Investigating the cytosolic NOT4 E3 ligase as a regulator of chloroplast function in Arabidopsis

Lead Research Organisation: University of Birmingham
Department Name: Sch of Biosciences




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Description This award allowed Dr Mark Bailey to travel to Turku in Finland, where he carried out essential experiments to investigate how mutating a specific protein in Arabidopsis called NOT4A affects photosynthesis. We showed that plants with reduced levels of NOT4A have lower levels of photosynthetic capacity, which therefore tells us that NOT4A plays a positive role in controlling photosynthesis. This accompanies our molecular data that shows NOT4A is required for regulating normal functions of the chloroplast through promoting the synthesis of proteins encoded by chloroplast genes. The outputs form the research visit have now been published in Bailey et al 2021 Nature Communciations.
Exploitation Route This data will contribute to an upcoming publication that identifies a new mechanisms controlling chloroplast form and function in relation to photosynthetic capacity. As such, it identifies new targets that could be manipulated to alter photosynthesis.
Sectors Agriculture, Food and Drink

Description MIBTP CASE studentship (Syngenta) 
Organisation Syngenta International AG
Department Syngenta Ltd (Bracknell)
Country United Kingdom 
Sector Private 
PI Contribution We have recently been awarded a BBSRC CASE studentship as part of the Midlands Integrative Biosciences Training Partnership (MIBTP), with Syngenta. This is based off the back of key work undertaken as part of this BBSRC award, which is yet to be published.
Collaborator Contribution We are currently shortlisting to recruit the student who will work on this project, which will commence in September 2020. the project is entitled: Characterisation and chemical inhibition of a novel regulatory module controlling chloroplast protein translation, and will be carried out in collaboration with Syngenta.
Impact n/a
Start Year 2020