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Understanding how food and beverages deliver improved nutrition across the lifecourse

Lead Research Organisation: University of Southampton
Department Name: Human Development and Health

Abstract

As people age the ability of their body to function can decline. This is most obvious for their muscles and bones and cognition but metabolism and immunity decline as well as do a lot of other body structures and functions. Because this decline in function worsens older people's health and well-being, we call the changes unhealthy ageing. Instead of this, we want to promote healthy ageing, because that means older people stay well. Diet is really important in affecting how fast our body's systems decline as we age. In addition, we now know that things that happen to people when they are young, even before they are born or when they are babies, not only affect their health when they are infants or children, but can carry over into later life. In fact, early life events can influence how fast we show the functional decline of ageing. Again, diet turns out to be really important. The diet of a woman when she is pregnant or breastfeeding and the diet of babies and children not only has immediate effects but has a long-lasting effect. So our early diet sets us up for what happens later on. We need to know more about the influence of a person's diet throughout their whole life on how well they grow, develop and function and then how quickly their function declines as they age. Once we know more about this, we can take steps to make sure that people eat the best foods and meals to ensure heathy ageing. To do this we need to study the effect of meals, individual foods and drinks, and specific nutrients and other components of foods on the body right across the lifecourse. To enable that to happen, scientists who understand how nutrition affects the body have to work more closely with industry who produce the foods that people eat. Ultimately, we need to make these foods more healthy. To do that, we need to carry out research so we know what is healthy at different stages of the lifecourse and also to know whether different people actually respond better (or worse) to different foods and food components. We plan to set up a series of partnerships linking researchers from universities with people from industry to foster better working together so that they can carry out the required research. Our ultimate aim is to create what we call an "Innovation Hub" that enables collaborative research involving academic researchers and industry that will in the end result in industry providing more healthful foods to the consumer, so promoting health across the lifecourse including in older age. To do this each year for five years we will distribute funds for research to researcher-industry partnerships. In some cases, industry will also need to put money into the research. So that the partnerships can be created, we will host workshops where researchers and industry can network and discuss their ideas. Once the funds are awarded for research, we will make sure that the research goes as well as it can. Some of the funds we distribute will be for researchers from universities to spend time in industry or for people from industry to spend time with a researcher at a university. These funds will be very appealing to researchers at an early stage in their career. They will really benefit from exchanging knowledge, getting new skills and having new work-place experiences. These things could be of huge benefit to their career. In this way, we hope to create a better skilled, more knowledgeable and engaged work force to carry out important research that will both give industry the opportunity to have more healthy products and enable the population to be more healthy as they age.

Technical Summary

As people age they can show loss of homeostasis of physiological systems and of resilience to challenge. Age-related functional decline has a major impact on the musculoskeletal, cognitive, metabolic and immune systems, amongst others. Unhealthy ageing has societal and economic costs. Poor diet is a contributor to age-related functional decline. However, early life events can have long-term consequences including on age-related functional decline. In order to promote healthy ageing, we need to know more about the influence of "diet" (dietary patterns, meals, foods, nutrients and other food components) throughout the lifecourse on growth, development, acquisition of function and functional decline. We need to understand how factors like age, sex and ethnicity modify the diet-physiological function axis and the mechanisms behind this. Stronger collaboration between academia and industry is needed for this. Our Innovation Hub will enable collaborative research involving academia and industry that will ultimately result in industry providing more healthful foods to the consumer, so promoting health across the lifecourse including in older age. Annually for five years we will distribute funds for research to academia-industry partnerships. In some cases, industry will need to match the funding. Linked to our funding calls, we will host workshops so researchers and industry can network, discuss their ideas and form partnerships. Once the funds are awarded, we will monitor progress. Some of the funds will be for mobility of individuals between universities and industry. These funds will be especially appealing to early career researchers who will benefit from knowledge exchange, skills acquisition and new work-place experiences. We hope to create a better skilled, more knowledgeable and engaged work force to carry out important research that will give industry the opportunity to produce more healthful products and enable the population to be more healthy as they age.

Publications

10 25 50
 
Title Details of studies included in scoping review: Probiotics, prebiotics and synbiotics as oral supplements for skin health, function and disease throughout the life course 
Description This scoping review aimed to map the body of literature on the role of oral probiotics, prebiotics and synbiotics in maintaining and optimising skin health and function as well as preventing and managing skin conditions through the life course. Six electronic databases were systematically searched and results considered for inclusion by two reviewers using previously established criteria. Finally, 516 studies were included in the scoping review, including 73 systematic reviews. 
Type Of Material Database/Collection of data 
Year Produced 2024 
Provided To Others? Yes  
URL https://kcl.figshare.com/articles/dataset/Details_of_studies_included_in_scoping_review_Probiotics_p...
 
Description Collaboration with Quadram Institute 
Organisation Quadram Institute Bioscience
Country United Kingdom 
Sector Academic/University 
PI Contribution Hub Management. Hub Leadership.
Collaborator Contribution Quadram Institute (Simon Carding) was Co-I in the application. They are a member of the Hub Management Team.
Impact Effective Hub Management. Successful first call.
Start Year 2023
 
Description Collaboration with University of Cambridge 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Hub Management. Hub Leadership.
Collaborator Contribution University of Cambridge (Albert Koulman) was Co-I in the application. They are a member of the Hub Management Team.
Impact Effective Hub Management. Successful first call
Start Year 2023
 
Description Collaboration with University of Leeds 
Organisation University of Leeds
Country United Kingdom 
Sector Academic/University 
PI Contribution Hub Management. Hub Leadership.
Collaborator Contribution University of Leeds (Louise Dye) was Co-I in the application. They are a member of the Hub Management Team.
Impact Effective Hub Management. Successful first call.
Start Year 2023
 
Description Collaboration with University of Reading 
Organisation University of Reading
Country United Kingdom 
Sector Academic/University 
PI Contribution Hub Management Hub Leadership
Collaborator Contribution University of Reading (Miriam Clegg) was Co-I in the application. They are a member of the Hub Management Team.
Impact Effective Hub Management. Successful first call.
Start Year 2023
 
Description Funded project at King's College London 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution From its first call, the i-NutriLife Hub funded a project at King's College London led by Dr Ana Rodriguez Mateos. The project is (Poly)phenols and probiotics to improve menopausal symptoms via the gut-brain axis". The sum awarded was £47,025, paid at 80%. There is an in-kind industry contribution of £7715 to the project.
Collaborator Contribution King's College London received the funding and conducted the research.
Impact None yet
Start Year 2023
 
Description Funded project at King's College London 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution From its first call, the i-NutriLife Hub funded a project at King's College London led by Dr Wendy Hall. The project is "Probiotics and prebiotics for maintenance and optimisation of skin health and function". The sum awarded was £29,317, paid at 80%. There is an in-kind industry contribution of £16,500 to the project.
Collaborator Contribution King's College London received the funding and conducted the research.
Impact 1. Presentation at the BDA Research Symposium, Birmingham, 4 December 2024 (presenting authors Emily Prpa and Holly Neill, Yakult UK & Ireland Ltd): "From Gut to Glow: The role of probiotics, prebiotics and synbiotics in skin health". Audience >120 student and practising dietitians. 2. Abstract presented as oral communication at the Nutrition Society Winter Conference, Royal Society, London, 21-22 January 2024 (presenting author Rebecca Hillier): "Oral probiotics, prebiotics, and synbiotics for maintenance and optimisation of skin health and function throughout the life course: a systematic scoping review". Audience >300 individuals with an interest in nutrition (academia, industry, government, dietitians). 3. Manuscript entitled "Probiotics, prebiotics and synbiotics as oral supplements for skin health, function and disease throughout the life course: a scoping review" currently under review by Advances in Nutrition, which publishes reviews focused on key findings and recent research in all areas of interest to nutritional scientists and biomedical researchers (submitted 17/12/2024). [received major revisions 15/02/25 and currently being revised by authors].
Start Year 2023
 
Description Funded project at University of East Anglia 
Organisation University of East Anglia
Department Faculty of Medicine and Health Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution From its first call, the i-NutriLife Hub funded a project at University of East Anglia led by Dr Matthew Pontifex. The project is "Efficacy of transgenic plant derived n-3 PUFAs in the prevention of menopause mediated brain dysregulation". Dr Pontifex is an ECR. The sum awarded was £49,621, paid at 80%.
Collaborator Contribution University of East Anglia received the funding and conducted the research. The funded research finished in 2024.
Impact None yet
Start Year 2023
 
Description Funded project at University of East Anglia 
Organisation University of East Anglia
Department Faculty of Medicine and Health Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution In its second call the i-NutriLife Hub awarded funding to University of East Anglia for a project led by Dr David Vauzour. The project is "Microalgae-based ingredients and impacts on cognition, mood, stress and the immune system through the gut microbiota regulation in a mouse model of low-grade inflammation". Value of funding is £53,523. There are cash and in-kind cntributions from industry that together match this sum.
Collaborator Contribution University of East Anglia received the funds and will conduct the research.
Impact None yet
Start Year 2024
 
Description Funded project at University of East Anglia 
Organisation University of East Anglia
Department Faculty of Medicine and Health Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution In its second call the i-NutriLife Hub awarded funding to University of East Anglia for a project led by Dr Inez Schoenmakers. The project is "The effect of vitamin D and probiotic supplements in older people on bone and mineral homeostasis and the modulatory effect of renal function". Value of funding is £28,127.
Collaborator Contribution University of East Anglia received the funds and will conduct the research.
Impact None yet
Start Year 2024
 
Description Funded project at University of Reading 
Organisation University of Reading
Department School of Psychology and Clinical Language Science
Country United Kingdom 
Sector Academic/University 
PI Contribution In its second call the i-NutriLife Hub awarded University of Reading funding with Dr Piril Hepsomali as recipient. The project is "Exploring the impact of chronic consumption of plant-based fibres on cognitive performance, gut microbiome and associated mental health outcomes in older adults with mild to moderate cognitive impairment". Dr Hepsomali is an ECR. The project received £44763 in funding. There is in-kind and cash funding from industry matching this.
Collaborator Contribution University of Reading has received the funding and will conduct the research.
Impact None yet
Start Year 2024
 
Description Partnership with Nestle 
Organisation Nestlé (Global)
Department Société des Produits Nestlé SA
Country Switzerland 
Sector Private 
PI Contribution In its second call the i-NutriLife Hub made an award to University of Southampton (Prof Philip Calder) with Nestle as the industry partner. Funding is £47,778.
Collaborator Contribution Nestle will make in-kind contribution to the research, mainly through staff time.
Impact None yet
Start Year 2024
 
Description Hub Kickoff meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact We held a one day kickoff meeting for our Hub in London on 19th May 2023. Attendance was 57 with about 2/3 from academic and 1/3 from industry. I presented the Hub in detail and talked about the other 5 Hubs too. There were two world cafe sessions each involving 4 tables aimed at generating important questions and targets for research. There was alot of discussion and engagement with the Hub, Membership increased greatly afterwards.
Year(s) Of Engagement Activity 2023
 
Description Presentation at British Nutrition Foundation webinar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact I gave a presentation on "Translating nutrition research to identify solutions: collaboration is the key" as part of the British Nutrition Foundation webinar on "Nutrition science and innovation" in June 2024. Audience was a mix of industry, academic, post-grad students and policymakers. Feedback was good and membership of the i-NutrLife Hub was increased.
Year(s) Of Engagement Activity 2024
 
Description Presentation at British Nutrition Foundation webinar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact I presented the i-NutriLife Hub as part of a webinar introducing all 6 Diet and Health ORIC Hubs to the community. Audience was a mix of industry and academia including ECRs. Discussion was good. I also hosted a breakout room for the i-NutriLife Hub where attendees could drop in and as specific questions. The event improved understanding of the Hubs. There has been a membership increase and email queries about the next funding call.
Year(s) Of Engagement Activity 2025