United States-UK partnering award:Co-infection and resistance (CORE)
Lead Research Organisation:
University of Glasgow
Department Name: College of Medical, Veterinary, Life Sci
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Doyle S
(2022)
Genomic landscape of drug response reveals mediators of anthelmintic resistance
in Cell Reports
Hodgkinson JE
(2019)
Refugia and anthelmintic resistance: Concepts and challenges.
in International journal for parasitology. Drugs and drug resistance
| Description | We had our first joint meeting at which all members of the Consortium were present in February 2017. In addition we were able to invite relevant individuals from the UK institutes (Universities of Liverpool and Glasgow) to participate in the meeting. The topic of the meeting was Co-infections and resistance and we had some excellent talks in this area. One outcome of this first meeting was a new collaboration between University of Glasgow and the University of Georgia, Athens, USA. We had our second joint meeting in May 2018 at the University of Glasgow Field Station at Loch Lomond. The topics was Refugia and its application in anthelmintic resistance. Again we invited several key colleagues who are not part of the CORE grant. This was a very successfull meeting from which a small BBSRC travel award was funded and two large collaborative applications for NSF-BBSRC funding emerged. In addition, we have written a review of Refugia and its role in mitigating anthelmintic resistance. Subsequent planned meetings had to be cancelled due to Covid. We received a no-cost extension to June 2022 so that we could hold a final meeting in My 2022. This was a hybrid meeting held at the Hydro in Crieff, with some presenters in person and some joining by Zoom. We had a total of 36 participants. The topic was "Landscapes, Pastures and Parasites" and it brought together a wider range of researchers than had been included in the original Core team. Given ongoing restrictions to travel, this meeting was dominated by the UK partners but did include some of the international partners. We also invited a number of ECRs from Glasgow, to enable them to be exposed to the international CORE team and to enhance future career opportunities. This was organised into a number of themes, spread over two days. As for the other meetings, the idea was to introduce others to different perspectives. SESSION 1: Role of landscape in influencing management of livestock parasites Moderator: Jane Hodgkinson, University of Liverpool Hannah Vineer, University of Liverpool:One size does not fit all: the role of spatial epidemiology in sustainable parasite control Roman Biek, University of Glasgow: Untangling the role of livestock and deer as tick maintenance hosts in a fragmented island system Louise Matthews, University of Glasgow: Extending anthelmintic drug life: Genetics, refugia and treatment strategies Juan Morales and Juan Gurevitz, National University of Comahue, Argentina: Ecology of Fasciola hepatica in Northern Patagonia SESSION 2: How landscapes structure and modify pathogen transmission and dispersal Moderator: Andy Fenton, University of Liverpool Christina Faust, University of Glasgow: Environmental and host effects on the distribution, abundance & transmission potential of wildlife parasites in the Southeastern US Andrew Park, University of Georgia: The ecology of transmission in a wild rodent system Emilia Johnson, University of Glasgow: Plasmodium knowlesi dynamics in fragmented landscapes SESSION 3: Understanding the livestock-wildlife interface across heterogenous space Moderator: Neil Sargison, Moredun Research Institute Eric Morgan, Queen's University, Belfast: Does climate change or altered host movement matter more to helminth transmission at the wildlife-livestock interface? Tom Morrison, University of Glasgow: The role of animal movement in infectious disease at the live-wildlife interface Liliana Salvador, University of Georgia: The role of wild furbearers and spatial structure in the transmission of Mycobacterium bovis in Michigan SESSION 4: Opportunities for applying new tools, techniques, and models to "parasite landscapes" Moderator: Steve Paterson, University of Liverpool Simon Babayan, University of Glasgow: Predicting vaccine efficacy from transcriptomics and demographics using machine learning and structural causal modelling Dan Haydon, University of Glasgow: Estimating how many things there are Luca Nelli, University of Glasgow: Interactive spatial modelling and mapping Tristan Dennis, University of Glasgow: Genetic structure and local adaptation in Anopheles mosquitoes in Southern Ghana |
| Exploitation Route | Our common interests have already spawned one new scientific collaboration and we have obtained a travel grant to further our objectives and two large collaborative grants directly stemming from CORE funding have been submitted, one of which has now been funded. However the COVID pandemic has meant that all face to face meetings were cancelled, although various members of the CORE team me regularly by Zoom, our funding was based around short stays in different labs for ECRs, which was still not possible, and meeting in person (also not possible). A review paper that resulted from our 2nd meeting has been well cited and is changing views in the field. This paper would not have been possible without the CORE funding because it was bringing together researchers from different research backgrounds that enabled us to write a perspective with novel insights. |
| Sectors | Agriculture Food and Drink |
| Description | BBSRC:Research Grant United States-UK partnering award |
| Amount | £47,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2016 |
| End | 04/2018 |
| Description | SHEFC GCRF |
| Amount | £40,000 (GBP) |
| Organisation | Government of Scotland |
| Department | Scottish Funding Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2017 |
| End | 09/2017 |
| Description | Travel Grant |
| Amount | £1,045 (GBP) |
| Funding ID | BB/S013725/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 12/2018 |
| Description | iBAHCM internal funding |
| Amount | £3,000 (GBP) |
| Organisation | University of Glasgow |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 08/2017 |
| Description | Serengeti worms |
| Organisation | University of Glasgow |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Dr Tom Morrison, an ecologist at the University of Glasgow, was invited to our first IPA meeting in Liverpool in 2017. He met Dr Vanessa Ezenwa there and they formed a collaboration based around their common interest in helminths that parasitise wildlife in Africa. They are interested in whether wild mammals (wildebeest) share the same parasitic helminths as domestic animals (cattle), whether migratory and resident wildebeest populations are equally parasitised and whether there is any evidence that migrating animals may facilitate the spread of drugs resistant worms. |
| Collaborator Contribution | Dr Grant Hopcraft applied as PI to the SHEFC GCRF funding call and was successful in obtaining funding, a small amount of which was allocated to Dr Morrison for the collection of parasite samples from migrating and resident wildebeest in the Serengeti. In addition, Dr Morrison successfully applied for funding from the University of Glasgow to enable additional sample collection. |
| Impact | Multidisciplnary |
| Start Year | 2017 |
| Description | A talk or presentation - Short talk at CORE meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A short presentation on research carried out (relating primarily to a faecal egg count reduction test and species diversity on a UK farm) was presented at a small meeting in Liverpool. Those present were gathered to discuss 'Co-infections and Resistance'. |
| Year(s) Of Engagement Activity | 2017 |
| Description | CORE meeting presentation 2017 by Vanessa Ezenwa: Conflicting effects of anthelmintic treatment and natural host resistance on the host response to bovine TB infection in wildlife |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at the first joint meeting of CORE. Outcome was a new collaboration between Dr Ezenwa (University of Athens, Georgia) and Dr Morrison (University of Glasgow) |
| Year(s) Of Engagement Activity | 2017 |
| Description | CORE meeting presentation: The stuff of life for a wood mouse? ?Food, sex, worms, and ticks |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presntation of my groups' work. Participation in discussions with the other CORE partners to set working theme priorities and identifying future collaboration and funding opportunities. |
| Year(s) Of Engagement Activity | 2017 |
| Description | CORE workshop 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | CORE workshop: "Landscapes, Pastures and Parasites". This workshop brought together researchers from two Universities in Scotland (Glasgow, Edinburgh) one University in England (Liverpool), and one in Northrn Ireland (Queen's University Belfast) with international researchers from the University of Georgia (USA) and Centro Regional University in Bariloche (Argentina). The workshop took place over two days at Crieff Hydro in Scotland but was run as a fully hyrid meeting, to increase participation among a broader range of people. Postgraduate students and postdoctoral research fellows presented short talks, alongside some of the core PIs from the project, to share ideas about how we can integrate tools from ecology and wild populations more effectively in investigations of epidemiology and control of parasites infecting livestock. Evening discussions added to information sharing and brainstorming of ideas for future projects. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited talk (keynote) at Anthelmintics III Meeting in Florida |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited talk on the use of a genetic cross to study anthelmintic resistance in a parasitic nematode of sheep, attended by roughly 100 participants from around the world, followed by good discussion regarding preliminary findings. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation to CORE group |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Study participants or study members |
| Results and Impact | Research talk to other members of the CORE research team, on the combination of empirical data and theory to understand occurrence and impact of coinfecting parasites on parasite dynamics and host health. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Short talk at conference Anthelmintic Resistance III |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A short talk was given at the international conference 'Anthelmintic Reisistance III' in Florida. Those present included researchers, postgraduate students and industry professionals. The talk described preliminary results from recent work using genome wide sequencing to identify genomic regions of selection following ivermectin treatment in a UK field population of T. circumcincta. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Talk at CORE meeting 2017 by Dr Robin Flynn: Mechanisms of Fasciola-induced immunosuppression; lessons from TB co-infection |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Flynn presented his work on co-infections at the first meeting of the CORE group in Liverpool in 2017 |
| Year(s) Of Engagement Activity | 2017 |
| Description | Workshops for BBSRC Resistance highlight call |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | I presented at two workshops to accompany the BBSRC Highlight call in Resistance in Agriculture |
| Year(s) Of Engagement Activity | 2016 |