Centre for Integrative Physiology and Pharmacology at Imperial
Lead Research Organisation:
Imperial College London
Department Name: Dept of Medicine
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
| Julia Buckingham (Principal Investigator) |
Publications
Druce MR
(2009)
Investigation of structure-activity relationships of Oxyntomodulin (Oxm) using Oxm analogs.
in Endocrinology
Dufton N
(2010)
Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation.
in Journal of immunology (Baltimore, Md. : 1950)
Edwards MR
(2009)
Targeting the NF-kappaB pathway in asthma and chronic obstructive pulmonary disease.
in Pharmacology & therapeutics
Fenske WK
(2012)
Exogenous peptide YY3-36 and Exendin-4 further decrease food intake, whereas octreotide increases food intake in rats after Roux-en-Y gastric bypass.
in International journal of obesity (2005)
Francis BN
(2014)
Effects of tetrahydrobiopterin oral treatment in hypoxia-induced pulmonary hypertension in rat.
in Pulmonary circulation
Freund-Michel VC
(2008)
Modulation of cholinergic contractions of airway smooth muscle by cathinone: potential beneficial effects in airway diseases.
in The European respiratory journal
Freund-Michel VC
(2010)
Beta(2)-agonists block tussive responses in guinea pigs via an atypical cAMP-dependent pathway.
in The European respiratory journal
Gardiner JV
(2010)
Cerebellin1 is a novel orexigenic peptide.
in Diabetes, obesity & metabolism
Gardiner JV
(2010)
The hyperphagic effect of ghrelin is inhibited in mice by a diet high in fat.
in Gastroenterology
| Description | As described in previous responses, the programme was responsible for training a number of MRes and PhD students in in vivo skills, and supporting in vivo training, and the careers of researchers working within in vivo research. |
| Exploitation Route | The students trained have gone on to many different careers, including within academic science and industry. The research findings made have contributed significantly to the literature in a number of fields, which have been built on by other researchers. |
| Sectors | Agriculture, Food and Drink,Education,Healthcare,Pharmaceuticals and Medical Biotechnology |
| Description | The major aim of the centre was to train young scientists to perform the physiological and pharmacological studies needed to understand the functions of genes, identify new drug targets and biomarkers, explore the pharmacokinetic properties of novel drugs and to facilitate the development of new medicines. The training programmes associated with the Centre trained 48 students to MRes level in such skills, and at least 30 subsequently began PhD training. In addition, the research staff associated with the Centre have continued to be promoted, make new findings and to train their own teams in in vivo techniques. |
| First Year Of Impact | 2012 |
| Sector | Agriculture, Food and Drink,Education,Healthcare,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Societal,Economic |
| Description | MRC clinical research fellowship (Anjali Amin). 'Role of T1R1/T1R3 in satiety' 2013-2016 |
| Amount | £294,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2013 |
| End | 06/2016 |
| Description | NC3Rs grant |
| Amount | £270,000 (GBP) |
| Funding ID | G0800720/1 |
| Organisation | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Reduction and refinement of murine models of bacterial infection |
| Amount | £270,000 (GBP) |
| Funding ID | G0800720/1 |
| Organisation | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2009 |
| End | 12/2011 |
| Description | Animals in research workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Developed and delivered a workshop on the use of animals in research - with examples of how animals are used for PhD work as well as using daphnia to model changes in heart rate from exposure to different chemicals. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Cheltenham Science Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | CIMPP received a grant from the Society for Endocrinology to put on demonstrations at the Cheltenham Science Festival (June 2012). The students (Ellie Hughes, Helen Smith, Renee Schalks, Katherine Banks and Paul Holloway) created ways to present emotions, attraction, appetite and exercise in a programme entitled, 'How Are Your Hormones'. Hundreds of children and adults participated. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Combat my Cough |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Event to keep our patients up to date with the work we are doing in our clinic and through our research to find a cure for chronic cough. The event provoked questions and discussion, and patients suggesting they would change behaviours. |
| Year(s) Of Engagement Activity | 2013,2014,2015,2016 |
| URL | https://www.combatmycough.com/events |
| Description | Combat my Cough - Manchester |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Presentation explaining our research to a group of chronic cough patients from a specialist cough clinic in Manchester. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.combatmycough.com/events |
| Description | Symposium (Animal Models and their Value in Predicting Drug Efficacy and Toxicity) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A two day symposium (Animal Models and their Value in Predicting Drug Efficacy and Toxicity, hosted jointly by the CIMPP, King's and New York Academy of Science) attracted approx 200 delegates from academia, pharma and regulatory bodies; discussions were lively and emphasised (a) the importance of scientists informing their studies with a better understanding of disease complexity (reverse translation) and (b) bias in the literature resulting from difficulties of publishing 'negative data' from well designed studies. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Talk at MRC Asthma Centre - "Environmental asthma triggers and sensory irritation in the airway: contribution to the asthma phenotype" (September 2016) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk on current research |
| Year(s) Of Engagement Activity | 2016 |
| Description | The Science Museum's Dana Centre, London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A series of public discussions at the Science Museum's Dana Centre was organised in 2011/12. Speakers (including students) from CIMPP talked openly about animal research in context with wider health issues such as neurodegeneration. In two events (Greying Matters and Brain Evolution) students put on displays and talked informally to the audience about their research. No Pain, No Gain Breathless Fat of the Land Greying Matters (in collaboration with the Society for Immunology) Magic of Medicine (with the British Pharmacological Society) Brain Evolution (with the British Neuroscience Association) |
| Year(s) Of Engagement Activity | 2011 |
| Description | Workshop on the use of animals in research |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Developed and delivered a workshop on the use of animals in research - with examples of how animals are used for PhD work as well as using daphnia to model changes in heart rate from exposure to different chemicals. |
| Year(s) Of Engagement Activity | 2016 |