Taiwan Partnering Award: Improving control of influenza viruses
Lead Research Organisation:
The Pirbright Institute
Department Name: Avian Viral Diseases
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
- The Pirbright Institute (Lead Research Organisation)
- Francis Crick Institute (Collaboration)
- National Agricultural Research Centre (Collaboration)
- Agricultural Research Centre (Collaboration)
- University of Veterinary & Animal Sciences (Collaboration)
- Zagazig University (Collaboration)
- IMPERIAL COLLEGE LONDON (Collaboration)
- Suez Canal University (Collaboration)
- UNIVERSITY OF OXFORD (Collaboration)
- University of Tokyo (Collaboration)
- THE PIRBRIGHT INSTITUTE (Collaboration)
- Royal Veterinary College (RVC) (Collaboration)
- UNIVERSITY OF EDINBURGH (Collaboration)
- Centres for Disease Control (Project Partner)
Publications
Abdelwhab EM
(2016)
Introduction and enzootic of A/H5N1 in Egypt: Virus evolution, pathogenicity and vaccine efficacy ten years on.
in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Ali M
(2019)
Avian Influenza A(H9N2) Virus in Poultry Worker, Pakistan, 2015.
in Emerging infectious diseases
Baron MD
(2018)
Recent advances in viral vectors in veterinary vaccinology.
in Current opinion in virology
Bayraktar E
(2018)
First Molecular Characterization of Avian Metapneumovirus (aMPV) in Turkish Broiler Flocks.
in Avian diseases
Bayraktara E
(2018)
First molecular characterisation of avian metapneumovirus (aMPV) in Turkish broiler flocks
in Avian Diseases
Beata Adamiak
(2014)
Selection and characterisation of DNA aptamers targeting influenza virus infections in poultry
in International Mathematical Virology Workshop
Bhat S
(2019)
Replicative fitness and transmission of G57 lineage and UDL01 like H9N2 viruses in chickens
in Access Microbiology
Chang P
(2019)
The application of CRISPR/Cas9 system in the generation of viral vectored avian influenza vaccines
in Access Microbiology
Chang P
(2019)
Amino Acid Residue 217 in the Hemagglutinin Glycoprotein Is a Key Mediator of Avian Influenza H7N9 Virus Antigenicity.
in Journal of virology
| Description | This partnership award allowed to establish close links with influenza virus researchers in Taiwan and provided opportunities to share samples, reagents and techniques on influenza viruses The joint work enable us to investigate antigenic and genetic diversity of influenza viruses infecting poultry and humans in Taiwan. The outcome of joint research identified molecular factors of influenza virus antigens that are implicated for failure of influenza vaccines and diagnostic. The outcomes of this project enabled selection of vaccine seed that induce broader cross-protective immunity in chicekns. |
| Exploitation Route | This collaborative research provide new opportunities to ourselves and other researchers around the globe to use our research to generate improved vaccines and diagnostics for batter control of influenza viruses in animals and humans. To extend the collaboration between UK and Taiwan a new project was submitted to BBSRC entitled "Taiwan-UK Partnering Awards: Surveillance of influenza viruses". The project enhanced collaborations with researcher from Taiwan. The collaborating partners gained training on testing the comparative efficacy of influenza vaccines in poultry and humans. |
| Sectors | Agriculture, Food and Drink,Education,Environment,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| URL | https://www.pirbright.ac.uk/users/prof-munir-iqbal |
| Description | This project enable us to to establish partnership and links between influenza virus researchers at the Pirbright Institute, National Institute for Medical Research in UK, and the researchers working at the Centre for Disease Control in Taiwan. The partnership enabled us to exchange expertise and training to researchers on emerging next generation biotechnological techniques. The partnership provided access to research facilities, samples and reagents that proven highly useful for enhancing our scientific capabilities to improve vaccines , diagnostic tools and strategies for the control of influenza viruses in both animals and humans. Based on the links developed through this project, new researchers link partnership was developed and funded by BBSRC linking reseachers from the pirbright Institute and from Taiwan CDC, National Medical Defence Institute and the Animal Health Research Institute. https://www.cdc.gov.tw/rwd/english https://ndmc.ndmctsgh.edu.tw/nss/s/en/index Based on this project, new funding from BBSRC was received to enhance research collaboration between UK and Taiwan. https://eng.nvri.gov.tw/fmodule/Default.aspx |
| First Year Of Impact | 2016 |
| Sector | Agriculture, Food and Drink,Creative Economy,Education,Environment,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Cultural,Societal,Economic,Policy & public services |
| Description | BBSRC International Partnering Awards |
| Amount | £49,500 (GBP) |
| Funding ID | BB/P025803/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2017 |
| End | 07/2021 |
| Description | Combating avian influenza through systematic analysis of antigenic drift, genetic variation, and development of novel diagnostic tools and vaccines |
| Amount | £1,571,970 (GBP) |
| Funding ID | BB/L018853/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2015 |
| End | 01/2018 |
| Description | Enhancing protective efficacy of avian influenza vaccines through targeted delivery of protective antigens to chicken immune cells |
| Amount | £98,212 (GBP) |
| Funding ID | BB/R50595X/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2017 |
| End | 09/2021 |
| Description | Food Security: improving approaches to prevent and control viral diseases of Livestock and Poultry |
| Amount | £32,000 (GBP) |
| Organisation | British Council |
| Department | British Council Researcher Links |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Japan Partnering Award |
| Amount | £49,500 (GBP) |
| Funding ID | BB/P025803/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2017 |
| End | 08/2021 |
| Description | Newton Institutional Links grant |
| Amount | £269,123 (GBP) |
| Funding ID | 261727271 |
| Organisation | Newton Fund |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2017 |
| End | 08/2019 |
| Description | Reducing the Economic and Zoonotic Impact of Avian Influenza (REZIAI): delivering novel vaccines and diagnostics from laboratory to the field. |
| Amount | £400,000 (GBP) |
| Funding ID | BB/S013792/1 |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 02/2019 |
| End | 01/2021 |
| Description | The Global Challenges Research Fund |
| Amount | £640,473 (GBP) |
| Organisation | Research Councils UK (RCUK) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2019 |
| End | 03/2024 |
| Description | iCASE studentship: Production and assessment of antiviral prophylactic properties of natural biomolecules against avian influenza and Newcastle disease viruses affecting poultry |
| Amount | £100,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2019 |
| End | 09/2023 |
| Title | Detection of HA antigens of avian influenza viruses |
| Description | Assay for detection of recombinant HVT expressing HA antigens of avian influenza viruses |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | This new method will help to detect recombinant HVT vaccine expressing HA antigen in infected cell. |
| Title | Procedures for production and analysis of potency and efficacy of avian influenza H5 and H9 vaccines in poultry |
| Description | 1. Provided training, methods and regents for production of recombinant herpesvirus Turkey (HVT) vector-based vaccines for field analysis. 2. Provided regents ( antigens and antibodies ( monoclonal and chicken a polyclonal antisera for establishment of assays for efficient diagnosis of avian influenza infections in poultry. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | The assays methods and reagents were provided to other patterns of this project at University of Veterinary and Animal Sciences Lahore, Pakistan. |
| Description | Avian influenza H7N9 virus evolution: defining the impact of internal genes on virus infection in avian and mammalian species |
| Organisation | Francis Crick Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | (1) Exchange of research methods and reagents |
| Collaborator Contribution | (1) Exchange of research methods and reagents. (2) Provision of training to PhD students and postdoctoral Scientist (3) Critical review of experimental data and manuscripts. |
| Impact | (1) Joint funding: BBSRC Newton Fund: UK-China-Philippines-Thailand Swine and Poultry Research Initiative (2018-2021). Understanding antigenic diversity, zoonotic potential and immunological prevention of avian influenza viruses affecting poultry. Value: £497,995.93. UK Co-Is: Prof John McCauley (Crick Institute), Dr Richard Reeve (University of Glasgow). Collaborators from China: Dr Yipeng Sun, Prof Jinhua Liu and Dr Juan Pu (China Agricultural University), Prof Yongqing Li (Beijing Academy of Agriculture and forestry Sciences), Dr Wenfei Zhu (National Institute for Viral Disease Control and Prevention, China CDC). |
| Start Year | 2007 |
| Description | BBSRC - Oxford University iCASE Studentship (October 2019- September 2023). Production and assessment of antiviral prophylactic properties of natural biomolecules against avian influenza and Newcastle disease viruses affecting poultry production |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | This collaboration between The Pirbright Institute (UK), Oxford University (UK) and industrial partners in Italy. This project will conceived and developed bu MI. The PhD student (Holly Everest) in my group is investigating the antiviral prophylactic properties of natural biomolecules against avian influenza and Newcastle disease viruses affecting poultry production. |
| Collaborator Contribution | The partners in Italy will produce and purify natural antiviral molecules effective against avian influenza and other poultry viruses. |
| Impact | This project started in January 2020. |
| Start Year | 2020 |
| Description | Commonwealth Scholarship. Molecular determinants impacting avian influenza H9N2 virus evolution, replication fitness and virulence |
| Organisation | Royal Veterinary College (RVC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I develop a research project proposal in which we are investigating how evolutionary changes in the H9N2 avian influenza virus modulate virus fitness and virulence in chickens. This PhD studentship project was funded by Commonwealth scholarship commission for 3 years. |
| Collaborator Contribution | The collaborating Partner Dr Nicola Lewis at Royal Veterinary College is a co-supervisor of the PhD student Thusitha Karunarathna. she provide necessary guidance to achieve prescribed objectives of this project. |
| Impact | The project is at its initial stage. |
| Start Year | 2019 |
| Description | Development of novel diagnostic tools and vaccines |
| Organisation | Francis Crick Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The outcomes of research led to incite new collaborations with following partners in UK, Vietnam and Pakistan. Together with partners we apply for the collaborative research grant to BBSRC entitled "Combating avian influenza through systematic analysis of antigenic drift, genetic variation, and development of novel diagnostic tools and vaccines". That led to further improvement avian influenza virus vaccines and diagnostics and a number of research publication. |
| Collaborator Contribution | The partners are evaluating the potency and efficacy of vaccines in countries where the disease is enzootic in poultry. |
| Impact | 1. Peacock TP, Benton DJ, Sadeyen J-R, Chang P, Sealy JE.,d, Bryant JE, Martin SR., Shelton H, McCauley JW, Barclay WS, Iqbal M (2017) Variability in H9N2 haemagglutinin receptor binding preference and pH of fusion. Emerging Microbes & Infections 6, e11 2. Peacock T, Reddy K, James J, Adamiak B, Barclay W, Shelton H, Iqbal M (2016). Antigenic mapping of an H9N2 avian influenza virus reveals two discrete antigenic sites and a novel mechanism of immune escape. Scientific Reports 5: 18745. doi: 10.1038/srep18745. 3. Thuy DM, Peacock TP., Bich VTN, . Iqbal M, Juliet E. Bryant (2016). Prevalence and diversity of H9N2 avian influenza in chickens of Northern Vietnam, 2014. Infection, Genetics and Evolution 44: 530-540 |
| Start Year | 2014 |
| Description | Development of novel diagnostic tools and vaccines |
| Organisation | Imperial College London |
| Department | School of Public Health |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The outcomes of research led to incite new collaborations with following partners in UK, Vietnam and Pakistan. Together with partners we apply for the collaborative research grant to BBSRC entitled "Combating avian influenza through systematic analysis of antigenic drift, genetic variation, and development of novel diagnostic tools and vaccines". That led to further improvement avian influenza virus vaccines and diagnostics and a number of research publication. |
| Collaborator Contribution | The partners are evaluating the potency and efficacy of vaccines in countries where the disease is enzootic in poultry. |
| Impact | 1. Peacock TP, Benton DJ, Sadeyen J-R, Chang P, Sealy JE.,d, Bryant JE, Martin SR., Shelton H, McCauley JW, Barclay WS, Iqbal M (2017) Variability in H9N2 haemagglutinin receptor binding preference and pH of fusion. Emerging Microbes & Infections 6, e11 2. Peacock T, Reddy K, James J, Adamiak B, Barclay W, Shelton H, Iqbal M (2016). Antigenic mapping of an H9N2 avian influenza virus reveals two discrete antigenic sites and a novel mechanism of immune escape. Scientific Reports 5: 18745. doi: 10.1038/srep18745. 3. Thuy DM, Peacock TP., Bich VTN, . Iqbal M, Juliet E. Bryant (2016). Prevalence and diversity of H9N2 avian influenza in chickens of Northern Vietnam, 2014. Infection, Genetics and Evolution 44: 530-540 |
| Start Year | 2014 |
| Description | Development of novel diagnostic tools and vaccines |
| Organisation | National Agricultural Research Centre |
| Country | Pakistan |
| Sector | Public |
| PI Contribution | The outcomes of research led to incite new collaborations with following partners in UK, Vietnam and Pakistan. Together with partners we apply for the collaborative research grant to BBSRC entitled "Combating avian influenza through systematic analysis of antigenic drift, genetic variation, and development of novel diagnostic tools and vaccines". That led to further improvement avian influenza virus vaccines and diagnostics and a number of research publication. |
| Collaborator Contribution | The partners are evaluating the potency and efficacy of vaccines in countries where the disease is enzootic in poultry. |
| Impact | 1. Peacock TP, Benton DJ, Sadeyen J-R, Chang P, Sealy JE.,d, Bryant JE, Martin SR., Shelton H, McCauley JW, Barclay WS, Iqbal M (2017) Variability in H9N2 haemagglutinin receptor binding preference and pH of fusion. Emerging Microbes & Infections 6, e11 2. Peacock T, Reddy K, James J, Adamiak B, Barclay W, Shelton H, Iqbal M (2016). Antigenic mapping of an H9N2 avian influenza virus reveals two discrete antigenic sites and a novel mechanism of immune escape. Scientific Reports 5: 18745. doi: 10.1038/srep18745. 3. Thuy DM, Peacock TP., Bich VTN, . Iqbal M, Juliet E. Bryant (2016). Prevalence and diversity of H9N2 avian influenza in chickens of Northern Vietnam, 2014. Infection, Genetics and Evolution 44: 530-540 |
| Start Year | 2014 |
| Description | Development of novel diagnostic tools and vaccines |
| Organisation | University of Oxford |
| Department | Oxford University Clinical Research Unit Vietnam (OUCRU) |
| Country | Viet Nam |
| Sector | Academic/University |
| PI Contribution | The outcomes of research led to incite new collaborations with following partners in UK, Vietnam and Pakistan. Together with partners we apply for the collaborative research grant to BBSRC entitled "Combating avian influenza through systematic analysis of antigenic drift, genetic variation, and development of novel diagnostic tools and vaccines". That led to further improvement avian influenza virus vaccines and diagnostics and a number of research publication. |
| Collaborator Contribution | The partners are evaluating the potency and efficacy of vaccines in countries where the disease is enzootic in poultry. |
| Impact | 1. Peacock TP, Benton DJ, Sadeyen J-R, Chang P, Sealy JE.,d, Bryant JE, Martin SR., Shelton H, McCauley JW, Barclay WS, Iqbal M (2017) Variability in H9N2 haemagglutinin receptor binding preference and pH of fusion. Emerging Microbes & Infections 6, e11 2. Peacock T, Reddy K, James J, Adamiak B, Barclay W, Shelton H, Iqbal M (2016). Antigenic mapping of an H9N2 avian influenza virus reveals two discrete antigenic sites and a novel mechanism of immune escape. Scientific Reports 5: 18745. doi: 10.1038/srep18745. 3. Thuy DM, Peacock TP., Bich VTN, . Iqbal M, Juliet E. Bryant (2016). Prevalence and diversity of H9N2 avian influenza in chickens of Northern Vietnam, 2014. Infection, Genetics and Evolution 44: 530-540 |
| Start Year | 2014 |
| Description | Development of novel diagnostic tools and vaccines |
| Organisation | University of Veterinary & Animal Sciences |
| Country | Pakistan |
| Sector | Academic/University |
| PI Contribution | The outcomes of research led to incite new collaborations with following partners in UK, Vietnam and Pakistan. Together with partners we apply for the collaborative research grant to BBSRC entitled "Combating avian influenza through systematic analysis of antigenic drift, genetic variation, and development of novel diagnostic tools and vaccines". That led to further improvement avian influenza virus vaccines and diagnostics and a number of research publication. |
| Collaborator Contribution | The partners are evaluating the potency and efficacy of vaccines in countries where the disease is enzootic in poultry. |
| Impact | 1. Peacock TP, Benton DJ, Sadeyen J-R, Chang P, Sealy JE.,d, Bryant JE, Martin SR., Shelton H, McCauley JW, Barclay WS, Iqbal M (2017) Variability in H9N2 haemagglutinin receptor binding preference and pH of fusion. Emerging Microbes & Infections 6, e11 2. Peacock T, Reddy K, James J, Adamiak B, Barclay W, Shelton H, Iqbal M (2016). Antigenic mapping of an H9N2 avian influenza virus reveals two discrete antigenic sites and a novel mechanism of immune escape. Scientific Reports 5: 18745. doi: 10.1038/srep18745. 3. Thuy DM, Peacock TP., Bich VTN, . Iqbal M, Juliet E. Bryant (2016). Prevalence and diversity of H9N2 avian influenza in chickens of Northern Vietnam, 2014. Infection, Genetics and Evolution 44: 530-540 |
| Start Year | 2014 |
| Description | Investigating antigenic determinants inducing stronger and broader cross-protective immunity among H5 avian influenza viruses |
| Organisation | Royal Veterinary College (RVC) |
| Department | Veterinary Basic Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The overarching aims of the proposed research are to improve controls against H5 subtype of avian influenza viruses infecting poultry by investigating underlying mechanisms that define how vaccines renders effectiveness and develop novel approaches enhancing the effectiveness of H5 avian influenza vaccines. We recently generated a panel of monoclonal antibodies (mAbs) that recognise a variety of different clades of H5 viruses. Propagation of AIV in eggs or cultured cells together with mAbs drives virus to escape from mAbs neutralisation activity. These classical virus neutralization assays (VN) followed by HA gene sequence analysis allowed us to defined the role of amino acid substitutions that are associated with evasion of antibody neutralization through emergence of antigenic variants and failure of vaccine efficacy. |
| Collaborator Contribution | provided intellectual input for achieving prescribed objectives of this work. |
| Impact | Talk entitled "Molecular determinants for antigenicity and vaccine efficacy of avian influenza viruses" was presented at Newton Agham Researcher Links Workshop " Novel Vaccines and Diagnostic Technologies against Emerging and re-emerging Veterinary Pathogens" at Rizal Park Hotel, Manila, Philippines, 4-7 February 2019. |
| Start Year | 2019 |
| Description | Investigating antigenic determinants inducing stronger and broader cross-protective immunity among H5 avian influenza viruses. |
| Organisation | Royal Veterinary College (RVC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We developed research programme to characterise diversity of antigenic epitopes induce protective immunity in chickens against H5 subtypes of avian influenza viruses. |
| Collaborator Contribution | Collaborating partner Dr Nicola Lewis at Royal Veterinary College provide advise to on cartography programme to visualize the antigenic similarity or difference among different strains of influenza viruses. |
| Impact | The work under this collaborative determined the antigenic differences among different clades of H5 avian influenza viruses circulating in birds. This project is multi-disciplinary. our laboratory mainly work on virology and immunology part of the project and we seek help on computer modeling part from the collaborating partner Dr Nicola Lewis. |
| Start Year | 2019 |
| Description | Rapid acquisition of mammalian characteristics by avian influenza virus in single host infections. |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provided reagents and day to day technical help for undertaking this project and supervising postdoctoral researcher working on this project. Reagents include influenza reverse genetic plasmids and H9N2 and H7N9-specific antibodies. |
| Collaborator Contribution | this project will aim to understand AIV genetics that facilitate the rapid acquisition of mammalian adaptation characteristics in a single host infection. The partners with our collaborations determined adaptive genetic changes in the H9N2 avian influenza virus following infection in mice (mammalian hosts). Different strains of avian influenza Viruses generated by reverse gentic techniques were inoculated into mice and lungs sampled daily. RNA recovered from lung homogenates were deep sequenced and mutations arising were characterised for adaptation. Relative viral fitness and the rapidity of the accumulation of mutations was measured and compared amongst the viral strains. |
| Impact | The results of the our experimental studies showed the avian-origin viruses rapidly acquired mutations that increase virus fitness in mammalian species. Therefore, these viruses pose zoonotic and pandemic threat to public health. |
| Start Year | 2018 |
| Description | Rapid acquisition of mammalian characteristics by avian influenza virus in single host infections. |
| Organisation | The Pirbright Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provided reagents and day to day technical help for undertaking this project and supervising postdoctoral researcher working on this project. Reagents include influenza reverse genetic plasmids and H9N2 and H7N9-specific antibodies. |
| Collaborator Contribution | this project will aim to understand AIV genetics that facilitate the rapid acquisition of mammalian adaptation characteristics in a single host infection. The partners with our collaborations determined adaptive genetic changes in the H9N2 avian influenza virus following infection in mice (mammalian hosts). Different strains of avian influenza Viruses generated by reverse gentic techniques were inoculated into mice and lungs sampled daily. RNA recovered from lung homogenates were deep sequenced and mutations arising were characterised for adaptation. Relative viral fitness and the rapidity of the accumulation of mutations was measured and compared amongst the viral strains. |
| Impact | The results of the our experimental studies showed the avian-origin viruses rapidly acquired mutations that increase virus fitness in mammalian species. Therefore, these viruses pose zoonotic and pandemic threat to public health. |
| Start Year | 2018 |
| Description | The GCRF One Health Poultry Hub |
| Organisation | Royal Veterinary College (RVC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The focus of the research is to achieve sustainable global intensification of poultry meat and egg production whilst reducing risks to human and animal health and welfare. We are undertaking research to investigate the diversity of avian influenza viruses prevalent in poultry and wild birds in south east Asia. |
| Collaborator Contribution | Royal Veterinary College, London is leading this GCRF One Health Poultry Hub. The project will address the need to meet rising demand for poultry meat and eggs in developing countries, while minimising risk to international public health. Population growth is driving global demand for poultry, meat and egg production; this unfortunately creates conditions in which animal diseases can spread to humans ('zoonoses'). These include bacterial food poisoning and strains with avian influenza with epidemic or pandemic potential. The GCRF One Health Poultry Hub will adopt a 'One Health' approach to the issue of combatting animal-to-human diseases by bringing together a team of laboratory, clinical, veterinary and social scientists. This team will test and evaluate novel interventions. The need for safe poultry production is most urgent in South and South East Asia, so the RVC and its partners will then use their local networks in these regions to put its positive research to immediate use. |
| Impact | Development of international interdisciplinary partnership of 55 investigators from 13 countries to address the emerging global challenges of food security and public health associated with intensification of poultry production. |
| Start Year | 2018 |
| Description | The Pirbright "Livestock Antibody Hub" funded by Bill & Melinda Gates Foundation |
| Organisation | The Pirbright Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Me and my team established collaboration in the "Livestock Antibody Hub" funded ($5.5 million) by the from Bill & Melinda Gates Foundation. Focus of our partnership is to develop techniques and capacity to analyse immune cells (B cells) of cattle, poultry and pigs that produce virus neutralizing antibodies. This research will support rational development of next generation of vaccines and to explore antibody-based passive immunization approaches for treatment and prophylaxis of infectious viral diseases affecting livestock and humans. Our initial focus is to target major animal viral pathogens that cause severe losses within Low and Middle-Income Countries (LMIC) animal production systems including avian influenza virus (AIV), Newcastle disease virus (NDV), infectious bursal disease virus (IBDV), infectious bronchitis virus (IBV) and foot-and-mouth disease virus (FMDV). |
| Collaborator Contribution | This is a collaborative project and partners are providing help in provision of reagents and techniques for analysis of diversity of B cells repertoire that produce infleunza virus-specific antibodies, single cell sequencing and bioinformatic analysis. This project will further strengthen our on-going research collaborations with many research groups in academia as well as with animal health industry (Zoetis, Boehringer Ingelheim Animal Health, Merck, CEVA, Jovac, YeBio, ILRI, Galvmed, The Roslin Institute, HuMabs, AbCellera and Distributed Bio) to take the research outputs from laboratory to the field. The outputs of research will be improved vaccines and diagnostics enabling to reduce the impact of infectious diseases on farm animals, which offer substantial direct and indirect economic, public health, environmental and social benefits to the UK and rest of the world. |
| Impact | Development of passive immunization approaches against avian influenza viruses affecting poultry (project incited in January 2020). |
| Start Year | 2020 |
| Description | The role of segment 3 in H9N2 avian influenza virus pathogenicity |
| Organisation | University of Edinburgh |
| Department | The Roslin Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | This is a Joint studentship project funded by The Pirbright Institute and The Roslin Institute. We identiifed molecular markers that are responsible for increase in virus pathogenicity and transmission. |
| Collaborator Contribution | The Roslin Institute contributed both intellectually and by proving research training, samples and regents to achieve the prescribed objectives this project. |
| Impact | 1. Oral Presentation Title: Identification of segment 3 sequence polymorphisms which alter shut off activity and pathogenicity of H9N2 avian influenza viruses in vivo. Anabel Clements, Saira Hussain, Holly Shelton, Paul Digard and Munir Iqbal. Global Alliance for Research Into Avian Diseases (GARAD). January 17th to 19th 2018. Fortuna Hotel, Lang Ha Street, Hanoi, VietNam 2. Poster title: What is the role of H9N2 avian influenza virus PA-X within an avian model?. Anabel Clements, Saira Hussain, Holly Shelton, Paul Digard & Munir Iqbal. UK- China CERAD (Centre of Excellence for Research on Avian Diseases), 3rd Symposium Recent Advances in Avian Disease Research. August 31st - 1st September 2017. The Harbour Hotel, Alexandra Terrace, Guildford, Surrey, UK. 3. Poster title: What is the role of H9N2 avian influenza virus PA-X within an avian model?. Anabel Clements, Saira Hussain, Holly Shelton, Paul Digard & Munir Iqbal. Microbiology Society Annual Conference. April 3rd-6th 2017. Edinburgh International Conference Centre (EICC), Edinburgh, UK. 4. Oral Presentation title: Identification of sequence polymorphisms in segment 3 of H9N2 avian influenza viruses that affect PA-X activity. Anabel Clements, Saira Hussain, Holly Shelton, Paul Digard & Munir Iqbal. Focused Meeting 2016: Molecular Biology and Pathogenesis of Avian Viruses. September 27th-29th 2016. Charles Darwin House, London, UK. 5. Oral Presentation title: The role of segment 3 in H9N2 avian influenza virus pathogenicity. Anabel Clements, Saira Hussain, Holly Shelton, Munir Iqbal & Paul Digard. UK -Taiwan BBSRC Partnering Award workshop: Improving Control of influenza viruses. 26th-27th April 2016. Taipei, Taiwan. 6. Oral Presentation title: Identification of sequence polymorphisms in segment 3 of H9N2 avian influenza viruses that affect PA-X activity. Anabel Clements, Saira Hussain, Holly Shelton, Munir Iqbal & Paul Digard. Microbiology Society Annual Conference 2016; virus Workshop: Negative strand RNA Viruses. 21st-24th March 2016. Arena and Convention Centre, Liverpool, UK. 7. Poster title: The role of segment 3 in H9N2 influenza virus pathogenicity. Anabel Clements, Saira Hussain, Holly Shelton, Munir Iqbal & Paul Digard. 7th Orthomyxovirus research conference. 16th-18th September 2015. Ecole Nationale Veterinaire de Toulouse, Toulouse, France. 8. Poster title: The role of segment 3 in H9N2 influenza virus pathogenicity. Anabel Clements, Saira Hussain, Holly Shelton, Munir Iqbal & Paul Digard. Edinburgh Infectious Diseases Annual Symposium. 20th May 2015. Royal College of Physicians, Edinburgh, UK. |
| Start Year | 2014 |
| Description | Understanding diversity of avian influenza viruses and improvement disease control in poultry and humans |
| Organisation | Agricultural Research Centre |
| Department | Veterinary Serum and Vaccine Research Institute |
| Country | Egypt |
| Sector | Public |
| PI Contribution | This project helped my research group to establish research collboration between the Pirbright Institute and the scientists at the collaborating laboratories listed above and an excellent opportunity for building a joint "ONE HEALTH" platfor. I am sharing knowledge, reagents and techniques to improve efficacious vaccines and diagnostic tools against avian influenza viruses. The easy availability of better control tools against avian influenza viruses will aid in the reduction of poultry production losses and thus be important for global food security and improved animal welfare whilst also reducing zoonotic transmission to humans. |
| Collaborator Contribution | Each collaborating institute and team member has specific expertise and facilities in areas relevant to this research programme. Collaborators in different institutions have extensive experience collecting field samples and implementing vaccination and large scale surveillance programmes. Each partner institutions have unique experience in monitoring the endemic prevalence of many animal diseases including avian influenza in both domestic and wild birds from which UK is under constant threat. The partners are sharing knowledge, expertise and facilities to investigate fundamental biology of influenza viruses and predict their epidemiological relevance, to assess potential risks and to devise appropriate intervention strategies. The knowledge, reagents and field samples will be available through this partnership. which will be essential for development of informed control policies and tools(vaccines and diagnostics) that may contribute to reducing the ever increasing threat from endemic, emerging and re-emerging influenza virus variants posing risk to animals and humans. Also, All researchers involved will benefit through ongoing professional development and advanced training in new technologies and new systems-level approaches to disease management. Exchange visits of researchers from collaborating laboratories to undertake training in a number of disciplines including disease surveillance, molecular virology, epidemiology, immunology, vaccinology and diagnostics will have a tangible impact on capacity building and training of next generation researchers in control of infectious animal and zoonotic diseases. |
| Impact | The ultimate aims of this collaboration are to reduce the impact of influenza virus on poultry production and reduce their zoonotic transmission to humans. The collaboration will improve resources and capacity for disease control systems. Achieving these specific goals will prove a step-change in AIV disease management and increase in poultry productivity directly drives economic prosperity of farmers and allied communities. The will directly impact on socio-economic well-being of partner countries. |
| Start Year | 2017 |
| Description | Understanding diversity of avian influenza viruses and improvement disease control in poultry and humans |
| Organisation | Francis Crick Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | This project helped my research group to establish research collboration between the Pirbright Institute and the scientists at the collaborating laboratories listed above and an excellent opportunity for building a joint "ONE HEALTH" platfor. I am sharing knowledge, reagents and techniques to improve efficacious vaccines and diagnostic tools against avian influenza viruses. The easy availability of better control tools against avian influenza viruses will aid in the reduction of poultry production losses and thus be important for global food security and improved animal welfare whilst also reducing zoonotic transmission to humans. |
| Collaborator Contribution | Each collaborating institute and team member has specific expertise and facilities in areas relevant to this research programme. Collaborators in different institutions have extensive experience collecting field samples and implementing vaccination and large scale surveillance programmes. Each partner institutions have unique experience in monitoring the endemic prevalence of many animal diseases including avian influenza in both domestic and wild birds from which UK is under constant threat. The partners are sharing knowledge, expertise and facilities to investigate fundamental biology of influenza viruses and predict their epidemiological relevance, to assess potential risks and to devise appropriate intervention strategies. The knowledge, reagents and field samples will be available through this partnership. which will be essential for development of informed control policies and tools(vaccines and diagnostics) that may contribute to reducing the ever increasing threat from endemic, emerging and re-emerging influenza virus variants posing risk to animals and humans. Also, All researchers involved will benefit through ongoing professional development and advanced training in new technologies and new systems-level approaches to disease management. Exchange visits of researchers from collaborating laboratories to undertake training in a number of disciplines including disease surveillance, molecular virology, epidemiology, immunology, vaccinology and diagnostics will have a tangible impact on capacity building and training of next generation researchers in control of infectious animal and zoonotic diseases. |
| Impact | The ultimate aims of this collaboration are to reduce the impact of influenza virus on poultry production and reduce their zoonotic transmission to humans. The collaboration will improve resources and capacity for disease control systems. Achieving these specific goals will prove a step-change in AIV disease management and increase in poultry productivity directly drives economic prosperity of farmers and allied communities. The will directly impact on socio-economic well-being of partner countries. |
| Start Year | 2017 |
| Description | Understanding diversity of avian influenza viruses and improvement disease control in poultry and humans |
| Organisation | Imperial College London |
| Department | MSk Lab |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | This project helped my research group to establish research collboration between the Pirbright Institute and the scientists at the collaborating laboratories listed above and an excellent opportunity for building a joint "ONE HEALTH" platfor. I am sharing knowledge, reagents and techniques to improve efficacious vaccines and diagnostic tools against avian influenza viruses. The easy availability of better control tools against avian influenza viruses will aid in the reduction of poultry production losses and thus be important for global food security and improved animal welfare whilst also reducing zoonotic transmission to humans. |
| Collaborator Contribution | Each collaborating institute and team member has specific expertise and facilities in areas relevant to this research programme. Collaborators in different institutions have extensive experience collecting field samples and implementing vaccination and large scale surveillance programmes. Each partner institutions have unique experience in monitoring the endemic prevalence of many animal diseases including avian influenza in both domestic and wild birds from which UK is under constant threat. The partners are sharing knowledge, expertise and facilities to investigate fundamental biology of influenza viruses and predict their epidemiological relevance, to assess potential risks and to devise appropriate intervention strategies. The knowledge, reagents and field samples will be available through this partnership. which will be essential for development of informed control policies and tools(vaccines and diagnostics) that may contribute to reducing the ever increasing threat from endemic, emerging and re-emerging influenza virus variants posing risk to animals and humans. Also, All researchers involved will benefit through ongoing professional development and advanced training in new technologies and new systems-level approaches to disease management. Exchange visits of researchers from collaborating laboratories to undertake training in a number of disciplines including disease surveillance, molecular virology, epidemiology, immunology, vaccinology and diagnostics will have a tangible impact on capacity building and training of next generation researchers in control of infectious animal and zoonotic diseases. |
| Impact | The ultimate aims of this collaboration are to reduce the impact of influenza virus on poultry production and reduce their zoonotic transmission to humans. The collaboration will improve resources and capacity for disease control systems. Achieving these specific goals will prove a step-change in AIV disease management and increase in poultry productivity directly drives economic prosperity of farmers and allied communities. The will directly impact on socio-economic well-being of partner countries. |
| Start Year | 2017 |
| Description | Understanding diversity of avian influenza viruses and improvement disease control in poultry and humans |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | This project helped my research group to establish research collboration between the Pirbright Institute and the scientists at the collaborating laboratories listed above and an excellent opportunity for building a joint "ONE HEALTH" platfor. I am sharing knowledge, reagents and techniques to improve efficacious vaccines and diagnostic tools against avian influenza viruses. The easy availability of better control tools against avian influenza viruses will aid in the reduction of poultry production losses and thus be important for global food security and improved animal welfare whilst also reducing zoonotic transmission to humans. |
| Collaborator Contribution | Each collaborating institute and team member has specific expertise and facilities in areas relevant to this research programme. Collaborators in different institutions have extensive experience collecting field samples and implementing vaccination and large scale surveillance programmes. Each partner institutions have unique experience in monitoring the endemic prevalence of many animal diseases including avian influenza in both domestic and wild birds from which UK is under constant threat. The partners are sharing knowledge, expertise and facilities to investigate fundamental biology of influenza viruses and predict their epidemiological relevance, to assess potential risks and to devise appropriate intervention strategies. The knowledge, reagents and field samples will be available through this partnership. which will be essential for development of informed control policies and tools(vaccines and diagnostics) that may contribute to reducing the ever increasing threat from endemic, emerging and re-emerging influenza virus variants posing risk to animals and humans. Also, All researchers involved will benefit through ongoing professional development and advanced training in new technologies and new systems-level approaches to disease management. Exchange visits of researchers from collaborating laboratories to undertake training in a number of disciplines including disease surveillance, molecular virology, epidemiology, immunology, vaccinology and diagnostics will have a tangible impact on capacity building and training of next generation researchers in control of infectious animal and zoonotic diseases. |
| Impact | The ultimate aims of this collaboration are to reduce the impact of influenza virus on poultry production and reduce their zoonotic transmission to humans. The collaboration will improve resources and capacity for disease control systems. Achieving these specific goals will prove a step-change in AIV disease management and increase in poultry productivity directly drives economic prosperity of farmers and allied communities. The will directly impact on socio-economic well-being of partner countries. |
| Start Year | 2017 |
| Description | Understanding diversity of avian influenza viruses and improvement disease control in poultry and humans |
| Organisation | Suez Canal University |
| Country | Egypt |
| Sector | Academic/University |
| PI Contribution | This project helped my research group to establish research collboration between the Pirbright Institute and the scientists at the collaborating laboratories listed above and an excellent opportunity for building a joint "ONE HEALTH" platfor. I am sharing knowledge, reagents and techniques to improve efficacious vaccines and diagnostic tools against avian influenza viruses. The easy availability of better control tools against avian influenza viruses will aid in the reduction of poultry production losses and thus be important for global food security and improved animal welfare whilst also reducing zoonotic transmission to humans. |
| Collaborator Contribution | Each collaborating institute and team member has specific expertise and facilities in areas relevant to this research programme. Collaborators in different institutions have extensive experience collecting field samples and implementing vaccination and large scale surveillance programmes. Each partner institutions have unique experience in monitoring the endemic prevalence of many animal diseases including avian influenza in both domestic and wild birds from which UK is under constant threat. The partners are sharing knowledge, expertise and facilities to investigate fundamental biology of influenza viruses and predict their epidemiological relevance, to assess potential risks and to devise appropriate intervention strategies. The knowledge, reagents and field samples will be available through this partnership. which will be essential for development of informed control policies and tools(vaccines and diagnostics) that may contribute to reducing the ever increasing threat from endemic, emerging and re-emerging influenza virus variants posing risk to animals and humans. Also, All researchers involved will benefit through ongoing professional development and advanced training in new technologies and new systems-level approaches to disease management. Exchange visits of researchers from collaborating laboratories to undertake training in a number of disciplines including disease surveillance, molecular virology, epidemiology, immunology, vaccinology and diagnostics will have a tangible impact on capacity building and training of next generation researchers in control of infectious animal and zoonotic diseases. |
| Impact | The ultimate aims of this collaboration are to reduce the impact of influenza virus on poultry production and reduce their zoonotic transmission to humans. The collaboration will improve resources and capacity for disease control systems. Achieving these specific goals will prove a step-change in AIV disease management and increase in poultry productivity directly drives economic prosperity of farmers and allied communities. The will directly impact on socio-economic well-being of partner countries. |
| Start Year | 2017 |
| Description | Understanding diversity of avian influenza viruses and improvement disease control in poultry and humans |
| Organisation | University of Tokyo |
| Department | International Research Center for Infectious Diseases |
| Country | Japan |
| Sector | Hospitals |
| PI Contribution | This project helped my research group to establish research collboration between the Pirbright Institute and the scientists at the collaborating laboratories listed above and an excellent opportunity for building a joint "ONE HEALTH" platfor. I am sharing knowledge, reagents and techniques to improve efficacious vaccines and diagnostic tools against avian influenza viruses. The easy availability of better control tools against avian influenza viruses will aid in the reduction of poultry production losses and thus be important for global food security and improved animal welfare whilst also reducing zoonotic transmission to humans. |
| Collaborator Contribution | Each collaborating institute and team member has specific expertise and facilities in areas relevant to this research programme. Collaborators in different institutions have extensive experience collecting field samples and implementing vaccination and large scale surveillance programmes. Each partner institutions have unique experience in monitoring the endemic prevalence of many animal diseases including avian influenza in both domestic and wild birds from which UK is under constant threat. The partners are sharing knowledge, expertise and facilities to investigate fundamental biology of influenza viruses and predict their epidemiological relevance, to assess potential risks and to devise appropriate intervention strategies. The knowledge, reagents and field samples will be available through this partnership. which will be essential for development of informed control policies and tools(vaccines and diagnostics) that may contribute to reducing the ever increasing threat from endemic, emerging and re-emerging influenza virus variants posing risk to animals and humans. Also, All researchers involved will benefit through ongoing professional development and advanced training in new technologies and new systems-level approaches to disease management. Exchange visits of researchers from collaborating laboratories to undertake training in a number of disciplines including disease surveillance, molecular virology, epidemiology, immunology, vaccinology and diagnostics will have a tangible impact on capacity building and training of next generation researchers in control of infectious animal and zoonotic diseases. |
| Impact | The ultimate aims of this collaboration are to reduce the impact of influenza virus on poultry production and reduce their zoonotic transmission to humans. The collaboration will improve resources and capacity for disease control systems. Achieving these specific goals will prove a step-change in AIV disease management and increase in poultry productivity directly drives economic prosperity of farmers and allied communities. The will directly impact on socio-economic well-being of partner countries. |
| Start Year | 2017 |
| Description | Understanding diversity of avian influenza viruses and improvement disease control in poultry and humans |
| Organisation | Zagazig University |
| Country | Egypt |
| Sector | Academic/University |
| PI Contribution | This project helped my research group to establish research collboration between the Pirbright Institute and the scientists at the collaborating laboratories listed above and an excellent opportunity for building a joint "ONE HEALTH" platfor. I am sharing knowledge, reagents and techniques to improve efficacious vaccines and diagnostic tools against avian influenza viruses. The easy availability of better control tools against avian influenza viruses will aid in the reduction of poultry production losses and thus be important for global food security and improved animal welfare whilst also reducing zoonotic transmission to humans. |
| Collaborator Contribution | Each collaborating institute and team member has specific expertise and facilities in areas relevant to this research programme. Collaborators in different institutions have extensive experience collecting field samples and implementing vaccination and large scale surveillance programmes. Each partner institutions have unique experience in monitoring the endemic prevalence of many animal diseases including avian influenza in both domestic and wild birds from which UK is under constant threat. The partners are sharing knowledge, expertise and facilities to investigate fundamental biology of influenza viruses and predict their epidemiological relevance, to assess potential risks and to devise appropriate intervention strategies. The knowledge, reagents and field samples will be available through this partnership. which will be essential for development of informed control policies and tools(vaccines and diagnostics) that may contribute to reducing the ever increasing threat from endemic, emerging and re-emerging influenza virus variants posing risk to animals and humans. Also, All researchers involved will benefit through ongoing professional development and advanced training in new technologies and new systems-level approaches to disease management. Exchange visits of researchers from collaborating laboratories to undertake training in a number of disciplines including disease surveillance, molecular virology, epidemiology, immunology, vaccinology and diagnostics will have a tangible impact on capacity building and training of next generation researchers in control of infectious animal and zoonotic diseases. |
| Impact | The ultimate aims of this collaboration are to reduce the impact of influenza virus on poultry production and reduce their zoonotic transmission to humans. The collaboration will improve resources and capacity for disease control systems. Achieving these specific goals will prove a step-change in AIV disease management and increase in poultry productivity directly drives economic prosperity of farmers and allied communities. The will directly impact on socio-economic well-being of partner countries. |
| Start Year | 2017 |
| Description | "Challenges for Poultry Industry". Organised by Fakieh Poultry at the Ritz-Carlton Hotel in Jeddah, Saudi Arabia, 2nd -3rd December 2018, |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Conference discussed prevention and control of infectious diseases affecting poultry production. |
| Year(s) Of Engagement Activity | 2018 |
| Description | "Interactive session with poultry stakeholders". Title: Overview of Avian Influenza group Research at The Pirbright Institute. Presented at University of Veterinary and Animal Sciences (UVAS) Lahore, Pakistan, 3rd August 2018. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The workshop discussed the economic impacts and prevention strategies against avian influenza viruses affecting poultry production and zoonotic infections. |
| Year(s) Of Engagement Activity | 2018 |
| Description | 1. Improvement of vaccines and diagnostics for avian influenza viruses. South West Chicken Association. 28th Annual Trade Fair and Conference, 19 April 2016. Bristol, UK. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | gave the overview of scientific advances for the control of avian influenza infection and spread in poultry to farmers and representative from poultry production chain.over 200 peoples attanded South West Chicken Association. 28th Annual Trade Fair and Conference, 19 April 2016. Bristol, UK. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.farminguk.com/agricultural-shows-and-events/South-West-Chicken-Association-Conference-Tr... |
| Description | 2. Overview of Avian Influenza group Research at The Pirbright Institute. Presented at "Interactive session with poultry stakeholders" at University of Veterinary and Animal Sciences (UVAS) Lahore, Pakistan, 3rd August 2018. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dissemination of research Project outcomes These include presenting research data for vaccine seed strains with emergent field avian influenza variants; The zoonotic risk posed by emerging avian influenza viruses circulating in the wild birds and poultry. Impact of virus evolution on vaccine efficacy and persistence in poultry. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Avian flu: our food chain is in crisis. |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The New paper "Telegraph" correspondent Sarah Newey (GLOBAL HEALTH SECURITY CORRESPONDENT) Interviewed Professor munir Iqbal regarding the impacts and threats of current wave if high pathogenicity avian influenza virus causing disease widespread losses to poultry production, mortality of wild birds and mammalian species (otters, foxes, minks sealions), The discussion focus on the impacts of avian influenza infections on the livelihood of farming comunities and threat of zoonotic infection to wider public. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.telegraph.co.uk/global-health/science-and-disease/what-bird-flu-pandemic-killedmillions-... |
| Description | BBSRC Partnering Seminar, University of Liverpool, Tamilnadu Veterinary and Animal Science University |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk presented entitled " Molecular determinants of antigenicity of H7 and H9 avian Influenza viruses". The research data shared with the colleagues working to reduce the impact of avian infectious diseases on poultry production. The discussion led to more collaboration and work together, acquiring reagents and protocols for further research and development activities. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Bird flu: What is it and what's behind the outbreak? ( BBC New) |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Discussion with BBC News Editors (Helen Briggs & Jeremy Howell). As the The world is going through its worst-ever outbreak of bird flu which led the deaths of hundreds of thousands of wild birds and millions of domestic ones. It is also being found in mammals, so what are the threats from this virus to economy, food security, animal welfare and public health. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.bbc.co.uk/news/science-environment-63464065 |
| Description | Could Bird Flu become a pandemic? (Aljazeera TV) |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The discussion ( Inside Story) has been impacts of high pathogenicity avian influenza on poultry and whether bird flu become a pandemic?. The inside story was presented by Al Jazeera English corresponded "Mohammed Jamjoom" the discussion focus remains as the world is experiencing its largest recorded outbreak of bird flu, populations of poultry and wild birds are becoming infected. So what are threats of these viruses on food supplies, economy and public health. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.youtube.com/watch?v=spp2Cg-jqoc |
| Description | Deimante Lukosaityte: Microbiology Society conference 2019. Poster presentation: Chicken protection against H9N2 virus by passive immunization |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Described techniques for development of next generation of vaccines against viral diseases affecting animals and humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Determinants of antigenicity of H9 Avian Influenza Viruses. UK-China Swine and Poultry Workshop.17-18 June 2019, The Pirbright Institute, UK. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Evolution of H9N2 avian influenza virus under immune pressure. Presented at 10th International Symposium on Avian Influenza, 15th - 18th April 2018, The Grand Hotel, Brighton, UK. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The primary aim of the workshop was to forge long-term research partnerships between early-career researchers, livestock industry and national disease control authorities in the UK and the Philippines. In addition, the activity hopes provide information about the emerging and next generation diagnostic and vaccine strategies and their utilization to reduce the impact of viral diseases on livestock and poultry. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.slideshare.net/zerep_cire/2019-newton-agham-researcher-links-workshop-vaccines-and-diagn... |
| Description | Evolutionary fitness of avian influenza viruses and development of improved vaccines and diagnostics. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Seminar entitled "Evolutionary fitness of avian influenza viruses and development of improved vaccines and diagnostics" was presented as invited speaker to Postgraduate students and staff at RVC (Hawkshead Campus), UK. 19 October 2016. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Evolutionary fitness of avian influenza viruses and development of improved vaccines and diagnostics. Seminar as inviated speaker at RVC (Hawkshead Campus), UK. 19 October 2016. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk delivered on the topic "improvement of vaccines and diagnostic for poultry at The pirbright Institute UK, as an invited speaker at Royal Veterinary College (RVC) London |
| Year(s) Of Engagement Activity | 2016 |
| Description | Genetic engineering speeds up poultry vaccine development |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Researchers report the rapid generation of a bivalent vaccine against Marek's disease and avian influenza Scientists at The Pirbright Institute have used genetic engineering to develop a vaccine that protects birds against both Marek's disease and avian influenza. They say the process is faster and more efficient compared to previous methods, which will allow poultry vaccine producers to rapidly update vaccine strains in order to keep up with virus evolution. In a study published in the journal Vaccines, the team used the gene editing tool CRISPR/Cas9 to insert an avian influenza gene into the turkey herpesvirus (HVT) that is used in Marek's disease vaccines. The gene codes for haemagglutinin (HA), an influenza protein that is key for virus entry into host cells and is therefore an important target of the host immune response to block infection. "HVT is already widely used in vaccines against Marek's disease and can be administered to eggs, enabling automated delivery and providing birds with protection from the day they hatch. The additional HA gene we have incorporated will be expressed by HVT when it replicates in host cells, meaning that a single dose of vaccine induces immunity against both viruses", explained Professor Munir Iqbal, Head of the Avian Influenza group at Pirbright. "The genetic engineering process we have developed using CRISPR/Cas9 is far quicker and more efficient than previous technologies, as well as being very consistent and accurate. These attributes are essential for providing fast and reliable vaccine production to protect poultry", Prof Iqbal added. Mutations can occur with high frequency in HA proteins, enabling influenza viruses to evade immunity generated by vaccines. Using CRISPR/Cas9 to create new vaccines will help tackle evolving viruses by reducing the time it takes manufacturing companies to adapt their vaccine strains to match these mutations, allowing faster responses to outbreaks and providing better protection. Although this gene editing method is very reliable, a small number of HVT viruses fail to incorporate the HA gene into their own genome effectively. To ensure HA is being expressed in the vaccine, the team exploited the HA protein's ability to bind to molecules on the surface of red blood cells. Chicken cells infected with the successfully modified HVT virus express HA on their surface which red blood cells attach to, forming a clump that can be visualised using microscopy. This simple test improves the speed at which suitable vaccine candidates can be identified and has a much broader application as it can also be used for other viruses that incorporate proteins which interact with red blood cells. "Improving how we make vaccines is critical for preventing avian influenza outbreaks. Our work could help reduce the spread of disease between birds and reduce the risk of infection for people who work closely with poultry", Prof Iqbal said. "Now that we have developed a rapid method for generating this modified vaccine, our next steps will be to study the vaccine's effectiveness in field trials." |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.cabi.org/vetmedresource/news/66612 |
| Description | H9N2 avian influenza viruses: impact of evolutionary changes on virus antigenicity, receptor binding and zoonotic potential. Presented at "Conference on Animal Infectious Diseases and Human Health" held at The Veterinary Biotechnology Branch of Chinese Association of Animal Science and Veterinary Medicine & the Veterinary Immunology Branch of Chinese Society for Immunology. August 7th-10th, 2018 Harbin, China. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Focus of the conference was to improve control against infectious diseases affecting poultry and livestock. |
| Year(s) Of Engagement Activity | 2018 |
| Description | H9N2 avian influenza viruses: impact of evolutionary changes on virus antigenicity, receptor binding and zoonotic potential. Presented at "Conference on Animal Infectious Diseases and Human Health" held at The Veterinary Biotechnology Branch of Chinese Association of Animal Science and Veterinary Medicine & the Veterinary Immunology Branch of Chinese Society for Immunology. August 7th-10th, 2018 Harbin, China. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dissemination of research outcomes to prevent and control of infectious diseases of animals and humans. - Avian influenza virus evolution and efficacy. - |
| Year(s) Of Engagement Activity | 2018 |
| Description | High pathogenicity avian Influenza (HPAI) H5 in Europe -Epidemiology and Surveillance. Presented via Webinar, organized by Boehringer Ingelheim, 3rd July 2020. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk entitled; High pathogenicity avian Influenza (HPAI) H5 in Europe -Epidemiology and Surveillance. talk was organized by Boehringer Ingelheim, 3rd July 2020 and presented via Webinar. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Identification of antigenic epitopes to broaden and enhance the efficacy of avian influenza vaccines. Presented at 6th Animal Vaccines and immune Adjuvant Technologies Salon & Advanced seminar, Shandong-Binzhou Animal Science and Veterinary Medicine Academy, China, 18-20 October 2019. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion was the best practices to improve control systems (vaccines and diagnostics) for prevention of avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Immuno-pathobiology of H9N2 avian influenza viruses: looking at how the viruses evolve and persist in poultry. Presented at "Techniques for Healthy Farming and Diseases Prevention & Control of Livestock and Poultry. Beijing, August 13th-15th, 2018. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Dissemination of research outputs. Improvement of vaccines and diagnostics. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Improving vaccines and diagnostics for Avian influenza viruses affecting poultry. Presented at the International Poultry Expo "Poultry Science Conference", Lahore, Pakistan, 13-15 September 2019. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion was the best practices to improve control systems (vaccines and diagnostics) for prevention of avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Innovate Guildford (Angita Shrestha): |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | GENERAL SCIENCE |
| Year(s) Of Engagement Activity | 2019 |
| Description | International Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Global Alliance for Research on Avian Diseases conference health in Hanoi 17-19 January 2018. Purpose of the conference was to establish global partnerships and links between academic researchers and the poultry industry to improve joined up work in regards to preventing, controlling and combating avian diseases. The conferences provided a forum for discussion and exchange of ideas around the single theme of exploiting available opportunities to deal with emerging and existing infectious avian diseases in poultry production systems and to safeguard food supplies and human health. Conference speakers discuused basic, applied and commercial aspects of research on avian diseases including: • Evolution and Epidemiology of Avian Pathogens • Host-Pathogen Interactions - Virulence and Pathogenicity • Pathogen Mechanisms of Immune Evasion • Next Generation Disease Control Strategies • Vaccines • Immunity • Diagnostics • Zoonoses and Socio-economic impacts of avian diseases • Global Research Opportunities and Threats |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.theeventsportal.com/GARAD-2018/3/Home |
| Description | Lorin Adams (Gordon's School Careers Fair) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Describe the research that lead to improve control systems against infectious viral diseases of animals and from animals to humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Mapping antigenic determinants of H9N2 avian influenza viruses and improving vaccines and diagnostics" presented at Foreign Talent Lecture: New strategies and new techniques for the prevention and control of major avian diseases. Shandong Binzhou Animal Science & Veterinary Medicine Academy, Binzhou, China. 6th August 2018. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The focus of the meeting was to improve the control systems against poultry diseases including development of improved vaccines and diagnostics |
| Year(s) Of Engagement Activity | 2018 |
| Description | Molecular Determinants for Antigenicity and Vaccine Efficacy of H9 and H7 Avian Influenza Viruses. Newton Agham Researcher Links Workshop: Novel vaccines and diagnostics technologies against Emerging and re-emerging veterinary Pathogens. 4-7 February 2019 at Rizal Pak Hotel, Manila, Philippines. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Molecular determinants modulating avian influenza H7N9 virus antigenicity. Presented at The Microbiology Society Annual Conference 2019, 8-11 April ICC Belfast, UK. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Molecular determinants of antigenicity of H7 and H9 avian Influenza viruses. Presented as invited speaker at BBSRC UK-India Partnering Award seminar: University of Liverpool. 2 May 2019. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Munir Iqbal: Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Describe the research that lead to improve control systems against infectious viral diseases of animals and from animals to humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | New rapid protection bird flu vaccine |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Article published in the magazine "Poultry World) by Freelance journalist Natalie Berkhout describing the development of a new methods have been developed to enhance the immune response that vaccines produce and reduce the amount of virus that birds shed into the environment. One technique involves tagging flu virus proteins with a marker that makes them easier for antigen-presenting cells (APCs) to capture. These immune cells can efficiently process the tagged proteins, resulting in a robust and long-lasting antiviral response in chickens. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.poultryworld.net/health-nutrition/health/new-rapid-protection-bird-flu-vaccine/ |
| Description | Newton Agham Researcher Links Workshop on "Novel Vaccines and Diagnostic Technologies Against Emerging and Re-emerging Veterinary Pathogens, Rizal Park Hotel, Manila, Philippines 4-7 February 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The primary aim of this workshop was to forge long-term research partnerships between early-career researchers, livestock industry and national disease control authorities in the UK and the Philippines. The workshop provided information on emerging and next generation diagnostic and vaccine strategies and their utilization to reduce the impact of viral diseases on livestock and poultry. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.slideshare.net/zerep_cire/2019-newton-agham-researcher-links-workshop-vaccines-and-diagn... |
| Description | Pengxiang Chang: Talk presentation:The application of CRISPR/Cas9 system in the generation of viral vectored avian influenza vaccines at Microbiology Society conference, UK. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of vaccines to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://microbiologysociety.org/event/annual-conference/annual-conference.html |
| Description | Pengxiang Chang:Influenza update meeting. The application of CRISPR/Cas9 in the development of vaccines against avian influenza virus |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Described techniques to improve and produce new effective vaccines against viral diseases of animals and humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Pirbright Institute research teams studying characteristics of influenza virus that may alter disease outcomes in poultry. |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Avian influenza, commonly known as "bird flu," is a disease caused by multiple strains of influenza virus. The viruses can infect a wide range of animals, including people and pigs, but the natural reservoir lies in populations of wild aquatic birds such as ducks and gulls, according to an announcement from The Pirbright Institute in the U.K., which is conducting research to better understand avian influenza viruses to help prevent the disease in poultry. Flu virus strains are categorized by the combination of the two proteins found on the outside of the virus: hemagglutinin (H) and neuraminidase (N) -- for example, H5N6 or H9N2. The H protein binds to cell receptors in order to initiate infection, while the N protein helps release new viruses from an infected cell, the institute explained. Strains are also classified by severity. Low-pathogenic avian influenza (LPAI) viruses cause clinical signs such as mild breathing problems, decreased egg production and growth. Some birds, particularly ducks and geese, do not display any signs of LPAI infection and are still able to spread the disease, Pirbright said. When LPAI viruses circulate in high-density poultry areas, the viruses can mutate into highly pathogenic strains. Highly pathogenic avian influenza (HPAI) viruses have severe and often fatal effects on some species of birds such as chickens, Pirbright noted, but some HPAI strains cause mild or no clinical signs of disease in wild birds and domestic waterfowl. These strains are notifiable, meaning government control measures must be put in place. Avian influenza can be carried vast distances by wild migratory birds and can infect domesticated poultry through direct contact or through contaminated droppings and bodily fluids, Pirbright said. Because of this, there is a year-round risk of avian influenza, which can increase depending on the disease status in a region and the migration season of wild aquatic birds. According to Pirbright, good biosecurity is essential in preventing poultry from being exposed to the disease and can be practiced on a commercial farm, with game birds or even with just a few backyard hens. Why is influenza so difficult to prevent? The institute explained that influenza viruses are constantly changing, and when they replicate, small errors called mutations are copied into their genome. Some of these will alter the virus's proteins, allowing the virus to escape detection by the immune system. All flu viruses also have the potential to undergo a process called reassortment, where two or more strains of influenza infect the same animal, allowing them to swap parts of their genome, Pirbright said. The resulting viruses can potentially have different characteristics than the original strains, such as the ability to replicate in different species, including people, the institute added. Avian influenza viruses such as H5N1 or H7N9 have infected people, predominantly in Southeast Asia, but in these cases, the virus has been transmitted directly from infected birds to people, with no onward spread. There is some evidence that avian influenza can be passed from person to person, and while there are no records of efficient or sustained human transmission, there is a constant risk that one of the new strains may spread easily among people, which could result in a new influenza virus pandemic, Pirbright said. Changes in the virus genetics from mutation or reassortment make it very difficult to anticipate how influenza viruses will spread through a population and whether current vaccines will be suitable for the strains that are circulating, Pirbright announced. The influenza research programs at Pirbright are progressing understanding of the virus and finding better ways to prevent its spread. Pirbright Institute group leaders Dr. Holly Shelton and professor Munir Iqbal are researching how the characteristics of influenza viruses can change the outcomes of disease. Studying flu at the molecular level allows them to find out how the virus evolves to overcome avian immunity and how changes in their genome can alter disease severity and their ability to affect different species, the announcement said. Shelton's and Iqbal's teams are working on identifying genetic markers for specific disease traits that can be used in surveillance systems to provide forewarning of strains that could cause pandemics. For example, Shelton's Influenza Viruses group is looking at which characteristics allow the viruses to become resistant to antiviral drugs that are currently used to treat human infections of influenza, allowing surveillance to provide an early warning of viruses that could cross into humans and be difficult to control, Pirbright said. The team is also investigating how long it takes for avian influenza viruses to adapt to new mammalian species. According to the institute, establishing which strains can rapidly adapt and identifying the genetic changes made to enable infection of mammalian cells will help with surveillance efforts and potentially lead to the development of techniques that will help prevent these mutations occurring. Vaccination and rapid diagnosis are very important for influenza prevention and control, but it is still not currently possible to protect against all influenza strains, Pirbright said, noting that Iqbal's Avian Influenza group is exploring which sites on the virus trigger the chicken immune system to respond quickly and fight off infection. This will better inform scientists' ability to match vaccines to strains in the field and could help to develop vaccines that are more effective. Iqbal's group is also developing multivalent vaccines that protect chickens and ducks from several avian influenza subtypes at once as well as test kits for rapid diagnosis of different subtypes at the flock-side, the announcement said. Visit Pirbright's Influenza Viruses and the Avian Influenza group pages to find out more about their research. Source: The Pirbright Institute, which is solely responsible for the information provided and is wholly owned by the source. Informa Business Media and all its subsidiaries are not responsible for any of the content contained in this information asset. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.feedstuffs.com/nutrition-health/protecting-poultry-avian-influenza |
| Description | Poultry Stakeholders meeting hosted by Al Dousari Veterinary Services and Agriculture Co (Qatar ) in Qatar, 15 October 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The focus of talk was best practices for prevention and control of Avian influenza disease outbreaks in poultry Vaccines and diagnostics for the control of avian influenza in poultry |
| Year(s) Of Engagement Activity | 2019 |
| Description | Poultry Stakeholders meeting hosted by Almarai, 15 October 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Engagement with Almarai Poultry. The focus of the meeting with Almarai Poultry disease control team was to share knowledge on improved vaccination and diagnostic techniques against avian influenza viruses affecting poultry production. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Poultry Stakeholders meeting in Kuwait city 16 October 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prevention and control of avian influenza outbreaks in poultry. Described new vaccination and diagnostic technologies that provide more robust cross-protective immunity in emerging antigenic divergent strains of avian influenza viruses. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Protecting poultry from avian influenza through passive immunisation. Presented at Foreign Experts Seminar "New strategies and new tools for the prevention and control of major poultry diseases. Shandong-Binzhou Animal Science and Veterinary Medicine Academy, China, 20-22 September 2019. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion was the best practices to improve control systems (vaccines and diagnostics) for prevention of avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Rebecca Daines: Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Described the research undertaken at the Pirbright Institute that lead to improve control systems against infectious viral diseases of animals and from animals to humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Recombinant single chain variable fragment (scFv) antibody protects chickens from avian influenza. Presented at Systems Immunology Workshop: Adaptive immune repertoires and beyond. 16th-17th January 2020. University of Surrey, UK |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A talk entitled "Recombinant single chain variable fragment (scFv) antibody protects chickens from avian influenza" was presented at the workshop exploring new technical advances for analysis and production of antibodies for prophylaxes and treatment of animal and humans diseases. Both academics and staff linked with animal and public health industry attended this workshop. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Sushant Bhat:Pirbright Dragon Fair |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Described the research undertaken at the Pirbright Institute that lead to improve control systems against infectious viral diseases of animals and from animals to humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Sustainable poultry (meat and eggs) production in Pakistan: Challenges and Opportunities. |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Discussion on sustainable poultry (meat and eggs) production in Pakistan: Challenges and Opportunities. Presented at UKRI-GCRF "Food Security, Agriculture, and Nutrition" workshop, Marriott Hotel, Islamabad, Pakistan. 9th- 10th March 2020. organised by UKRI GCRF team. The outcomes include the establishment of collaborative links with key stakeholders including policymakers and disease control officials. Closer links were established with official responsible for animal health and food security officials including Minister for Science and Technology of Pakistan, High commissioner of UK High Commission in Pakitan. Discussion agenda and key outcomes were also communicated to the President of Pakistan, Chairman of Higher Education Commission Pakitan and representatives from FAO and UKRI GCRF team. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.thenews.com.pk/print/626768-upsign-network-ukri-to-organise-global-development-workshops |
| Description | Talk Presented at 2nd International Congress of Veterinary Microbiology, 16th -19th October 2018. Sherwood Breezes Resort-Lara, Antalya, Turkey. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Conference discussed improving prevention and control of viral diseases of poultry. |
| Year(s) Of Engagement Activity | 2018 |
| Description | The Pirbright Village Duck Fair held on 16 June 2018 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Local Village Fair, interaction with local residence to expanse research aims and activities of The Pirbright Institute and benefits to UK and around the globe to prevent and control infectious diseases of animals and humans. |
| Year(s) Of Engagement Activity | 2018 |
| Description | The co-Circulation of Low and High-path-AIV in the same country with sub-optimal bio-security: Virus evolution and impact on vaccine efficacy. Presented at the 11th Scientific conference of Egyptian Veterinary Poultry Association, Conference "Towards a National strategy to control poultry industry problems in Egypt". 20-23 April 2019. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | The global Situation and pathobiology of Avian Influenza in different Avian Species. Presented at the 11th Scientific conference of Egyptian Veterinary Poultry Association, Conference "Towards a National strategy to control poultry industry problems in Egypt". 20-23 April 2019.. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Time for rethink on farming poultry as experts warn bird flu has slipped 'through our fingers (Sky News) |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Discussion with Sky New UK corresponded Tom Clarke (Science and technology editor @aTomClarke) on continued avian influenza viruses are becoming endemic in bird populations in Europe and North America with some areas seeing a 600% increase in infection over the past few months in September -November 2022. In the UK, every day now, two or three new premises have been testing positive for bird flu. If they do, their flocks are culled and over 50 million birds culled in Europe this year and a similar number in North America. There is a need for an improved disease control strategies against these viruses. just culling of infected and at risk will not reduce viruses prevalence and spread, because virus in circulating in wild birds. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://news.sky.com/story/time-for-rethink-on-farming-poultry-as-experts-warn-bird-flu-has-slipped-... |
| Description | UK-China Philippines-Thailand Swine and Poultry Research Initiative project kick-off workshop" at China Agriculture University, Beijing, 26th-28th September 2018. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Emerging new approaches were discussed for prevention and control of infectious diseases affecting swines and poultry. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Understanding Antigenic Diversity, Zoonotic potential and immunological prevention of avian influenza viruses affecting poultry. Presented at "UK-China Philippines-Thailand Swine and Poultry Research Initiative project kick-off workshop" at China Agriculture University, Beijing, 26th-28th September 2018. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Meeting focus was to share research plans funded under "UK-China-Philippines-Thailand Swine and Poultry Research Initiative". Research projects investigate pathogens, zoonotic pathogens or "commensals" associated with food safety issues affecting poultry and swine. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://bbsrc.ukri.org/funding/filter/joint-swine-poultry-initiative/ |
| Description | Understanding antigenic diversity, zoonotic potential and immunological prevention of avian influenza viruses affecting poultry. Presented at UK-China-Philippines-Thailand Swine and Poultry Research Initiative: Interim Project Workshop 13th-15th January 2020 Hilton Hotel, Bracknell, UK |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Outcomes of the research project entitled "Understanding antigenic diversity, zoonotic potential and immunological prevention of avian influenza viruses affecting poultry" were presented to colleagues working on prevention and control of infectious diseases affecting animals and humans. the work led to incite further research collaborations with different groups from UK, China, Thailand and Philippine. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Understanding avian influenza virus evolution and development of next generation vaccines. Presented at 459th Scientific Meeting of The Veterinary Research Club at The Farmers Club, 3 Whitehall Court London Friday 14th February 2020. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A talk presented entitled"Understanding avian influenza virus evolution and development of next generation vaccines". The discussion with senior staff from DEFRA and UKRI- BBSRC, researchers and veterinary professional like with control and prevention of animal diseases in United kingdom |
| Year(s) Of Engagement Activity | 2020 |
| Description | Understanding avian influenza virus evolution, antigenic diversity and vaccine failure. Presented at the 2019 Symposium on techniques for healthy breading and disease prevention & control of livestock and poultry, Golden Harbor Hotel, Beijing, 21-23 August 2019. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk and discussion on the control of infectious animal diseases including avian influenza. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Visit to Cairo Poultry Company (CPC) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Industry/Business |
| Results and Impact | Discussion and talk on prevention and control of poultry diseases (avian influenza and Newcastle Disease) and molecular factors affecting vaccine efficacy. The discussion and talk to present data, describing factors the directly influence protective efficacy of in use vaccines, and how they evaluate/ test vaccine failure. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Visit to Dakahlia Poultry Egypt |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Industry/Business |
| Results and Impact | Discussion and talk presented at Dakahlia Poultry Egypt head office to workers involved in poultry production. The talk amis were to provide update on the impact of evolutionary genetic changes in the avian influenza and Newcastle disease viruses on the efficacy of vaccines and diagnostics. The molecular changes in virus genetic makeup allow virus to escape from vaccine induced immunity results vaccine and diagnostics failure. Consequently the avian influenza viruses continue to circulates in vaccinated flocks. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Why wet markets will never close - despite the global threat to human health (The Telegraph) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | This discussion was due to current enormous global spread of bird flu and widespread poultry outbreak has generated unprecedented opportunities for the virus to jump to humans and potentially even mutate to better spread between people. Since the Live bird markets have been identified as key factors in the spread, persistence and evolution of avian influenza viruses,. Therefore, there is an increased risk to public at the live birds markets and how these risks can be reduced to increase food safety, security and public health. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.telegraph.co.uk/global-health/science-and-disease/why-wet-markets-will-never-close-despi... |