The development of novel AOX inhibitors for the cacao pathogen Moniliophthora perniciosa

Lead Research Organisation: University of Sussex
Department Name: Sch of Life Sciences



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Description This grant was for a travel award to enable Professor Moore to visit UNICAMP, Campinas Brazil to discuss the opportunities for a collaboration with Prof. Pieriera on testing our current anti-fungals on the fungus Witches broom which attacks the cocoa plant. We also discussed the long term possibility that should the anti-fungals prove successful what commercialisation routes would be available in Brazil. I met a graduate student whilst at UNICAMP and we discussed the possibility for this student spending 6 months in my laboratory to purify the fungal protein and check inhibitor sensitivity.
Exploitation Route We arranged for Mario Barsottini to come to Brighton for 6 months the outcome of which proved highly successful in the development of novel techniques to rapidly assay the effect of these inhibitors on Moniliophthora perniciosa
Sectors Agriculture, Food and Drink

Description Expression and purification of M. perniciosa AOX 
Organisation State University of Campinas
Country Brazil 
Sector Academic/University 
PI Contribution We have provided both the expertise, intellectual input and trained the staff. We have taught them how to successfully express rAOX
Collaborator Contribution They have provided the intellectual expertise on understanding the nature of the M. perinciosa pathogen.
Impact Outcomes include the successful identification of inhibitors which can inhibit the growth of M. perniciosa and the submission of a grant to cover joint travel expenses between Brazil and Uk covered by BBSRC-FAPESP memorandum of Agreement.
Start Year 2017