Physiologically relevant modelling of the aerodigestive tract as a delivery and screening platform for drugs and bioactives

Lead Research Organisation: Newcastle University
Department Name: Inst for Cell and Molecular Biosciences

Abstract

We have previously developed and made commericaly available a model of the upper digestive tract. This project will expand our modelling capability throughout the aerodigestive tract, specifically to include a lung airway model, and develop the first integrated model of the large intestine including the microbiome, mucus layer and large intestinal epithelia.

In vitro systems with improved predictability allow the pharmaceutical industry to make data driven decisions early in their development pipeline, and the commercial applications for these systems are widespread and supported by the letters attached. We envisage that the first applications of these systems would be for colon and lung specific drug delivery studies, pre- and pro- biotics research, faecal transplantation studies, reflux, and host-microbiome studies.

These systems will provide platforms for modelling organ specific drug delivery, disease states and interactions between these systems.

Publications

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Description We are further developing a novel integrated model gut system with an absorptive and digestive phase to it and we have characterised a library of compounds in this model that have human data.
Exploitation Route This technology is now being offered commercially through our spin out company Aelius Biotech. The company already has generated over £200,000 in business since late 2017.
Sectors Agriculture, Food and Drink,Chemicals,Environment,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology

URL https://aeliusbiotech.co.uk/
 
Description This technology is now being offered commercially through our spin out company Aelius Biotech. The company already has generated over £200,000 in business since late 2017.
First Year Of Impact 2017
Sector Agriculture, Food and Drink,Chemicals,Environment,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology