Type-II NADH dehydrogenase from the food pathogen Liseria and other microbes as "druggable" target.

Lead Research Organisation: University of Leeds
Department Name: School of Biomedical Sciences


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Description New antibiotics are required to tackle the increasing problem of "antimicrobial resistance". However, in some cases the mode of action of candidate antibiotics are not well understood or different researchers propose different mode of actions. In a collaborations with the University of Otago, New Zealand, we studied the proposed mode of action of a group of possible antibiotic agents, known as phenothiazines, and found that these do NOT work in the way that some groups have proposed. Instead, we have proposed a a different mode of action.This knowledge is important for the further development of phenothiazines and other agents with proposed antimicrobial activity.
Exploitation Route The outcomes of this collaboration are important for the further development of phenothiazines and other agents as potential antimicrobial agents.
Sectors Pharmaceuticals and Medical Biotechnology

Description University of Otago 
Organisation University of Otago
Department Department of Microbiology & Immunology
Country New Zealand 
Sector Academic/University 
PI Contribution We provided a research tool/methodology. The partner will visit the University of Leeds to use this research method.
Collaborator Contribution The partner will contribute a purified enzyme that will be studied as part of this collaboration.
Impact At the time of writing, experiments are still to be performed, so no outputs or outcomes have resulted yet. An BBSRC partnership award was applied for and funded (this information is provided under 'grants').
Start Year 2018