China Partnering Award: Nutrition, the ageing lipidome and mitochondrial dysfunction

Lead Research Organisation: University of Surrey
Department Name: Faculty of Health and Medical Sciences

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

10 25 50

Related Projects

Project Reference Relationship Related To Start End Award Value
BB/M028100/1 29/06/2015 30/11/2016 £25,229
BB/M028100/2 Transfer BB/M028100/1 01/03/2017 26/07/2018 £22,605
 
Description please see version 1 of this grant.

We aimed to understand how the way that cells use fat when dietary nutrient intake is not balanced. We focused our attention on how liver and adipose tissue fat metabolism changes. We identified that both organs change their secretory behaviour to exert distant effects on other organs. We found for the first time that adipose tissue secretes an enzymes known as superoxide dismutase 3 after a high fat diet and that liver cell reduce the secretion of beneficial fats. Finally, we showed that when dietary nutrient intake is not balanced, the gut microbiome becomes less diverse. The gut microbiota are less able to produce metabolically protective fats after a high fat diet.
Exploitation Route please see version 1 of this grant

there are two new angles to this work.
the first lies in the targeting of gut microbiota to improve hepatic mitochondrial function and a paper is in preparation to describe our findings. we anticipate that a future intervention study may be developed to investigate this hypothesis.
the second outcome has been realised into new funding through Neutrocure which involves targeting mitochondrial reactive oxygen species metabolism to generate oxylipids and modulate inflammation.
Sectors Agriculture, Food and Drink,Healthcare,Pharmaceuticals and Medical Biotechnology

 
Description please see version 1 of this grant report on research fish Through the InClusilver project, I have been in close contact with SMEs and in January 2020, I presented to 30 SMEs in Aarhuus on nutrient imbalance in older adults on health outcomes and the the impact of dietary nutrient imbalance on gut microbiota.
First Year Of Impact 2019
Sector Agriculture, Food and Drink
Impact Types Economic

 
Description Neutrocure
Amount £420,000 (GBP)
Funding ID FETOPEN-01-2018-2019-2020 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2020 
End 12/2024
 
Description Visiting position, Xi'an Jao Tong University 
Organisation Xi'an Jiaotong University
Country China 
Sector Academic/University 
PI Contribution Several outgoing visits were made by me and my team to XJTU. During visits, we contributed to research programme development, gave lectures/seminars and supported sample collection. We have collaborated on one primary publication and one review article to date. One further primary publication and another review are in preparation. One PhD student who was involved in the collaboration has submitted his PhD and has been appointed as a post-doctoral researcher in Wake Forest, USA.
Collaborator Contribution Dr Gao has been exploring the effect of lipids on metabolism in vivo and contributes preclinical and molecular expertise to the partnership. She actively supported the training of a PhD student who as now completed his PhD successfully.
Impact 1: Gao D, Hu S, Zheng X, Lin W, Gao J, Chang K, Zhao D, Wang X, Zhou J, Lu S, Griffiths HR, Liu J. SOD3 Is Secreted by Adipocytes and Mitigates High-Fat Diet-Induced Obesity, Inflammation, and Insulin Resistance. Antioxid Redox Signal. 2020 Jan 20;32(3):193-212. doi: 10.1089/ars.2018.7628. PubMed PMID: 31680537. 2: Griffiths HR, Gao D, Pararasa C. Redox regulation in metabolic programming and inflammation. Redox Biol. 2017 Aug;12:50-57. doi: 10.1016/j.redox.2017.01.023. Epub 2017 Feb 12. Review. PubMed PMID: 28212523; PubMed Central PMCID: PMC5312548. 3: Russell WR, Baka A, Björck I, Delzenne N, Gao D, Griffiths HR, Hadjilucas E, Juvonen K, Lahtinen S, Lansink M, Loon LV, Mykkänen H, Östman E, Riccardi G, Vinoy S, Weickert MO. Impact of Diet Composition on Blood Glucose Regulation. Crit Rev Food Sci Nutr. 2016;56(4):541-90. doi: 10.1080/10408398.2013.792772. Review. PubMed PMID: 24219323.
Start Year 2016
 
Description A talk at the InClusilver final event, hosted by the Danish Food Cluster 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact The INCluSilver final event - a showcase of innovative start-ups and SMEs from all over Europe with presentations by leading keynote speakers was held in Aarhus, Denmark on January 21-23. At the conference the participants got keen insights into the nutritional challenges for older adults and how companies and knowledge institutions are working together to find solutions.

At the conference, the participants were also introduced to new opportunities from the EU's Horizon Europe program.

This event was aimed at startups, SMEs and large corporates from all over Europe with an interest in nutrition for the growing silver economy.
Year(s) Of Engagement Activity 2020
URL https://www.inclusilver.eu/innovation-conference-2020/
 
Description GRC Il Ciocca - Gordon conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact the purpose of this debate was to discuss career development, particularly for women in science.
Year(s) Of Engagement Activity 2017