Interactions between metabolic, cognitive and reward processes in appetite

Lead Research Organisation: University of Birmingham
Department Name: School of Psychology

Abstract

Recent research has helped us understand the processes that lead us to prefer certain foods over others and the factors that influence how much we eat. We know that through experience we learn that some foods are very rewarding to eat and this learning influences our food choices. We also know that signals relating to the ingestion of food arising from the body (metabolic signals) modulate processes in the brain that are important for determining how much a food is desired. Food is less attractive when we have just eaten for this reason. Our food choices are also influenced by cognitive processes such as attention and memory, for example, when thinking about food we are likely to pay attention to food in the environment and may be more likely to eat. Although we know that metabolic signals and cognitive processes directly influence food reward we know very little about how these factors interact to affect eating. New evidence from our research team suggests that metabolic signals may affect food reward indirectly via modulation of higher cognitive functions. The aim of this research programme is to investigate this idea by examining the effects of specific metabolic signals on cognitive processes and food reward. This is a new approach to the study of food choice and the results will have implications for both theory and practice. Potential practical benefits will include the possibility of developing more effective interventions to help people control their food intake.

Technical Summary

The frequency and size of meals are influenced by activity in brain circuitry that processes nutritional state signals and food reward value. Thus, consumption of food is associated with reduced activity in reward circuitry and decreased incentive value of food, which is reflected in reduced responses to appetitive stimuli in reward-related brain areas. Eating is also influenced by higher cognitive functions such as attention and memory that also affect reward processing. Recent evidence from our laboratory suggests that metabolic signals related to nutritional signals may also have indirect effects on food reward via alterations in higher cognitive functions. We have pilot data showing that eating to fullness after a natural inter-meal interval is accompanied by increased activity in the dorsolateral prefrontal cortex (dlPFC), an area that is associated with attention, memory and cognitive control. These data suggest that the termination of a usual meal is associated with changes in cognitive control mechanisms that supress intake. We have also recently reported the novel finding that the 5-HT2C receptor agonist mCPP, which is known to reduce food intake, enhances memory. Our overarching aim is to test the hypothesis that metabolic signals have effects on specific higher cognitive control functions and that these effects are related to eating behaviours via changes in reward-related responding. We will conduct three large scale experimental studies assessing the effects of intranasal insulin (study 1) the serotonin 2C agonist mCPP (Study 2) and ghrelin (Study 3) on inhibitory control, attention, memory, eating behaviour and fMRI BOLD responses. In each study the effect of drug administration will be tested in both lean and obese participants.

Planned Impact

The results of this project will be of interest to industry, health professionals and policy makers as well as the general public. Economic and societal impacts include adding to the knowledge base on controls of eating that could later lead to improvements in health and well-being. Given the health costs associated with unhealthy eating patterns it is important to explore new avenues for improving the Nation's diet through developing comprehensive models of appetite control that open the way for thinking about new interventions and advice on nutrition. The idea that metabolic signals may affect appetite control via novel mechanisms will be of interest to both the food and pharmaceutical industry and the results could lay the groundwork for further testing of products aimed at enhancing appetite control. This will be facilitated by the involvement of the industrial partner P1vital. Wide dissemination of the results (see pathways to impact plan) will ensure that a range of stakeholders are reached and beneficiaries of this project are not be limited to those in the UK. Engagement with the public will enhance understanding of the complexities of appetite control and interactions with the public will be important for improving the quality of research and its impact. It will also ensure wide communication of the results and inspire the next generation of researchers. The work will also contribute to the development of a promising early career researcher. The named RF will be given the opportunity to develop further experimental skills and experience that will enable him to further establish himself as an up and coming research star.
 
Description In our first study we have found that metabolic signals associated with satiation affect specific cognitive processes. These data are currently being analysed in detail to be written up for publication. Our second study is nearing completion for the data collection and the third study is underway.
Exploitation Route To early to say
Sectors Pharmaceuticals and Medical Biotechnology

 
Description P1vital 
Organisation P1vital Consortium
Country United Kingdom 
Sector Private 
PI Contribution We are working with the CEO of P1vital Colin Dourish on BBSRC project grant "Interactions between metabolic, cognitive and reward processes in appetite".
Collaborator Contribution Colin is a CI providing input on the research steering group and advising on experimental design, research governance, interpretation of data and report writing. He will also be involved in translating the results.
Impact 1. Higgs, S., & Spetter, M. S. (2018). Cognitive Control of Eating: the Role of Memory in Appetite and Weight Gain. Current obesity reports, 1-10. 2. Thomas, J. M., Dourish, C. T., Tomlinson, J., Hassan-Smith, Z., Hansen, P. C., & Higgs, S. (2018). The 5-HT 2C receptor agonist meta-chlorophenylpiperazine (mCPP) reduces palatable food consumption and BOLD fMRI responses to food images in healthy female volunteers. Psychopharmacology, 235(1), 257-267. 3. Higgs, S., Spetter, M. S., Thomas, J. M., Rotshtein, P., Lee, M., Hallschmid, M., & Dourish, C. T. (2017). Interactions between metabolic, reward and cognitive processes in appetite control: Implications for novel weight management therapies. Journal of Psychopharmacology, 31(11), 1460-1474.
Start Year 2016
 
Description Association for Science Education presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact I gave a presentation to School teachers as part of the Association for Science Education Annual Conference.
Year(s) Of Engagement Activity 2018
 
Description ESRC estival of Science 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact We had an evening event in a pub (The Botanist) as part of the ESRC Festival of Science where we engaged the public in presentations, quiz's, activities and Q and A about the psychology of eating. It was a ticketed event that was sold out.
Year(s) Of Engagement Activity 2018
 
Description Interview for a magazine 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact I gave an interview for Proto Magazine
Year(s) Of Engagement Activity 2018
URL http://protomag.com/articles/how-poor-diet-shapes-brain
 
Description Masterclass to schools 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact 120 pupils attended a masterclass at the research organisation which included discussion and questions and the evaluation reported increased interest in the research area and interest in studying at University
Year(s) Of Engagement Activity 2016
 
Description Pint of Science 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Maartje Spetter (post doc) took part in the Pint of Science event in Birmingham in a pub/cafe in Birmingham to talk about our research.
Year(s) Of Engagement Activity 2017
 
Description Postgraduate workshop 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Weight management and appetite - a transferable skills workshop. Key note speaker.
Year(s) Of Engagement Activity 2018
 
Description Presentation at FoodMatters live event 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Presentation on influences on eating behavior at a congress open to the public (FoodMatters live)
Year(s) Of Engagement Activity 2018
URL https://www.foodmatterslive.com/
 
Description School visit to talk about research 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact I visited a school in Shropshire to talk to year 12 pupils about my research during an A level psychology class.
Year(s) Of Engagement Activity 2016