Japan Partnering Award: The Generation of Eye Tissues from Human Induced Pluripotent Stem (iPS) Cells.
Lead Research Organisation:
Cardiff University
Department Name: Optometry and Vision Sciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Ashworth S
(2020)
Chondroitin Sulfate as a Potential Modulator of the Stem Cell Niche in Cornea.
in Frontiers in cell and developmental biology
Baba K
(2021)
The generation of fluorometholone nanocrystal eye drops, their metabolization to dihydrofluorometholone and penetration into rabbit eyes.
in International journal of pharmaceutics
Baba K
(2020)
Cell jamming, stratification and p63 expression in cultivated human corneal epithelial cell sheets.
in Scientific reports
Fujimoto S
(2019)
KLF4 prevents epithelial to mesenchymal transition in human corneal epithelial cells via endogenous TGF-ß2 suppression.
in Regenerative therapy
Hayashi R
(2018)
CD200 facilitates the isolation of corneal epithelial cells derived from human pluripotent stem cells.
in Scientific reports
Kobayashi Y
(2020)
Ocular surface ectoderm instigated by WNT inhibition and BMP4.
in Stem cell research
Nomi K
(2021)
Generation of functional conjunctival epithelium, including goblet cells, from human iPSCs.
in Cell reports
Shibata S
(2018)
Selective Laminin-Directed Differentiation of Human Induced Pluripotent Stem Cells into Distinct Ocular Lineages.
in Cell reports
Shiraki N
(2022)
PAX6-positive microglia evolve locally in hiPSC-derived ocular organoids.
in Stem cell reports
Wang K
(2020)
Cell compaction is not required for the development of gradient refractive index profiles in the embryonic chick lens.
in Experimental eye research
| Description | Initial meetings have taken place between vision researchers in Cardiff, Newcastle, Nottingham, UCL, Osaka, Kyoto and Kobe and two of proposed six ECR PDRA placements have taken place. |
| Exploitation Route | UK-Japan collaborations in the vision sciences will be established. |
| Sectors | Healthcare |
| Description | JPA collaboration |
| Organisation | Newcastle University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Research collaboration between Cardiff Newcastle and Osaka |
| Collaborator Contribution | Research collaboration between Cardiff Newcastle and Osaka |
| Impact | None yet |
| Start Year | 2018 |
| Description | JPA link Nottingham Trent |
| Organisation | Nottingham Trent University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | New research in lens development and beamtime at the Japan synchrotron |
| Collaborator Contribution | New research in lens development and beamtime at the Japan synchrotron |
| Impact | Data being written up |
| Start Year | 2018 |
| Description | Nishida SEAM collaboration |
| Organisation | Osaka University |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | The joint ongoing study of iPS cell derived eye-like cells |
| Collaborator Contribution | The joint ongoing study of iPS cell derived eye-like cells |
| Impact | Preliminary, unpublished data as part of this new collaborative project with long-standing partners |