European Partnering Award: Pichia pastoris as a vehicle for synthetic biology

Lead Research Organisation: University of Cambridge
Department Name: Biochemistry


Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.


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Gangadharan N (2019) Metaheuristic approaches in biopharmaceutical process development data analysis. in Bioprocess and biosystems engineering

Description Contacts were established with the following Pichia researchers:

Prof Brian McNeil (Strathclyde Institute of Pharmacy and Biomedical Sciences)
Assoc Prof Rui Manuel Freitas Oliveira (Universidade Nova de Lisboa, Associate Professor Chemical and Biochemical Engineering, FCT/UNL)
Dr Ian Archer (Head of Process Development, Ingenza Ltd.)
Prof Anton Glieder (Graz University of Technology Austrian Centre of Industrial Biotechnology)
Prof Diethard Mattanovich (University of Natural Resources & Life Sciences, Vienna)

A meeting was held in Cambridge with all of these researchers. Subsequent to this meeting, outline research proposal for Horizon 2020 was prepared.

Subsequent meetings were held in Helsinki with:

Dr Jäntti Jussi (VTT Technical Research Centre of Finland)
Dr Mikko Arvas (VTT Technical Research Centre of Finland)

And in Perugia (Italy) with:

Prof Diethard Mattanovich (University of Natural Resources and Life Sciences, Vienna)
Dr Brigette Gasser (University of Natural Resources and Life Sciences, Vienna)

These meetings discussed building on work conducted in BRIC and FP7 to formulate a combined bioinformatics and experimental proposal for Horizon 2020.
Exploitation Route Cannot be taken forward unless Horizon 2020 issues a relevant call.
Sectors Chemicals,Manufacturing, including Industrial Biotechology

Description Genome annotation and genome-scale models for Pichia pastoris 
Organisation University of Natural Resources and Life Sciences
Country Austria 
Sector Academic/University 
PI Contribution Generation of a tool for the GO annotation of the Pichia genome that will enable community collaboration. Production of a consolidated and executable genome-scale model of the Pichia pastoris metabolic network.
Collaborator Contribution Generation of a genome sequence for the most widely used strain of Pichia pastoris. Generation of a draft metabolic model.
Impact Relevant papers about to be submitted,
Start Year 2015