Technological evaluation and commercial assessment of a novel technology platform for pharmacophore generation

Lead Research Organisation: University of Leeds
Department Name: Sch of Molecular & Cellular Biology

Abstract

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Publications

10 25 50
 
Description The work was to explore the use of a technology developed at Leeds University as a method to help Pharma companies discover new drugs against. The consultants working with the University of investigated how the University may work with industry and whether the methods of drug discovery has previously been used or whether the method is applicable to a drug discovery pipeline. It was concluded that the process is applicable to certain target proteins which has led to new collaborations between the University of industry. This will hopefully lead to the generation of drugs against a range of diseases.
Exploitation Route We are working with a new industrial partners using Affimer reagents as drug discovery tools
Sectors Healthcare,Pharmaceuticals and Medical Biotechnology
 
Description The findings have contributed to the fact the technology could help the discovery of new small molecules against hard to target proteins. This has allowed the initiation of work with and industrial partner to explore this further against one of their targets
First Year Of Impact 2020
Sector Healthcare,Pharmaceuticals and Medical Biotechnology
Impact Types Economic
 
Description Pharmeable - testing inhibitors against an Affimer mediated pocke 
Organisation PharmEnable Limited
Country United Kingdom 
Sector Private 
PI Contribution We're testing compounds using a range of techniques using Affimer reagents
Collaborator Contribution They have used AI to discovery compounds against a particular target
Impact No outcomes yet
Start Year 2021
 
Description Testing Affimer reagents to prevent Ras dimerisation 
Organisation University of Texas Health Science Center San Antonio, BrainMap Database
Country United States 
Sector Academic/University 
PI Contribution We have generated Affimer reagents that block Ras function. We have supplied plasmids containing the Affimer reagents for them to test
Collaborator Contribution They are currently testing the Affimer reagents in their assays to assess their ability to block Ras dimerisation.
Impact NA
Start Year 2019
 
Description Testing the ability of anti-Ras Affimers in PROTAC systems 
Organisation Medicines Discovery Catapult
Country United Kingdom 
Sector Private 
PI Contribution We've isolated Affimer reagents that target Ras and inhibit function through different mechanisms.
Collaborator Contribution The anti-Ras Affimers will be used to assess their ability in PROTAC systems for targeted protein degradation. The Medicines Discovery Catapult will be assessing the Affimers by fusing them with VHL and testing them using their cellular systems. The University of Glasgow are providing my laboratory with halo tag PROTAC chemicals so a MRES student can assess them in Leeds. The Halo-tag Ras constructs were made as part the BBSRC tools and technologies grant.
Impact No outcomes of yet, besides the start of a new research student in the laboratory.
Start Year 2021
 
Description Testing the ability of anti-Ras Affimers in PROTAC systems 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution We've isolated Affimer reagents that target Ras and inhibit function through different mechanisms.
Collaborator Contribution The anti-Ras Affimers will be used to assess their ability in PROTAC systems for targeted protein degradation. The Medicines Discovery Catapult will be assessing the Affimers by fusing them with VHL and testing them using their cellular systems. The University of Glasgow are providing my laboratory with halo tag PROTAC chemicals so a MRES student can assess them in Leeds. The Halo-tag Ras constructs were made as part the BBSRC tools and technologies grant.
Impact No outcomes of yet, besides the start of a new research student in the laboratory.
Start Year 2021
 
Description Using Affimer Ras interactions to build new technology platforms for measuring conformational changes in protein dynamics 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution We have generate Affimer reagents that alter conformation of Ras proteins
Collaborator Contribution The Affimer reagents will form the basic components to test the principle of measuring conformational changes in proteins using graphene sensors.
Impact Yes, it's multidisciplinary Leeds - protein biochemistry and molecular biology Plymouth - physics and biophysics Cambridge - biophysics and molecular modeling
Start Year 2019
 
Description Using Affimer Ras interactions to build new technology platforms for measuring conformational changes in protein dynamics 
Organisation University of Plymouth
Country United Kingdom 
Sector Academic/University 
PI Contribution We have generate Affimer reagents that alter conformation of Ras proteins
Collaborator Contribution The Affimer reagents will form the basic components to test the principle of measuring conformational changes in proteins using graphene sensors.
Impact Yes, it's multidisciplinary Leeds - protein biochemistry and molecular biology Plymouth - physics and biophysics Cambridge - biophysics and molecular modeling
Start Year 2019