UK-Japan partnership to explore the role of subepithelial mesenchymal stromal cells in M cell-development and homeostasis

Lead Research Organisation: University of Edinburgh
Department Name: The Roslin Institute

Abstract

Publications

10 25 50
 
Description I undertook the activities in this collaborative travel grant to learn more about working with and analysing a particular type of stromal cell within the gut-associated lymphoid tissues that plays an important role in inducing the formation of specialised M cells in the gut epithelium. To-date all our knowledge of these stromal cells has come from the study of the mouse intestine. Nothing is known of the role of these cells in large animals, especially domestic animals such as cattle. From this exchange the PI and the collaborator applied for a BBSRC Japan Partnering Award grant in November 2018 to continue these studies (BB/S019294/1) and identify important cellular and molecular factors the aid the differentiation of M cells in the intestines of livestock species. This application was successful and the new 4 year partnership will start in September 2019.
Exploitation Route From data in publications which arise from this collaboration.
From databases of mRNA-sequencing data describing M cell differentiation in the gut epithelium of livestock species.
Sectors Agriculture, Food and Drink,Healthcare

 
Description Japan Partnering Award: Defining the factors that regulate M cell-development in the intestines of livestock
Amount £42,125 (GBP)
Funding ID BB/S019294/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 06/2019 
End 06/2023
 
Description Study of role of genes and transcription factors in M-cell development 
Organisation Keio University
Country Japan 
Sector Academic/University 
PI Contribution This collaboration aims to determine the role of genes and transcription factors in M-cell development in large animal species. Prof. Mabbott obtained a BBSRC travel award in 2017 to enable him to visit the Japanese partner Prof. Koji Hase in Tokyo, Japan, to discuss a potential collaboration. Prof. Mabbott through obtaining the travel award initiated this collaboration and provided the means to explore potential collaborations.
Collaborator Contribution Prof. Koji Hase, the Japanese partner, has provided his extensive expertise in the role of genes and transcription factors in M cell development. During my visit his institution also provided in-kind support for our meetings and small workshop. Since this visit our discussions have continued and a BBSRC Japan partnering award was submitted in November 2018 to provide further pump priming support.
Impact A BBSRC Japan partnering award was submitted in November 2018
Start Year 2017
 
Description Study of role of subepithelial mesenchymal stromal cells in M-cell development 
Organisation Hokkaido University
Country Japan 
Sector Academic/University 
PI Contribution This collaboration aims to determine the role of subepithelial mesenchymal stromal cells in M-cell development in large animal species. Prof. Mabbott obtained a BBSRC travel award in 2017 to enable him to visit the Japanese partner Prof. Sawa in Hokkaido, Japan, to discuss a potential collaboration. Prof. Mabbott through obtaining the travel award initiated this collaboration and provided the means to explore potential collaborations.
Collaborator Contribution Prof. Sawa, the Japanese partner, has provided his extensive expertise in subepithelial mesenchymal stromal cells. During my visit his institution also provided in-kind support for our meetings and small workshop. Since this visit our discussions have continued and a BBSRC Japan partnering award was submitted in November 2018 to provide further pump priming support.
Impact Submission of BBSRC Japan partnerinig award in November 2018.
Start Year 2017