Commercial opportunities for scaling up therapeutic exosome production
Lead Research Organisation:
Imperial College London
Department Name: Infectious Disease
Abstract
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Organisations
People |
ORCID iD |
| Paul Freemont (Principal Investigator) |
Publications
Kelwick R
(2023)
Opportunities to accelerate extracellular vesicle research with cell-free synthetic biology
in Journal of Extracellular Biology
| Description | We anticipate academic-industry engagements as a direct consequence of this and a continuum of subsequent EV engineering/manufacturing grants. Specifically: >Sumitomo Pharma reached out to the Industry Partnerships and Commercialisation Team in Imperial's Enterprise Division in Jan 2023 expressing their interest in our cell-free EV engineering work and we will begin to explore potential collaborative opportunities in the very near future. >A US biotechnology company, Edge Foods, is also interested in our EV manufacturing/engineering work and is in the process of signing an Imperial CDA so that we can continue discussions on potential collaborative opportunities. >Fujifilm Nordic AB is also interested in our EV manufacturing/engineering work and is in the process of signing an Imperial CDA so that we can discuss potential collaborative opportunities and the possibility of licensing previously developed exosome isolation IP (Imperial managed and at PCT stage PCT/GB2020/052302). The insights from our pathfinder award have focused our ongoing EV manufacturing and engineering work towards translational applications and have been useful for ongoing and extensive academic-industry networking and discussions that are still valuable. |
| First Year Of Impact | 2023 |
| Sector | Agriculture, Food and Drink,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Economic |
| Description | 21ENGBIO PROJECT ECHO: Modular exosome prototyping & engineering |
| Amount | £100,695 (GBP) |
| Funding ID | BB/W012987/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2022 |
| End | 10/2022 |
| Description | Commercial opportunities for an automated extracellular vesicle biofoundry |
| Amount | £150,081 (GBP) |
| Funding ID | BB/T017147/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2020 |
| End | 05/2021 |
| Description | Future Biomanufacturing Research Hub |
| Amount | £10,668,316 (GBP) |
| Funding ID | EP/S01778X/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2019 |
| End | 03/2026 |
| Description | EV/nano-flow cytometry presentation at Department of Infectious Disease (DoID) Early Career Researchers day |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Around 50 postgraduate students/postdoctoral researchers attended (in person or digitally) the Department of Infectious Disease Early Career Researchers Day 2022. I (Dr Kelwick) presented our research on cell-free EV engineering and characterisation using nano flow cytometry. This sparked useful discussions around EV engineering and analyses. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.eventbrite.co.uk/e/department-of-infectious-disease-early-career-researchers-day-2022-ti... |
| Description | Participation in an activity, workshop or similar - Oral presentation at UKEV Forum 10th Dec 2019. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Richard Kelwick attended and was invited to give an Oral presentation on our research at UKEV Forum 10th Dec 2019 entitled "AL-PHA beads: bioplastic-based biosensors for detection of extracellular vesicle-associated metalloproteinase biomarkers". |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.ukev.org.uk/ukev-forum-2019/ |
| Description | Participation in an activity, workshop or similar - Poster presentation at ISEV workshop: Open, transparent and reproducible EV research in Ghent |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Participation and Poster presentation at ISEV workshop: Open, transparent and reproducible EV research in Ghent on the 2nd-3rd Dec 2019. The presented poster was entitled: "Heterogeneity and batch variation of extracellular vesicles manufactured from hollow fibre cell culture." The workshop involved networking and open discussion with UK and EU researchers, industry and/or regulators on standards for EV therapeutics and diagnostics applications. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.isev.org/events/EventDetails.aspx?id=1196703 |