Association genetics of UK elite barley
Lead Research Organisation:
James Hutton Institute
Department Name: Genome Dynamics
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
- James Hutton Institute (Lead Research Organisation, Project Partner)
- Scottish Government (Co-funder)
- Nickerson Ltd (Project Partner)
- The Maltsters' Association of Great Britain (United Kingdom) (Project Partner)
- Syngenta Seed Ltd (Project Partner)
- Advanta Seeds UK Ltd (Project Partner)
- Coors Brewers Ltd (Project Partner)
- LS Plant Breeding (United Kingdom) (Project Partner)
- Scotch Whisky Research Institute (Project Partner)
- Econova (Sweden) (Project Partner)
- Agriculture and Horticulture Development Board (Project Partner)
- Agrii (United Kingdom) (Project Partner)
- Calibre Control International Ltd (Project Partner)
- KWS (United Kingdom) (Project Partner)
- Campden BRI (United Kingdom) (Project Partner)
Publications
Rostoks N
(2006)
Recent history of artificial outcrossing facilitates whole-genome association mapping in elite inbred crop varieties.
in Proceedings of the National Academy of Sciences of the United States of America
Waugh R
(2009)
The emergence of whole genome association scans in barley.
in Current opinion in plant biology
Moragues M
(2010)
Effects of ascertainment bias and marker number on estimations of barley diversity from high-throughput SNP genotype data.
in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik
Waugh R
(2010)
Whole-genome association mapping in elite inbred crop varieties.
in Genome
Druka A
(2011)
Genetic dissection of barley morphology and development.
in Plant physiology
Comadran J
(2011)
Patterns of polymorphism and linkage disequilibrium in cultivated barley.
in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik
Ramsay L
(2011)
INTERMEDIUM-C, a modifier of lateral spikelet fertility in barley, is an ortholog of the maize domestication gene TEOSINTE BRANCHED 1.
in Nature genetics
Comadran J
(2012)
Natural variation in a homolog of Antirrhinum CENTRORADIALIS contributed to spring growth habit and environmental adaptation in cultivated barley.
in Nature genetics
Visioni A
(2013)
Genome-wide association mapping of frost tolerance in barley (Hordeum vulgare L.).
in BMC genomics
Tondelli A
(2013)
Structural and Temporal Variation in Genetic Diversity of European Spring Two-Row Barley Cultivars and Association Mapping of Quantitative Traits
in The Plant Genome
| Description | The AGOUEB project pioneered the use of highly parallel single nucleotide polymorphism genetic markers for use in a new type of genetic analysis called Genome Wide Association Scans. It used a large collection of elite barley genotypes to identify genetic markers linked to morphological and developmental DUS traits. SInce then the marker platform has expanded from 1500 to 50000 genetic markers and this is being sed throughout the barley genetics community. Many genes have been identified using the materials and approaches pioneered in AGOUEB and links with the breeding community were significantly strengthened by their involvement. |
| Exploitation Route | The project formed the basis of a switch to highly parallel genetic marker technology in the research and breeding communities and some of the genetic outputs (associations) have already been used to identify several genes. The populations are still being used - in fact have been expanded - for inclusion in other projects (e.g. IMPROMALT) and have a real legacy value. The databases (GERMINATE) associated with the project hold valuable genotypic and phenotypic data and are still used. |
| Sectors | Agriculture, Food and Drink,Education |
| URL | https://www.barleyhub.org/projects/agoueb/ |
| Description | Yes. we developed marker technology that is used by all barley geneticists and commercial breeding companies across the world. We also identified a number of diagnostic markers that are being used for MAS. The GWAS population has been distributed to several groups and has been used to identify a number of important barley genes. A number of high impact papers have been published based on the concepts explored in this grant and using the basic population. It has led to further direct followup funding through the ongoing 'IMPROMALT program. |
| Sector | Agriculture, Food and Drink |
| Impact Types | Economic |
| Description | AHDB research call |
| Amount | £65,000 (GBP) |
| Funding ID | 21130015 Integrated platforms for barley breeding and genetic research (INTEGRA-2) |
| Organisation | Agricultural and Horticulture Development Board |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2016 |
| End | 03/2017 |
| Title | 50K SNP chip |
| Description | We developed a 50K SNP chip using illumina technology for use by the entire barley genetics and breeding communities. A publication describing the resource has been uploaded to the publication outputs. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | The platform has had widespread uptake in the barley genetics and breeding communities with in the region of 20,000 assays (genotypes) already collected through research in the public domain. The extent of usage in the commercial sector is - we believe- considerable but accessing the specific numbers impossible. |
| URL | https://ics.hutton.ac.uk/50k |
| Title | SNP Genotyping Platform |
| Description | A high multiplex SNP assay platform for cultivated barley |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | Yes |
| Impact | Used heavily by the worldwide barley breeding and academic (genetics) sectors |