for metabolic flux and biosynthesis in plants with a small genome (70-220 Kb). Chloroplast transformation and can result in hyperproduction of proteins, sometimes accumulating to a level of more than 50% of soluble protein in the plant. We have commenced the development of an engineering platform for building and testing synthetic chloroplast genomes in Marchantia.
5. The pending influx of thousands of new plant genome sequences provides an opportunity for efficient identification of metabolic enzymes and regulatory elements by bioinformatics. This will provide a toolbox for engineering the bioproduction of new high value products.
6. HyperTrans in planta expression and Cas9-mediated genome surgery will continue to undergo rapid development, especially as tools for testing gene circuits and introducing engineered traits into crop species.
7. Transient plant expression technology is proving to be a rapid and powerful means of prototyping candidate plant natural product biosynthetic genes and pathways predicted on the basis of genomics.  Building on our success to date, we are developing this platform in order to be able to systematically access 'designer' molecules and analogs for specific applications at preparative scale.
8. The simple genome and exposed nature of Marchantia development allows the prospect of assembling complete digital models of the simple plant. Whole organism models would bring together the genetic, physical and chemical processes of growth, at different scales. While an ambitious goal, even partial models would prove useful as testbeds for engineering experiments.
Sectors Agriculture, Food and Drink,Chemicals,Education,Energy,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology

URL https://www.openplant.org
 
Description 2014-2015 • Funding of 16 mini-grants that incorporate broad interdisciplinarity and collaboration between Cambridge and Norwich - including hardware, wetware development and support for collaboration between OpenPlant and African scientists. • Support for a joint Cambridge-JIC iGEM2015 team in the Hardware Track. • Support for a Synbio Beta Activate event in Cambridge, to promote entrepreneurial interactions. • Organisation of the OpenPlant Forum and international exchange. • Delivery of two summer schools on Plant Synthetic Biology and CRISPR Technology in Plants, co-sponsored by ERA-SynBio and Plant Methods/GarNET, respectively. • Delivery of three Science, Art and Writing educational workshops, and two school outreach events. 2015-2016 • Funded of 30 mini-grants that incorporate broad interdisciplinarity and collaboration between Cambridge and Norwich, including projects for SynBio training and capacity building in Africa and resources for schools and universities in South America. • Cambridge-JIC iGEM2015 team won a gold medal at the international Jamboree, with a hardware project entitled "OpenScope". • Support for a joint Cambridge-JIC iGEM2016 undergraduate team with a plant-based project: chloroplast engineering in Chlamydomonas. Obtained co-sponsorship from Cambridge Consultants and Wellcome Trust/BBSRC/SEB fund. • Developing collaborative projects through the Virtual Institute of Responsible Innovation. • OpenPlant researchers contribute to a Bioengineering Horizon Scanning Exercise run by CSER. Workshop in November 2016. Outcomes will be published in a co-authored paper. • Responsible and Open Innovation workshop with Dr. Kathy Liddell, Law Faculty, Cambridge. • OpenPlant continues to work with international IP working group and collaborate with the Biobricks Foundation to implement OpenMTA and facilitate exchange of DNA parts. • OpenPlant participated in the inaugural meeting of BioNet group at Asilomar and supports an open technology platform for exchange and tracking of biomaterials (http://www.bionet.io). • OpenPlant is supporting a workshop on 'Genetic Resources in the Age of the Nagoya Protocol and gene/genome synthesis' in November 2016 (led by Dominic Berry, Edinburgh). • Organised OpenPlant All Hands meeting for scientific exchange, Newmarket. • Participated in Open Technology for Biology workshop, Chile. • OpenTechnology Week events in Cambridge, including Technology for the Bottom Billion workshop and Makethon, coordinated with the Centre for Global Equality. • Workshops on ethics and openness, outreach for OpenPlant scientists with the SAW Trust, and BBSRC Media Training (March 2016). Also ran joint training workshops and provided support for synthetic biology outreach activities at Edinburgh SBRC. • Showcased OpenPlant science in interactive exhibits and workshops at festivals and schools workshops, including Latitude Festival (Suffolk; July 2016). • Nineteen graduate students are participating in projects funded by the OpenPlant Fund. Three PhD students have been recruited directly to OpenPlant (Cambridge) this year. • Undergraduates have formed a student society for Synthetic Biology at the University of Cambridge (http://cusbs.soc.srcf.net) with OpenPlant support. • Students and postdocs at OpenPlant institutes are being recruited to share projects, resources and equipment, through ROC, a group of self organised, highly effective junior researchers 2016-2017 • Outreach and Responsible Innovation • Revision and launch of new OpenPlant branding and website (Jan 2017). • Launched new website, www.biomaker.org, to promote SynBio SRI, OpenPlant Fund and Biomaker Challenge projects (Jun 2017). • OpenPlant organised and participated in a wide range of workshops over the last year: • Training workshop on LithographX for plant image analysis, organised by Haseloff group, delivered by software developer, Dr Pierre Barbier de Reuille (Cambridge, Aug 2016) • Training workshop on the BY2 cell pack system ("cookies"; developed by Fraunhofer Institute, Aachen, Germany), run by the Lomonossoff group (Norwich, Jul 2016). • Delivered two cell-free expression workshops with Vincent Noireaux (2016) and Keith Pardee (2017). • Established a working group to develop new, open curriculum materials based on cell-free and other fast and frugal technologies (Jul 2017) • Presented at standards & responsible governance (PAGIT) workshop (London, Mar 2017) • OpenPlant & Earham DNA Foundry co-sponsored a BBSRC-GCRF funded workshop (S. Africa, Feb 2017). Produced report on capacity building for future bioeconomy in Africa. • Participation in working group on Plant Genetic Resources and Sustainable Development Goals: Needs, Rights and Opportunities (Rockerfeller Foundation, Bellagio Center, Nov 2016). Report was submitted to Plant Genetic Resources in Food and Agriculture Treaty. • Workshop on Genetic resources in the age of the Nagoya Protocol and gene/genome synthesis, with Edinburgh University Engineering Life Project (Cambridge, Nov 2016). • Public SAW workshop "the Global Garden" run as a collaboration between OpenPlant, the SAW Trust, social scientist Dr Nick Lee (WISB) and the Writers Centre Norwich. • Presentation on SynBio and Nagoya Protocol at HVCfP workshop (London, Jan 2017). • CSER Biorisk workshop (Cambridge, Mar 2017). • Talk and discussion panel at Kew Garden's "State of the World's Plants" Symposium. • Outreach and public engagement activities: • Delivered two SAW workshops to disseminate the SAW model and share best practice with SynthSys & UK Centre for Mammalian Synthetic Biology (University of Edinburgh). • Norwich Science Festival (Oct 2016): Two-day OpenPlant Exhibit; talk on 'The green vaccine machine' (Lomonossoff). • Youth STEMM Award Mid-Year Conference OpenPlant Exhibit for yrs 9 + 10 (Jan 2017). • Talks on 'Finding drugs in the garden' (Osbourn), 'Just Eat Your Greens - A New Way of Vaccinating?' (Lomonossoff) and '20,000 Leagues Under the Microscope: Viruses & Nanomachines' (Castells-Graells) at Norwich Pint of Science Festival (May 2017). • The SAW Trust delivered four workshops in primary schools inspired by the work of the Lomonossoff lab, Osbourn lab, biodiversity, plant evolution and genetics. • Secured funding to build DNA robot for Cambridge Science Festival as part of OpenPlant exhibit "Synthetic Biology for the Senses" (Matthewman & Jenni Rant, SAW, Mar 2017). • OpenPlant and SAW teamed up to deliver a science tent for exploration of plant natural products in "Marvellous Medicines" at Boomtown festival (Aug 2017). • Open tools and technologies • The OpenPlant Fund supported £5K mini-projects: 14 in July 2016, 10 in Dec 2016, and 12 new proposals to be pitched in Jul 2017. • Establishment of the Biomaker Challenge: 41 £1K micro-projects to promote interdisciplinary exchange in Cambridge and Norwich. • Supporting development of Biomakespace in old MRC Laboratory of Molecular Biology Building under leadership of Dr. Jenny Molloy, due to open 2017. • Established Norwich Biomakers network: https://www.meetup.com/Norwich-Biomakers/ • Supported and contributed to the OpenMTA initiative: website at http://www.openmta.org/ which includes simple text and video descriptions of the OpenMTA • Cambridge-JIC iGEM 2016 team was awarded a gold medal and was winner of the Best Plant Synthetic Biology prize at the iGEM Giant Jamboree, Boston. • Dr Nicola Patron awarded catalyst grant by SynBioLEAP to pursue making open-source enabling technologies for plant biotechnology available to less-developed world regions • OpenPlant Fund project "Big Algae Open Experiment" (http://bigalgae.com/) joined the OpenPlant stand at Latitude Festival (Jul 2016). • Roger Castells-Graells (PhD student, JIC), won a UEA Engagement Award in recognition of his work on OpenPlant Fund project "Accessible 3D Models of Molecules". • Supported open source hardware documentation and repository: www.DocuBricks.com 2017-2018 • Jenny Molloy awarded Shuttleworth Fellowship to explore impact of open technologies on innovation in biology at an international scale. • The OpenPlant Fund has funded 19 new projects over the last year, to bring the total to 71 interdisciplinary and cross-institute projects. • Organisation of cell-free hands-on workshops to encourage the development of cell-free technologies through the OpenPlant Fund • Initiated two projects working with African researchers, with JR Biotek Foundation Workshop in Cambridge, attended by 20 African researchers from 8 different countries and culminating in the UK-Africa Food Security Symposium, and working with the Kumasi Hive and Lab_13 project in Ghana to develop resources for teaching synthetic biology in low-resource settings. • Organised the second annual Biomaker Challenge for interdisciplinary teams to build low-cost instruments for biology. In two years, we have funded 61 projects involving close to 200 participants from Cambridge, Norwich and beyond. • Implementation of a 5-session training series aimed at teaching basic hardware and software for scientists. • Adopted the visual programming interface XOD to tackled some of the bottlenecks and difficulties that non-programmers face when building electronics. • Publication of tutorial material at www.biomaker.org. • Establishment of the Norwich Biomakers group to bring together an interdisciplinary network interested in biology, design, technology, engineering, electronics, software, art and more - to gain a membership of 180 members in the first year. • Ran ten Norwich Biomaker sessions over the first year. The network has led to several new collaborations. • The 2018 OpenPlant Forum focused on engineering plants for bioproduction, and explored a range of examples of products that can be made in plants, tools for engineering for bioproduction and both the global challenges and opportunities for harnessing biodiversity. • The Forum was coupled with the OpenPlant Fund pitches, and a Curriculum Hacks event showcasing educational activities and resources developed through OpenPlant Fund and Biomaker Challenge projects, as well as by partners such as Science and Plants for Schools (SAPS), Cambridge Biomakespace, and the University of East Anglia. • A new working group was established to investigate new models for documentation, distribution and publication by bioengineers - in particular focusing on documentation and distribution of characterisation data for DNA parts. • We have delivered seven OpenPlant-themed workshops in primary schools, designed and delivered by research scientists in collaboration with the SAW Trust. • We have engaged with the public by delivering interactive exhibits at the Norwich Science Festival and Cambridge Science Festival, and delivered science activities at Kidztown at the Boomtown Fair music festival and Latitude mixed arts Festival. • SAW developed training workshops to enable dissemination and to share best practice with other research centres, SynthSys and the UK Centre for Mammalian Synthetic Biology (University of Edinburgh), and the Warwick Integrative Synthetic Biology Centre. • An International conference established by the SAW Trust in collaboration with Norfolk County Council brought together education specialists from across the world locally and internationally to share learning platforms and develop ideas, at which SAW presented its school projects with OpenPlant. • Ran the Global Garden workshop, a collaborative project with the SAW Trust and Social Scientist Dr Nick Lee (Warwick Integrative Synthetic Biology Centre). • Secured funding from the Biochemical Society to create and exhibit a machine that explains the processes of transcription and translation in a fun and interactive way - DNA Dave the robot.
First Year Of Impact 2014
Sector Agriculture, Food and Drink,Education,Environment,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology
Impact Types Societal,Policy & public services

 
Description Attendance at Department for International Trade meeting
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
Impact Development of export opportunities
 
Description BBSRC IBBE Strategy Panel
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
Impact The Strategic panel provided advice and guidance for the setting up of the Networks in Industrial Biotechnology & Bioenergy (NIBBs), which aim to foster increased awareness and interaction between academics and industrialists in the bioeconomy. It was also important for the thinking behind the IB Catalysts, joint with Innovate UK & EPSRC. Many of the grants and proof-of-concept awards are aimed at increased sustainability through the use of IB solutions
URL http://www.bbsrc.ac.uk/funding/filter/networks-in-industrial-biotechnology/
 
Description Engagement with All-Party Parliamentary Group on Agriculture and Food for Development: Implications of the 2018 European Court of Justice ruling on genome editing
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Engagement with the Parliamentary Scientific Committee: implications of the 2018 European Court of Justice ruling on Genome Editing
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Expert member of the plant synthetic biology working group for the European Food Standards Agency (EFSA)
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
 
Description Invited submission to the ad hoc technical expert group (AHTEG) on digital sequence information on genetic resources of the the Convention on Biological Diversity
Geographic Reach Multiple continents/international 
Policy Influence Type Gave evidence to a government review
URL https://www.cbd.int/abs/dsi-gr/ahteg.shtml#submissions
 
Description Nuffield Council on Bioethics: A workshop to discuss "The Culture of Research in the UK"
Geographic Reach National 
Policy Influence Type Participation in a national consultation
URL http://nuffieldbioethics.org
 
Description Plant bioengineering and global climate change summit
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Science and Technology Committee, House of Commons - implications to the UK of the 2018 Euporean Court of Justice ruling on Genome Editing
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Scientific Advisor to Synthetic Biology Project, Woodrow Wilson Institute, Washington DC, USA
Geographic Reach North America 
Policy Influence Type Participation in a advisory committee
URL http://www.synbioproject.org
 
Description Submission to the International Treaty on Plant Genetic Resources for Food and Agriculture ( ITPGRFA) on access and benefit sharing of digital sequence information
Geographic Reach Multiple continents/international 
Policy Influence Type Gave evidence to a government review
 
Description Agri-Inno: Stimulating Innovation and Entrepreneurship in Egypt's Agricultural Sector
Amount £28,520 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2017 
End 01/2017
 
Description BBSRC GCRF IAA
Amount £9,500 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 11/2016 
End 03/2017
 
Description BBSRC High Value Chemical from Plants Network Proof of Concept Funds
Amount £57,099 (GBP)
Funding ID POC-OCT15-03 (OSBOURN) 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2016 
End 11/2016
 
Description BBSRC Responsive Mode
Amount £459,425 (GBP)
Funding ID BB/P010490/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2017 
End 09/2020
 
Description BTT EAGER - Breakthrough Technologies to Advance Crop Breeding
Amount £400,000 (GBP)
Funding ID BB/S020853/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 03/2019 
End 02/2021
 
Description Bio-cosmetics from Lithops
Amount £5,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 09/2015 
End 03/2016
 
Description Bio-engineering non-sugar modifications of saponins - BBSRC CTP studentship
Amount £41,000 (GBP)
Funding ID BB/R505584/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 11/2017 
End 10/2021
 
Description Bioinformatics and Biological Resources (BBR) Fund
Amount £603,560 (GBP)
Funding ID BBS/E/T/000GP076 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 09/2016 
End 03/2017
 
Description Business Interaction Voucher
Amount £10,000 (GBP)
Funding ID PHYCBIV-23 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Department Networks in Industrial Biotechnology and Bioenergy (NIBB)
Sector Academic/University
Country United Kingdom
Start 04/2018 
End 10/2018
 
Description EPSRC GCRF Diagnostics, Prosthetics and Orthotics
Amount £1,541,002 (GBP)
Funding ID EP/R014000/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 02/2018 
End 02/2021
 
Description ERA CoBioTech
Amount € 1,643,000 (EUR)
Funding ID BB/021554/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 04/2018 
End 03/2021
 
Description Engineering saponin surfactants
Amount £71,590 (GBP)
Organisation Unilever 
Sector Private
Country United Kingdom
Start 07/2018 
End 06/2019
 
Description Follow on Fund Innovation Fellow Funds - PI Anne Osbourn
Amount £20,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 04/2018 
End 05/2020
 
Description GCRF Pump-priming Fund
Amount £80,000 (GBP)
Organisation University of Cambridge 
Sector Academic/University
Country United Kingdom
Start 12/2018 
End 07/2019
 
Description Genome to Natural Products Network Award
Amount £5,500,000 (GBP)
Funding ID U101GM110699 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 08/2015 
End 04/2020
 
Description H2020 Grant: Building the product pipeline for commercial demonstration of plant molecular factories
Amount £631,808 (GBP)
Funding ID 774078 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 11/2017 
End 10/2021
 
Description Implementing Algebra guidelines to risk assessments of scale-up of non-native species
Amount £9,500 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 05/2017 
End 10/2017
 
Description Institute Strategic Funds: Starch analysis on high-amylose potatoes
Amount £5,316 (GBP)
Organisation John Innes Centre 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2018 
End 03/2018
 
Description LCVD: Low-cost Cell-extract Viral Diagnostics
Amount £1,800,000 (GBP)
Funding ID EP/R014000/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 02/2018 
End 01/2021
 
Description Metabolic characteristics of terrestrial algae and plants in Antarctica - research visit to Antarctica
Amount £74,000 (GBP)
Organisation British Antarctic Survey 
Sector Academic/University
Country United Kingdom
Start 05/2014 
End 03/2015
 
Description NRP DTP
Amount £120,000 (GBP)
Funding ID MARTIN_J18DTP: Natural blues: structure meets function in plant natural products 
Organisation Norwich Research Park 
Sector Private
Country United Kingdom
Start 10/2018 
End 09/2022
 
Description Norwich Research Park Translational Fund
Amount £51,119 (GBP)
Funding ID REF 3.1 - Novel commercial saponins from synthetic biology 
Organisation Norwich Research Park 
Sector Private
Country United Kingdom
Start 07/2015 
End 06/2016
 
Description OpenPlant-Earham Foundry GCRF Workshop for Practical Synthetic Biology in Africa
Amount £39,250 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 11/2016 
End 03/2017
 
Description Playground to Polar - how do we measure Antarctic and UK biodiversity?
Amount £3,000 (GBP)
Organisation The Royal Society 
Sector Academic/University
Country United Kingdom
Start 11/2017 
End 06/2018
 
Description Regulation of polyphosphate metabolism in Chlamydomonas and potential for exploitation as phosphorus sink in nutrient recovery systems
Amount £65,772 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2016 
End 10/2019
 
Description Research Fellows Enhancement Award: Early Land Plant mechanisms to accommodate filamentous microbes - Sebastian Schornack
Amount £92,500 (GBP)
Funding ID RGF\EA\180002 
Organisation The Royal Society 
Sector Academic/University
Country United Kingdom
Start 12/2017 
End 12/2020
 
Description Responsive Mode: Exploiting the power of heterologous expression in plants to discover new virus structures
Amount £563,036 (GBP)
Funding ID BB/R00160X/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2017 
End 09/2020
 
Description Science Outreach Grant: The Transcription-Translation Machine
Amount £940 (GBP)
Organisation Biochemical Society 
Sector Learned Society
Country United Kingdom
Start 12/2016 
End 03/2017
 
Description Shuttleworth Fellowship
Amount $261,000 (USD)
Organisation Shuttleworth Foundation 
Sector Charity/Non Profit
Country South Africa
Start 03/2018 
End 03/2019
 
Description Strategic Research Initiative for Synthetic Biology
Amount £150,000 (GBP)
Organisation University of Cambridge 
Sector Academic/University
Country United Kingdom
Start 10/2013 
End 10/2016
 
Description Super Follow on Fund: Engineering Quillaja saponin biosynthesis pathways for bio-production of QS-21. 2018-2020 - Prof Anne Osbourn
Amount £1,538,805 (GBP)
Funding ID BB/R005508/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 04/2018 
End 05/2020
 
Description Syngenta
Amount £71,000 (GBP)
Organisation Syngenta International AG 
Department Syngenta Ltd (Bracknell)
Sector Private
Country United Kingdom
Start 01/2016 
End 12/2019
 
Description Synthetic Biology Strategic Research Initiative
Amount £165,000 (GBP)
Organisation University of Cambridge 
Sector Academic/University
Country United Kingdom
Start 11/2016 
End 10/2019
 
Description Synthetic Biology Strategic Research Initiative 2016-2019
Amount £165,000 (GBP)
Organisation University of Cambridge 
Sector Academic/University
Country United Kingdom
Start 10/2016 
End 09/2019
 
Description Targeted gene knockouts in crops using RNA-guided Cas9 nuclease
Amount £603,560 (GBP)
Funding ID BB/N019466/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 09/2016 
End 08/2019
 
Description UK Vaccine Network Project
Amount £1,988,841 (GBP)
Funding ID 16-107-04 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 11/2016 
End 08/2018
 
Description UKVRDN Grant
Amount £1,988,841 (GBP)
Funding ID GHR Project:16/107/04 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 11/2016 
End 08/2018
 
Description Undiscovered High Value Products from Polar Algae.
Amount £19,961 (GBP)
Organisation Unilever 
Sector Private
Country United Kingdom
Start 09/2014 
End 03/2015
 
Description University of Cambridge Centre for Research in Arts, Social Sciences and Humanities Faculty Research Group Award
Amount £1,500 (GBP)
Organisation Andrew W. Mellon Foundation 
Sector Private
Country United States
Start 09/2017 
End 09/2018
 
Description University of Cambridge EPSRC GCRF Workshop Grants
Amount £500 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 10/2016 
End 03/2017
 
Description University of Cambridge SRI/SRN Small Grants
Amount £10,000 (GBP)
Organisation University of Cambridge 
Department Isaac Newton Trust
Sector Academic/University
Country United Kingdom
Start 03/2017 
End 12/2017
 
Description University of Cambridge SRI/SRN Small Grants
Amount £5,000 (GBP)
Organisation University of Cambridge 
Department Isaac Newton Trust
Sector Academic/University
Country United Kingdom
Start 12/2017 
End 10/2018
 
Description University of Cambridge SRI/SRN Small Grants
Amount £5,000 (GBP)
Organisation University of Cambridge 
Department Isaac Newton Trust
Sector Academic/University
Country United Kingdom
Start 09/2016 
End 06/2017
 
Description University of Cambridge Wellcome Trust ISSF Workshop Grant
Amount £4,000 (GBP)
Organisation Wellcome Trust 
Department Wellcome Trust Institutional Strategic Support Fund
Sector Charity/Non Profit
Country United Kingdom
Start 09/2015 
End 09/2016
 
Description University of Cambridge-JIC iGEM 2016 team
Amount £30,000 (GBP)
Organisation iGEM 
Sector Charity/Non Profit
Country United States
Start 06/2016 
End 11/2016
 
Description Wellcome Trust ISSF Junior Interdisciplinary Fellowship
Amount £100,000 (GBP)
Organisation Wellcome Trust 
Department Wellcome Trust Institutional Strategic Support Fund
Sector Charity/Non Profit
Country United Kingdom
Start 10/2017 
End 09/2018
 
Description Wellcome Trust ISSF Junior Interdisciplinary Fellowship
Amount £100,000 (GBP)
Organisation Wellcome Trust 
Department Wellcome Trust Institutional Strategic Support Fund
Sector Charity/Non Profit
Country United Kingdom
Start 10/2015 
End 09/2016
 
Description iGEM2014
Amount £30,000 (GBP)
Organisation University of Cambridge 
Sector Academic/University
Country United Kingdom
Start 06/2014 
End 11/2014
 
Description iGEM2015
Amount £45,000 (GBP)
Organisation University of Cambridge 
Sector Academic/University
Country United Kingdom
Start 06/2015 
End 11/2015
 
Title Establishment of a common syntax for plant synthetic biology 
Description Inventors in the field of mechanical and electronic engineering can access multitudes of components and, thanks to standardization, parts from different manufacturers can be used in combination with each other. The introduction of BioBrick standards for the assembly of characterized DNA sequences was a landmark in microbial engineering, shaping the field of synthetic biology. Here, we describe a standard for Type IIS restriction endonucleasemediated assembly, defining a common syntax of 12 fusion sites to enable the facile assembly of eukaryotic transcriptional units. This standard has been developed and agreed by representatives and leaders of the international plant science and synthetic biology communities, including inventors, developers and adopters of Type IIS cloning methods. Our vision is of an extensive catalogue of standardized, characterized DNA parts that will accelerate plant bioengineering. To this end we have proposed a common syntax for exchange of DNA parts for plant synthetic biology. This is supported by the international community and has been published. 
Type Of Material Improvements to research infrastructure 
Year Produced 2015 
Provided To Others? Yes  
Impact The establishment of a common plant syntax has paved the way for the introduction of an Open MTA for material transfer, now trialled and published (Kahl et al. 2018, Nature Biotechnology 36: 923), simple and open systems for recusrsive fabrication of DNA circuits (Pollak et al. 2018, New Phytologist: https://doi.org/10.1111/nph.15625) and for discussions with Addgene, the nonprofit global plasmid repository, archives and distributes plasmids for scientists. These advances are catalytic and we envisage that they will promote and accelerate plant biology research within the UK and internationally. 
 
Title In planta cytometry 
Description Published method for in vivo quantification of plant gene expression in vivo, using combined ratiometric fluorescence measurement and microscopic segmentation. 
Type Of Material Technology assay or reagent 
Year Produced 2012 
Provided To Others? Yes  
Impact Published as Federici F, Dupuy L, Laplaze L, Heisler M & Haseloff J. Integrated genetic and computation methods for in planta cytometry. Nature Methods, 9:483-485 (2012). Forms the basis for a number of new approaches. 
 
Title Loop Assembly 
Description High efficiency methods for DNA assembly are based on sequence overlap between fragments or Type IIS restriction endonuclease cleavage and ligation. These have enabled routine assembly of synthetic DNAs of increased size and complexity. However, these techniques require customisation, elaborate vector sets and serial manipulations for the different stages of assembly. As part of a collaboration between the University of Cambridge, Earlham Institute and the Universidad Católica de Chile. Bernardo Pollak and Fernan Federici have devised a new method for gene assembly based on two Type IIS restriction endonuceases, BsaI and SapI. Loop Assembly allows rapid and efficient production of large DNA constructs, is compatible with widely used Level zero (L0) DNA parts such as Phytobricks, and can be easily automated. Alternate use of two Type IIS restriction endonucleases and corresponding vector sets allows efficient and parallel assembly of large DNA circuits. Plasmids containing standard Level 0 parts can be assembled into circuits containing 1, 4, 16 or more genes by looping between the two vector sets. The vectors also contain modular sites for hybrid assembly using sequence overlap methods. Loop assembly provides a simple generalised solution for DNA construction with standardised parts. The cloning system is provided under an OpenMTA license for unrestricted sharing and open access. A preprint has been published: https://www.biorxiv.org/content/early/2018/01/15/247593 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? Yes  
Impact The method is being developed for automation of DNA Assembly at the Earlham Institute and for building constructs for the OpenPlant Marchantia distribution, impacts are expected to increase during 2018 particularly following peer-reviewed publication. 
URL https://www.biorxiv.org/content/early/2018/01/15/247593
 
Title Measurement of intrinsic properties of promoters 
Description Combined software and technical approach to reducing noise and providing accurate estimations of promoter properties in microbial systems, based on multi-parameter measurement and use of integrated models of cell proliferation and gene expression. 
Type Of Material Technology assay or reagent 
Year Produced 2014 
Provided To Others? Yes  
Impact Being used to evaluate gene circuit components prior to assembly of elaborate circuits, e.g.: Grant PK, Dalchau N, Brown JR, Federici F, Rudge TJ, Yordanov B, Patange O, Phillips A, Haseloff J. Orthogonal intercellular signaling for programmed spatial behavior. Molecular Systems Biology 12:849-861, (2016). 
 
Title MoClo Toolkit for Chlamydomonas 
Description A kit of 119 standard DNA parts that can be used for Golden Gate (Modular Cloning, MoClo) cloning to prepare constructs for genetic modification of Chlamydomonas reinhardtii. 
Type Of Material Biological samples 
Year Produced 2018 
Provided To Others? Yes  
Impact The kit is freely available to the community (for a small distribution fee) and should enable much more rapid preparation of clones and then easy comparison between results from different groups 
 
Title Phytobricks 
Description Help to establish a common syntax for plant DNA parts, allowing rapid assembly of gene circuits via Type IIS restriction enzyme cloning. The Phytobrick standard (RFC-106) has been established in the iGEM community and widely propagated within the professional plant biology community. 
Type Of Material Technology assay or reagent 
Year Produced 2015 
Provided To Others? Yes  
Impact Establishment of the first publicly distributed Phytobricks in the iGEM Synthetic Biology competition, and establishment of the Plant Track and Prize in 2016. 
URL https://www.openplant.org/dnaparts/
 
Title Speed breeding for crop breeding and model plant research 
Description To meet the challenge of feeding a growing population, breeders and scientists are continuously looking for ways to increase genetic gain in crop breeding. One way this can be achieved is through 'speed breeding' (SB), which shortens the breeding cycle and accelerates research studies through rapid generation advancement. The SB method can be carried out in a number of ways, one of which involves extending the duration of a plant's daily exposure to light (photoperiod) combined with early seed harvest in order to cycle quickly from seed to seed, thereby reducing the generation times for some long-day (LD) or day-neutral crops. We have developed glasshouse and growth chamber-based SB protocols with supporting data from experimentation with several crop species. These protocols describe the growing conditions, including soil media composition, lighting, temperature and spacing, which promote rapid growth of spring and winter bread wheat, durum wheat, barley, oat, various members of the Brassica family, chickpea, pea, grasspea, quinoa and the model grass Brachypodium distachyon. Points of flexibility within the protocols are highlighted, including how plant density can be increased to efficiently scale-up plant numbers for single seed descent (SSD) purposes. Conversely, instructions on how to perform SB on a small-scale by creating a benchtop SB growth cabinet that enables optimization of parameters at a low cost are provided. We also outline the procedure for harvesting and germinating premature wheat, barley and pea seed to reduce generation time. Finally, we provide troubleshooting suggestions to avoid potential pitfalls. 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? Yes  
Impact This methodology opens up opportunities to accelerate and revolutionise crop improvement programmes and the field of plant biology research more broadly. 
URL https://www.nature.com/articles/s41477-017-0083-8
 
Title Transient plant expression technology for triterpene production at preparative scale 
Description We have develop a method for transient heterologous expression of biosynthetic enzymes in N. benthamiana for production of high-value triterpenes. Agro-infiltration is an efficient and simple means of achieving transient expression in N. benthamiana. The process involves infiltration of plant leaves with a suspension of Agrobacterium tumefaciens carrying the expression construct(s) of interest. Co-infiltration of an additional A. tumefaciens strain carrying an expression construct encoding an enzyme that boosts precursor supply significantly increases yields. After a period of five days, the infiltrated leaf material can be harvested and processed to extract and isolate the resulting triterpene product(s). This is a process that is linearly and reliably scalable, simply by increasing the number of plants used in the experiment. We have developed a protocol for rapid preparative-scale production of triterpenes utilizing this plant-based platform. The protocol utilizes an easily replicable vacuum infiltration apparatus, which allows the simultaneous infiltration of up to four plants, enabling batch-wise infiltration of hundreds of plants in a short period of time. 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? Yes  
Impact Generation of gram-scale quantities of 98% pure triterpenes and demonstration that we can rapidly carry out combinatorial expression of enzymes from our triterpene toolkit to generate known and new-to-nature compounds. This had attracted considerable interest from industry and led to four new projects directly funded by different companies in the pharma, ag, food and drink and home and personal care sectors. 
URL https://www.jove.com/video/58169/transient-expression-nicotiana-benthamiana-leaves-for-triterpene
 
Title pUAP1 plasmid vector 
Description We have constructed, a "clean" plasmid vector (pUAP1) suitable for cloning of Level zero DNA parts. Further, we have constructed two families of Loop plant transformation vectors, based on pCambia and pGreen backbones, respectively. These differ in replication origins and copy number in bacterial hosts. 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? Yes  
Impact None 
URL https://www.biorxiv.org/content/early/2018/01/15/247593
 
Title Marpodb.io 
Description DNA parts- centric database for the description of genome resources from Marchantia polymorpha - a synthetic biology database 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact Marpodb is providing a framework for design and characterisation of synthetic gene parts in Marchantia (http://marpodb.io/query) 
URL http://marpodb.io
 
Title Research data supporting Cell size control driven by the circadian clock and environment in cyanobacteria 
Description This record contains data on birth and division times, as well as on birth and division lengths, of single cells of the cyanobacterium S. elongatus. Data for wild type and clock-null (deletion of kaiBC operon) cells are included. 3 environmental conditions (constant light, graded 12 h light : 12 h dark, and graded 16 h light : 8 h dark) were assayed. Data were obtained from time-lapse microscopy movies, which were acquired on an inverted Nikon Ti-E microscope. Acquired images were subsequently analysed in Matlab using the software Schnitzcells. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
 
Title S. elongatus circadian clock model 
Description Dr Bruno Martins and Dr James Locke (both UCam) developed S. elongatus constructs for examining the circadian clock and its outputs at the single cell level. This software model was published in Molecular Systems Biology and made available in Systems Biology Markup Language (SBML) format. Publication: Martins et al. (2016). Frequency doubling in the cyanobacterial circadian clock. Molecular Systems Biology 12(12):896. doi: 10.15252/msb.20167087. 
Type Of Material Computer model/algorithm 
Year Produced 2016 
Provided To Others? Yes  
Impact None 
URL http://msb.embopress.org/content/12/12/896
 
Description An improved bioproduction system for proteins and small molecules 
Organisation John Innes Centre
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Lead applicant on joint funding proposal
Collaborator Contribution Co-aplicants on joint funding proposal
Impact Funding Award BB/P010490/1
Start Year 2017
 
Description An improved bioproduction system for proteins and small molecules 
Organisation Leaf Expression Systems
PI Contribution Lead applicant on joint funding proposal
Collaborator Contribution Co-aplicants on joint funding proposal
Impact Funding Award BB/P010490/1
Start Year 2017
 
Description Analysis of potatoes subjected to Cas9-mediated mutagenesis of SBE genes in potato 
Organisation Quadram Institute Bioscience
Department Food & Health Programme
Country United Kingdom 
Sector Academic/University 
PI Contribution We partnered with colleagues in the Quadram Institute Bioscience to conduct analyses of starch structure in potato tubers generated at JIC in which starch branching enzymes genes were mutated by introduction of the Cas9 gene and sgRNAs targetting both sets of SBE homoeoalleles.
Collaborator Contribution QIB used state-of-the-art HPLC-SEC and 1H-NMR tools to examine the chain-length distributions and the ratio of alpha 1,4 to alpha 1,6 linkages in starch from wild-type and mutated potatoes in this analysis
Impact Manuscript submitted for publication to a peer-reviewed journal. The work made use of biophysical techniques for analysis of polymer structure, synthetic biology, and plant biochemistry and molecular biology
Start Year 2018
 
Description Biomakespace Cambridge 
Organisation Biomakespace
PI Contribution Prof Jim Haseloff and Alexandra Ting (OpenPlant Cambridge) develop and implement the Biomaker Challenge that funds interdisciplinary team-based projects at the intersection of biology, engineering, sensor technology, and low-cost instrumentation. Participants in the Biomaker Challenge are encouraged to use the Biomakespace (and allowed to use funding to pay for membership) as a resource and prototyping space for their projects, and to contribute to a community dedicated to open science in Cambridge.
Collaborator Contribution Founded by former Cambridge OpenPlant coordinator Jenny Molloy, Biomakespace is Cambridge's first community based, open access biology and prototyping space. Biomakespace provides members with affordable access to a well-equipped lab and prototyping space as well as to training and social events. The Biomakespace is a crucial resource for the development of the Biomaker initiative as it provides an open lab space, as well as training, for interdisciplinary teams that may not have access to one.
Impact During the 2018 summer challenge, two multidisciplinary Biomaker Challenge teams developed their projects at Biomakespace: 1. Microbial Bioreactor: an open source, benchtop, batch bioreactor to optimise yield of enzymes producing recombinant proteins for molecular biology such as Taq polymerase or for cell-free extract production. This will build on existing open source projects to further reduce the cost of components and pay particular attention to their global accessibility. By generating a modular design with thorough and useful documentation of different options to suit budget and accuracy requirements, the devices will be easier to build and maintain for a wider range of users in universities, companies and biomaker spaces: in particular those in resource-constrained contexts. Project documentation on Hackster (8,782 views) 2. Spectre: low-cost whole-cell biosensors for environmental and medical surveillance. The team has created a minimum viable product (MVP) for proof-of-concept purposes. By using a low-cost fluorometer, signal processing unit and 3D-printed imaging chambers, we can detect green fluorescent protein signal with appreciable gains. The measuring capability of our MVP is comparable to a high-end plate reader, which is traditionally used for a similar purpose but only under controlled laboratory environment. Project documentation on Hackster (228 views)
Start Year 2017
 
Description Collaboration with Cambridge Glycoscience 
Organisation Cambridge Glycoscience Ltd
PI Contribution We have jointly investigated the production of novel carbohydrates from plant cell walls.
Collaborator Contribution The company has attempted scale up of products
Impact We have obtained collaborative grant awards.
Start Year 2017
 
Description Cryo-EM of VLP structures 
Organisation University of Leeds
Department Astbury Centre for Structural Molecular Biology
Country United Kingdom 
Sector Academic/University 
PI Contribution Production of VLPs in plants
Collaborator Contribution Cryo-EM analysis of the structure of plant-produced VLPs
Impact This is a multi-disciplinary collaboration using plant-based expression (JIC) to produce VLPs. The structure of these can be determined by near -atomic resolution cryo-EM (Leeds).
Start Year 2017
 
Description Developing resources for science activities in schools 
Organisation Interdisciplinary Research Centre
Country France 
Sector Academic/University 
PI Contribution Off the back of two OpenPlant Fund projects, a new collaboration has been formed to exchange knowledge, resources and tools for integrating multidisciplinary activities, learning and research projects into schools. The collaboration is with both the Open Science School (http://openscienceschool.org/) and the EU-funded project, doing it together science (DITOs; http://togetherscience.eu/) both based at the Centre Recherches Interdisciplinaire (CRI) in Paris. We have exchanged expertise and ideas to support their projects and once ready will share tools and resources developed by OpenPlant, for use in France and beyond.
Collaborator Contribution The DITOs project have contributed a number of practicals for use in UK schools, and their learning from developing and testing these together with teachers.
Impact A visit to paris to present on OpenPlant projects in outreach and engagement. A plan for an extension of one of the DITOs practicals. The nature of the collaboration is to develop multidisciplinary teaching resources in the context of synthetic biology. To date, disciplines include biology, design, chemistry, maths, electronics, and information technology.
Start Year 2016
 
Description ENGINEERING SMALL RNA-BASED GENE REGULATION PATHWAYS IN THE PRIMITIVE PLANT Marchantia polymorpha 
Organisation University of Veracruz
Country Mexico 
Sector Academic/University 
PI Contribution We have helped to construct a series of knock-out mutants of Marchantia polymorpha for genes expected to interfere in small RNA metabolism
Collaborator Contribution Mario Arteaga's group is characterising the above mutants. We expect to produce modified plants that have dual use for studying natural RNA metabolism and plant chassis that will have application for transgenic work in synthetic biology.
Impact Scientific reagents, protocols and plant lines
Start Year 2015
 
Description Engineering plant responses to environmental nitrogen 
Organisation University of California, Davis
Department UC Davis Genome Cente
Country United States 
Sector Academic/University 
PI Contribution Contributed epxertise in genome engineering in plants. Contributed to two joint grant proposals.
Collaborator Contribution Contributed expertise on epigenetics and plant nitrogen reponse networks. Contributed to two joint grant proposals.
Impact Two collaborative grant proposals submitted: NSF-BIO, USDA-NIFA and BBSRC joint activity - Early Concept Grants for Exploratory Research (EAGER) - Breakthrough Technologies to Advance Crop Breeding. BBSRC-NSF Lead Agency Opportunity - Synthetic approaches to address fundamental biological questions.
Start Year 2018
 
Description Investigating carbon flux between lignin and chlorogenic acid biosynthetic pathways 
Organisation State University of Campinas
Country Brazil 
Sector Academic/University 
PI Contribution Supervision of visiting FAPESP graduate fellow
Collaborator Contribution Sponsor of FAPESP graduate fellow
Impact Sucessful FAPESP graduate fellowship for Nathalia Volpi, who spent six months in the UK progressing this project. Co-publications.
Start Year 2016
 
Description Mint Genome Project 
Organisation Michigan State University
Country United States 
Sector Academic/University 
PI Contribution We are collaborating with the Mint genome project group which includes Robin Buell, Doug and Pam Soltis and Natalia Dudareva. Post-doc Benjy Lichman has discovered and s developing new enzymatic tools from the sequence data generated in this collaboration. http://mints.plantbiology.msu.edu
Collaborator Contribution We are collaborating with the Mint genome project group which includes Robin Buell, Doug and Pam Soltis and Natalia Dudareva. Post-doc Benjy Lichman has discovered and s developing new enzymatic tools from the sequence data generated in this collaboration. http://mints.plantbiology.msu.edu
Impact Two manuscripts are currently submitted.
Start Year 2015
 
Description Plant lines with selectable insertion sites 
Organisation University of Essex
Department University of Essex EssexLab
Country United Kingdom 
Sector Academic/University 
PI Contribution Production of DNA contraucts and experiment design
Collaborator Contribution Production of plant lines
Impact Production of reserach materials. Other outputs are in progress.
Start Year 2017
 
Description Promoting algae for industrial biotechnology 
Organisation Rothamsted Research
Country United Kingdom 
Sector Academic/University 
PI Contribution I have been very active in promoting the idea of using algae as industrial biotechnology (IB) hosts. This has led to a successful BBSRC sLoLa award, and also contributed to the debate about how to cement the rather fragmented algal expertise in the UK. Ultimately the introduction of the BBSRC networks in IB (NIBBs) were borne out of this debate, and these include Phyconet, which is specifically algal biotechnology. In addition several other NIBBs consider using algae as source of novel products, pathways, genes (NPRONet, HVCfP), or as platforms for community based metabolism (ADNET)
Collaborator Contribution Research and development collaborations with colleagues in the algal biotechnology field, but also in metabolic engineering and SMEs in algal biotechnology
Impact sLoLa Several BBSRC NIBBs, with Phyconet as specific one on algal biotechnology IB Catalyst award
Start Year 2009
 
Description Promoting algae for industrial biotechnology 
Organisation University College London
Department Division of Biosciences
Country United Kingdom 
Sector Academic/University 
PI Contribution I have been very active in promoting the idea of using algae as industrial biotechnology (IB) hosts. This has led to a successful BBSRC sLoLa award, and also contributed to the debate about how to cement the rather fragmented algal expertise in the UK. Ultimately the introduction of the BBSRC networks in IB (NIBBs) were borne out of this debate, and these include Phyconet, which is specifically algal biotechnology. In addition several other NIBBs consider using algae as source of novel products, pathways, genes (NPRONet, HVCfP), or as platforms for community based metabolism (ADNET)
Collaborator Contribution Research and development collaborations with colleagues in the algal biotechnology field, but also in metabolic engineering and SMEs in algal biotechnology
Impact sLoLa Several BBSRC NIBBs, with Phyconet as specific one on algal biotechnology IB Catalyst award
Start Year 2009
 
Description Promoting algae for industrial biotechnology 
Organisation University of Aberdeen
Country United Kingdom 
Sector Academic/University 
PI Contribution I have been very active in promoting the idea of using algae as industrial biotechnology (IB) hosts. This has led to a successful BBSRC sLoLa award, and also contributed to the debate about how to cement the rather fragmented algal expertise in the UK. Ultimately the introduction of the BBSRC networks in IB (NIBBs) were borne out of this debate, and these include Phyconet, which is specifically algal biotechnology. In addition several other NIBBs consider using algae as source of novel products, pathways, genes (NPRONet, HVCfP), or as platforms for community based metabolism (ADNET)
Collaborator Contribution Research and development collaborations with colleagues in the algal biotechnology field, but also in metabolic engineering and SMEs in algal biotechnology
Impact sLoLa Several BBSRC NIBBs, with Phyconet as specific one on algal biotechnology IB Catalyst award
Start Year 2009
 
Description Sustainable Bioproduction of Pheromones for Insect Pest Control in Agriculture 
Organisation National Institute of Biology
Country Slovenia 
Sector Charity/Non Profit 
PI Contribution Co-applicant on funding application
Collaborator Contribution Co-applicant on funding application
Impact Sucessful funding application (ERA-CoBioTech).
Start Year 2017
 
Description Sustainable Bioproduction of Pheromones for Insect Pest Control in Agriculture 
Organisation Spanish National Research Council (CSIC)
Department Institute for Plant Molecular and Cellular Biology
PI Contribution Co-applicant on funding application
Collaborator Contribution Co-applicant on funding application
Impact Sucessful funding application (ERA-CoBioTech).
Start Year 2017
 
Description Sustainable Bioproduction of Pheromones for Insect Pest Control in Agriculture 
Organisation Technical University of Darmstadt
Country Germany 
Sector Academic/University 
PI Contribution Co-applicant on funding application
Collaborator Contribution Co-applicant on funding application
Impact Sucessful funding application (ERA-CoBioTech).
Start Year 2017
 
Title Metabolic engineering 
Description Genes and polypeptides which have utility in engineering or modifying quillaic acid production or hydrolysis in host cells. 
IP Reference PCT/EP2018/086430 - 20/12/17 
Protection Patent application published
Year Protection Granted 2017
Licensed Commercial In Confidence
Impact This patent has been pivotal to the development of a large collaboration with a major pharma company.
 
Title CellModeller 
Description High performance software tool for modelling cellular behaviour in large populations, that provides a physico-genetic model. 
Type Of Technology Software 
Year Produced 2010 
Open Source License? Yes  
Impact Cell modeller allows precise description of fractal-like cell buckling and cohort behaviour in biofilms: Rudge TJ, Steiner PJ, Kan A and Haseloff J. Cell shape-driven instability generates self-organised, fractal patterning of cell layers. ACS Synthetic Biology, 2:705-714, (2013). Rudge TJ, Steiner PJ, Phillips A and Haseloff J. Computational modeling of synthetic microbial biofilms. ACS Synthetic Biology, 1:345-352, (2012). The software has also been used to model plant cell growth and dynamics: Dupuy, L., Mackenzie, J. and Haseloff, J. Coordination of plant cell division and expansion in a simple morphogenetic system. Proc. Natl. Acad. Sci. USA 107:2711-6 (2010). 
URL http://haselofflab.github.io/CellModeller/
 
Title DNA Dave 
Description Dr Jenni Rant (SAW) and Dr Colette Matthewman (JIC) secured funding from the Biochemical Society to work with designer Molly Barratt to design and build a "Transcription-Translation machine" for education and publica engagement. The outcome was DNA Dave, an interactive robot to explain how proteins are made using instructions encoded in DNA. DNA Dave has been a great success with general public and school groups at the 2017 Cambridge Science Festival, the JIC 50th Anniversary open day, and Norwich Science Festival. Teachers are keen to take DNA Dave into the classroom, so we are now exploring possible routes to make the robot available to schools. 
Type Of Technology Physical Model/Kit 
Year Produced 2017 
Impact Teachers have commented that the description of the processes of DNA transcription and translation to make proteins is very difficult to put across in the classroom, but when DNA Dave was used to explain these processes, they could see the lightbulb moments in their pupils where they suddenly understood and engaged with the process. Subsequently we have had enquireys about loaning DNA Dave to schools. 
URL https://www.openplant.org/blog/2017/3/23/cambridge-science-festival-stand-20-improved-design
 
Title DocuBricks 
Description DocuBricks is an open source documentation tool for open hardware. The DocuBricks editor helps to easily create documentation that is modular and explained. The DocuBricks format is designed to enable modular sharing, better readability and community quality management. 
Type Of Technology Webtool/Application 
Year Produced 2016 
Impact The platform is the preferred option for documenting hardware published in the new Journal of Open Hardware (Ubiquity Press) and has seven projects already documented. 
URL http://docubricks.com/
 
Title MarpoDB 
Description Software framework for an open registry of Marchantia polymorpha genetic parts 
Type Of Technology Webtool/Application 
Year Produced 2016 
Impact MarpoDB is a gene-centric database developed for genetic engineering and synthetic biology. This is the result of dealing with highly fragmented genomic data (from a non-sequenced organism, Marchantia polymorpha) and compiling it into an accessible resource for sequence exploration and retrieval. The database framework, however, can be used with any type of genetic data and can be set up locally. 
URL https://github.com/HaseloffLab/MarpoDB
 
Title One-click installation of JBEI ICE DNA registry 
Description A simple method for the one-click installation of a DNA database has been implemented. In collaboration with Nathan Hilson (JBEI), we have compiled a public OSX based version of the ICE DNA registry. The resulting IceApp is available and documented as an open source project on Github (https:// github.com/fathomlabs/IceApp) and provides a platform for compilation and distribution of the ICE in app form, for individual and local use as a one-click installation for the DNA database. 
Type Of Technology Software 
Year Produced 2016 
Impact None 
URL https://github.com/fathomlabs/IceApp
 
Title Open Pi-Image: A low cost-open source plant growth imaging and analysis platform 
Description OpenPi is a near infrared image capture system based on a Raspberry Pi computer and PiNoir camera and custom 3D printed parts. This runs an extensible and modular open source software suite we developed called Open Pi Image that controls automated image capture and spawns image analysis. The Pi software can be accessed on any external system (e.g. a laptop) via a web server running on the Pi and the system can be embedded in inaccessible places. Open Pi Image is designed to incorporate new user provided scripts for analysis and can be easily extended and customised. 
Type Of Technology Software 
Year Produced 2016 
Open Source License? Yes  
Impact Software is still in testing phase in a small number of labs 
URL https://github.com/TeamMacLean/install_opimage/blob/master/README.md
 
Title Open Source Autonomous Imaging Station 
Description An open source fluorescent imaging system that integrates low-cost and open-source hardware, software and genetic resources. The project was published in PLOS and was the Editor's Pick on the PLOS Open Source Toolkit Channel in Dec 2017. All hardware designs, software and protocols are openly licensed and shared. Publication: Nuñez, I., Matute, T., Herrera, R., Keymer, J., Marzullo, T., Rudge, T., & Federici, F. (2017). Low cost and open source multi-fluorescence imaging system for teaching and research in biology and bioengineering. PLOS One, 12(11), e0187163. Project Lead: Fernan Federici (UCam and PUC) 
Type Of Technology Systems, Materials & Instrumental Engineering 
Year Produced 2017 
Impact None 
URL http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187163
 
Title Plant electro-mechanics hardware 
Description Project is developing an affordable, open source, hardware-software "sandbox" to allow plant scientists to explore the possibilities of in-vivo experimentation with plant electrophysiology. Built based on the existing Plant SpikerShield* system, which consists of electrodes (positioned on the plant by means of a 3d printed "manipulator") whose signal is amplified by a custom made electronic circuit which then is sent to a computer via an Arduino microcontroller. We have built a number of 3D manipulators prototypes for the positioning of electrophysiology probes, and the control boxes that allow controlling them via a cheap Playstation 2 controller. The micromanipulators plans are available on the project's github repository, which contains also all the schematics and software for building all the tools we developed (https://github.com/calugo/OpenPlant-Electrophysiology ). Intructions and more specific details about assembling the kits are or soon will available in the project's website (http://calugo.github.io/OpenPlant-Electrophysiology/ ). 
Type Of Technology Physical Model/Kit 
Year Produced 2017 
Impact The hardware and software is still undergoing development. It will be used by the researchers involved in this project and be made openly available for others wishing to use the product. 
URL http://calugo.github.io/OpenPlant-Electrophysiology/
 
Title Plant-ProChip 2.0 
Description Development of on-chip encapsulation and analysis of protoplasts isolated from the emergent plant model Marchantia polymorpha at processing rates of >100,000 protoplasts per hour. The technology demonstrated on-chip sorting of droplets containing YFP-expressing protoplasts from wild type cells using dielectrophoresis force and opens the door to droplet-based microfluidic analysis of plant cells for applications ranging from high-throughput characterisation of DNA parts to single-cell genomics. Publication: Yu, Z., Boehm, C. R., Hibberd, J. M., Abell, C., Haseloff, J., Burgess, S. J., & Reyna-Llorens, I. (2017). Droplet-based microfluidic analysis and screening of single plant cells. bioRxiv, 199992. 
Type Of Technology New/Improved Technique/Technology 
Year Produced 2017 
Impact None 
URL https://www.biorxiv.org/content/early/2017/10/08/199992
 
Title Synthetic gene expression system in the green alga Chlamydomonas reinhardtii 
Description A platform was developed by Dr Francisco Navarro and Dr Marielle Vigouroux that allows testing of the the expression of fluorescent reporters in different strain backgrounds. It includes the first Chlamydomonas-specific MoClo DNA parts following the common syntax for gene assembly in plant synthetic biology co-authored by many members of OpenPlant. Some of these parts are already being used by other researchers of the Plant Sciences department of the University of Cambridge, who have since contributed new parts to the repertoire available for Chlamydomonas research. 
Type Of Technology New/Improved Technique/Technology 
Year Produced 2017 
Impact None 
URL https://www.biomaker.org/projects/new-codon-optimization-tools
 
Title Whiskeroscope: rodent whisker inspired sensor for use in analysis of plant tissue structure 
Description Understanding mechanical properties of plant biomass is crucial for multiple industries, including building construction and production of lignocellulosic biofuels. Current methods to analyse mechanical properties of biomass are slow and provide little accuracy. The aim of the project was to develop a prototype of a novel type of mechanical sensor which addresses challenges outlined above. The device is inspired by rodent whiskers and relies on two inputs, obtained using thin steel rod, to quantify stiffness. During each measurement the primary, macromotion, dataset is obtained by analysing the extent to which the whisker bend during the contact with the material. Additional information is obtained by overlaying the macromotion data with the impact of the whisker contacting the material on its micro-oscillation. The instrument successfully discriminated between materials with unlike mechanical properties (steel and foam) and differently aged stem samples from willow. Whiskeroscope was also applied to study Arabidopsis thaliana stems with altered composition of secondary cell walls. The project and the background information on plant cell walls were demonstrated to the wider public as a part of the Open Plant's contribution to the Cambridge University Science Festival. 
Type Of Technology Detection Devices 
Year Produced 2016 
Impact No further use currently. 
URL https://github.com/Cyberius/Whiskeroscope
 
Title smFISH for imaging single RNA molecules at the cellular level in Arabidopsis thaliana tissues and the liverwort Marchantia polymorpha 
Description Improvements to current smFISH technology allowed researchers to image three, rather than two, RNA targets simultaneously and led to amplified signals which were compatible with confocal imaging. RNA could also be visualized in more differentiated root cells than previously possible, e.g. root hairs. LGC are now promoting the technique at conferences and have made Dr Susan Duncan an expert collaborator. Publications: Duncan, S., & Rosa, S. (2017). Gaining insight into plant gene transcription using smFISH. Transcription, 1-5. Project Lead: Susan Duncan (EI) 
Type Of Technology New/Improved Technique/Technology 
Year Produced 2017 
Impact Posters describing smFISH work were presented at the 2016 RNA Society conference in Kyoto and OpenPlant Forum in Norwich. Whilst in Japan, Susan gave invited smFISH seminars to plant scientists at Kobe University, the University of Tokyo and RIKEN Institute in Yokohama Following invitations, details of the existing method have now been submitted to the open platform Bio-Protocol (http://www.bio-protocol.org) and the smFISH probe manufacturers, LGC (http://www.biosearchtech.com). Once published online, these versions of the protocol will increase open access options for researchers wishing to find out more about this technology. In addition to extending the existing smFISH method to the Haseloff lab in Cambridge, ongoing support has been provided to other groups interested in this method - most notably to labs led by Prof. Anne Osbourn (JIC) and Prof. Fujiwara (University of Tokyo). In recognition of her ongoing efforts to promote plant smFISH, LGC has made Susan an expert collaborator. The company will present posters at both the Plant and Animal Genome Asia and Asia Plant Genomics and Gene Expression conferences to explicitly promote Susan's method. There are ongoing discussions for Susan to organise an LGC funded workshop that would enable researchers to visit Norwich and gain hands-on experience of smFISH and Susan presented her smFISH work at the Norwich Single Cell Symposium at the Earlham Instute in May. 
URL https://www.biomaker.org/projects/advancing-the-ability-to-image-single-rna-molecules-at-the-cellula...
 
Company Name Colorifix 
Description Colorifix has developed a new method to dye textiles where microbes are used to produce, deposit and fix pigments to fabric. The patent pending process can use engineered microbes 
Year Established 2016 
Impact The method developed by Colorifix is sustainable and can be made into a circular economy. Importantly, the production of pigments are mostly from engineered microbes that are produced using synthetic biology methods developed in the UK, supported by RCUK (BBSRC, EPSRC). These include DNA assembly methods, LOOP and BASIC. Importantly, the company also has engaged with DNA foundries in London and in Norwich (Earlham Institute). From an environmental standpoint, compared to conventional methods based on petrochemical dyes and dyeing: No hazardous chemicals (no taxes or fines for use/disposal) No extraction of pigment (80% cost of fermented products) 90% reduction of water use 30% reduction in energy use <1% dye waste (3x better than industry standard) Combines two processes: lower carbon footprint
Website https://colorifix.com/
 
Company Name Iceni Diagnostics Ltd 
Description Iceni Diagnsoptics offers bespoke solutions to third parties with requirement in carbohydrate and bioconjugation chemistry. It also has an in house program of glycodiagnostics development. 
Year Established 2014 
Impact Too early
 
Company Name Leaf Systems International 
Description Leaf Systems® International Limited is a new contract development business specialising in the expression and production of proteins, metabolites and complex natural products for research and bio-medical applications using a proprietary, transient expression technology. Leaf Systems uses the proprietary Hypertrans® expression technologies developed by Prof.George Lomonossoff at the John Innes Centre, UK. The Hypertrans system allows for the simultaneous production of multiple gene products in a controlled and coordinated manner within the tissues of plants. Using gene synthesis and modular vectors, new products can be developed, validated, scaled and produced very quickly. Leaf Systems is employing state of the art containment facilities to produce and engineer its feedstock plants and has industry standard downstream processing capabilities to ensure production quality and bio-security. Leaf Systems works with companies as a contract development organisation to develop and scale the production of their products or intermediates. We also work alongside academic scientists to translate their science into scalable processes or to develop new enabling technologies, including as a collaborator on grants. Leaf Systems has SME status and is available to participate in translational research and development consortia, including EU framework programs. 
Year Established 2016 
Impact As it is less than a year old, it is too soon for Leaf Systems to have had an impact yet.
Website http://leafsystems.com
 
Company Name NORFOLK PLANT SCIENCES LIMITED 
Description NPS has developed genetically modified purple-fleshed tomatoes, to contain the high levels of anti-oxidants and anthocyanins normally found in fruits such as blueberries and blackberries. Many independent studies show that antioxidants and anthocyanins can reduce incidence of cancer, improve cardiovascular function and improve health and well-being. Lab studies also suggest these compounds could help alleviate irritable bowel syndrome. Although purple-skinned tomato varieties exist, they do not accumulate useful levels of these compounds within the fruit. e want to bring the benefits of our tomatoes to the consumer. We need innovative growers and processors who can help us to create new tomato products. 
Year Established 2007 
Impact Three granted patents: Luo, J., Butelli, E., Jones, J., Tomlinson, L. and Martin, C.R., Norfolk Plant Sciences Limited, 2017. Methods and compositions for modifying plant flavonoid composition and disease resistance. U.S. Patent 9,580,725. Martin, C. and Butelli, E., Norfolk Plant Sciences, Ltd., 2017. Methods for increasing the anthocyanin content of citrus fruit. U.S. Patent 9,574,202. Luo, J., Butelli, E., Jones, J., Tomlinson, L. and Martin, C.R., Norfolk Plant Sciences Limited, 2014. Method for modifying anthocyanin expression in solanaceous plants. U.S. Patent 8,802,925.
Website http://www.norfolkplantsciences.com/
 
Company Name Persephone Bio Ltd 
Description Persephone Bio is a plant natural products company (Company Number 9128375) producing bioactive compounds for the cosmetics and skin therapeutics sector. It was spun-out by CM and Eugenio Butelli supported by their prize money for the BBSRC's most promising innovation of 2014. Its mission is to establish routes to market for non-food ingredients produced in tomato, in particular for cosmetics 
Year Established 2014 
Impact Proprietary TomPro production system for making extracts from tomatoes without use of chemicals
Website http://persephonebio.co.uk/
 
Description 2017 Youth STEMM Gold Awards 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Presentation on synthetic biology followed by a practical workshop on designing genetic circuits. Sudents then presented their ideas, asked technical questions and discussed the potential impacts of synthetic biology and biotechnology on society.
Year(s) Of Engagement Activity 2017
URL http://ysawards.co.uk
 
Description PBVAB Conference Presentation 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation "Combining transient expression and high resolution cryo-electron microscopy to produce novel virus-like particles" by Walden M., Meshcheriakova Y., Marsian J., Hesketh E., Ranson N., Lomonossoff G. P. PBVAB 2017, Albufeira, Portugal, ,5-7th June 2017
Year(s) Of Engagement Activity 2012,2014,2017
 
Description A Horizon Scan of Bioengineering Issues 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Jim Haseloff, Nicola Patron, Jenny Molloy, Benjamin Lichmann and Colette Matthewman from OpenPlant joined an international working group to participate in a 'horizon scanning' exercise organised by Bonnie Wintle from the Centre for the Study of Existential Risk (CSER) in Cambridge. The aim of the exercise was to identify new and emerging issues in bioengineering and to gain a better understanding of current and future risks and opportunities in the field. A paper summarising and analysing the emerging issues has been written collaboratively between all working group members and submitted for publication.
Year(s) Of Engagement Activity 2016
 
Description A visit to the Vavilov 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A short article in the International Society for Plant Molecular farming (ISPMF) newsletter describing a visit to the Vavilov Institute in St. Petersburg, Russia by George Lomonossoff and Ian Gibson , Jul 2017
Year(s) Of Engagement Activity 2017
 
Description Agritech Sixth Former Course 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact In 2016 we ran a pilot course for sixth formers to give them an insight into careers in the Agritech sector. The students spent one day at the John Innes Centre learning about academic research into crops with lots of hands-on practical work and a second day at Easton & Otley agricultural college to learn how research is applied and the innovations in precision agriculture.
The course was funded by Robert Carter, Royal Norfolk Show president of 2015, who came to JIC to open the first day and also commissioned a video of the course. We presented the results to the Royal Norfolk Agricultural Association trustees and are currently fund raising to run another course this year for a larger number of students in collaboration with the University of East Anglia.
Year(s) Of Engagement Activity 2015
URL https://drive.google.com/file/d/0B2tX0hct-CoZLUVWN0gzX1REeEU/view?pref=2&pli=1
 
Description AlgaeEurope 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Presentation of research into algal synthetic biology to the principle conference in Europe aimed at supporting and developing the algal biotechnology sector. About half the participants were from industry (including large multisector, SMEs and startups)and 10% or so policy makers and officials eg from EU. The aim was to inform this group about the potential of synthetic biology in developing algal industrial biotechnology, providing the impetus to consider algae as production platforms for high value products as well as simply for biomass production. As a result, a consortium has been formed of academic colleagues who will share best practice and resources in SynBio.

I also described our recently opened Algal Innovation Centre (AIC), where it is possible to carry out pilot-scale algal cultivation, including of GM algae. As a result of the talk several contacts have been made with companies who are interested in the AIC.
Year(s) Of Engagement Activity 2015
 
Description ArtCell Exhibition 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Scientific art exhibit with microscopy images from Jim Haseloff and Fernan Federici, opened by the Mayor of Cambridge and open to the public.
Year(s) Of Engagement Activity 2011
 
Description BBC Radio 4 interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Interview about the potential impact of Synthetic Biology
Year(s) Of Engagement Activity 2010
 
Description BBSRC Exploring Innovation Workshop - Progress in intellectual property rights for plant science and crop breeding 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact OpenPlant Case Study was presented by Jenny Molloy "OpenPlant and a two-tier model for IP and open innovation".
Year(s) Of Engagement Activity 2016
URL https://members.niab.com/sites/default/files/civicrm/persist/contribute/files/IPR%20A4%20programme%2...
 
Description BBSRC NIBB IBCarb, Cambridge UK - September 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Presented a talk at BBSRC NIBB IBCarb Event
Year(s) Of Engagement Activity 2017
 
Description BBSRC Taiwan partnering award meeting 23-24 March, 2015 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact BBSRC Taiwan partnering award meeting 23-24 March, 2015. I gave a 20 min presentation on metabolic pathway engineering in the Osbourn group.
Year(s) Of Engagement Activity 2015
 
Description Big Algae Open Experiment 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact The Big Open Algae Experiment team were funded by OpenPlant Fund to help enhance algal knowledge by performing the biggest parallel algae experiment in history. They are inviting universities and citizen scientists to participate in an open-source data collection experiment on outdoor microalgal growth. During the OpenPlant Fund project, low-cost bioreactors, the website and app were constructed (http://bigalgae.com/about). In this last two years we have been running the "Big Algae Experiment" and have interacted with school groups at Latitude Festival, the New Scientist Festival, Rugby School and through events in Cambridge. Big Algae was showcased at the CRI, Paris and at the Open Source Tech conference in Santiago, Chile. As part of UCL Engineering's programme of CPD activities for teachers, we have also organised sessions with STEM teachers to demonstrate the bioreactors and train them in how to run the experiments. The concept is being developed into an 'Algaegotchi' pet with the Iaac Advanced Architecture Group in Barcelona.
Year(s) Of Engagement Activity 2016,2017
 
Description Biodiversity Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact New SAW workshop delivered at Bignold Primary School on World Biodiversity Day to introduce year 4 children to the importance of biodiversity for people and the planet and to some of the factors that are causing species decline across the globe. The children were amazed by the wealth of species, their importance in the ecosystem and how humans utilise natural products and shocked by the driving forces to extinction, a term they believed to only apply in the past, linked to dinosaurs, and not something that was ongoing.
Year(s) Of Engagement Activity 2018
URL https://www.sawtrust.org/in-schools/world-biodiversity-day-at-bignold-primary-school/
 
Description Bioengineering Horizon Scanning Workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Several members of OpenPlant took part in a one day horizon scanning exercise organised by the Centre for the Study of Existential Risk. This has resulted in a submitted publication and a follow up workshop is planned with a focus on biorisk and biosecurity.
Year(s) Of Engagement Activity 2016
 
Description Bioinformatics training in kenya 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact The OpenPlant Fund supported a bioinformatics training From 30th November to 5th December 2015 for 37 students from nine African countries. The course was held at ICIPE in Nairobi, Kenya and involved six days of theory and practical work, starting from the principles of Unix and programming, through to advanced scientific programming and visualisation. Towards the end of the week students worked on specific analysis methods in various areas of genetics and genomics, with a special focus session on synthetic biology delivered by Richard Smith-Unna. An ongoing student-led study group, coordinated online, will help the students keep the momentum from the course going and the course was also repeated with a new cohort in 2016. The course materials were made freely available online.
Dr Jelena Aleksic explained why such courses can have such an enormous impact in Africa "In an environment where all scientists above undergraduate level are expected to lecture regularly, the impact of advanced training courses quickly goes beyond the original participants. All our students hold Masters qualifications or above and work at African research institutions. We estimate that each of our course attendees will have the chance to pass on some of those skills to an additional 200 colleagues within the first year alone, and many more on an ongoing basis from there."
Year(s) Of Engagement Activity 2015
 
Description Bioluminescence display 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Collaboration between Bernardo Pollak and Anton Kan (Haseloff lab, Cambridge) and Victoria Geany (Royal College of Arts) to create a bioluminescent dress design. This resulted in public displays as part of the eLuminate Festival in Cambridge, and Display at the RCA, London - followed by a photo essay in Wired UK magazine in January 2017
Year(s) Of Engagement Activity 2016,2017
 
Description Biomaker Challenge and OpenPlant Fund Mixer - June 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact This event, held in Cambridge, provided an opportunity for participants to discuss ideas for OpenPlant Fund proposals for innovative and interdisciplinary projects in plant synthetic biology or prototyping projects for the Biomaker Challenge. Several researchers traveled from Norwich to join the event.
Year(s) Of Engagement Activity 2017
URL https://www.openplant.org/events-calendar/2017/6/14/biomaker-challenge-and-openplant-fund-mixer
 
Description Biomaker Fayre 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Forty interdisciplinary teams exhibited their prototypes for the 2017 Biomaker Challenge at the Department of Engineering. Projects covered everything from spectrometers for measuring the colour of penguin guano, microfluidics for tissue culture, to ultrasonic systems for measuring plant height and 3D printed modular microscopes. Each group was given a £1000 grant and four months to turn their big ideas for open source and DIY research tools into reality and over 100 people came along to the final event.
The Challenge and Fayre aimed to show the value of open, low-cost and DIY technologies as convening points for interactions between biologists and engineers.
Year(s) Of Engagement Activity 2017
URL https://www.synbio.cam.ac.uk/news/biomaker-fayre-showcases-40-open-source-low-cost-biological-instru...
 
Description Biomaker.org website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact We established this new website to host project information and outcomes from the OpenPlant Fund and Biomaker Challenge funding schemes. There are now over 100 projects documented on the website, and we have had around 4,000 independent visitors to the site.
Year(s) Of Engagement Activity 2017
URL http://www.biomaker.org
 
Description Biotech Gamechangers: Introduction to Synthetic Biology 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Workshop for secondary school students, organised by Hethel Innovation. Hannah Griffiths contributed a talk, and ran an activity.
Year(s) Of Engagement Activity 2019
 
Description Botanical workshop for children 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact A botanical drawing workshop for 20 children was held at the John Innes Centre of 29 June 2015. This was led by a botanical artist from Kew Gardens who had been on many international plant hunting expeditions to document new species, who told stories about her travels. The JIC rare books collection was used to show the children historic collections and to highlight how plant natural products were discovered and documented. The children then made their own botanical drawings. They also learned about seed banks and the importance of maintaining biodiversity.
Year(s) Of Engagement Activity 2015
 
Description Built new image library for the Norwich Research Park 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact To help raise awareness of the high quality research carried out across the Norwich Research Park, we developed an open access image library to showcase images of NRP science accompanied by accessible legends suitable for a general audience. The image library has the potential to attract new traffic to the NRP institute websites and research group homepages and will allow groups such as the media, schools, the general public and other researchers to gain a glimpse of the great depth and diversity of research that is being carried out in Norwich. Although all the images are freely available to download and use, people are required to sign up to use the library and are asked to enter information at the time of download about their intended use of the image. This helps to capture who is using the library and where the images are being used. So far images have been downloaded 582 times and have been used in presentations, publications, on websites, for education and advertising. We ran an image competition to raise awareness across the NRP site and then assembled a judging panel to select the top 12 images which were used to create an NRP calendar for 2016. The calendar was sent to politicians, business leaders, industry and academics at institutions in the UK and internationally. The competition featured in the local paper, the Eastern Daily Press and an overall winner was picked and used to make a large canvas which is hanging in the new Centrum building. We have received many positive comments about the libraries ease of use for finding good quality, copyright free images to use in presentations from fellow researchers across the site. In October 2016 we put on a two-week, large scale image exhibition at the Forum in Norwich as part of the first Norwich Science Festival. The images attracted a lot of interest and several artists have been in touch with scientists whose research images were on display to set up new collaborations using science to inform artistic practice. We will post outcomes of these endeavours onto the image library website to widen our exposure to new audiences.
Year(s) Of Engagement Activity 2015,2016
URL http://images.norwichresearchpark.ac.uk/
 
Description CPSC PhD course: SYNthetic BIOlogy, From pro- to eukaryotic SYStems (SYNBIOSYS) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Delivered lectures and workshops as part of the University of Copenhagen's CPSC PhD course: SYNthetic BIOlogy, From pro- to eukaryotic SYStems (SYNBIOSYS)
Year(s) Of Engagement Activity 2017
URL http://cpsc.ku.dk/calendar/2017/cpsc-phd-summer-course-2017-synbiosys/
 
Description Cafe Synthetique Synthetic Biology Graduate Student Talks 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Cafe Synthetique is an informal monthly pub meeting for Synthetic Biology in Cambridge. In July 2017 it highlighted graduate student work in synthetic biology including algae, arsenic testing and automated labs. Algal synthetic biology featured heavily as Aleix Gorchs Rivera, Stefan Grossfurthner and Patrick Hickland from Prof Alison Smith's Lab, in the Department of Plant Sciences, presented different approaches to engineering algae to generate valuable products, such as pigments and medicinal compounds. Jan Lyczakowski (Department of Biochemistry) from Prof Paul Dupree's lab described his efforts to engineer the structure of the plant sugar xylan in order to extract more biofuel from woody biomass. Tess Skyrme represented the Sensors Centre for Doctoral Training (Department of Chemical Engineering and Biotechnology), where 12 students have spent the summer designing and prototyping an arsenic biosensor. Clayton Rabideau (Department of Chemical Engineering and Biotechnology) provided an introduction to the current state of the art in machine learning and automation in synthetic biology. Another event will be run in 2018 following popular demand and one of the speakers went on to curate their own Cafe Synthetique meetings, giving valuable networking opportunities and organisational experience.
Year(s) Of Engagement Activity 2017
 
Description Cafe Synthetique: Towards Engineering Circadian Rhythms 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Pub meeting in Cambridge with talks to 25 people by OpenPlant PDRA Lukas Muller (Department of Plant Sciences) on "Approaches to investigate the circadian system in Marchantia" and John O'Neill (MRC-LMB) on "Circadian Rhythms - Everything you always wanted to know about jet lag (but were too tired to ask)". There was excellent discussion after the event.
Year(s) Of Engagement Activity 2017
 
Description Cambridge Biomakespace 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Set up a community bio lab in the ex-MRC Laboratory of Molecular Biology building in Cambridge
Year(s) Of Engagement Activity 2016,2017
URL https://biomake.space
 
Description Cambridge Crash Course in Synthetic Biology 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Annual 2-week interdisciplinary course in Synthetic Biology for professionals and students.
Year(s) Of Engagement Activity 2009,2010,2011,2012
 
Description Cambridge Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Designed and ran interactive activities at the Cambridge Science Festival to show what synthetic biology is and how we can apply this to plants to use either
to gain deeper understanding about biological processes or to design new applications of benefit to society. The stand invited people to play games that generated different ideas for using synthetic biology in plants which created a great starting point for discussions around responsible innovation. Our stand won an award from the Cambridge BID (Business Improvement District) Awards following some 'mystery shoppers' evaluating stands across the Cambridge Science Festival.
Year(s) Of Engagement Activity 2016
URL http://www.sciencefestival.cam.ac.uk/2016-event-recordings
 
Description Cambridge Science Festival, Cambridge UK - March 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other audiences
Results and Impact Particiapated in the Cambridge Science Festical at the Department of Chemistry.
Year(s) Of Engagement Activity 2017
 
Description Cambridge-JIC iGEM Team (iGEM Giant Jamboree) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact OpenPlant sponsored the Cambridge-JIC iGEM 2015 team. The team recruited 10 undergraduate students from across disciplines to the new iGEM Hardware Track, focusing on software-controlled electronic, optical, mechanical and chemical interfaces with biological systems.

The team chose to build an ultra low-cost 3D-printed motorised web-streaming autofocus microscope for synthetic biologists,. This allows researchers to tailor the microscope to their needs - allowing imaging on any lab-bench, in the incubator, fume-hood or the field using remote access and battery power, or use many OpenScopes for parallel rapid preliminary screening. The microscope offers fluorescence imaging for schools and laboratories with small budgets, based on low-cost (£200 in its most expensive set-up) and easily sourced components.

In addition to developing hardware and software for OpenScope, the team authored a guide on open hardware licensing for other iGEM teams and open teaching materials for use with high school students and undergraduates, including a 'Learning to Program with Arduino' pack. They visited the NRP-UEA team in Norwich and maintained useful contact with other teams in the UK and internationally during the competition.

OpenScope was awarded a gold medal at the iGEM Giant Jamboree in Boston, where >2500 people attended, many of whom saw the project and poster. They were nominated by the judging team for four awards:
? Best Hardware Project
? Best Software Tool, Undergrad
? Best Applied Design, Undergrad
? Best Poster, Undergrad

A working set-up of OpenScope and the software was demonstrated to huge interest from other teams and supervisors. A number of team supervisors mentioned that they were considering using OpenScope as an alternative to commercial microscopes in their teaching laboratories, both to reduce costs and as setting up the microscope would be an educational experience in itself.

OpenPlant and the Synthetic Biology SRI in Cambridge are providing a funding mechanism to follow up collaborations. The iGEM students have founded a Synthetic Biology Student Society and are continuing to develop OpenScope with support from the Cambridge SynBio Fund. There are plans to collaborate with Norwich students and potentially apply for further OpenPlant funding.

As part of broader engagement of OpenPlant with the iGEM competitions, a cross-track prize for plant projects has been established by a team including two OpenPlant PIs. The Cambridge-JIC 2016 team will again be supported by OpenPlant and will work with plant systems.
Year(s) Of Engagement Activity 2015
URL http://2015.igem.org/Team:Cambridge-JIC
 
Description Canadian Mission to UK SynBio Centres 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation of OpenPlant to a Canadian delegation of 10 participants from academia, industry, funding bodies and policy making organisations as part of their mission to to provide a better understanding of the global impact of the Synthetic Biology; to explore/enhance international collaborative opportunities (including research, funding and investment); strengthen collaborations with UK synthetic biology research centres; and to influence/inform Canadian policy makers.
Year(s) Of Engagement Activity 2015
 
Description Case study to be used as A-level resource for teachers 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Lomonossoff G. P., Thuenemann E., Bushell C."Plants as biofactories" - Case study to be published by Pearson in A-level text book
Year(s) Of Engagement Activity 2016
URL http://www.pearsonschoolsandfecolleges.co.uk
 
Description Cell-Free workshop and presentation at Community Biotechnology Summit (MIT Media Lab) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Dr Jenny Molloy and Dr Fernan Federici presented the work of the OpenPlant Curriculum Development working group and ran an accompanying practical workshop at the Community Biotechnology Summit at MIT Media Lab in Oct 2017. This reached >200 people from community organisations, artists, researchers, makers, engineers, media professionals and more. There was positive follow up with several groups leading to new collaborations and an invitation to run the workshop at Genspace, New York which will take place in April 2018.
Year(s) Of Engagement Activity 2017
 
Description Cereal engineering workshop: 3 min talk and participation to the debate on synthetic biology technics applied for cereal engineering. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Cereal engineering workshop: 3 min talk and participation to the debate on synthetic biology technics applied for cereal engineering. Held at MIT in Boston on the 8th and 9th of June 2015
Year(s) Of Engagement Activity 2015
 
Description Co-lab OpenPlant 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact OpenPlant teamed up with the Open Science School at the Centre de Recherche Interdisciplinaire (CRI), Paris to deliver a series of three "Co-Lab" workshops where scientists, designers, artists and makers came together to learn from each other and design project proposals. Several of these projects were supported further to create prototypes at a big Making Weekend. A report on the workshop methods and outcomes has been produced and will be distributed. The project has fostered a longer term collaboration between organisers from the Open Science School, Cambridge University and the John Innes Centre who are working together to develop synthetic biology teaching tools and information.
Year(s) Of Engagement Activity 2016
URL http://openscienceschool.org/
 
Description Collaboration on Floreana, musical composition 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Collaboration on Floreana with music composer Rosalind Page as part of The Origin Cycle, an avant garde music and media piece that celebrated Charles Darwin, and incorporated plant microscopy images related to collections made on the voyage of the Beagle. The piece was performed at the Harvard Natural History Museum, Boston, and Australian Museum, Sydney.
Year(s) Of Engagement Activity 2009,2010
 
Description Curriculum Hacks event 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presented a large display on engagement activities developed and run by the SAW Trust for OpenPlant at a variety of events to share ideas with other people working in synthetic biology.
Year(s) Of Engagement Activity 2018
 
Description DITOs/OSS Leadership Programme 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Colette Matthewman presented on OpenPlant, the Synthetic Biology for Schools project and the SAW Trust to a group of french secondary school biotechnology teachers in Paris as part of the Doing it together science (DITOs) EU project and the Open Science School.
Year(s) Of Engagement Activity 2017
URL http://togetherscience.eu/
 
Description DNA workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact We delivered a Science Art and Writing workshop on the theme of DNA at a local Junior school in a deprived area who were hosting a visiting group of Chinese children. Due to the language barriers, the local children paired up with a Chinese child to work through the activities together which meant they had to first understand the required process before helping their partner to complete tasks. This gave a new depth to the learning process which was reinforced by the local children having to take on the role of the instructor in their pair. This built confidence in the children.
Year(s) Of Engagement Activity 2018
 
Description Decoding and recoding Biological Systems 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The Norwich Research Park Industrial Biotech Alliance event "Decoding and recoding Biological Systems" was a one day symposium that involved several OpenPlant researchers from both Norwich and Cambridge. The aim of the workshop was to bring together scientists working across interdisciplinary interfaces spanning genomics, computational and synthetic biology and to provide a forum for enhanced interactions and collaborative research opportunities. Jim Haseloff, Nicola Patron and George Lomonossoff all gave scientific talks on their research. Anne Osbourn hosted the event and Colette Matthewman helped with the organisation and chaired the poster presentations.
Year(s) Of Engagement Activity 2017
URL http://www.nrp.ac.uk/decoding-and-recoding-biological-systems/
 
Description Development of an Open Source Autonomous Imaging Station for Distribution in High Schools, Universities, and Emerging DIY Scientific Communities 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact The advent of easy-to-use open source microcontrollers, off-the-shelf electronics and customizable manufacturing technologies has facilitated the development of inexpensive scientific devices and laboratory equipment. The team developed and published (Nuñez et al., 2017) an imaging system that integrates low-cost and open-source hardware, software and genetic resources. The multi-fluorescence imaging system consists of readily available 470 nm LEDs, a Raspberry Pi camera and a set of filters made with low cost acrylics. This device allows imaging in scales ranging from single colonies to entire plates. The team have used these resources in workshops in high schools, community spaces and cultural centres; and implemented advanced practicals to teach in vitro synbio, DNA fab and microbiology. The open source and low cost nature of the resources has allowed citizens to better understand the principles behind gene expression analysis and modelling.
Year(s) Of Engagement Activity 2017
 
Description E. chromi museum displays 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact E. chromi at the Wellcome Trust, display of iGEM biological designs for human health and new biosensors, scientific collaborator with designers Daisy Ginsberg and James King. This was followed by displays at: Design Museum, London; Museum of Modern Art, New York, and a travelling exhibition in Australia and New Zealand.
Year(s) Of Engagement Activity 2010,2011,2012
URL http://www.echromi.com
 
Description EPSO/FESPB Joint Congress 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact I was chair of the scientific advisory committee for this biennial meeting held in Copenhagen in 2018.
Year(s) Of Engagement Activity 2018
 
Description ERA-SYNBIO/BBSRC OPENPLANT Summer School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact A summer schools at the John Innes Centre, Norwich, UK designed to provide participants with 'An introduction to synthetic biology in plant systems' in conjunction with OpenPlant, a collaborative plant-focussed Synthetic Biology Research Centre linking the University of Cambridge, John Innes Centre and The Sainsbury Laboratory.
Year(s) Of Engagement Activity 2013
URL http://onlinelibrary.wiley.com/doi/10.1111/nph.13433/abstract
 
Description EU 2WAYS hands-on exhibit for Synthetic Biology 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact Constructed a touch-screen based interface for computer modelled growth of flowers, as part of a collaboration with Christophe Godin, Montpellier. A simple interface allowed children to explore the genetic control of plant growth and explore different floral structures. The interactive exhibit was teamed with a display board of floral architecture.
Year(s) Of Engagement Activity 2009,2010,2011
 
Description Early Years Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Set up an exhibition stand at the Early Years conference to showcase SAW materials and in particular our Plant Growth and Development lesson plan developed for OpenPlant. We had a lot of interest from early years educators and we are now working with a local nursery school to trial some new plant-themed activities.
Year(s) Of Engagement Activity 2018
 
Description Edinburgh Science Festival: Designer Life 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Panelist on public debate on Synthetic Biology, transmitted as part the "Material World" programme radio.
Year(s) Of Engagement Activity 2010
 
Description Festival of Plants at Cambridge Botanic Garden on the 16th of May 2015 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Helped Jenni Rant to hold a stand describing the scientific research ongoing at JIC, at the Festival of Plants at Cambridge Botanic Garden on the 16th of May 2015
Year(s) Of Engagement Activity 2015
URL http://www.botanic.cam.ac.uk/Botanic/Event.aspx?p=27&ix=597&pid=2718&prcid=0&ppid=2718&edit=n
 
Description Festival of Plants, Botanical Garden, Cambridge 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Exhibit at the Festival of Plants (was called Fascination of Plants in 2012) in Cambridge University Botanic Garden. It provided basic information about algae, showcased our scientific work, and then explained how we were using this in collaboration with companies to carry out remeidation of waste water. There were activities such as viewing microalgae with microscopes and observing algae phototaxis. Children could handcraft their own algae using pipe cleaners or take part in an interactive algae quiz to win prices. Several members of the public asked for additional information.

Interest from several visitors about how to incorporate algal growth in their activities, eg anaerobic digestion or green energy generally
Year(s) Of Engagement Activity 2012,2013,2014,2015
URL http://www.botanic.cam.ac.uk/Botanic/Event.aspx?p=27&ix=351&pid=2718&prcid=0&ppid=2718
 
Description Food Matters Live 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Eugenio Butelli gave a presentation entitled "synthetic biology to design novel healthy foods" at the Future Nutrition Seminar at Food Matters Live, November 2016, including presenting OpenPlant research from the Martin lab.
Year(s) Of Engagement Activity 2016
URL https://www.foodmatterslive.com/
 
Description GAP Summit, Cambridge 2016 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact I was part of an expert panel designed to promote Leadership in Biotechnology. The meeting took place on 05/04/16 in Trinity College, Cambridge.
Year(s) Of Engagement Activity 2015,2016
URL http://www.cambridgeahead.co.uk/2016/02/gapsummit-2016/
 
Description GARNET-OPENPLANT CRISPR WORKSHOP 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact CRISPR technology is fast emerging as the breakthrough technology for precise genome editing in a range of experimental systems. In order to highlight the current developments and future potential for using this technology in plants, Nicola worked with Colette Matthewman (OpenPlant) and Geraint Parry and Ruth Bastow (GarNET) to organise a workshop including a day of seminars as well as a hands-on workshop on day 2.
Year(s) Of Engagement Activity 2015
URL http://plantmethods.biomedcentral.com/articles/10.1186/s13007-016-0104-z
 
Description Gardeners Question Time Display 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The John Innes Centre hosted Gardeners Question time for BBC Radio 4 and as part of the event put up several displays for the audience to view before and after the recorded event. We put a display up about the Global Garden workshop we have been running to showcase the outputs and to raise awareness for future workshops.
Year(s) Of Engagement Activity 2018
 
Description Gatsby plant science summer school: engineering plants for farming and pharming 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact Presented a lecture and particilaped in a discussion session with undergraduates as part of the Gatsby Plant Science Summer School. The summer school is an opportunity for first year undergraduate students in the UK to discover the challenge and opportunities of studying plant science. 76% of students rated this particular talk as good or very good with some very positive comments such as, 'I realised how much I loved to learn about Synthetic aspect of biology after the talk by Dr Nicola Patron
Year(s) Of Engagement Activity 2018
URL http://intobiology.org.uk/dr-nicola-patron-engineering-plants-for-farming-and-pharming/
 
Description Genetic resources in the age of the Nagoya Protocol and gene/genome synthesis 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Jim Haseloff, Jenny Molloy, Orr Yarkoni and Colette Matthewman participated in a one-day workshop, part-funded by an OpenPlant Fund award and organised by Dominic Berry and Deborah Scott from the Engineering Life project, University of Edinburgh. The aim of the workshop was to collect information on current developments, share views, highlight potential areas of concern, and establish grounds upon which to build better understanding of the interactions between and implications of the Nagoya Protocol and gene synthesis for collection, circulation, and use of genetic resources. A report will be prepared and published on this event.
Year(s) Of Engagement Activity 2016
URL http://www.stis.ed.ac.uk/engineeringlife
 
Description Genome Editing Reflection Afternoon 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Colette Matthewman supported a Genome Editing Reflection Afternoon at Norwich High School. There she talked about the work of OpenPlant, supported debate amongst the students on social and ethical questions related to genome editing in humans and participated in a panel discussion with student representatives of each discussion group. Here she reflected on the science process, ethical practices and regulations and commented on some existing research in this area.
Year(s) Of Engagement Activity 2016
 
Description Global garden 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Following on from the pilot of the Global Garden workshop in 2017 we ran a public workshop as part of the Norwich Science Festival that invited anyone to explore plant natural products and the regulations and ethics around access and benefit sharing. We then ran another session for a group of scientists which provided an interesting contrast of opinions around ethics compared to those shared by members of the public. This is an ongoing project that seeks to raise awareness of these issues as well as to get people thinking and talking about the importance of plants.
Year(s) Of Engagement Activity 2018
 
Description Great British Bioscience Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact We were successful in a winning a BBSRC science communication award to develop a new science stand called 'Nature's Factories' to run at local events and as part of the BBSRC's Great British Bioscience Festival showcasing the best of British bioscience in its 20th anniversary year.
Human evolution is tightly linked to our use of plants for food, building materials, fuel, medicines etc., and we continue to look for innovative ways to use natural resources to provide us with sustainable solutions that support our lifestyles. Scientific research is enabling us to discover and develop new plant products that improve our lifestyles by creating better medicines, healthier foods and greener technologies whilst also demonstrating the importance of protecting plant species diversity and ecosystems.
The Nature's Factories stand was designed to enable the public to find out how science is exploring and exploiting the valuable variety of chemicals made by plants as well as making natural remedies to take away and pick leaves from our fact-tree.

We took the stand to the Science in Norwich Day at the Forum in Norwich (1st June 2014), to the Cambridge Botanic Gardens (19th August 2014) and on the 12th November 2014 used the stand for a training workshop for EU scientists to learn how to create interactive displays for public events. On 14-16 November 2014, our exhibit headed to Museum Gardens, Bethnal Green, London to be showcased at BBSRC's Great British Bioscience Festival. The festival, delivered in partnership with London Science Festival was open to the general public and free to attend.
Since then the exhibit has featured at the Bury St Edmunds family science festival (21st March 2015), the Fascination of Plants day at the John Innes Centre (14th May 2015), the Festival of Plants at Cambridge Botanic Gardens (16th May 2015) and at the Youth Stem Awards (13th January 2016). We plan to use the exhibit throughout 2016.
Year(s) Of Engagement Activity 2014,2015,2016
URL http://www.bbsrc.ac.uk/engagement/exhibitions/gb-bioscience-festival/
 
Description HVCfP ABS/Nagoya workshop 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Colette Matthewman gave a presentation on Synthetic Biology and the Nagoya Protocol at a 1-day workshop on Access and Benefit Sharing (ABS) and the Nagoya Protocol, run by the High Value Chemicals from Plants NIBB.
Year(s) Of Engagement Activity 2017
URL https://hvcfp.net/events/sharing-natures-genetic-resources-implementing-the-nagoya-protocol-on-acces...
 
Description Hackster.io biomaker collection 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Design files for twenty six projects, mostly funded through the Biomaker Challenge scheme, have been documented on the hackster.io website. This website enables a user friendly documentation style for maker projects. A biomaker collection has been established to tie these projects together.
Year(s) Of Engagement Activity 2017
URL https://www.hackster.io/biomaker/projects
 
Description High Value Chemicals from Plants- Harnessing the potential of synthetic biology for industrial biotechnology. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact High Value Chemicals from Plants- Harnessing the potential of synthetic biology for industrial biotechnology. 13-14 July 2015, Dunston Hall, Norwich. I delivered a 20min talk about the use of the HyperTrans system in goldengate vectors and its benefits for metabolic engineering.
Year(s) Of Engagement Activity 2015
 
Description High Value Products from Plants conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Presentation of algal synthetic biology approaches to help support algal industrial biotechnology. This was at a Network in Industrial Biotechnology & Bioenergy (NIBB) meeting organised by the High Value Compounds from Plants NIBB. Interest was sparked amongst researchers to consider using algae, as well as plants, and production platforms.
Year(s) Of Engagement Activity 2015
 
Description Inside Synthetic Biology 2015 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact A one-hour interactive workshop exploring synthetic biology as part of a three-day course for 17 gifted and talented pupils from years 11-13. Three activies explored standards in plant synthetic biology, gene circuits and natural product engineering using synthetic biology.
Year(s) Of Engagement Activity 2015
 
Description IntoBiology resource 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact A final year undergraduate student in Plant Sciences produced a webpage describing work on algae in Plant Sciences and Biochemistry. The webpage is part of the programme established by IntoBiology, aimed at encouraging school children to consider studying plant biology.
Year(s) Of Engagement Activity 2015
URL http://intobiology.org.uk/unlocking-the-potential-of-algae-how-the-green-stuff-in-your-pond-might-go...
 
Description Introducing Norwich Biomakers Network 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact At this event participants were introduced to the Norwich biomarkers: Norwich Biomakers brings together an interdisciplinary network of people from across NorwichCity and the Norwich Science Park that share an interest in the cross-over of biology with design, technology, engineering, electronics and software. This group meets monthly at a variety of local spaces for events including talks, training in the use of technologies and to work on projects.
Year(s) Of Engagement Activity 2019
 
Description John Innes Centre Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact The John Innes Centre opened its doors to the public in celebration of the 50th anniversary of the centre's move to the current site. This included a host of interactive exhibits and activities to engage visitors with the science of the centre. The Osbourn and Lomonossoff labs teamed up to put on an exhibit about using plants as production systems. Visitors could infiltrate Nicotiana benthamiana plants (with water), design their own protein piece to be added to a growing virus like particle, extract a natural product from oat roots which glows under UV light, and learn about the science behind these activities.
Year(s) Of Engagement Activity 2017
URL https://www.jic.ac.uk/news-and-events/blog-copy/2017/09/open-day/
 
Description KEC Science Innovation Showcase 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Presentations to visitors from local/national/ international companies showcasing the research done at JIC.
Year(s) Of Engagement Activity 2018
 
Description Keynote Speaker Future Food Festival Toowoomba Queensland Australia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact I was a Keynote Speaker at the Future Food Festival Toowoomba Queensland Australia, giving 3 presentations to scientists, two to school kids and one grand discovery presentation at Queensland University of Technology to the general public
Year(s) Of Engagement Activity 2018
 
Description Latitude Festival OpenPlant Exhibit, 14-17.07.16 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Latitude Festival

Led by Jenni Rant from the SAW Trust, Michael Stephenson, Colette Matthewman, Marc Jones and Dorota Jakubczyk (JIC) worked with Paolo Bombelli, Katrin Geisler (Cambridge University), Brenda Parker (UCL) and Marin Sawa (Imperial) to deliver a 3-day OpenPlant exhibit entitled "The Power of Plants" in the wildlife, weird science and adventure area at the Latitude Festival, Suffolk, from 14-17 July 2016. The exhibit showcased the potential applications of synthetic biology in plants in a hands-on and accessible way. The first day was dedicated to hosting organised school groups where children spent 40 minutes with us experimenting with a variety of plants to learn how scientists are using them in new and novel ways. The second and third day were run as a drop-in style to cater for family groups giving opportunities to engage with children and adults. Visitors were very interested to see science research straight from the labs and amazed by new innovations being developed through synthetic biology. The event was very tiring but the opportunity to work as a team with members from different institutes on a shared science theme was very enjoyable and rewarding whilst also expanding our understanding of each others work.
Year(s) Of Engagement Activity 2016
URL http://www.latitudefestival.com/stage/wildlife-weird-science-adventure
 
Description Live television interview with Australian Broadcasting Corporation 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Live television interview with 'The World', international news and current affairs show (Australian Broadcasting Corporation). Received multiple enquiries and comments from academics and general public following broadcast.
Year(s) Of Engagement Activity 2017
URL http://www.abc.net.au/news/2017-01-26/the-year-of-crispr:-scientists-celebrate-new/8213772
 
Description London Science Museum Lates: Engineering Natural Products, The Year of the Engineer 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact On the last Wednesday of every month, the London Science Museum opens its doors late into the evening to welcome adults to an engaging and free evening out, as part of the Science Museum Lates. Each evening is themed around a different science topic, attracts around 4,000 guests per night and offers a relaxed atmosphere where you can walk around with a drink in hand whilst talking science. OpenPlant participated in this event under the theme 'The year of the engineer' with a stand called 'Engineering Natural Products' to inform the general public about the activities of OpenPlant.
Year(s) Of Engagement Activity 2018
URL https://www.openplant.org/blog/2018/11/16/late-night-biological-engineering-in-london
 
Description Ludham Primary School SAW workshop 2015 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact OpenPlant teamed up with the Science Art Writing Trust to run a workshop at Ludham Primary School for 34 pupils age 9-11 in which they explored DNA, genetics, mendelian genetics, trait inheritence, Marchantia as a model plant organism and Synthetic Biology through science practicals, writing and art. The poetry that the pupils created showed a very impressive understanding of the science covered. At the beginning of the day, most pupils said they did not consider science as an interesting career option, but by the end of the day most all of the class said they would like to be scientists.
Year(s) Of Engagement Activity 2015
URL http://www.sawtrust.org/sawtrust/in-schools/openplant-saw-project-at-ludham-primary-school/
 
Description Mad Hatters Tea Party, Boomtown Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact OpenPlant and the SAW Trust organized science, art and writing activities to excite young minds at the BoomTown Fair. BoomTown Fair attracts up to 60, 000 people and many of those came to visit our stand. The children were tasked with many exciting science-based activities.
Year(s) Of Engagement Activity 2018
URL https://www.openplant.org/blog/2018/8/22/the-mad-hatters-tea-party-at-boomtown
 
Description Marvellous Medicines at Boomtown Festival Kidztown 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact OpenPlant and SAW teamed up this year to deliver a science tent for exploration of "Marvellous Medicines" in Kidztown at Boomtown festival (Aug 2017), which attracts over 50,000 people each year. This was the first time that the kids' area offered a science tent. The interactive exhibition included a natural products periodic table filled with different plants for extracting colours, scents, and citric acid. Kids could choose a selection of plants to make a potion from, which would change colour, fizz and give off a scent as the experiment progressed. Throughout, the children learned about a plant's ability to make different compounds that define their features such as colour, scent and taste. They extracted the colour pigment themselves and used other natural extracts to complete their potions, observing how we can use things that plants make for our own products. The older children also learned about pH and colour indicators, a classic chemistry practical they will no doubt carry out in secondary school. A further use for plants was discovered in the art stand: the plant materials could be used as 3D elements to decorate the potion bottles.
Year(s) Of Engagement Activity 2017
URL https://www.openplant.org/blog/2017/9/14/boomtown-fair-august-2017
 
Description Meeting on Norwich Research Park 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Presentation "Transient expressions of synthetic biology in plants" at Earlham Institute, Norwich Research Park, Meeting "Decoding and Recoding Biological Systems", 19/05/17
Year(s) Of Engagement Activity 2017
 
Description Metabolic Engineering: From Model Plants to Medicinal Plants OpenPlant Forum, Cambridge, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Yang Zhang, Eugenio Butelli and Cathie Martin gave an oral presentation "Metabolic Engineering: From Model Plants to Medicinal Plants" on 29.07.2015 at the OpenPlant Forum, Cambridge, UK
Year(s) Of Engagement Activity 2015
 
Description Molecular Biotechnology Laboratory Training Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The overall purpose of the workshop was to build capacity of early- and mid-African agricultural researchers and academics who can help advance innovative research and contribute to food security in Africa. This event was sponsored through an OpenPlant Fund grant, Nicola Patron presented, Susana Sauret-Gueto and Efty Frangedakis ran practical sessions.
Year(s) Of Engagement Activity 2018
URL https://www.biomaker.org/projects/2017/7/2/plant-prochip-j4sb3-flzfp-kx5mc-jkg9j
 
Description Molecular Training Workshop for African Scientists, University of Cambridge 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Lectures deleivered as part of a two week training evint for agricultural research scientists, academics and PhD students from across Africa. This was followed by discussion and follow-up questions by email.
Year(s) Of Engagement Activity 2018
URL http://www.jrbiotekfoundation.org/cambridge-lab-training-2018/
 
Description NRP DTP Summer Conference 2015 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact NRP DTP Summer Conference 2015 held in the assembly house in Norwich. 15 min talk: Pathway engineering using the GoldenGate MoClo system.

Norwich Research Park Doctoral Training Partnerships
Year(s) Of Engagement Activity 2015
URL http://www.biodtp.norwichresearchpark.ac.uk/
 
Description NRP-UEA 2015 iGEM Team (iGEM Giant Jamboree, Science in Norwich, Norwich Writers Centre Workshop) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Instructed an undergraduate iGEM team that presented at the iGEM Giant Jamboree in Boston, MA. The team also interacted with various audiences at Science in Norwich public outreach event, a workshop for scientists and poets at the Norwich Writers Centre, and to large numbers of students at the iGEM Giant Jamboree. The team also collaborated with other teams in Spain and the Netherlands. The project took different approaches to increase butyrate levels in the colon to protect against colonic cancer and also interacted with Cancer charities to discuss preventative measures to combat cancer and the use of bioengineering to make healthy foods and medicines.
Year(s) Of Engagement Activity 2015
URL http://2015.igem.org/Team:NRP-UEA-Norwich
 
Description NanoBioMater 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Lectured on "Plant viruses and virus-like particles as building blocks for bionanotechnology" at the NanoBioMater summer school, Bad Herrenalb, Germany, 22/06/15
Year(s) Of Engagement Activity 2015
 
Description Norwich Bio Makers 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Involvement by GP Lomonossoff in Norwich Bio Makers "Building Nanostructures in Plants", St. Andrews Brew House, Norwich, UK 13 Dec 2017
Year(s) Of Engagement Activity 2017
 
Description Norwich Biomaker Event: 3D Printing for Beginners 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Norwich Biomakers brings together an interdisciplinary network of people from across NorwichCity and the Norwich Science Park that share an interest in the cross-over of biology with design, technology, engineering, electronics and software. At this meetup, Brian Norman from the Norwich Hackspace gave a beginners introduction to 3D printing: including an explanation of some of the different types of printers, how to access and adapt files for printing from thingiverse (https://www.thingiverse.com/), and how to use openly available software to create your own designs.
Year(s) Of Engagement Activity 2018
URL https://www.meetup.com/Norwich-Biomakers/events/248890539/
 
Description Norwich Biomaker Event: Arduinos: Electronics from basics to projects 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Norwich Biomakers brings together an interdisciplinary network of people from across NorwichCity and the Norwich Science Park that share an interest in the cross-over of biology with design, technology, engineering, electronics and software. This biomakers meetup provided a beginners introduction and chance to explore projects based on Arduinos. Arduinos are small open-source electronics platform based on easy-to-use hardware and software. During the session, time was spent on working in multi-disciplinary teams to come up with ideas, plans and designs of Biomaker projects that involve the use of arduinos.
Year(s) Of Engagement Activity 2017
URL https://www.meetup.com/Norwich-Biomakers/events/244658016/
 
Description Norwich Biomaker Event: Artificial Intelligence in Life Sciences 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Norwich Biomakers brings together an interdisciplinary network of people from across NorwichCity and the Norwich Science Park that share an interest in the cross-over of biology with design, technology, engineering, electronics and software. At this meetup, Dr Ji Zhou from the Earlham Institute introduced his work in artificial intelligence and deep learning and it's uses in the life sciences, including projects such as in field monitoring of wheat growth and automated seed germination screening.
Year(s) Of Engagement Activity 2019
URL https://www.meetup.com/Norwich-Biomakers/events/258268625/
 
Description Norwich Biomaker Event: Building Nanostructures in Plants 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Norwich Biomakers brings together an interdisciplinary network of people from across NorwichCity and the Norwich Science Park that share an interest in the cross-over of biology with design, technology, engineering, electronics and software. In this session, Professor George Lomonossoff from the John Innes Centre talked about his work using plants to produce virus-like particles - tiny non-infectious nanospheres - which can be used as effective vaccines, and potentially for a variety of other purposes. PhD student Roger Castells-Graells brought along a variety of models to explain how these nanostructures form.
Year(s) Of Engagement Activity 2017
URL https://www.meetup.com/Norwich-Biomakers/events/244753486/
 
Description Norwich Biomaker Event: Building circuits with DNA 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Norwich Biomakers brings together an interdisciplinary network of people from across NorwichCity and the Norwich Science Park that share an interest in the cross-over of biology with design, technology, engineering, electronics and software. At this meetup, Nicola Patron (Earlham Institute) and Millie Stanton (John Innes Centre) talked about the relatively new scientific/engineering field of synthetic biology, and explained some of the basics of DNA.
Year(s) Of Engagement Activity 2018
URL https://www.meetup.com/Norwich-Biomakers/events/251989408/
 
Description Norwich Biomaker Event: Discover the Power Beneath Your Feet 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Norwich Biomakers brings together an interdisciplinary network of people from across NorwichCity and the Norwich Science Park that share an interest in the cross-over of biology with design, technology, engineering, electronics and software. This Norwich Biomakers meetup included a short talk from Prof Julea Butt to introduce the 'rock-breathing bacteria' that act as biobatteries and consider how they can be harnessed as a sustainable source of power. Discussions were held on how different disciplines - such as design, engineering, electronics, computing, biology etc - feed into such a project, and what biomakers could contibute to the multifaceted challenge of generating energy using biological organisms.
Year(s) Of Engagement Activity 2017
URL https://www.meetup.com/Norwich-Biomakers/events/243884032/
 
Description Norwich Biomaker Event: Explore Visual Programming with XOD 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Norwich Biomakers brings together an interdisciplinary network of people from across NorwichCity and the Norwich Science Park that share an interest in the cross-over of biology with design, technology, engineering, electronics and software. This meetup provided an opportunity for participants to discuss ideas for innovative and interdisciplinary projects in plant synthetic biology. The focus of this meetup was to build up resources in XOD for use when building low-cost sensors and instruments for biology.
Year(s) Of Engagement Activity 2018
URL https://www.meetup.com/Norwich-Biomakers/events/256838944/
 
Description Norwich Biomaker Event: How to generate electricity from plants 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Norwich Biomakers brings together an interdisciplinary network of people from across NorwichCity and the Norwich Science Park that share an interest in the cross-over of biology with design, technology, engineering, electronics and software. In this meetup, Dr Paolo Bombelli from the University of Cambridge talked about his work understanding plant and algae photosynthesis, and discussions were held on investigating ways for harnessing electricity directly from these plants.
Year(s) Of Engagement Activity 2018
URL https://www.meetup.com/Norwich-Biomakers/events/247546753/
 
Description Norwich Biomaker Event: Light-powered bacteria as biofactories 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Norwich Biomakers brings together an interdisciplinary network of people from across NorwichCity and the Norwich Science Park that share an interest in the cross-over of biology with design, technology, engineering, electronics and software. At this meetup, David Lea-Smith (UEA) discussed how cyanobacterial strains can be genetically engineered to improve growth and produce compounds of interest. Discussion were held on the development of photobioreactors that may make this a commercially viable technology.
Year(s) Of Engagement Activity 2018
URL https://www.meetup.com/Norwich-Biomakers/events/249032432/
 
Description Norwich Biomaker Event: Sensors and plant growth 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Norwich Biomakers brings together an interdisciplinary network of people from across NorwichCity and the Norwich Science Park that share an interest in the cross-over of biology with design, technology, engineering, electronics and software. This meetup was focused on learning about how different types of sensors and sensing equipment can be used to track and measure plant growth. Oscar Gonzalez (Quadram Institute) and Ricardo Ramirez Gonzalez (John Innes Centre) gave a hands-on demonstration of their ultrasonic ruler for measuring plant height in the field, showing the different sensors used in their setup.
Year(s) Of Engagement Activity 2018
URL https://www.meetup.com/Norwich-Biomakers/events/255634010/
 
Description Norwich Biomaker Event: Speedy breeding for crop plants 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Policymakers/politicians
Results and Impact Norwich Biomakers brings together an interdisciplinary network of people from across NorwichCity and the Norwich Science Park that share an interest in the cross-over of biology with design, technology, engineering, electronics and software. At this meetup, Sreya Ghosh (John Innes Centre) told the story of how speed breeding technology was developed, and Oscar Gonzales (Quadram Institute) and Ricardo Ramirez-Gonzalez (John Innes Centre) talked about a low-cost desktop chamber for the speed chamber he has built to enable this technology to be used on a smaller scale.
Year(s) Of Engagement Activity 2018
URL https://www.meetup.com/Norwich-Biomakers/events/248891990/
 
Description Norwich Biomakers 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Norwich Biomakers brings together an interdisciplinary network of people from across NorwichCity and the Norwich Science Park that share an interest in the cross-over of biology with design, technology, engineering, electronics and software. This group meets monthly at a variety of local spaces for events including talks, training in the use of technologies and to work on projects.
Year(s) Of Engagement Activity 2017,2018,2019
URL https://www.meetup.com/Norwich-Biomakers/
 
Description Norwich Science Festival 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Our exhibit on plant natural products at the 2017 Norwich Science Festival was so popular that we had a constant queue of people waiting for their turn to try out the activities. These included extracting plant pigments, making "potions" using these pigments which changed colour under acid and alkali conditions, and then creating a volcano effect due to the reaction of the acid and alkali together. We also had displays about different plant natural products that are already readily used by society, and some that are less well known but are being researched by scientists. We provided a handout that children and parents could take home to experiment further at home.
Year(s) Of Engagement Activity 2017
 
Description Norwich Science Festival John Innes Centre Exhibit 22.10.16 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Norwich Science Festival.

The interactive 'Power of Plants' stand from the Latitude Festival made another appearance at the first Norwich Science Festival with Katrin Geisler coming over from Cambridge University to join JIC scientists Michael Stephenson, Hannah Griffiths, Colette Matthewman, Zhenhua Liu, Nadiatul Radzman, Dorota Jakubczyk, Don Nguyen, Miriam Walden, Jenni Rant and Roger Castells-Graells for two days as part of the Norwich Research Park's 'solving problems with science' weekend. A new addition to the stand was developed by Roger who introduced visitors to the structure of viruses through his challenge to build a giant virus particle. Plants are being used to produce virus particles for use as vaccines and so for visitors this deeper look at viruses in combination with a hands-on experience of mock infiltration of Nicotiana benthamiana plants with water enabled the scientists to explain the techniques involved and exactly what is being made by plants in this system. People were very interested in the variety of science on display and asked lots of questions. It was good to showcase our research at the first Norwich Science Festival and to show people locally how far reaching the work taking place in essentially a rural county can be in terms of impact to societies across the globe.
Year(s) Of Engagement Activity 2016
URL http://norwichsciencefestival.co.uk/
 
Description Norwich Science Festival Schools Week 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Following the creation of DNA Dave, a robot made using funding from a Biochemical Society grant to explain how DNA is transcribed and translated into protein, we were asked by the organisers of the Norwich Science Festival if they could borrow Dave for the schools week of the festival. We delivered Dave to the Forum in Norwich and gave a group of volunteers some training in how Dave works and how to use him while explaining the processes to the public. Dave then spent a week meeting groups of school children and helping them understand this fundamental principle. Teachers feedback highlighted how effective DNA Dave had been in getting students to piece together the various steps they had learned in school but not quite grasped. We have since been asked if Dave could make visits into classrooms to help with teaching this concept.
Year(s) Of Engagement Activity 2017
 
Description Norwich Science Festival: Super charged plants 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The general public is informed on the activities of OpenPlant during the Norwich Science Festival.
Year(s) Of Engagement Activity 2018
 
Description Norwich Single Cell Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Colette Matthewman presented on the OpenPlant Fund and Biomkaer Challenge opportunities at the Norwich Single Cell symposium. The Norwich Single Cell Symposium aimed to bring researchers curious about single cell genomics together with external speakers presenting advanced single cell research, to highlight the developing single cell capabilities available at Earlham Institute and to act as a platform to catalyse future development and application of single cell genomics approaches in the region. At least two OpenPlant Fund projects were proposed and funded as the result of this activity.
Year(s) Of Engagement Activity 2017
URL http://www.earlham.ac.uk/norwich-single-cell-symposium
 
Description Open digital tools and infrastructures in biology workshop (Newcastle) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The thematic focus of the workshop was on open digital tools and infrastructures in biology. The discussions was organized in three sessions: The two first sessions presenting tools and infrastructures that have been developed by different communities in a out of institutional settings -with a special focus on the Synthetic Biology Open Language (SBOL) and DIYbio projects. The third and last section will be a collective discussion. Jenny Molloy presented on OpenPlant activities in relation to open science.

There were around 25 attendees and requests and follow up contact was made with two people, who continue to look for ways to collaborate.
Year(s) Of Engagement Activity 2016
 
Description OpenPlant All-hands meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Colette Matthewman organised and facilitated a 1-day meeting on 6th may 2016 to bring together OpenPlant researchers from across the entire programme to discuss cross-cutting topics such as methods for sharing information, data, tools and technologies, research synergies and opportunities for increasing impact. Among other things, this event led to the identification of several new synergies, the establishment of an online discussion forum for OpenPlant researchers, and open sharing of a collection of protocols on protocols.io
Year(s) Of Engagement Activity 2016
URL https://www.protocols.io/groups/openplant-project
 
Description OpenPlant Exhibit at SynBioBeta London 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact The 6 UK SBRCs shared an exhibit space at SynBioBeta London 2016. A new banner and leaflet about OpenPlant were developed for this event, and Colette Matthewman manned the exhibit and talks to a wide range of people at the event. This was felt to be a very useful exercise and as a result the SBRCs are planning to repeat this together with the UK Foundaries at SynBioBeta London 2017.
Year(s) Of Engagement Activity 2016
URL http://synbiobeta.com/conferences/synbiobeta-london-2016/
 
Description OpenPlant Forum 2015 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The 2015 OpenPlant Forum provided a focus point for gathering members of the OpenPlant consortium and others in the field of plant (and broader) synthetic biology, open technologies and exchange. The event was held as part of Open Technology Week in Cambridge which included activities for developing fundamental tools for synthetic biology and beyond, including a Maker Faire, Open Technology Workshop, Pitches for the OpenPlant Fund and a meeting of the OpenPlant working group that is informing the development of the OpenMTA, a key focus of OpenPlant's aims to promote freedom to operate. All these activities fed into the theme of the OpenPlant Forum, which focused on access, openness and enabling technologies and attracted a strongly interdisciplinary, intersectorial group of ~90 participants. A SynBioBeta Activate! Event "Reprogramming Life with Synthetic Biology" provided a networking event with local, national and international industry during the Forum. The event was instrumental for showcasing the work of OpenPlant to a broader audience and engaging with the synthetic biology community and external experts that will add value to the OpenPlant programme.

Feedback from attendees, including the OpenPlant Scientific Advisory Board, was positive and various discussions were seeded that shaped plans for OpenPlant Forum 2017 and interim activities.
Year(s) Of Engagement Activity 2015
URL http://openplant.org/openplantforum/
 
Description OpenPlant Forum 2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The 2016 OpenPlant Forum was based on the theme of "Reprogramming Agriculture", with invited keynote talks from Allan Green (CSIRO, Australia), Johnathan Napier (Rothamsted Research) Patrick Jarvis (AB Sugar, Wissington), Dominic Berry (University of Edinburgh), Spencer Adler (Bioeconomy Capital), Tom Knight (Ginkgo Bioworks), Peter Murray-Rust (ContentMine, Cambridge), commentary from Monique Simmonds (Kew Gardens), Wieke Betten (University of Amsterdam) and industry perspectives from Leaf Systems, NCG:Earlham Institute, OxSyBio, Cambridge Consultants, Rainbow Seed Fund/Midven, and Plant Bioscience. The event was held at the John Innes Conference Centre and included an industry showcase, a variety of talks from OpenPlant researchers and invited speakers, panel discussions, and poster sessions. Around 130 people participated and engaged with the Forum across the three days intiating discussions and sparking ideas that have fed into subsequent activities. Feedback was very positive, including that of the OpenPlant Science Advisory Board.
Year(s) Of Engagement Activity 2016
URL https://www.openplant.org/blog/blog/2016/09/openplant-forum-2016-reprogramming-agriculture-with-synb...
 
Description OpenPlant Forum 2016, JIC, Norwich 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact I delivered a talk entitled "Making all kinds of everything - The joy of plant-based transient expression" at OpenPlant Forum 2016, JIC, Norwich on 26th July 2016.
Year(s) Of Engagement Activity 2015,2016
URL http://www.openplant.org
 
Description OpenPlant Fund Mixer - Nov 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact This event was a mixer for the winter 2017 OpenPlant Fund call. It provided an introduction to the opportunities offered by the OpenPlant Fund, a chance to present initial project ideas and to meet potential collaborators, a team-based activity emphasising the importance of effective documentation of projects, and a brief training on communication.
Year(s) Of Engagement Activity 2017
URL http://www.openplant.org/fund
 
Description OpenPlant Fund Mixer Dec 2016, Cambridge 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact A mixer event for the OpenPlant Fund was held in Cambridge on Monday 21 November, together with the Cafe Synthetique evening on microfluidics. A group of participants joined from Norwich. The mixer initiated several new collaborations across the two sites and contributed to the development of 10 applications pitched for OpenPlant Funds.
Year(s) Of Engagement Activity 2016
URL https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/235487332/
 
Description OpenPlant Fund Mixer: Innovation and Entrepreneurial Opportunities 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact This event, held in Norwich, provided an opportunity for participants to discuss ideas for OpenPlant Fund proposals for innovative and interdisciplinary projects in plant synthetic biology. Several researchers traveled from Cambridge to join the event.
Year(s) Of Engagement Activity 2018
URL https://www.openplant.org/events-calendar/2018/6/22/openplant-fund-mixer-open-innovation-entrepreneu...
 
Description OpenPlant Fund mixer activity at NoCaSS 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact The Norwich-Cambridge Student Symposium for Plant and Microbial Sciences is organised by and brings together postgraduate students across Norwich and Cambridge. Jenny Molloy and Colette Matthewman participated in the 2017 symposium, which was held at the John Innes Centre, Norwich. They presented on the OpenPlant Fund and Biomaker Challenge funding shemes, and ran a mixer activitiy during the lunch break which was designed to build bridges between Norwich and Cambridge students, generate new ideas, and help the students to undestand the role of these funding schemes.
Year(s) Of Engagement Activity 2017
URL http://nocass.org/
 
Description OpenPlant Fund mixer event, Cambridge 2015 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact A mixer event aimed at post-graduate students and post-docs, to present the OpenPlant Fund and set up new multidisciplinary project collaborations between Norwich Bioscience Institutes and Cambridge University.
Year(s) Of Engagement Activity 2015
 
Description OpenPlant Fund mixer event, Cambridge 2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact A mixer event run in Cambridge but with participants from both Norwich Bioscience Institutes and Cambridge University, aimed at post-graduate students and post-docs, to present the OpenPlant Fund and set up new multidisciplinary project collaborations between Norwich Bioscience Institutes and Cambridge University.
Year(s) Of Engagement Activity 2016
 
Description OpenPlant Fund mixer event, Norwich 2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact A mixer event run in Norwich with participants from both Norwich Bioscience Institutes and Cambridge University, aimed at post-graduate students and post-docs, to present the OpenPlant Fund and set up new multidisciplinary project collaborations between Norwich Bioscience Institutes and Cambridge University.
Year(s) Of Engagement Activity 2016
 
Description OpenPlant Fund presentation, BBSRC SynBio for Growth meeting, Edinburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Colette Matthewman gave a presentation at the BBSRC-EPSRC Synthetic Biology for Growth meeting in Edinburgh in November 2016. There was a lot of interest in the funding scheme which led to other SBRCs considering similar schemes, and an invitation for Colette to present at the Synthetic Biology Leadership Council open meeting.
Year(s) Of Engagement Activity 2016
URL https://www.openplant.org/fund/
 
Description OpenPlant Intellectual Property Working Group 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Twenty four experts were recruited to the first OpenPlant working group on the topic of IP solutions for OpenPlant and the wider SynBio community, specifically an open Material Transfer Agreement (MTA) that would allow materials such as DNA parts to be exchanged between institutions with a standard contract that allows for redistribution and commercial use. A meeting of the IP Working Group took place on 30 July 2015. The purpose of the meeting was to bring together academic researchers, technical experts, and legal practitioners to explore the challenges and solutions for creating and sustaining an international platform of open technologies for plant synthetic biology. A report on the meeting was drafted and will be made available online along with the draft OpenMTA Linda Kahl from the BioBricks Foundation is compiling. Decisions and refinement of this draft was a direct outcome of the meeting. The working group had regular teleconferences following the meeting and BioBricks Foundation and University of Cambridge have recently entered the Wellcome Trust/NIH/HHMI supported Open Science Prize for additional funding to continue this collaboration.
Year(s) Of Engagement Activity 2015
 
Description OpenPlant Twitter account 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The OpenPlant twitter channel is used as a wide-reaching route to share and exchange information about events, opportunities, methods and tools, and research and other outcomes relevant to OpenPlant.
Year(s) Of Engagement Activity 2015,2016
URL https://twitter.com/_openplant
 
Description OpenPlant Website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The OpenPlant website is a central information point for those on the OpenPlant programme and those interested in it. The website contains information about the programme, upcoming events and opportunities, and blogs commenting on events that have happened. We are currently looking at expanding the website audience base by setting it up to host information for the general public, teaching resources and outcomes and resources generated by OpenPlant.
Year(s) Of Engagement Activity 2014,2015,2016
URL http://www.openplant.org
 
Description OpenPlant Working Group on Open Curriculum Development for Cell-Free Synthetic Biology 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact In 2017 an OpenPlant working group was established which focuses on curriculum development and teaching resources for fast and frugal biotechnology, specifically cell-free synthetic biology. The first meeting of the working group took place on Thursday 27 July 2017, after the annual OpenPlant Forum. A range of key stakeholders and influencers were invited, including researchers at the cutting edge of cell-free technology, educationalists and outreach experts. The working group focused on the educational opportunities offered by cell-free systems and freeze-dried components to provide a platform for teaching synthetic biology at low-cost and without use of GMOs. The first meeting lay the groundwork for assembly of open and modular curriculum components that could be combined into different teaching frameworks across multiple disciplines, drawing on existing work from organisations such as BioBuilder, the National Centre for Biotechnology Education, Science and Plants in Schools and the ARM Education Programme. There was a high level of interest in continued activities and plans include: includ
Year(s) Of Engagement Activity 2017
 
Description Oral presentation at AAB Conference "Advances in Plant virology", 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lomonossoff G. P.(2018) Synthetic virus-like particles and how to make them in plants AAB meeting "Advances in Plant Virology", Jury's Inn, Birmingham 12-13th April 2018
Year(s) Of Engagement Activity 2018
 
Description Oral presentation at ISPMF Helsinki, 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lomonossoff G. P., Marsian J., Paley R., Hurdiss D. L., Ranson N. A.(2018) Global food security - Plant-made Virus-Like Particles as a candidate vaccine against Nervous Necrosis Virus. Oral presentation at the 3rd meeting of the International Society for Plant Molecular farming (ISPMF), 11-13th June 2018
Year(s) Of Engagement Activity 2018
 
Description Oral presentation at ISPMF meeting, Helsinki 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Peyret H., Lomonossoff G. P.(2018) Using a synthetic biology approach to develop a novel, easy to use, and open access transient expression system
Helsinki, Finland, 3rd ISPMF conference, 11-13th June 2018
Year(s) Of Engagement Activity 2018
 
Description Oral presentation at Ninth International Virus Assembly Symposium, Madeira 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Castells Graells R., Johnson J. E., Lomonossoff G. P.(2018) Studying virus maturation stages with an insect virus Madeira - Portugal, Ninth International Virus Assembly Symposium, 6th-10th May 2018
Year(s) Of Engagement Activity 2018
 
Description Oral presentation at SEB Florence 2018 symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lomonossoff G. P.(2018) Transient expression of virus-like particles for use in biomedicine and bionanotechology SEB Florence 2018 symposium "Plant Biotechnology for health and nutrition,
Year(s) Of Engagement Activity 2018
 
Description Oral presentation at VLPNPV, Bern 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Saunders K., Hesketh E. L., Fisher C., Ranson N. A., Lomonossoff G. P.(2018) The generation of aberrant geminivirus-like particles in infiltrated plant leaves Inselspital, Universitatsspital, Bern, Switzerland. The Fifth International Conference on: Virus-Like Particle & Nano-Particle Vaccines - VLPNPV 2018 25-27th September 2018
Year(s) Of Engagement Activity 2018
 
Description Outreach at Botanic Gardens Festival of Plants 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Outreach at Botanic Gardens Festival of Plants - Paul Dupree
Year(s) Of Engagement Activity 2016
 
Description PAGIT Project: Synthetic Biology/Gene Editing Workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Colette Matthewman participated in a workshop for the BSI/ESRC PAGIT Project: Proportionate and Adaptive Governance of Innovative Technologies, on Synthetic Biology/Gene editing. The workshop presented an updated version of the PAGIT Framework and discussed proposals for implementation of a more proportionate and adaptive approach to governance of syntheric biology/gene editing.
Year(s) Of Engagement Activity 2017
URL https://www.eventbrite.com/e/pagit-project-synthetic-biologygene-editing-workshop-tickets-3109292878...
 
Description PAGIT workshop on the role of standards in shaping SynBio regulation 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The Proportionate and adaptive governance of innovative technologies (PAGIT) project is a collaborative project led by the Innogen Institute and the British Standards Institution. Colette Matthewman participated in the PAGIT Project: Synthetic Biology/Gene Editing Workshop on the role of standards in shaping regulation and supporting innovation. Discussions from this workshop will form the basis of a report aimed at influencing decision-makers.
Year(s) Of Engagement Activity 2017
URL https://www.bsigroup.com/en-GB/about-bsi/uk-national-standards-body/BIS-Exploring-new-areas-with-gov...
 
Description PHYCONET (BBSRC NIBB) Meeting: "UK Microalgal biotechnology, creating a unified vision" Cambridge February 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact A workshop of academia, funders, policy makers and industry, aimed at identifying ways to augment and support the UK microalgal business. As a result of the meeting, we made links with several companies and have obtained two Business Interaction Vouchers
Year(s) Of Engagement Activity 2018
URL http://www.phyconet.org.uk/document_category/uk-microalgal-biotechnology-creating-a-unified-vision
 
Description Phyconet (BBSRC NIBB) Annual Meeting, Plenary speaker 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact The talk was aimed at showing that the potential exploitation of algae for industrial purposes needs to be underpinned by fundamental biological understanding. Several industrial colleagues agreed, saying they recognise the need for better algal taxonomy and physiology to support their activities and ensure their IP can be protected.
Year(s) Of Engagement Activity 2017
URL http://www.phyconet.org.uk/wp-content/uploads/2017/09/PAC17_programme.pdf
 
Description Pint of Science 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact I presented a talk on the potential uses of algae for bioenergy production as part of the Pint of Science festival in Cambridge, where scientists engage with people having a drink in a local pub. This takes place in London, Cambridge, Bristol and other university towns each year. As result of my talk and questions afterwards, although most people were not aware initially what algae were, nor how they could be used to generate energy, their opinions became more positive and optimistic towards biofuels generally. Pint of Science was awarded "Points of Light" by the Prime Minister David Cameron in November 2015 and the founders were interviewed about it on London Live TV.
Year(s) Of Engagement Activity 2014,2015
URL https://en.wikipedia.org/wiki/Pint_of_Science
 
Description Pint of Science Festival 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Presentations by R Castells-Graells and G.P. Lomonossoff at Pint of Science Festival Norwich - Medicinal Viruses: From Foe To Friend, 16 May 2017
Year(s) Of Engagement Activity 2017
URL https://pintofscience.co.uk/event/medicinal-viruses-from-foe-to-friend
 
Description Pint of Science: 20,000 Leagues Under the Microscope: Viruses & Nanomachines 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact PhD Student and OpenPlant Fund holder Roger Castells-Graells presented to a sell out audience at the Norwich 2017 Pint of Science Festival. Roger's presentation '20,000 Leagues Under the Microscope: Viruses & Nanomachines' took the audience on a journey into the nano world of viruses. During the entertaining talks, the audience took part in various activities such as making a virus molecule out of pipe cleaners and creating virus inspired sketches on beer mats. To help the audience engage with the research, Roger used 3D printed models of viruses produced through his OpenPlant Fund project.
Year(s) Of Engagement Activity 2017
URL https://www.openplant.org/blog/2017/11/23/openplant-scientists-take-part-in-norwich-pint-of-science-...
 
Description Pint of Science: Finding Drugs in The Garden 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Professor Anne Osbourn presented to a sell-out audience at the 2017 Norwich Pint of Science Festival. Anne took to the stage at the St Andrews Brewhouse to present on 'Finding Drugs in The Garden'. Anne's talk invited people into the plant kingdom to hear about its very own chemistry toolkit. She presented her teams current work harnessing the DNA that encodes the pathways to these chemicals and using them to produce designer molecules for medicinal, agricultural and industrial applications. The talk was followed by a lively discussion.
Year(s) Of Engagement Activity 2017
URL https://www.openplant.org/blog/2017/11/23/openplant-scientists-take-part-in-norwich-pint-of-science-...
 
Description Pint of Science: Just Eat Your Greens - A New Way of Vaccinating? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Professor George Lomonossoff gave a talk to a sell out audience at the Norwich Pint of Science Festival. George's talk was entitled 'Just Eat Your Greens - A New Way of Vaccinating?' and took place at the York Tavern. It covered the use of a highly efficient transient expression system developed in his laboratory. This Hypertrans® system allows for the relatively quick and cheap production of large quantities of virus-like particles in plants, which have been proven to be effective as experimental vaccines.
Year(s) Of Engagement Activity 2017
URL https://www.openplant.org/blog/2017/11/23/openplant-scientists-take-part-in-norwich-pint-of-science-...
 
Description Pitch in a Punt 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Applicants for the 2015 OpenPlant Fund round were invited to attend the Pitch in a Punt workshop to learn about pitching for money, prior to their short pitches for OpenPlant funding. Most of the participants had not been exposed to this method of presenting their ideas and proposals and so found the course very useful for improving their skills.
Year(s) Of Engagement Activity 2015
URL http://openplant.org/fund/
 
Description Plant Genetics Resources and the Sustainable Development Goals: Needs, Rights, and Opportunities. Rockefeller Bellagio Center, Bellagio, Italy 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact 18 experts from a range of disciplines were hosted by The Rockefeller Foundation at its Bellagio Center in Italy to discuss how plant genetic resources relate to and can be instrumental in meeting the United Nations' Sustainable Development Goals (SDGs).

The group had three objectives, which were to:
• Advance the ongoing global dialogue about how science, technology, data, and digital information about plant genetic resources (PGR) may impact and potentially help agriculture adapt to the changing climate and augment food and nutritional security, particularly in the developing world
• In the context of the SDGs, explore the interaction between emerging R&D opportunities (emanating from scientific and technological advances and increased data sharing capability) and the current policy framework related to access, use, and benefit-sharing of PGR and related information.
• Identify pathways for harmonizing the PGR policy framework with rapid developments in science and information technology to ensure safeguards and enhance opportunities to address the SDGs.
The group agreed to pursue three outputs, to be completed in the next six months:
• As a group, the participants will develop a comprehensive meeting report for public distribution. This report was initiated during the meeting and will be completed early in 2017.
• During the meeting, participants from the Diversity Seek Initiative (DivSeek) gathered input for their response to an invitation by the Secretary of the International Treaty for Plant Genetic Resources in Food and Agriculture (ITPGRFA) "to report on the implications for the objectives of the Treaty of the technologies underlying the DivSeek initiative" (as per paragraph 6 of Resolution 3/2015 of the Sixth Session of the Treaty Governing Body). This outcome can be used by the Secretariat to compile a synthesis on this report for consideration by the Governing Body of the Treaty at its Seventh Session in 2017. Participants agreed to provide additional input on the draft submission to the Treaty upon request from DivSeek.
• Finally, at least one scholarly article will be published as a result of this meeting describing the issues discussed and exploring potential solutions and bottlenecks to progress. The group agreed that it would be ideal to aim to develop a balanced treatment such that all participants would be happy to be identified as authors or contributors where their expertise was relevant to the subject matter. Participants also discussed how best to communicate the results with other audiences and agreed to consult with one another if any developed blog posts or articles related to the meeting.
Year(s) Of Engagement Activity 2016
 
Description Plant Synthetic Biology Hackathon at TGAC (Norwich) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The hackathon engaged technologists and users from diverse scientific backgrounds to build on and use ContentMine tools to liberate synthetic biology scientific literature. The workshop centered on novel methods for discovering information about plants from the existing literature ("Content Mining"). Peter Murray-Rust and 3 other colleagues from Cambridge prepared ContentMine software specifically for the workshop on the basis that "anyone can run it and get useful results".

The hackathon took place over 2 days, with the first day comprising talks and demos from the ContentMine team, alongside an afternoon of splitting into groups based on skills and/or interests gleaned from the morning, and installing the software on whatever operating system they commonly used. The second day saw the groups continuing to work on developing and improving ContentMine functionality, fixing software bugs, and using the tools to gather papers and facts from synthetic biology terms.
Year(s) Of Engagement Activity 2016
 
Description Plants in iGem Workshops 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Workshop on Plants in synthetic biology held at the iGEM Giant Jamboree every year since 2014. Members of many international iGEM teams, industry and civil society representatives, as well as the iGEM executive team attend. The workshops comprise short talks followed by discussion (with audience participation) and information-sharing about plant synthetic biology tools and techniques.
these workshops, together with other activities have resulted in
- The establishment of a Plant Committee at iGEM
- The acceptance of parts in the Common Plant Syntax in the iGEM Registry
- The establishment of a Special Award for excellence in Plant Synthetic Biology in the iGEM competition (from 2016 onwards)
Year(s) Of Engagement Activity 2014,2015,2016
URL http://2016.igem.org/Resources/Plant_Synthetic_Biology
 
Description Plenary Speaker IAPB Congress Dublin Ireland 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact I was a Plenary Speaker at the IAPB Congress Dublin Ireland
Year(s) Of Engagement Activity 2018
 
Description Plenary Speaker SEB Meeting Florence 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Plenary speaker at SEB Meeting in Florence. England beat Colombia on penalties in the World Cup.
Year(s) Of Engagement Activity 2018
 
Description Plenary Speaker at Foods of the Future Workshop in Koln 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact I was a Plenary Speaker at Foods of the Future Workshop in Koln
Year(s) Of Engagement Activity 2018
 
Description Plenary speaker, International meeting on plant genomics, Verona Italy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact I was a Plenary speaker, at the International meeting on plant genomics, Verona Italy
Year(s) Of Engagement Activity 2018
 
Description Posdoc talk at the Plant Sciences Departmental Seminar - Gonzalo Mendoza 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Plant Metabolism Group member and OpenPlant-funded postdoc Gonzalo I Mendoza-Ochoa, gave a 25-minute talk to postgraduate students and postdocs within the Department. During the seminar, he talked about his previous and current research work and expertise. The aim was to present himself as a new member of the department and to seek interactions and collaborations with his colleagues.
Year(s) Of Engagement Activity 2018
URL http://www.talks.cam.ac.uk/talk/index/82681
 
Description Post Doctoral Retreat 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Presented career pathways in science communication to a large group of Post Doctoral Researchers and led a discussion on the need and importance of engaging society with research.
Year(s) Of Engagement Activity 2018
 
Description Poster and Oral Presentation by Ingo Appelhagen Colour bio-factories: towards scale-up production of anthocyanins in plant cell cultures 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentations by Ingo Appelhagen at the 3rd Conference of the International Society for Molecular Farming, Helsinki, 11-16 June 2018
Year(s) Of Engagement Activity 2018
 
Description Presentation and discussion at Norwich Science Festival 2018 (Engineering Day) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Presentation on biomanufacturing to general public including interactive activity with biochemical pathways and debate about the meaning of the word 'natural', biological vs chemical manufacturing methods and whether manufacturing can be sustainable.
Year(s) Of Engagement Activity 2018
URL https://norwichsciencefestival.co.uk/events/building-with-biology/
 
Description Presentation at BISON workshop 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Presented synthetic biology-themed science engagement approaches to a group of academics for a BISON workshop in Norwich.
Year(s) Of Engagement Activity 2018
URL http://bison.ceitec.cz/
 
Description Presentation at BrisSynBio 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact On 22/02/17 I visited BrisSynBio in Bristol to talk to people working there and to tour the facilities. I also delivered a lecture entitled: Transient expressions of synthetic biology in plants
Year(s) Of Engagement Activity 2007,2017
URL http://www.bristol.ac.uk/brissynbio/
 
Description Presentation at the European Parliament Plants, Diet and Health 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Presentation to the European parliament on the importance of fruit and vegetables in the diet. we discussed how best to implement lower costs, greater access and greater consumption of fruit and vegetables.
Year(s) Of Engagement Activity 2018
 
Description Presentation by D.Ponndorf, Korea 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Ponndorf D., Peyret H., Meshcheriakova Y., Dobon Alonso A., Lomonossoff G.(2018) Virus-like particles from plants: Versatile tools for research in vaccine development
Korean Society for Plant Biotechnology: from Farming to Pharming .
Year(s) Of Engagement Activity 2018
 
Description Presentation for Norwich Research Park Industrial Biotech Alliance 2016 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presented OpenPlant industrial biotech case studies to the Industrial Biotechnology Alliance Science Advisory Board
Year(s) Of Engagement Activity 2016
 
Description Presentation on Responsible Governance at PAGIT workshop 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The Proportionate and adaptive governance of innovative technologies (PAGIT) project is a collaborative project led by the Innogen Institute and the British Standards Institution. Colette Matthewman gave a presentation entitled "How standards can contribute to responsible governance of innovation: a perspective from synthetic biology" at the PAGIT Project: Responsible Research and Innovation (RRI) Workshop on delivering 'responsibility' in the development of innovative technologies through standards. Colette also contributed to discussions which will form the basis of a report aimed at influencing decision-makers.
Year(s) Of Engagement Activity 2017
URL https://www.bsigroup.com/en-GB/about-bsi/uk-national-standards-body/BIS-Exploring-new-areas-with-gov...
 
Description Presentation to DBT consortium 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Plant-expressed Proteins, The technology and its use for BTV Meeting for BBSRC/DBT India Grant Consortium, School of Veterinary Sciences, Sutton Bonnington, University of Nottingham, UK
Year(s) Of Engagement Activity 2018
 
Description Programmable biology for diagnostics: impacting global health and development (as part of BB/GCRF-IAA/04) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact This activity was funded by IAA grant BB/GCRF-IAA/04. On 16 March 2017, we gave a workshop titled Programmable biology for diagnostics: impacting global health and development. Around 25 people attended the workshop, 15 of whom also stayed for the sandpit session in the afternoon. The event kicked off with a presentation on the progress of OpenDiagnostics, followed by two guest speakers. Richard Echodu, a professor from Gulu University in Uganda, gave a presentation about challenges and opportunities for crop disease diagnostics in Africa. The second guest speaker was Keith Pardee, an assistant professor at the University of Toronto and co-founder of the technology on which cell-free paper-based diagnostics rest. During the afternoon, participants formed three sandpit groups: biology, hardware, and open technology & development. They proposed projects that could contribute to the Open Diagnostics projects. We also ran a hands-on practical to complement the OpenDiagnostics Forum for potential collaborators and others interested in finding out more about cell-free diagnostics. This was attended by around 20 postdocs and PhD students from a range of disciplines, including computer science, engineering and physics as well as biological sciences.
Year(s) Of Engagement Activity 2017
 
Description RRI Workshop, 2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Workshop for post-docs employed within or associated with the OpenPlant SBRC, providing an overview of responsible research and innovation and exploring bioethics, styles of argumentation, and openness in science. These topics sparked much discussion amongst the group, as well as consideration and questioning of how to incorporate responsible research and innovation into the participants own research projects. This workshop was associated with the SAW Workshop for researchers which explored engagement with the public through art and writing.
Year(s) Of Engagement Activity 2016
 
Description Responsible and open innovation with large bioresources: goals, challenges and proposals (UK) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact An OpenPlant Fund supported workshop (funds to Kathy Liddell, Nicola Patron, Rob Doubleday). Organised by the Centre for Science and Policy at the University of Cambridge this workshop sough to explore the access and ownership issues surrounding large-scale bioresources such as Synthetic Biology Repositories of Biological Parts, TheStructural Genome Project, and the 100,000 Genome Project. Attendees from government, academia, investment and industry discussed Openness and bio-resource policies that would support both academic research and market-driven private investment.
Year(s) Of Engagement Activity 2016
URL http://www.csap.cam.ac.uk/media/uploads/files/3/draft-programme-for-28-january-policy-workshop-1.pdf
 
Description Royal Society Meeting for New Fellows introductory presentation 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact I presented my research that underpinned my election as a Fellow of the Royal Socity
Year(s) Of Engagement Activity 2018
 
Description Royal Society: Future Technologies 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Public discussion at South Bank, London with Sir Tim Burners-Lee, Stephen Fry, Prof. Dame Wendy Hall and Bill Thompson
Year(s) Of Engagement Activity 2010
 
Description SAW Project on DNA and Cells 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Delivered a SAW project with a year 6 class at a local primary school on DNA and cells and also talked about careers in science with the children.
Year(s) Of Engagement Activity 2019
 
Description SAW School Visit & teacher training (China) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact In December 2012 we were invited by the Tianyang Foundation and the Xuhui Education Bureau to visit Shanghai to launch the Science Art and Writing(SAW) initiative in China. This was the beginning of a very exciting partnership that enables Chinese teachers and children to develop their creativity using the SAW philosophy. We worked with a group of children and delivered a training workshop to enable teachers and volunteers to explore SAW techniques and begin experimenting with how SAW could be used in their classrooms. As the John Innes Centre strengthens its links with the Chinese Academy of Sciences, the scheme will be rolled out more widely with support from Norfolk County Council's International Schools Partnership. We returned in 2014 to give further training to new schools and found that since the launch they had used SAW with about 1000 children in 18 schools and kindergartens in the Xuhui district, training 140 teachers and involving around 50 social volunteers! In December 2015 we hosted a visit to the UK by a group of Chinese teachers who use SAW in China so they could see how it works here. During 2016 we supported collaborations between teachers locally in Norfolk and in Shanghai working on SAW Lunchbox Science projects to assist Norfolk County Council in strengthening partnerships between international schools. In April 2017, in collaboration with Norfolk County Council, we took a group of teachers from Norfolk schools who had been participating in the Lunchbox Science projects to visit the teachers in Shanghai that ad also been working on this for a series of sharing presentations, demo lessons and visits to several schools in the city. We also moved further out of the centre to deliver a SAW Plant Natural Products training workshop for 40 new Chinese teachers. Further visits are being planned for 2018.
Year(s) Of Engagement Activity 2012,2014,2015,2016,2017
URL http://www.jic.ac.uk/news/2013/02/dr-jenni-rant-takes-science-and-eternal-rainbows-to-china/
 
Description SAW School Visit to Salem State University, Boston, USA 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact The Science Art and Writing initiative has been used to run complementary projects with educationalists in the US since its inception in 2005. In 2008 we visited the School of Education at Salem State College to work with 7-9 year olds exploring the theme of 'Maple Syrup' through science art and writing, and trainee teachers attended a SAW training workshop. Salem State has long been an advocate of the SAW approach, and SAW exercises continue to be part of the teacher training delivered by the institution. On the 28th April 2015 we returned to Salem State University to run a SAW project on the theme of photosynthesis with a class of 9-10 year old children and were joined by trainee teachers who wanted to learn the process. We have been invited back in 2016 to further develop training and partnerships in the Boston area.
Year(s) Of Engagement Activity 2015
 
Description SAW Science Inspired Poetry Workshops at the Writers Centre Norwich 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact The SAW Trust have begun a new collaboration with the Writers Centre Norwich(WCN) to provide science-inspired poetry workshops for adults using current science topics as a starting point for writing.
The first pilot project took place on the evening of 18th August 2015 and was delivered as a partnership with a group of undergraduate students from the University of East Anglia competing in an international synthetic biology challenge called iGEM ( http://igem.org/Main_Page ). The students wanted a novel approach to exploring the human practices component of their project so the SAW Trust helped the team link with Jonathan Morley from WCN to set up a poetry workshop. Jonathan invited Esther Morgan, a highly experienced poet and workshop provider to lead the poetry session (http://www.esthermorgan.net/). Esther came to visit the students at the Norwich Research Park prior to the session and had an afternoon of tours around the laboratories to see what the students were working on.
The poetry session began with a presentation by the students on the science to give all the attending writers an insight into the aims of the research. Esther then took over providing some warm-up activities linked to the science and then got the scientists to break out into pairs with the writers to discuss the scientific language in more detail.

A great selection of poetry emerged from the workshop and was presented at a jamboree for all competing teams by the Norwich iGEM team in Boston, USA, which is the final stage of the competition. The team were delighted to be awarded a gold medal for their project and be rated in the top 5 of all 280 teams for their approach to education and public engagement.

We have since run an antibiotics-themed poetry workshop on 12th February 2016 and have plans for a further 3 workshops throughout the year.
Year(s) Of Engagement Activity 2015
 
Description SAW Workshop 'Green factories' at Tunstead Primary School Yr3 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact 'Green factories' was a cross-disciplinary Science, Art and Writing (SAW) project at Tunstead Primary School based on the work of the Osbourn group and the importance of plants for production of useful chemicals. The 7-8 year olds took part in a range of a activities including infiltrating plants, penning potion poetry and creating beautiful leaf artwork
Year(s) Of Engagement Activity 2017
URL http://sawtrust.org/news/saw-in-action/
 
Description SAW Workshop: Tunstead Primary School Year 5/6 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact OpenPlant / SAW Trust intern Emma McKechnie Welsh ran a SAW workshop for the year 5/ year 6 class (age 10/11 years) at Tunstead Primary School, Norwich, working with writer Mike O'Driscoll and artist Chris Hann with a day themed around plant evolution. Te class began by guessing the number of different plant species on earth and the children suggested why plants are useful. In groups, they were given cards representing each component of photosynthesis and had to arrange them to think about the process. The topic of pollination was covered, and its importance for increasing genetic variation. The children dissected plants to look up close at the reproductive parts under the microscope. Different types of seed dispersal were covered and the importance of varying environmental conditions for evolution. Then children carried out DNA extraction from strawberries after learning a bit about what DNA was and how important it was in controlling the appearance of the plant, with a single mutation in a gene coding region potentially greatly changing this. Following on from DNA extraction there was a game to match the numbers of genes to different organisms. After the morning science sessions the children had poetry and art sessions based on the content.
Year(s) Of Engagement Activity 2017
URL https://www.openplant.org/blog/plant-science-saw-projects-at-tunstead-primary-school
 
Description SAW Workshop: Tunstead primary School Yr 1 + Yr 2 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact OpenPlant / SAW Trust intern Emma McKechnie Welsh ran a SAW workshop for the year 1/ year 2 class (age 4/5 years) at Tunstead Primary School, Norwich, working with writer Julia Webb and artist Lara Nicole. The aim was to get children thinking about the functions of different parts of a plant. To start off the lesson they played a "build a plant" game to get more familiar with the main parts of a plant, their function, and what plants use from their environment to grow. Each child also put a cut flower in coloured water to think about the use of the stem. Then the children were given a selection of fruit and vegetables and asked to decide what part of the plant each came from. They were given a flower to look more closely at the reproductive parts and think about how seeds are formed by pollination. Finally, they looked at different types of seeds in a seed kit and we discussed the different types of seed dispersal tactics plants use. The children wrote poems imagining that they were a seed growing up, and made flower hand puppets after designing a flower
Year(s) Of Engagement Activity 2017
URL https://www.openplant.org/blog/plant-science-saw-projects-at-tunstead-primary-school
 
Description SAW Workshops at the Cambridge Science Centre 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact A new festival that celebrates everything to do with light took place in Cambridge in February 2013. For the e-Luminate festival, the SAW Trust worked with the Cambridge Science Centre and artist Jenny Walsh to run a workshop entitled 'Lighting up inspiration'. Families learned about the relationship between the colour spectrum and light wavelengths. Light was then used to create a collaborative piece of art that explored the iridescent properties seen in oily puddles and in nature to create a peacock.
For the 2013 Festival of Ideas in Cambridge we worked with scientist Andy Osborne who specialises in eye research. We ran a drop-in workshop at the Cambridge Science Centre for families where they could learn about how the eye works and the variety of different eye diseases and disorders that can impact on sight. Andy had some great vision altering glasses that helped people to understand what sufferers of different eye conditions can see. We were joined by artist Jenny Walsh and some sixth form students who invited people to help build a giant eye sculpture to learn more about the rods and cones in the eye.
Year(s) Of Engagement Activity 2013
 
Description SAW stand at the Royal Norfolk Show 2015 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact 2015 marked the 150 year anniversary of a presentation of research to the Natural Science Society in Brno by Austrian monk Gregor Mendel, who is regarded as the "father of modern genetics". In 1865, Mendel presented his work from studies done on pea plants in the gardens of the monastery in Brno that provided the first description of the Laws of Inheritance.

To celebrate Mendel's work and enable children to follow his methods to understand how the Laws of Inheritance work, we ran an interactive stand in the Discovery Zone at the Royal Norfolk Show. The stand provided a mix of hands-on science led by scientists from the John Innes Centre and an art activity that invited children to contribute to the build of some giant pea pods led by environmental artist Ruth MacDougall.
Year(s) Of Engagement Activity 2015
 
Description SAW workshop for OpenPlant researchers 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact An evening workshop to introduce the SAW Trust to OpenPlant post-docs, and to show the power of using poetry and art to explore science with the general public. The workshop focused on plant synthetic biology from the OpenPlant programme and enabled participants to explore write poetry and create artwork based on their own research area.
Year(s) Of Engagement Activity 2016
 
Description SMART.map - Industrial Dialogue on Synthetic Biology 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact SMART-map is an EU-funded project to develop RoadMAPs to Societal Mobilisation for the Advancement of Responsible Industrial Technologies. Colette Matthewman participated in their Industrial Dialogue on Synthetic Biology and contributed to a proposal for a tool for framing, guiding and encouraging best practice in responsible research and innovation. This particular tool is to be presented to the SBLC for consideration. The SMART-map consortium will be reporting on the outcomes of the workshop.
Year(s) Of Engagement Activity 2010,2017
URL http://projectsmartmap.eu/
 
Description STEMM Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Helped to set up a STEMM conference aimed at sixth form students and provided a workshop on plant breeding, nodulation and working towards reduced toxicity in grass pea for consumption in Africa. The session was well attended (students got to choose from a range of sessions) and the pupils enjoyed the hands-on activities but also liked hearing about the research into grass peas and its potential impact.
Year(s) Of Engagement Activity 2018
 
Description School visit (St Alban's) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact I gave a talk to 6th form biology students.
Year(s) Of Engagement Activity 2018
 
Description Science Café, Maddermarket Theatre, Norwich 19th April 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Norwich Science Café at the Maddermarket Theatre entitled "Building with Biology". A presentation and interactive activity for identification of aromatic plant natural products and understanding biosynthetic pathways. This was followed by an extensive discussion on the meaning of the words 'synthetic', 'synthesis' and 'natural' and the relative benefits to the environment and health of synthetic biology approaches for manufacturing. Audience members expressed interest in adult-focussed lab-based workshops and bio-make spaces.
Year(s) Of Engagement Activity 2017
URL https://twitter.com/scicafenorwich
 
Description Science Makers: DIY DNA 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact This was a two part workshop at Cambridge Makespace with 20-25 participants listening to talks and then completing practical exercises in i) Plant PCR and gel electrophoresis; ii) programming a NAND gate in synthetic DNA and expressing it in cell-free system; iii) building an open source transilluminator. The event was a success and got a good level of engagement from the attendees, some of whom approached afterwards for advice on adult education courses and part time degrees in biology.
Year(s) Of Engagement Activity 2017
 
Description Science Makers: Electrophysiology 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Introduction to electrophysiology and workshop to build a plant electrophysiology board designed as part of an OpenPlant Fund grant to Carlos Lugo and Marco Aita. Successful meeting with almost all boards working and self-reported skills gained by participants e.g. soldering.
Year(s) Of Engagement Activity 2017
 
Description Science Makers: Learning physical computing with venus fly traps 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Workshop by Carlos Lugo following on from OpenPlant Fund to show people how to programme microprocessors and obtain results from sensors which can be displayed via a website. Excellent feedback from participants who were interested to apply the skills learned to their own projects.
Year(s) Of Engagement Activity 2017
 
Description Science in Norwich day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Helped Jenni Rant (SAW) to hold a stand describing the scientific research ongoing at JIC, at the Science in Norwich Day at the Forum on the 1st of June 2014 .
Year(s) Of Engagement Activity 2014
URL http://soin.org.uk/2014/04/science-in-norwich-day-2014/
 
Description Science on Saturday, part of SET week in Cambridge 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact We had a stand in the science tent outside Dept of Plant Sciences. We demonstrated what algae are, what we use for now and how they might be used in the future for energy production. There were activities such as viewing microalgae with microscopes, extracting different light-harvesting pigments, and observing algae phototaxis. Children could handcraft their own algae using pipe cleaners or take part in an interactive algae quiz to win prices.

School asked for visit to talk to years 10-13.

Established the material to mount a Royal Society Summer Science Exhibit
Year(s) Of Engagement Activity 2006,2007,2008,2015,2016
 
Description Science on Sundays 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Short talk and Q&A on the nature of algae and how their characteristics could be used for sustainable energy, water remediation, or other green tech solutions. Held in the Cambridge Botanic Garden, the audience were interested in plants, and so this was an opportunity to provide information on what algae are, and how they might be used in novel ways. The audience fed back that they felt much better informed.
Year(s) Of Engagement Activity 2015
URL http://www.botanic.cam.ac.uk/Botanic/NewsItem.aspx?p=27&ix=196
 
Description Science, Art and Writing (SAW) project on plant natural products, Suffolk 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact A Science, Art and Writing (SAW) project on plant natural products was run for 90 students at St Benedicts Secondary School, Suffolk, UK on 3 July 2015. The students collected plant samples from the school grounds and used them in chromatography experiments to see how many different types of pigments they could extract.
Year(s) Of Engagement Activity 2015
 
Description Scientific Advisory Board Centre for Agricultural Genomics (CRAG) Barcelona 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact I chaired the Scientific Advisory Board Centre for Agricultural Genomics (CRAG) Barcelona, and compiled the report for the institution. I also set up the twinning program between JIC and CRAG through liaison with the director, Jose-Luis Reichmann
Year(s) Of Engagement Activity 2018
 
Description Scientific Advisory Board Meeting, on Banana Biofortification Gates project 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact I advised on scientif direction for the Biofortification of Banana project funded by BMGF in Kampala Uganda
Year(s) Of Engagement Activity 2018
 
Description Scientific Advisory Board Plant and Food Research, New Zealand 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact I attended the Scientific Advisory Board Meeting Plant and Food Research, New Zealand, listened to and advised their emerging scientists and advised on scientific policy.
Year(s) Of Engagement Activity 2018
 
Description Seminar at NUIG 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Synthetic virus-like particles and how to make them in plants Seminar at National University of Ireland - Galway (NUIG), Galway, Republic of Ireland.
Year(s) Of Engagement Activity 2018
 
Description Seminar, Glasgow 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Lomonossoff G. P.(2018) Plant-based transient expression of virus-like particles for use in biomedicine and bionanotechology Seminar at University of Glasgow, Glasgow, UK
Year(s) Of Engagement Activity 2018
 
Description Seminar: Transcription factors as gateway for metabolic engineering 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact OpenPlant Forum seminar entitled Transcription factors as gateway for metabolic engineering
Presenter Ingo Appelhagen
Year(s) Of Engagement Activity 2018
 
Description Stapleford Community Primary School SAW workshop 2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact OpenPlant teamed up with the Science Art Writing Trust workshop for year 6 pupils at Stapleford Community Primary School exploring excitable media and circuits of plants, linking them to biological systems like the brain, heart and muscle through science practicals, writing and art.
Year(s) Of Engagement Activity 2016
URL http://openplant.org/blog/2016/02/openplant-science-art-and-writing-workshop-a-success/
 
Description Submitted scientific images to the Norwich Research Park image library 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The NRP image library consists of images arising from research in life and environmental sciences on the Norwich Research Park . The aim of NRP research is to deliver solutions to the global challenges of healthy ageing, food and energy security, sustainability and environmental change and this is reflected in the images in the library.
Year(s) Of Engagement Activity 2016
URL http://images.norwichresearchpark.ac.uk/searchresults.aspx?query=leveau
 
Description Synbio and bioinformatics workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact A lesson plan was developed to cover how bioinformatics is used in research and how this links to synthetic biology and delivered in a secondary school to a group of science sixth form students. Synthetic biology is not well represented in the curriculum and so we worked with a teacher to create a session that enabled students to learn about the processes and to see real examples of how this is being used to create products of use to society.
Year(s) Of Engagement Activity 2018
URL https://www.sawtrust.org/news/saws-latest-intern/
 
Description Synthetic Biology Leadership Council Open Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Colette Matthewman gave an invited presentation at the Synthetic Biology Leadership Council open meeting about the OpenPlant Fund model and impacts in November 2016.
Year(s) Of Engagement Activity 2016
 
Description Synthetic Biology and Designing Gene Circuits, NRP BIO DTP Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Colette Matthewman gave a presentation on Synthetic Biology and OpenPlant for 140 PhD students. Together with PIPS intern Millie Stanton, she ran an interactive activity on designing with biology and responsible research and innovation considerations, which catalysed discussions.
Year(s) Of Engagement Activity 2018
 
Description Synthetic Biology and the Senses, Cambridge Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact For the third year in a row, OpenPlant teamed up with the SAW Trust and Cambridge Synthetic Biology SRI to deliver a variety of activities on our interactive stand at the Cambridge Science Festival. The purpose of this event was to engage with the general public and make people aware of OpenPlant activities.
Year(s) Of Engagement Activity 2018
URL https://www.openplant.org/blog/2018/4/3/cambridge-science-festival-march-2018
 
Description Synthetic Biology and the Senses: Cambridge Science Festival exhibit 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact OpenPlant, SAW, Cambridge SynBio SRI and Imperial College teamed up to deliver and exhibit on Synthetic Biology and the Senses at Cambridge Science Festival. Activities included the newly built DNA Dave to explain how proteins are made using the instructions held in DNA, designing a synthetic flower, and smelling bacteria that were producing different scent chemicals. On display were bioluminescent bacteria, fabric samples dyed using bacteria (from company Colorifix) and information about a project on spicy tomatoes.
Year(s) Of Engagement Activity 2017
URL https://www.synbio.cam.ac.uk/news/synthetic-biology-and-the-senses-at-the-cambridge-science-festival
 
Description Synthetic Biology in Chile 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Participation in a public workshop to promote Synthetic Biology in Santiago, Chile, with Profs Drew Endy and Tom Knight.
Year(s) Of Engagement Activity 2012
 
Description Synthetic biology session and discussion panel at the London Festival of Genomics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Chaired a session on synthetic biology session and participated in a panel discussion at the London Festival of Genomics, 2017. This brought the synthetic biology to a new audience of industry, investors and the general public. There was a lengthy discussion with the general public, investors and industry representatives from diverse fields (e.g. computing and engineering) about the ethics and potential of biological engineering at the panel discussion and also following the workshop.
Year(s) Of Engagement Activity 2017
URL http://www.festivalofgenomicslondon.com/full-agenda
 
Description Talk at "Pint of Science" event, Guildhall, Norwich 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact I delivered a talk entitled "Just eat your greens - a new way of vaccinating?" on 27/10/16 at this event as part of the Norwich Science Festival.
Year(s) Of Engagement Activity 2016
URL https://pintofscience.com/
 
Description Talk at Norwich Science Festival 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact This talk, entitled "The Green Vaccine Machine" was delivered as part of the Norwich Science Festival on 24/10/16 at The Forum in Norwich.
Year(s) Of Engagement Activity 2013,2016
 
Description Talk on Cambridge Biomakespace for Norwich BioMakers 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Dr Jenny Molloy visited Norwich Research Park to present experiences in setting up the Cambridge Biomakespace and participate in a discussion about setting up Norwich BioMakers with representatives from academia, the Norwich Hackspace, knowledge transfer professionals and researchers. The group then went ahead to set up a series of meetings (see other engagement activities) and practical workshops.
Year(s) Of Engagement Activity 2017
 
Description Talk to JIC All by ingo Appelhagen From colourful mysteries to natural blues 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact JIC All presentation on use of Metabolomics by Ingo Appelhagen From colourful mysteries to natural blues
Year(s) Of Engagement Activity 2018
 
Description Talking Plants Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Delivered a workshop at the Talking Plants Conference at Cambridge Botanic Garden. This conference takes place at a different botanic garden nationally each year and brings together garden staff and other organisations that work with plants and the public. Our workshop showcased some of the best plant-themed outreach projects we have delivered to share ideas and activities that provide a platform to engage people with plants.
Year(s) Of Engagement Activity 2018
URL https://bgen.org.uk/conferences/talking-plants-2018-conference-proceedings/
 
Description The Colour Institute 'A sense of colour' at Cambridge Festival of Ideas 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact This family event 'A sense of colour' on 17 October 2017 was co-organised by a Biomaker Challenge team (Sophie Weeks, Gareth Rees and Praveen Teleti) and Dr Jenny Molloy. It saw parents and children making DIY colour measuring machines designed by Praveen through the Biomaker Challenge funding provided by OpenPlant and questioning how we sense colour. Our eyes tell us that the colour of real and fake grass is very similar but if we augment our eyes with machines and look at the infrared end of the colour spectrum they appear very different. Participants learnt about the chemistry and physics of colour and split white light apart with DIY spectrometers made from cardboard and blank CDs.
During the two sessions, participants met some 'colour makers' from the arts and sciences: Nabil Ali is an artist who researches natural pigment and ran a hands-on paint-making workshop using sources like indigo, madder, saffron and plants grown in his own back garden. Dr Edwige Mouyrod (Sainsbury Lab) and Rox Middleton (Department of Chemistry) introduced us the world of structural colour and iridescence. The workshop ran twice in succession reaching over 50 people in total and there was great interest in further opportunities.
Year(s) Of Engagement Activity 2017
URL https://www.synbio.cam.ac.uk/news/the-colour-institute-biological-colour-takes-centre-stage-at-the-f...
 
Description The Colour Institute Art Science Soiree at Cambridge Festival of Ideas 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact The Colour Institute Art & Science Soiree on 19 October 2017 brought together makers, writers, artists and scientists for talks on the use of colour in synthetic biology, scanning and printing works of art, remote sensing, the history of pigment and the use of colour in art. Activities and colourful surprises were provided, with the aim of inspiring creativity, fostering collaboration and interdisciplinary research. One of the talks by Dr Jenny Molloy featured OpenPlant work regarding use of chromoproteins and other marker genes for biological imaging. There was a great level of excitement and interest in the event from both scientists and artists.
Year(s) Of Engagement Activity 2017
URL https://www.synbio.cam.ac.uk/news/the-colour-institute-biological-colour-takes-centre-stage-at-the-f...
 
Description The Essex Synthetic Biology School (ESBS), University of Essex, UK : 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Presented lectures on "Engineering Plant Genomes for Farming and Pharming" and "Sharing Biology in the Information Age: Perceived Threats of Dematerialisation and Open Data". These were followed by discussions on the use of biotechnologies in agricultures and a debate on access and benefit sharing of genetic resources. Participants reported changes in their views on the common practices used to share information relating to genetic resources as well as physical resources.
Year(s) Of Engagement Activity 2018
URL https://esbs.essex.ac.uk
 
Description The Global Garden 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Prof Anne Osbourn (JIC), Dr Colette Matthewman (JIC), Dr Jenni Rant (SAW Trust) and social scientist Dr Nick Lee (Warwick Integrative Synthetic Biology Centre) designed and delivered an interdisciplinary workshop to explore issues around global genetic plant resource sharing. The workshop, which was held at the John Innes Centre, was advertised to the public. Participants took part in a practical science exercise to extract chemicals from plants. They discussed case studies that illustrated the history, sourcing and use of high value products from plants (drugs, sweeteners, flavourings). Following that, they extracted DNA from plants and learned about the genetic code. They then reviewed and responded to the theme creatively by writing poetry and generating artwork. Participants commented that discussions "stretched my thinking about the ethics of biopiracy" and "changed my view of plants". A write-up of this workshop, at which Katie Beckett (Access and Benefit Sharing Project Manager for the UK) was also present, is being prepared for submission to an international science journal, and further workshops with different audiences are being planned in other locations across the UK and internationally for 2018/19.
Year(s) Of Engagement Activity 2017
URL https://www.openplant.org/global-garden
 
Description The Life Scientific on BBC Radio 4 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact I was interviewed by Jim Al-Khalili about my scientific career and interest in algae and vitamins. The programme "The Life Scientific" was broadcast on BBC Radio 4 and was also available on BBC iPlayer and as a podcast. As a result I have had numerous contacts about possible scientific and industrial collaborations, as well as enquiries from the general public about the various topics.
Year(s) Of Engagement Activity 2017
URL http://www.bbc.co.uk/programmes/b08bzl8y
 
Description Training Workshop - Edinburgh 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact For the third year we returned to the University of Edinburgh to deliver a Science Art and Writing training workshop for scientists, artists, writers and teachers. Following the workshop, the participants formed SAW teams and partnered with schools to deliver workshops about a variety of synthetic biology topics for children to experience with practical science, poetry and art activities.
Year(s) Of Engagement Activity 2016,2017,2018
 
Description Training workshop (Edinburgh) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact OpenPlant is working with the SAW Trust to deliver some of its engagement activities, particularly with schools. The SAW team were invited by the University of Edinburgh SynthSys & UK Centre for Mammalian Synthetic Biology to deliver a training workshop for scientists, artists, writers and teachers to enable them to design and deliver SAW projects in schools around Edinburgh. This approach to engaging children in current scientific research in an accessible way provides an excellent tool for scientists who wish to use diverse methods to showcase the potential impacts of their research. Working in teams with professionals from the arts fuels creative thinking and innovation around engagement styles whilst also providing novel science themes for artistic interpretation. Working with teachers helps to inform knowledge on current research to provide new examples for use in the classroom and the whole process enables co-learning from a science starting point in a multi-disciplinary way. Several SAW projects took place in Edinburgh schools in the months following the workshop where they were greatly received. We returned in 2017 to provide training for more people and again in 2018 and so the pool of SAW-trained scientists, artists and writers has grown significantly and the popularity of SAW in schools is providing a constant network for scientists to deliver novel engagement activities with children.
Year(s) Of Engagement Activity 2016,2017,2018
 
Description UK Africa Food Security Symposium 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The symposium took place at the Sainsbury Laboratory, University of Cambridge on 11 September and brought together participants with diverse backgrounds, from plant biologists to social scientists, to attend talks and discuss approaches that could be taken to address food insecurity in Africa. This event was sponsored through an OpenPlant Fund grant, and Colette Matthewman gave a presentation on the OpenPlant Fund.
Year(s) Of Engagement Activity 2018
URL https://www.globalfood.cam.ac.uk/news/tackling-food-insecurity-in-africa-2013-uk-africa-food-securit...
 
Description Web Article - Spotlight on Synthetic Biology. Yaomin Cao 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Interview with Yaomin Cai of Nicola Patron's DNA Foundry at Earlham Institute, on how he got into synthetic biology, how it can help us to tackle biological questions, and what the future has in store. -SOCIAL MEDIA- Engagement x92, Impressions x70456
Year(s) Of Engagement Activity 2017
URL http://www.earlham.ac.uk/articles/spotlight-on-synthetic-biology
 
Description Wired magazine interview and pictorial articles 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Published interview about Synthetic Biology and article about engineering living systems. "Building new life forms at the iGEM Jamboree", and "At home with the DNA hackers".
Year(s) Of Engagement Activity 2009
 
Description Workshop Manchester 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Participated in Workshop: Production of pharmaceutical and industrial proteins in microalgae and plants, Manchester, UK, 01/05/15. Delivered lecture entitled "Making all kinds of everything: the joy of transient expression".
Year(s) Of Engagement Activity 2015
 
Description Workshop on Genetic resources in the age of the Nagoya Protocol and gene/genome synthesis 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The ongoing improvement of gene and whole genome sequencing and synthesis technologies presents possibilities of new practices, and demands discussion and debate in light of the long history of global bioresource management. This workshop in November 2016 acted as a venue for collecting information on current developments, sharing views, highlighting potential areas of concern, and establishing grounds upon which to build better understanding of the interactions between and implications of the Nagoya Protocol and gene synthesis for collection, circulation, and use of genetic resources. A report is in preparation.
Year(s) Of Engagement Activity 2016
 
Description Workshop on UN Sustainable Development Goals 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Workshop organised by EPSO on UN SDGs and how Plant Science could contribute
Year(s) Of Engagement Activity 2018
 
Description Workshop on assessing anti-inflammatory effects of plant polyphenolics 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact African Summer School on health promoting metabolites from plants
Year(s) Of Engagement Activity 2016
 
Description Workshops and conference presentation in Shanghai 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact We visited Shanghai to deliver some training workshops for teachers new to the SAW methodology and also for teachers who have been working with SAW for several years. We introduced the Plant growth and development lesson plan to teachers at our hub school and we also presented SAW at a large international education conference showcasing a plant natural products projects to describe the process,
Year(s) Of Engagement Activity 2018
URL https://www.sawtrust.org/news/saw-returns-to-shanghai/
 
Description Year 10 Summer Science Camp SynBio day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact A one-day workshop on synthetic biology as part of a week long Science Camp for 13 promising year 10 pupils with an interest in careers in science. We covered activities from gene circuits and understanding important concepts of standardisation and modularisation, cloning and transformation of E.coli, engineering nitrogen symbiosis into crop plants, the design-build-test cycle. We had a lively debate on responsible research and innovation.
Year(s) Of Engagement Activity 2015
 
Description Youth STEMM Award Mid-Year Conference OpenPlant Exhibit 26.01.17 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Colette Matthewman, Michael Stephenson, Don Nguyen and Nadiatul Radzman (JIC) developed an interactive exhibit to span engineering, biology and chemistry in the context of synthetic biology for the Youth STEMM Awards mid-term conference for 14-18 year old students. The exhibit included interaction with electronic circuits and an explanation of genetic circuits and the importance of standards, infiltration of Nicotiana benthamiana (with water) and a new SynBio card game developed by Michael Stephenson. The new game served to showcase, in an accessible way, the concept of exploiting transient expression in Nicotiana benthamiana towards drug discovery via combinatorial biosynthesis. Scientists and exhibitors explained their science to enthusiastic students the Youth STEMM mid-year conference. Example blog from a year 10 attendee: http://ysawards.co.uk/2017/02/01/madelines-experience-at-the-women-of-the-future-conference/.
Year(s) Of Engagement Activity 2017
URL http://ysawards.co.uk/
 
Description Youth STEMM Award mid-year conference 2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Exhibited at the Youth STEMM Award mid-year conference. The exhibit provided information on case studies in plants using synthetic biology, an electronics practical explaining gene circuits, and infiltration of tobacco leaves to explain how scientists get DNA into plants for genetic engineering.
Year(s) Of Engagement Activity 2016
URL https://www.jic.ac.uk/news/2016/01/-youth-stemm-mid-year/