The Flux Capacitor: How mitochondria modulate metabolic flux and gene expression
Lead Research Organisation:
University College London
Department Name: Genetics Evolution and Environment
Abstract
Mitochondria are often called the powerhouses of the cell as they produce nearly all the energy needed for living. Recent research shows that mitochondria do much more than generate energy: they integrate virtually all metabolic inputs and outputs of cells. These inputs and outputs depend on diet, temperature, growth, age and physical demands. If mitochondria cannot match metabolic supply to demand, they signal a stress state to the nucleus resulting in changes in the activity of genes. These changes might ameliorate the stress, or if that fails, tip the cell towards programmed death. Mitochondria can be seen as 'flux capacitors'.
The problem is that mitochondria are uniquely vulnerable to mechanical faults. This is because the vital proteins that carry out respiration are encoded by two different genomes that have a tendency to diverge - genes in the mitochondria mutate nearly 50 times faster than those in the nucleus, and are inherited from the mother only, whereas genes in the nucleus are recombined by sex every generation. These radical differences in inheritance can result in mismatches that affect the performance of mitochondria - the flux capacitor itself becomes faulty, which impacts on both the inputs and outputs of the cell, and its stress state.
Mutations in either the mitochondrial or nuclear genes encoding the proteins involved in respiration can cause catastrophic diseases, and more subtle genetic differences contribute to common conditions such as diabetes, cancer, neurodegeneration and ageing. But the extent to which mismatches between mitochondrial and nuclear genes affect health through the lifecourse is uncertain, as there are hundreds of mitochondria in every cell, and their performance can differ substantially. Animal models show that 'mitonuclear mismatches' really do affect health, for example causing male infertility and altered lifespan. Even when the health effects are too subtle to notice, mitonuclear mismatches can alter the activity of thousands of genes. Because these mismatches are produced every generation, they most likely have substantial health impacts. Until recently, though, this has been nearly impossible to verify.
Our programme of research will analyse how mitonuclear mismatches affect the inputs and outputs of mitochondria, and how these changes impact on gene activity and health. We will use a model organism, the fruitfly Drosophila, in which mitochondrial genes have been deliberately mismatched to the nuclear genome. These flies have known health outcomes such as male infertility, but how their faulty mitochondria cause these defects is unknown; treatments that might improve their health are unknown for the same reasons.
We will address these questions using cutting-edge experimental methods. Specifically, we will measure mitochondrial performance in real time to establish how mitonuclear mismatches alter the function of different tissues over the lifecourse of males and females, and how mitochondrial performance is altered by dietary treatments. We will generate global profiles of metabolite levels, allowing us to relate mitochondrial function to the 'metabolomic profile' of each tissue. Finally, we will use Next Generation Sequencing to measure changes in gene activity in each tissue, with each treatment, in males and females. We will use this information to build a set of mathematical models that map changes in mitochondrial function to shifts in metabolic flux, gene activity and health, allowing us to generalise our conclusions to be valuable for human and animal health.
Our pilot studies show that we can indeed measure real-time changes in mitochondrial performance linked with male infertility. Antioxidant treatments have remarkably different outcomes depending on mitonuclear mismatches, in one case improving male fertility yet causing high (90%) mortality in female flies. We therefore anticipate our findings will have important implications for lifelong health.
The problem is that mitochondria are uniquely vulnerable to mechanical faults. This is because the vital proteins that carry out respiration are encoded by two different genomes that have a tendency to diverge - genes in the mitochondria mutate nearly 50 times faster than those in the nucleus, and are inherited from the mother only, whereas genes in the nucleus are recombined by sex every generation. These radical differences in inheritance can result in mismatches that affect the performance of mitochondria - the flux capacitor itself becomes faulty, which impacts on both the inputs and outputs of the cell, and its stress state.
Mutations in either the mitochondrial or nuclear genes encoding the proteins involved in respiration can cause catastrophic diseases, and more subtle genetic differences contribute to common conditions such as diabetes, cancer, neurodegeneration and ageing. But the extent to which mismatches between mitochondrial and nuclear genes affect health through the lifecourse is uncertain, as there are hundreds of mitochondria in every cell, and their performance can differ substantially. Animal models show that 'mitonuclear mismatches' really do affect health, for example causing male infertility and altered lifespan. Even when the health effects are too subtle to notice, mitonuclear mismatches can alter the activity of thousands of genes. Because these mismatches are produced every generation, they most likely have substantial health impacts. Until recently, though, this has been nearly impossible to verify.
Our programme of research will analyse how mitonuclear mismatches affect the inputs and outputs of mitochondria, and how these changes impact on gene activity and health. We will use a model organism, the fruitfly Drosophila, in which mitochondrial genes have been deliberately mismatched to the nuclear genome. These flies have known health outcomes such as male infertility, but how their faulty mitochondria cause these defects is unknown; treatments that might improve their health are unknown for the same reasons.
We will address these questions using cutting-edge experimental methods. Specifically, we will measure mitochondrial performance in real time to establish how mitonuclear mismatches alter the function of different tissues over the lifecourse of males and females, and how mitochondrial performance is altered by dietary treatments. We will generate global profiles of metabolite levels, allowing us to relate mitochondrial function to the 'metabolomic profile' of each tissue. Finally, we will use Next Generation Sequencing to measure changes in gene activity in each tissue, with each treatment, in males and females. We will use this information to build a set of mathematical models that map changes in mitochondrial function to shifts in metabolic flux, gene activity and health, allowing us to generalise our conclusions to be valuable for human and animal health.
Our pilot studies show that we can indeed measure real-time changes in mitochondrial performance linked with male infertility. Antioxidant treatments have remarkably different outcomes depending on mitonuclear mismatches, in one case improving male fertility yet causing high (90%) mortality in female flies. We therefore anticipate our findings will have important implications for lifelong health.
Technical Summary
Mitochondria are central to metabolism but vulnerable to dysfunction, as respiratory proteins are encoded by two genomes (nuclear and mitochondrial) with radically different modes and tempi of evolution. Mitonuclear mismatches are produced each generation and can disrupt health, e.g. causing male infertility, altering lifespan and perturbing gene expression. But the incomplete penetrance of mitochondrial conditions means it has proved difficult to establish clear causality from alterations in mitochondrial function to changes in metabolic flux, shifts in gene expression and distinct phenotypes. Drosophila can give unparalleled insights into the consequences of mitonuclear mismatches, as these can be isolated from confounding factors that affect other models. We will therefore use a fly model to elucidate how mitonuclear incompatibilities affect (i) mitochondrial physiology (using high-resolution fluororespirometry on individual fly tissues), (ii) metabolomic profile, and (iii) gene expression (using Next Generation Sequencing) enabling us to (iv) construct predictive metabolic flux models for both males and females. We will use one coadapted control line and two experimental lines in which the mitochondrial genome is mismatched to the nuclear genome, combined with three treatments designed to interfere with signalling between the mitochondria and nucleus. Finally, we will assess how mitochondrial function, metabolomic profile, gene expression and phenotypes evolve over the lifecourse of flies. Our pilot data has already uncovered striking differences in response to the antioxidant NAC, determined by mitonuclear incompatibilities; in one line male fertility improved but 90% of females died; NAC did not affect mortality in other lines. We therefore anticipate that our work will generate fundamental biological knowledge on how mitonuclear variations cause differences in physiology, wellbeing, drug interactions and lifelong susceptibility to disease between individuals.
Planned Impact
Who will benefit from this research?
Our considerations have highlighted seven particular groups of end users that we wish to target through our pathway to impact activities:
1) Investigators and scholars of the evolutionary history of eukaryotes (Academic/Public Sector Researchers e.g. Evolutionary Biologists)
2) Researchers and other stakeholders of eukaryote based biotechnological applications (Academic/Public Sector Researchers, Organisations e.g. Bioprocessing Research Industry Club (BRIC), and Private Sector/Industry)
3) Medical researchers of mitochondrial, metabolic, and ageing related diseases (Academic/Public Sector Researchers, Medical Practitioners)
4) Health policy makers and government bodies interested in increasing general population quality of life through healthy ageing. (Public Sector Health Researchers e.g. NIHR related, Public Sector Health Policy Makers e.g. NIHR, HRA and Department of Health)
5) Regulatory policy makers and regulatory body for treatments impacting on mitochondrial function and metabolism. (Public Sector Regulator e.g. EMA, MHRA)
6) Researchers, producers and distributors of nutritional supplements that may impact health via mitochondrial interventions. (Private Sector Stakeholders e.g. Pharma/Nutritional Supplement developers/producers)
7) Members of the public interested in mitochondria and healthy ageing guidelines. (General Public)
How will they benefit from this research?
Researchers interested in mitonuclear evolution and metabolism will gain insights from our data. Not only will we produce empirical data that with give vital insights into mitochondrial metabolism, but we will merge all the empirical data to produce a flux model. What we will deliver from this grant will be of interest to a wide range of scientists; from evolutionary ecologists to functional biologists.
Biomedical scientists, policy makers and government bodies will be interested in our findings because of their relevance to human complex diseases (the accumulation and impact of mitochondrial mutations), the disruption of adaptive mitonuclear combinations by human migration (the scope for the coevolution of beneficial mitonuclear combinations) and the limits of mitonuclear compatibility. Biomedical researchers and policy makers will rely on such data in order to develop rigorous, but sensitive, management of medical interventions, including mitochondrial replacement therapy and three-parent IVF, and to establish appropriate policies that regulate these applications.
By addressing the role of mitochondrial function in supporting healthy ageing this work could influence not only researchers but also policy makers and clinical practitioners, with consequent impact upon quality of life for the wider public. Moreover, our work will touch upon the effects of mitonuclear genomic incompatibility in determining health outcomes from pharmacological or other medical interventions. This could influence not only those involved in the research, development, and production of such interventions but also those tasked with setting and consequently those adhering to policy on medical and pharmacological regulation.
Finally, our research will be of broad interest to the wider community and school pupils. They have a natural fascination in mitochondrial disease and mitochondrial replacement therapy as a cure. The project findings will be made readily available to the general public and the project team will engage directly with schools, to make sure that the project findings are placed into a broad context of evolution and the life sciences.
Our considerations have highlighted seven particular groups of end users that we wish to target through our pathway to impact activities:
1) Investigators and scholars of the evolutionary history of eukaryotes (Academic/Public Sector Researchers e.g. Evolutionary Biologists)
2) Researchers and other stakeholders of eukaryote based biotechnological applications (Academic/Public Sector Researchers, Organisations e.g. Bioprocessing Research Industry Club (BRIC), and Private Sector/Industry)
3) Medical researchers of mitochondrial, metabolic, and ageing related diseases (Academic/Public Sector Researchers, Medical Practitioners)
4) Health policy makers and government bodies interested in increasing general population quality of life through healthy ageing. (Public Sector Health Researchers e.g. NIHR related, Public Sector Health Policy Makers e.g. NIHR, HRA and Department of Health)
5) Regulatory policy makers and regulatory body for treatments impacting on mitochondrial function and metabolism. (Public Sector Regulator e.g. EMA, MHRA)
6) Researchers, producers and distributors of nutritional supplements that may impact health via mitochondrial interventions. (Private Sector Stakeholders e.g. Pharma/Nutritional Supplement developers/producers)
7) Members of the public interested in mitochondria and healthy ageing guidelines. (General Public)
How will they benefit from this research?
Researchers interested in mitonuclear evolution and metabolism will gain insights from our data. Not only will we produce empirical data that with give vital insights into mitochondrial metabolism, but we will merge all the empirical data to produce a flux model. What we will deliver from this grant will be of interest to a wide range of scientists; from evolutionary ecologists to functional biologists.
Biomedical scientists, policy makers and government bodies will be interested in our findings because of their relevance to human complex diseases (the accumulation and impact of mitochondrial mutations), the disruption of adaptive mitonuclear combinations by human migration (the scope for the coevolution of beneficial mitonuclear combinations) and the limits of mitonuclear compatibility. Biomedical researchers and policy makers will rely on such data in order to develop rigorous, but sensitive, management of medical interventions, including mitochondrial replacement therapy and three-parent IVF, and to establish appropriate policies that regulate these applications.
By addressing the role of mitochondrial function in supporting healthy ageing this work could influence not only researchers but also policy makers and clinical practitioners, with consequent impact upon quality of life for the wider public. Moreover, our work will touch upon the effects of mitonuclear genomic incompatibility in determining health outcomes from pharmacological or other medical interventions. This could influence not only those involved in the research, development, and production of such interventions but also those tasked with setting and consequently those adhering to policy on medical and pharmacological regulation.
Finally, our research will be of broad interest to the wider community and school pupils. They have a natural fascination in mitochondrial disease and mitochondrial replacement therapy as a cure. The project findings will be made readily available to the general public and the project team will engage directly with schools, to make sure that the project findings are placed into a broad context of evolution and the life sciences.
Publications
Nunes Palmeira R
(2022)
Supplementary information from The limits of metabolic heredity in protocells
Jardine MD
(2021)
A non-coding indel polymorphism in the fruitless gene of Drosophila melanogaster exhibits antagonistically pleiotropic fitness effects.
in Proceedings. Biological sciences
Nunes Palmeira R
(2022)
The limits of metabolic heredity in protocells.
in Proceedings. Biological sciences
Colnaghi M
(2022)
Repeat sequences limit the effectiveness of lateral gene transfer and favored the evolution of meiotic sex in early eukaryotes.
in Proceedings of the National Academy of Sciences of the United States of America
Camus MF
(2020)
Impact of mitonuclear interactions on life-history responses to diet.
in Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Description | Still mostly in talks to wide audiences, see specific examples. Also new awards from the BMGF to develop some of the fiundings in the grant in more applied directions. |
Sector | Education,Energy,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
Impact Types | Cultural Societal |
Description | Drugs to Control Cellular Decision-making in Metabolic Space |
Amount | $78,221,200 (USD) |
Funding ID | INV-068658 |
Organisation | Bill and Melinda Gates Foundation |
Sector | Charity/Non Profit |
Country | United States |
Start | 03/2024 |
End | 02/2026 |
Description | The role of mitonuclear interactions in thermal and dietary adaptation |
Amount | € 224,933 (EUR) |
Funding ID | 101030803 |
Organisation | European Commission H2020 |
Sector | Public |
Country | Belgium |
Start | 09/2021 |
End | 09/2023 |
Title | Engineered acetoacetate-inducible whole-cell biosensors based on the AtoSC two-component system |
Description | Data and code for manuscript. |
Type Of Material | Database/Collection of data |
Year Produced | 2021 |
Provided To Others? | Yes |
URL | https://zenodo.org/record/4783409 |
Description | Mitonuclear panel of fruit flies |
Organisation | University College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Dr Flo Camus has contributed to the Flux Capacitor grant and is now funded by the Leverhulme Trust for a related project on which I am a Co-I. This project involves generating a larger panel of mitonuclear fruitflies, with a wider range of phenotypes. We will be able to implement some of the information from this project into the Flux Capacitor project. |
Collaborator Contribution | Collaboration using equivalent mitonuclear fly model, with a wider panel but less detailed metabolic analysis then the Flux Capacitor, therefore complementary project funded by the Leverhulme Trust |
Impact | Just started. |
Start Year | 2019 |
Description | Stalk-eyed fly metabolism in relation to gene drive |
Organisation | University College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Respirometry on male-female differences in stalk-eyed flies in relation to gene drive |
Collaborator Contribution | pilot studies of stalk-eyed fly metabolism in relation to Drosophila |
Impact | None yet |
Start Year | 2020 |
Description | BBC Radio 3 Free Thinking, Humours and the body |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | A BBC Radio 3 programme about the history of the humours and the relationship that mitochondrial medicine might have to the old humopral view of health |
Year(s) Of Engagement Activity | 2023 |
URL | https://www.bbc.co.uk/programmes/m001r9c6 |
Description | BBC Radio 3 Private Passions |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Interview with Michael Berkeley, October 2021 |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.bbc.co.uk/programmes/m0011sb1 |
Description | BBC Radio 4 In Our Time, guest on mitochondria |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Guest on BBC Radio 4 programme with estimated reach of 3-4 million people per episode worldwide |
Year(s) Of Engagement Activity | 2023 |
URL | https://www.bbc.co.uk/programmes/m001md34 |
Description | Bedales School, Eckersley Lecture |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | Major annual lecture that has been going for more than 50 years. Bedales school plus several other local schools including St Swithuns, plus public through local radio station. Interacted with pupils for 2 hrs beforehand and had 1 hr Q&A afterwards |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.bedales.school/news/award-winning-biochemist-delivers-annual-eckersley-lecture |
Description | Big Biology podcast with Art Woods and Marty Martin |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | podcast on big ideas in biology, in this case on the role of energy flow in structuring evolution |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.bigbiology.org/season-3#episode49 |
Description | CBC Ideas, Canadian radio, contribution to documentary |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | CBC (Canadian radio) documentary on the nature of life, bodies and cells |
Year(s) Of Engagement Activity | 2023 |
URL | https://www.cbc.ca/radio/ideas/human-body-cells-nanomachines-1.7100594 |
Description | Cambridge University Genetics Department seminar |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Postgraduate students |
Results and Impact | Seminar, usual Q&A sessions and full-day discussions with faculty and students, including local companies working on ageing (Methuselah). Invited to give lecture on the role of mitochondria in ageing at a major conference on ageing later this year as a result. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.gen.cam.ac.uk/events/genetics-seminar-series-professor-nick-lane |
Description | Cheltenham Science Festival, invited lecture, June 2022 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Theatre audience at Cheltenham Science Festival; full house. |
Year(s) Of Engagement Activity | 2022 |
URL | https://issuu.com/cheltenhamfestivals/docs/csf_2022_brochure_final |
Description | City of London School, Science Week |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Talk during science week, extended Q&A session afterwards |
Year(s) Of Engagement Activity | 2020 |
Description | Darwin College public lecture, 'Revolution', Cambridge March 2024 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | A public lecture in the Darwin College Cambridge annual lecture series, with the general theme of Revolution in 2024. The online version has had more than 10,000 views in 1 week. |
Year(s) Of Engagement Activity | 2024 |
URL | https://www.youtube.com/watch?v=Lh98fyNtPKM |
Description | Guy Foundation online lecture |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | Lecture on the role of fields and quantum tunnelling in biology and especially bioenergetics |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.theguyfoundation.org/wp-content/uploads/2020/11/GMT20201118-141526_ProfNickLane_1920x108... |
Description | Hans Westerhoff festschrift, Free University of Amsterdam |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Part of a symposium that made a serious effort to influence policy decisions based on systems biology. Dutch media presence and EU policy makers. Video available of whole symposium (link below); my contribution from around 1:27. |
Year(s) Of Engagement Activity | 2020 |
URL | https://av-media.vu.nl/mediasite/Play/de9c6bd53a34405fa80c01b39253f4551d |
Description | Highgate School, Science Week |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | A talk and Q&A top Highgate School plus other local schools invited. |
Year(s) Of Engagement Activity | 2020 |
Description | How the Light Gets In Festival, Kenwood House, September 2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Gave a 45 minute lecture, a 10 minute filmed interview, and took part in a 1-hour debate on the evolution of life. Led to other invitations to give talks including at Highgate school and impacted on unusual audiences, including very positively on Brian Eno who was in the audience. |
Year(s) Of Engagement Activity | 2019 |
URL | https://iai.tv/video/the-mystery-of-life?utm_source=YouTube&utm_medium=pinnedcomment |
Description | How the Light Gets In Festivcal, Hay on Wye |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Public lecture and two debates. |
Year(s) Of Engagement Activity | 2023 |
URL | https://iai.tv/articles/cracking-the-creation-of-life-nick-lane-auid-2435 |
Description | How the Light Gets In May Festival |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | 'Alive in the universe', debate with Jocelyn Bell Burnell, Avi Loeb and Catherine Heymans, May 2021 |
Year(s) Of Engagement Activity | 2022 |
URL | https://iai.tv/video/alive-in-the-universe |
Description | How the Light Gets In winter revel |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | How the Light Gets In Wintrer Revel - took part in two online debates with Danniel Dennet, Sara Walker and Gunes Taylor; also gave a standalone public lecture. Took part in more informal discussions after each event with members of the public. |
Year(s) Of Engagement Activity | 2021 |
URL | https://howthelightgetsin.org/festivals/winter/debates-and-speakers/speakers |
Description | Interview and short film with Quanta Magazine, July 2022 |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Profile of my research and writing for Quanta Magazine including a short video that has been viewed >70,000 times on Youtube alone |
Year(s) Of Engagement Activity | 2022 |
URL | https://www.quantamagazine.org/a-biochemists-view-of-lifes-origin-reframes-cancer-and-aging-20220808... |
Description | Interview with Phil Ball for Nautilus Magazine, July 2022 |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Profile of my research and writing for Nautilus Magazine |
Year(s) Of Engagement Activity | 2022 |
URL | https://nautil.us/the-big-thinker-238542/ |
Description | Lecture to Eton College Scientific Society |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Lecture to the Eton College Scientific Society, including discussion beforehand with members and an extensive Q&A session afterwards |
Year(s) Of Engagement Activity | 2019 |
Description | Lex Fridman podcast |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | famous podcast which has had now 1.6 million views and thousands of comments, bridging from the origin of life to mitochondrial function and ageing and consciousness. |
Year(s) Of Engagement Activity | 2022 |
URL | https://www.youtube.com/watch?v=tOtdJcco3YM&t=8498s |
Description | Migala YouTube channel, transmission especial |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | In-depth podcast interview on Mexican Youtube channel, attracting 30,000 viewers live plus another 10,000 afterwards |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.youtube.com/watch?v=UrL8Krm-Hls&t=5364s |
Description | Mindscape podcast, interview with Sean Carroll, June 2022 |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Around 18 000 views on Youtube; many other outlets too |
Year(s) Of Engagement Activity | 2022 |
URL | https://www.youtube.com/watch?v=9IZ_CVu2M68&t=141s |
Description | Molecular Frontiers lecture |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Schools |
Results and Impact | 1 hour lecture followed by a 1-hour Q&A session here: https://www.youtube.com/watch?v=GJsUc29yajU&t=2893s and lots of networking and interactions with school children at the University of Stockholm, see for example here: https://www.youtube.com/watch?v=2oluTiaxB5s |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.youtube.com/watch?v=Ag6csAska_s&t=723s |
Description | Royal Institution, lecture and book launch, May 2022 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Lecture at the Royal Institution, with audience of ~150 people to launch book Recorded and released on Ri Youtube channel Has had 229,000 views so far |
Year(s) Of Engagement Activity | 2022 |
URL | https://www.youtube.com/watch?v=vBiIDwBOqQA |
Description | Sheffield University, Animal and Plant Sciences |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | Invited by ACCE DTP students in Sheffield as their annual seminar speaker (contributing the the Dept Animal and Plant Sciences seminar series). |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.sheffield.ac.uk/aps/research/seminar-programme |
Description | Smithsonian Institution, Washington, invited online lecture, July 2022 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Online lecture to the the Smithsonian Museum series linked to launch of new book in USA |
Year(s) Of Engagement Activity | 2022 |
URL | https://smithsonianassociates.org/ticketing/tickets/krebs-cycle |
Description | St Paul's Girls' School talk |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | St Paul's Girls' School plus other local schools invited. Lecture plus Q&A session, direct inspiration for girls to enter science |
Year(s) Of Engagement Activity | 2019 |
URL | https://spgs.org/about/news/professor-nick-lane-visits-st-pauls/ |
Description | St Pauls' School, Biomedical Society |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Talk to St Paul's School plus local schools invited. Aim to inspire next generation to go into science. |
Year(s) Of Engagement Activity | 2019 |
Description | Student Christmas Crick Lecture |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | Invited Christmas lecture for PhD students at the Crick Institute, plus broader audience of other researchers and some public. About 400 attendees. Good Q&A session afterwards followed by discussion at drinks reception. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.crick.ac.uk/whats-on/student-christmas-crick-lecture-nick-lane |
Description | Symposium on Synthetic Biology, Bremen University |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Online keynote lecture in PhD student symposium |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.uni-bremen.de/fb2/news/detailansicht/bmb-symposium-2020-synthetic-biology-a-canvas-for-c... |
Description | Talk at City of London School |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Talk in school, about 100 pupils attended plus the teachers. |
Year(s) Of Engagement Activity | 2021 |
Description | UCLA quantum biology, talk and public debate |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | A talk and a public debate on the origins of life and possible associations with quantum biology, with leading international figures. |
Year(s) Of Engagement Activity | 2023 |
URL | https://cnsi.ucla.edu/event/from-physics-to-life/ |
Description | University of Melbourne Derek Denton Lecture |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Several related networking events and smaller seminars, valuable discussion particularly relating to metabolism in cancer |
Year(s) Of Engagement Activity | 2019 |
URL | https://events.unimelb.edu.au/presenters/9534-professor-nick-lane |