Regulation of protein synthesis as a mechanism of nutritional programming and developmental origins of optimal health
Lead Research Organisation:
University of Cambridge
Department Name: Clinical Biochemistry
Abstract
The diet of an individual can have important health consequences at any stage of life. However there is evidence to suggest that the diet of women during pregnancy and while breastfeeding is particularly important as it has major long-term implications for the health of her baby. It has been shown that individuals with a low birth weight are not only less likely to survive delivery but are also at substantially increased risk of developing type 2 diabetes, high blood pressure and heart disease in adulthood and are more likely to die at a younger age. The underlying causes of the relationship between early growth and adult disease are not known, but it is thought that the quality of the diet of women during pregnancy and breastfeeding is critically important. Studies in animal models can be very useful in helping to decipher mechanisms of human diseases. We have shown that if pregnant and lactating rats have too little protein in their diet their offspring are small at birth and later develop diabetes. We have studied fat tissue and have identified key proteins that are much less abundant both in young men who had a low birth weight and in offspring of protein restricted rat mothers. The central dogma of biology is that the genetic material DNA is copied to an intermediary molecule RNA that is then translated into proteins. Our recent results suggest that the second step of this process is permanently altered (or 'programmed') in the offspring of animals or humans that had a sub-optimal diet. In our project we will study RNA from rat and human fat cells to identify new genes that are programmed to be expressed at different levels as a result of poor early life nutrition. We will also determine why it is that their RNA is not translated properly to make the corresponding proteins. Understanding these processes will enable us to identify individuals at risk and to develop intervention strategies to improve the health of pregnant and breast-feeding women and their offspring.
Technical Summary
Fetal and early life nutrition has long-term (ie programmed) consequences for health. This has been termed the Developmental Origins of Health and Disease. Despite numerous studies confirming the concept of nutritional programming and its associations with long term health, the molecular mechanisms by which a phenomenon that occurs in utero or during very early life has phenotypic consequences many years later are poorly understood. This proposal addresses the fundamental underlying molecular mechanisms of nutritional programming. We hypothesise that programmed responses to sub-optimal nutrition in early life are significantly mediated by regulation of gene expression at a post-transcriptional level. We further hypothesise that diet-induced changes in regulatory factors such as miRNAs alter cellular memory and consequently impact on long term health of the organism. We will adopt an integrated approach to test these hypotheses, combining whole body nutritional programming, functional genomics and transcriptomics using both the well established maternal low protein rat model and human biopsy material. This will include both genome-wide and gene-specific analysis of adipose tissue. Understanding the mechanisms involved in nutritional programming could ultimately lead to diagnosis, prevention and treatment of the long term effects of diet on health.
Organisations
Publications
Warner MJ
(2010)
Mechanisms involved in the developmental programming of adulthood disease.
in The Biochemical journal
Tarry-Adkins JL
(2010)
Poor maternal nutrition leads to alterations in oxidative stress, antioxidant defense capacity, and markers of fibrosis in rat islets: potential underlying mechanisms for development of the diabetic phenotype in later life.
in FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Tarry-Adkins JL
(2013)
Poor maternal nutrition followed by accelerated postnatal growth leads to alterations in DNA damage and repair, oxidative and nitrosative stress, and oxidative defense capacity in rat heart.
in FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Stelzhammer V
(2012)
Analysis of the rat hypothalamus proteome by data-independent label-free LC-MS/MS.
in Proteomics
Shelley P
(2009)
Altered skeletal muscle insulin signaling and mitochondrial complex II-III linked activity in adult offspring of obese mice.
in American journal of physiology. Regulatory, integrative and comparative physiology
Sandovici I
(2013)
Developmental and environmental epigenetic programming of the endocrine pancreas: consequences for type 2 diabetes.
in Cellular and molecular life sciences : CMLS
Rooney K
(2011)
Maternal over-nutrition and offspring obesity predisposition: targets for preventative interventions.
in International journal of obesity (2005)
Ozanne SE
(2011)
Maternal diet, aging and diabetes meet at a chromatin loop.
in Aging
Ozanne S
(2011)
The Metabolic Syndrome
Oben JA
(2010)
Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice.
in Journal of hepatology
| Description | It is widely accepted by the scientific community and the general public that nutrition (both quality and quantity) has profound effects on health and well being through out life, and ultimately on lifespan. Less well known is that a woman's diet (and other environmental influences) during pregnancy and while she is breast-feeding, can have profound and lasting effects on the health of her offspring during their life. In particular, the fetal and early postnatal environment influences susceptibility to metabolic diseases such as obesity, type 2 diabetes and cardiovascular disease. It is believed that suboptimal nutrition during fetal and very early postnatal life, while tissues and organs are still developing, may permanently alter their structure and function. This "programming" may be beneficial to survival in continued conditions of poor postnatal nutrition. However if childhood and adult nutrition is plentiful and especially if it is excessive, there is conflict with the earlier programming and disease can ensue. This has been called the 'developmental origins of health and disease' hypothesis. Despite extensive studies in both humans and animal models strongly supporting this hypothesis, the underlying mechanisms by which it is mediated remain poorly defined. Our recent work has given novel insight into what appears to be an important mechanism underlying the developmental programming of metabolism by early life nutrition. We have shown in fat cells from both laboratory animals and humans who had a low birth weight that the levels of some molecules called microRNAs are altered by early growth and nutrition during fetal and early postnatal life. These effects are permanent and do not change even if we are fed a healthy diet after weaning. These microRNAs control the amounts of key proteins, which in turn set the overall metabolism and function of the fat cells. In particular we believe that some of these microRNAs influence how well a person is able to store fat, especially when they eat an unhealthy high fat diet as an adult. Our results suggest that if we have inappropriate levels of a specific microRNA called miR483 because of exposure to a suboptimal diet in very early life we are less able to store fat in our adipose tissue. The excess fat that we eat therefore gets stored in our liver and muscle where it is very toxic and impairs the function of these important tissues and makes us much more likely to develop type 2 diabetes and fatty liver disease. We believe that regulation of microRNA levels by nutrition in early life could have widespread significance as a mechanism of programming. If we understood these processes better we might be able to devise tests to predict who is at risk, devise ways of counteracting the programming, and best of all, advise people on how to avoid the problem in the first place. |
| Exploitation Route | We identified miRNAs that are programmed in adipose tissue as a consequence of suboptimal maternal nutrition. In the future these stable molecules may be useful biomarkers of disease risk. |
| Sectors | Other |
| Description | The role of microRNAs in the developmental programming of Type 2 diabetes, and their value as biomarkers of disease risk |
| Amount | £227,000 (GBP) |
| Funding ID | 12/0004508 |
| Organisation | Diabetes UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2013 |
| End | 12/2015 |
| Description | The role of microRNAs in the developmental programming of Type 2 diabetes, and their value as biomarkers of disease risk |
| Amount | £227,000 (GBP) |
| Funding ID | 12/0004508 |
| Organisation | Diabetes UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2013 |
| End | 12/2015 |
| Description | 3rd Annual DREAM (Diabetes Research Envisioned and Accomplished in Manitoba) Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Presentation on "How 9 months in the womb shapes your diabetes risk" N/A |
| Year(s) Of Engagement Activity | 2014 |
| Description | 112th Abbott Nutrition Research Conference on pregnancy, nutrition and later health outcome, Columbus, Ohio, 2011 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk given: Mechanisms of early programming during pregnancy no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2011 |
| Description | 12th International Congress on Obesity Malaysia March 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on epigenetic programming of metabolic disease- what have we learned from animal models N/A |
| Year(s) Of Engagement Activity | 2014 |
| Description | 13th Insulin receptor and insulin action meeting. Programming by maternal over-nutrition: a developing obesity crisis. Nice France 20-22nd April 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. 13th Insulin receptor and insulin action meeting. Programming by maternal over-nutrition: a developing obesity crisis. Nice France 20-22nd April 2017 |
| Year(s) Of Engagement Activity | 2017 |
| Description | 14th Human Genome meeting 2010: Next generation genomics and medicine, 2010 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk given: Mechanisms linking poor early nutrition and later risk of type 2 diabetes no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2010 |
| Description | 1st International Symposium on Neuroendocrine Programming of obesity, Rouen, France, 2010 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | paper presentation |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk given: Programming of early balance by early growth and nutrition no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2010 |
| Description | 2019 Sino-UK Cardiovascular Diseases Symposium Nanjing, China 24th May 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title: Programming of cardiometabolic disease by maternal diet-induced obesity: a developing problem |
| Year(s) Of Engagement Activity | 2019 |
| Description | 20th EASE-Hagedorn Oxford Workshop, 7-10 August 2015 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on Under and over-nutrition and offspring biology. |
| Year(s) Of Engagement Activity | 2015 |
| Description | 23rd of the Italian Diabetes Society, Padua, Italy, 2010 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | paper presentation |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk given: Early programming of insulin sensitivity and longevity. no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2010 |
| Description | 28th International symposium on Diabetes & Nutrition, Oslo, Norway, 2010 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk given: Mechanisms linking early nutrition to long term risk of type 2 diabetes no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2010 |
| Description | 2nd Nutrenvigen-G+D Factors Master Mtg, Santander, Spain |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 2nd Nutrenvigen-G+D Factors Master Meeting, 15-18 September 2010, Santander, Spain 1: " The transition from fetal growth restriction to accelerated postnatal growth: a potential role for insulin signaling in skeletal muscle" 2: Neuroendocrine mechanisms responsible for programming" NA |
| Year(s) Of Engagement Activity | 2010 |
| Description | 2nd Workshop of the International Network on Telomere Biology, 2-4 November 2015, Drymen, Scotland |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on Impact of early nutrition on telomere length. |
| Year(s) Of Engagement Activity | 2015 |
| Description | 3rd Diabetes Masters Conference. Tokyo, Japan, 5 Dec 2009 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk given: Mechanisms linking poor early growth, insulin resistance and type 2 diabetes. no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2009 |
| Description | 50th EASD Meeting, Vienna, Austria 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on new insights into developmental programming and type 2 diabetes N/A |
| Year(s) Of Engagement Activity | 2014 |
| Description | 54th Annual Meeting of the European Society for Paediatric Endocrinology, 1-3 October 2015, Barcelona, Spain |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on Transgenerational programming of endocrine disease. |
| Year(s) Of Engagement Activity | 2015 |
| Description | 5th International Meeting on Research on Physical Activity and Nutrition |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on mechanisms underlying the nutritional programming of type 2 diabetes and metabolic syndrome N/A |
| Year(s) Of Engagement Activity | 2014 |
| Description | 68th Gerontological Society of America Annual Meeting 18-21 November 2015, Orlando, USA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on Nutritional programming: how life in the womb determines our health span and lifespan. |
| Year(s) Of Engagement Activity | 2015 |
| Description | 6th European Nutrigenomics Conference, Montecatini, Italy, 2009 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | paper presentation |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk given: Mechanisms responsible for effects of early life nutrition on the ageing trajectory. no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2009 |
| Description | 6th International Achieving Improved Outcomes in Neonatology and Academic Association Joint Conference. Cardiff Wales 13-15th March 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title: Short and long-term impact of maternal obesity on offspring. |
| Year(s) Of Engagement Activity | 2019 |
| Description | 70th Scientific Session of the American Diabetes Association, Orlando, Florida, USA, 2010 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk given: Long term effects of early diet on adult health no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2010 |
| Description | 70th Scientific Sessions of the American Diabetes Association, Orlando, Florida, 2010 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk given: Long term effects of early diet on adult health no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2010 |
| Description | 7th Mediterranean Neuroscience Conference Marrakech, Morocco 23rd-27th June 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title: Nutritional programming of cardio-metabolic disease by maternal obesity |
| Year(s) Of Engagement Activity | 2019 |
| Description | 7th World conference on the Developmental origins of Health & Disease, Portland, Oregon, USA, 2011 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk given: Programming molecular pathways to insulin resistance no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2011 |
| Description | 80th Scientific Sessions of the American Diabetes Association (virtual) 12-16 June 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk title: Sex differences in metabolic programming by maternal obesity. |
| Year(s) Of Engagement Activity | 2020 |
| Description | 8th Colloque Ipsen conference, Paris |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on "Perinatal Endocrinology. Perinatal programming and obesity" 20-21 November 2014. |
| Year(s) Of Engagement Activity | 2014 |
| Description | 9th International Congress o fComparative Physiology and Biochemistry (ICCPB), 23-28 August 2015, Krakow, Poland |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on Nutrition during pregnancy: consequences for the next generation. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Alberta Childrens Hospital Research Institute Symposium 2014 April 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on suboptimal early nutrition and long term metabolic health- does mum hold the answers N/A |
| Year(s) Of Engagement Activity | 2014 |
| Description | American Heart Association Scientific Sessions 2019 Transforming the Cardiovascular Health of Youth for Generations to come. Philadelphia USA 16th -19th November 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title: Cardiovascular health and Risk - Molecular Mechanisms |
| Year(s) Of Engagement Activity | 2019 |
| Description | Angers annual summer school 2019, Angers France 27th June 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | Invited lecture. Title: What is fetal programming? |
| Year(s) Of Engagement Activity | 2019 |
| Description | Angers annual summer school, 1-2 July 2015, Angers, France |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Undergraduate students |
| Results and Impact | What is fetal programming? Summer school session. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Annual Covian Symposium (virtual) Ribeiro Preto, Brazil 1 October 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk title: Nutritional programming of cardio-metabolic health: a developing problem |
| Year(s) Of Engagement Activity | 2020 |
| Description | Annual Dutch Diabetes Research Meeting 2019, Oosterbeek 28th-29th November 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title: Programming of cardio-metabolic health by maternal obesity: a developing problem |
| Year(s) Of Engagement Activity | 2019 |
| Description | Australia National Health and Medical Research Council CEO Round Table April 2014 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on programming by maternal diet-induced obesity Document on research priorities released by NHMRC |
| Year(s) Of Engagement Activity | 2014 |
| Description | BBSRC - Global Food Security |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Volunteer stand presenter, Global Food security event. DENISE FERNANDEZ-TWINN |
| Year(s) Of Engagement Activity | 2011 |
| URL | http://www.bbsrc.ac.uk/news/food-security/2015/150529-n-gfs-develops-new-funding-programme/ |
| Description | BHF CRE Annual Symposium 2019 Cambridge UK 9th May 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title: Programming of cardio-metabolic disease by maternal diet-induced obesity: a developing problem |
| Year(s) Of Engagement Activity | 2019 |
| Description | Biocenter Oulu Day 'Fifty Shades of Fat' conference, Oulu, Finland 23rd March 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker, Biocenter Oulu Day 'Fifty Shades of Fat' conference, 23rd March 2017, Oulu, Finland. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Biomedical Research Institute Programme, Dundee, Scotland |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Biomedical Research Institute Programme, 19 October 2010, Dundee, Scotland "You are what your mother ate: the developmental origins of type 2 diabetes and the metabolic syndrome" NA |
| Year(s) Of Engagement Activity | 2010 |
| Description | British Council-FAPESP Metabolic Programming Workshop, Sao Paulo, Brazil 2-4 February 2015 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on Mechanisms underlying developmental programming of metabolic disease: insight into prevention strategies. |
| Year(s) Of Engagement Activity | 2015 |
| Description | CUDOS conference on understanding molecular mechanisms underlying cardiovascular disease, diabetes, obesity and stroke, Doha, Qatar 10-12 April 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. CUDOS conference on understanding molecular mechanisms underlying cardiovascular disease, diabetes, obesity and stroke. Nutritional programming of health and disease: are we ready to intervene? Doha, Qatar 10-12 April 2017 |
| Year(s) Of Engagement Activity | 2017 |
| Description | Cambridge Trophoblast Research Centre Annual Meeting 13-14 July 2015, St John's College, Cambridge |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on Diet-induced obesity and maternal interventions. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Cardiovascular Division Seminar, Kings College London, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Paper Presentation |
| Geographic Reach | Local |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Cardiovascular Division Seminar at Kings College London, 1 November 2010, Kings College London "Developmental programming of type 2 diabetes and the metabolic syndrome" NA |
| Year(s) Of Engagement Activity | 2010 |
| Description | Consequences of experimetnal IUGR on body weight and glucose homeostasis. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Talk given at the ' Perinatal Programming the state of the art' meeting, Berlin, Germany no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2010 |
| Description | Consequences of maternal over-nutrition: mechanisms of hyperphagia and insulin resistance |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Talk given at the ILSI Europe roundtable Workshop on the effects of pre- and postnatal nutrition of infants of obese mothers: metabolic imprinting and later health outcomes, Brussels, Belgium no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2009 |
| Description | Crick Symposium: Nutrition and the Developmental Origins of Health and Disease, 25th June 2015, Wellcome Trust, London |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on Mechanisms underlying the developmental origins of health and disease: what do they tell us about intervention strategies? |
| Year(s) Of Engagement Activity | 2015 |
| Description | DNA damage, repair and lifespan: the influence of the early environment |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Talk given at the biennial colloquium series, nutrition, metabolism and the brain on " Energy regulation from conception to old age", Groningen, The Netherlands no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2011 |
| Description | Dept of Women's Health, Kings College London. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Department of Women's Health, KCL, 11 March 2010, Kings College London "You are what your mother ate: the developmental origins of type 2 diabetes and the metabolic syndrome" NA |
| Year(s) Of Engagement Activity | 2010 |
| Description | Developmental Origins of Health and Disease 11th World Congress. Picking apart obesity and diabetes in pregnancy, Melbourne Australia 20th-23rd October 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker and Council Member. Talk title: Is it maternal hyperglycaemia or is it obesity that affects offspring health? |
| Year(s) Of Engagement Activity | 2019 |
| Description | Developmental programming - what have we learned from animal models |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk given at Diabetes in Pregnancy Study Group Annual meeting, Cambridge, UK no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2011 |
| Description | Developmental programming of metabolism-from global diabetes epidemiology to molecular mechanisms in animals and humans. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Taught PhD course in Copenhagen ;Programming of metabolism in rodents; no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2009 |
| Description | Developmental programming of type 2 diabetes |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Talk given in Lund, Sweeden during the Epigenetics and the Environment: implications for behaviour and disease meeting no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2010 |
| Description | Diabetes UK Annual Professional Conference, London, UK, 2011 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk given: Foetal programming: looking at their future now no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2011 |
| Description | Diabetes: lets save the next generation. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Paper Presentation |
| Geographic Reach | International |
| Primary Audience | Participants in your research or patient groups |
| Results and Impact | Talk given at the OHSU Heart Research Centre 17th Annual Lecture, Portland, Oregon no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2010 |
| URL | http://www.abc.net.au/radionational/programs/scienceshow/genome-research---achievements-and-hopes/30... |
| Description | EASD-Hagedorn Oxford workshop on Obesity August 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on developmental programming in response to maternal over-nutrition N/A |
| Year(s) Of Engagement Activity | 2014 |
| Description | ENDO 2014 Chicago June 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on early environmental influences on type 2 diabetes risk N/A |
| Year(s) Of Engagement Activity | 2014 |
| Description | Early Life Developmental Effects: Unifying Evolutionary and Biomedical Perspectives Workshop, 9-12 September 2015, Falmouth, UK |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on Early Life programming - current knowledge and future potential. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Early nutrition and long term health - the role of epigenetic programming |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Talk given at the ESRC International Symposium on social science and epigenetics: opportunities and challenges, Edinburgh, Scotland no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2012 |
| Description | EpiScope Colloquium, 12 October 2015, Sydney, Australia |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on Mechanisms underlying the developmental origins of metabolic disease: are we ready to intervene? |
| Year(s) Of Engagement Activity | 2015 |
| Description | Epigenetics and developmental programming, Newcastle, UK, 2011 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | paper presentation |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk given: Nutritionally programmed influences on gene expression - a role for epigenetic regulation no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2011 |
| Description | Epigenetics, neonatal environment and nutrition |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Talk given a the 10th Agricultural Biotechnology International Conference, Saskatoon, Canada no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2010 |
| Description | European Atherosclerosis Society Annual Meeting, Glasgow, UK 22-25 March 2015 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on Epigenetic programming of metabolism by diet. |
| Year(s) Of Engagement Activity | 2015 |
| Description | European Congress for Obesity 2009, Amsterdam, The Netherlands |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk given: Developmental and epigenetic origins of obesity no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2009 |
| URL | http://www.karger.com/Book/Home/248347 |
| Description | European Society for Paediatric Gastroenterology, Hepatology and Nutrition 48th annual meeting, 6-9 April 2015, Amsterdam, The Netherlands |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on Early life nutrition and metabolic health: mysteries and mechanisms. |
| Year(s) Of Engagement Activity | 2015 |
| Description | European Teratology Society 43rd Conference, 30 August - 2 September 2015, Amsterdam, The Netherlands |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on Nutrition during pregnancy and long-term risk of type 2 diabetes. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Experimental Biology 2009 meeting, New Orleans, Louisiana, USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk given: Exploring the mechanisms linking suboptimal nutrition and increased risk of type 2 diabetes and obesity no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2009 |
| Description | Experimental Biology conference 2017, Chicago, USA 22nd - 26th April 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Experimental Biology 2017 Epigenetics and the developmental origins of obesity, type 2 diabetes and cardiovascular disease: knowns, unknowns and possibilities. Chicago USA 22nd-26th April 2017 |
| Year(s) Of Engagement Activity | 2017 |
| Description | Fetal Programming symposium, German Diabetes Congress 2012, Stuttgart, Germany, 17-18th May 2012. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A talk as Invited speaker: "Early life nutritional programming". DENISE FERNANDEZ-TWINN |
| Year(s) Of Engagement Activity | 2012 |
| Description | Genome Regulation: Genomics Centre KCL |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Regional |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Genome Regulation: Environment and Disease 22nd November 2013 - King's College London "Epigenetic programming of type 2 diabetes by maternal nutrition". N/A |
| Year(s) Of Engagement Activity | 2013 |
| Description | Harold Hamm Diabetes Centre Metabolic Research Conference, (virtual) Oklahoma City USA, 2nd November 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk title: Programming by maternal obesity: a developing problem |
| Year(s) Of Engagement Activity | 2020 |
| Description | Hosting school children for work experience, University of Cambridge, Cambridge UK |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Hosting school children for work experience in February 2015 (at the Ozanne Lab) |
| Year(s) Of Engagement Activity | 2015 |
| Description | Human Nutrition Research Center (CRNH) Mtg, Clermont Ferrand, France |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Paper Presentation |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Human Nutrition Research Center (CRNH), 28-29 May 2009, Clermont Ferrand, France "Nutritional programming of type 2 diabetes, obesity and longevity" NA |
| Year(s) Of Engagement Activity | 2009 |
| Description | In-Utero MRI 2020 Queen Anne's College Oxford, UK 8th - 10th January 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title: Early Programming |
| Year(s) Of Engagement Activity | 2019 |
| Description | Infant Nutrition Workshop, 10th February 2016, Nestlé Research Center, Lausanne, Switzerland |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Expert panel discussion on infant nutrition and the role that complementary feeding plays on the short- and long-term effects on metabolic health. |
| Year(s) Of Engagement Activity | 2016 |
| Description | International Conference on Molecular Medicine, Chennai, India, 2009 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | paper presentation |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk given: Metabolic programming of type 2 diabetes and obesity no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2009 |
| Description | International Congress of Neuroendocrinology 2014 Sydney 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on nutritional programming by maternal diet-induced obesity N/A |
| Year(s) Of Engagement Activity | 2014 |
| Description | International Union of the Physiological Society Annual Meeting 2009, Kyoto, Japan. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk given: Molecular mechanisms underlying the early origins of insulin resistance no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2009 |
| Description | Ipsen symposium on perinatal endocrinology Paris France 20th-21st November 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on Perinatal programing and obesity N/A |
| Year(s) Of Engagement Activity | 2014 |
| Description | Joint Annual Conference of the International Society for Paediatric and Adolescent Diabetes and the Australiasian Paediatric Endocrine group, 7-10 October 2015, Brisbane, Australia |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Mechanisms underlying the developmental origins of metabolic health - insight into intervention strategies. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Keynote lecture at Institute of Food Research Metabolomics Group, Norwich, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Regional |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Keynote lecture at Institute of Food Research Metabolomics Group, 6 October 2011, Norwich, UK "Mechanisms linking the early environment to long-term metabolic health" NA |
| Year(s) Of Engagement Activity | 2011 |
| Description | MRC Symposium, MRC Centre for Reproductive Health, Edinburgh 24th February 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title: Mechanisms underlying the programming of cardio-metabolic health by maternal obesity |
| Year(s) Of Engagement Activity | 2020 |
| Description | MSD Merck Diabetes Mtg, Seattle, USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Paper Presentation |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | MSD Merck Meeting, 17-19 April 2010, Seattle, USA "Type 2 diabetes: Emerging Science" NA |
| Year(s) Of Engagement Activity | 2010 |
| Description | Maternal diet induced epigenetic changes and their implications for health |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Talk given at the 5th Congress of the International Society Of Nutrigenetics and Nutrigenomics, Beijing, China no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2011 |
| Description | Mechanisms and evolution of intergenerational change 2019, Wellcome Genome Campus. Hinxton UK 24th -26th September 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title: Programming by maternal over-nutrition - a plentiful problem |
| Year(s) Of Engagement Activity | 2019 |
| Description | Mechanisms of early life programming |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Talk given at the Gordon Research Conference on Ageing, Ventura, USA no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2012 |
| Description | Metabolic Discussion Group Symposium, London, UK, 2011 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | paper presentation |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk given: You are what your mother ate. no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2011 |
| URL | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2022676/ |
| Description | Nutricia Research Scientific Symposium Mechanisms of metabolic programming: what can we learn from translational research? Groningen, The Netherlands. 31st January 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Nutrition and Health Event Cambridge Food Security Forum and EIT Food Initiative, St John's College Divinity School, Cambridge, 15th August 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Participation on the panel for this event. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Nutritionally programmed influences on gene expression - a mechanism underlying the developmental origins of health and disease. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Talk given at the 6th Congress of the International Society of Nutrigenetics and Nutrigenomics (ISNN), Sao Paulo, Brazil no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2012 |
| Description | OCDEM Seminar, Oxford Centre for Diabetes, Endocrinology and Metabolism Oxford UK 20th November 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker. Talk title: Programming of cardio-metabolic disease by maternal over-nutrition: a developing crisis |
| Year(s) Of Engagement Activity | 2019 |
| Description | OHSU Heart Research Center's Annual Lecture, Portland, Oregon, USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | OHSU Heart Research Center's Annual Lecture, 1 April 2012, Portland, Oregon, USA You are what your mother ate: The developmental origins of type 2 diabetes and obesity" NA |
| Year(s) Of Engagement Activity | 2010 |
| Description | Obesity Week 2019 Las Vegas, USA 3rd-7th November 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title? Is sugar an epigenetic trigger for obesity? |
| Year(s) Of Engagement Activity | 2019 |
| Description | Obesity: a physiological perspective (Physiological Society Meeting) Newcastle September 2014 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | N/A |
| Year(s) Of Engagement Activity | 2014 |
| Description | Oral presentation, Chile 2009 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk as an invited speaker: "Programming of increased early mammary tumour risk is additively and independently augmented by post-pubertal obesity". 6th World Congress on Developmental Origins of Health and Disease November 19th-22nd 2009, Santiago, Chile. DENISE FERNANDEZ-TWINN |
| Year(s) Of Engagement Activity | 2009 |
| URL | http://www.imtf.org/6th-world-congress-on-developmental-origins-of-health-and-disease/ |
| Description | Oxidative Stress and Disease Gordon Conference, Ventura USA 17th - 21st March 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title: Redox metabolomics and transcriptomics in metabolic disease phenotyping. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Pennington Scientific Symposium, Baton Rouge, Louisiana, USA 7-9 December 2014 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on Nutritional Programming - current knowledge and future potential. |
| Year(s) Of Engagement Activity | 2014 |
| Description | PhD course in Developmental programming of metabolism and behaviour, 2011 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Taught PhD course in Developmental programming of metabolism and behaviour- from global diabetes epidemiology to molecular mechanisms in animals and humans no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2011 |
| Description | Placenta and Fetal Physiology in Pregnancy Disorders mini-symposium, 17th April 2015, Santiago, Chile |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on Programming by maternal over-nutrition: a developing obesity crisis. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Power of Programming Conference Munich March 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | N/A |
| Year(s) Of Engagement Activity | 2014 |
| Description | Press release |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Type Of Presentation | Paper Presentation |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Extensive press coverage Continued contact from journalists |
| Year(s) Of Engagement Activity | 2012 |
| Description | Quebec Obesity Symposium, 13 November 2015, Quebec, Canada |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on Programming by maternal over-nutrition: a developing obesity crisis. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Rank Prize Funds Mini Symposium on Obesity: from prevention to molecular mechanisms. Grasmere UK 15th-18th July 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title: Programming by maternal over-nutrition: a developing obesity crisis |
| Year(s) Of Engagement Activity | 2019 |
| Description | Rank Prize Funds Mini-Symposium on Oxidative Stress |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Position paper written N/A |
| Year(s) Of Engagement Activity | 2014 |
| Description | Seminar Series MRI, Cambridge, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Paper Presentation |
| Geographic Reach | Local |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Seminar Series 2010 MRI, 12 May 2010, Cambridge "Developmental programming and ageing" NA |
| Year(s) Of Engagement Activity | 2010 |
| Description | SickKids - Physiology and Experimental Research Seminar, 20 January 2016, Toronto, Canada |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on Mechanisms underlying the developmental origins of health and disease |
| Year(s) Of Engagement Activity | 2016 |
| Description | Society for Free Radical Research Europe 2014 Paris september 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on nutrigenomic programming of cardiovascular and metabolic diseases N/A |
| Year(s) Of Engagement Activity | 2014 |
| Description | Society for Gynaelogical Investigation Annual Meeting Florence Italy March 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on preventive and intervention strategies in developmental programming- what have we learned from animal models N/A |
| Year(s) Of Engagement Activity | 2014 |
| Description | Society for Maternal and Fetal Medicine 40th Annual Pregnancy Meeting Texas, USA 3rd - 8th February 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title: Comparative impact of pharmacological treatments for gestational diabetes on neonatal anthropometry: systematic review and meta-analysis |
| Year(s) Of Engagement Activity | 2020 |
| Description | Society for Reproductive Investigations 62nd Annual Scientific Meeting, 25-27 March 2015, San Francisco, USA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on Programming by maternal over-nutrition - a developing obesity crisis. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Summer School, University of Angers. What is fetal programming? Angers, France 29th June 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | University of Angers summer school. What is fetal programming? Angers, France 26th June - 7th July 2017 |
| Year(s) Of Engagement Activity | 2017 |
| Description | Symposium on cellular energy, metabolism and cancer. Houston, Texas, USA 2-4 April 2009 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk given: The developmental origins of type 2 diabetes, obesity and breast cancer no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2009 |
| Description | Tea Talk Series, Dept of Zoology, Cambridge, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Paper Presentation |
| Geographic Reach | Local |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Tea Talk Series, Dept of Zoology, 21 January 2010, Cambridge "The developmental origins of type 2 diabetes and the metabolic syndrome" NA |
| Year(s) Of Engagement Activity | 2010 |
| Description | The Power of Programming meeting, 2010 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk given: Mechanisms of early life programming-current knowledge and future directions no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2010 |
| Description | The Power of Programming, Munich, Germany, 2010 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk given: Mechanisms of early life programming-current knowledge and future directions no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2010 |
| Description | The influence of early diet on the ageing trajectory |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Talk given at the China/UK Joint Workshop on Healthy Ageing - Diet and nutrition across the life course, Beijing, China no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2010 |
| Description | UCL Genetics, Evolution and Environment seminar series, Institute of Healthy Ageing UCL, London (virtual) 13th May 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Seminar title: Mechanisms underlying the developmental origins of cardio-metabolic health |
| Year(s) Of Engagement Activity | 2020 |
| Description | University of Nottingham Division of Medical Sciences External Seminar Series Event (virtual), 29th January 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk title: Programming by maternal obesity: a developing problem. |
| Year(s) Of Engagement Activity | 2021 |
| Description | VI SLIMP and V LASRI Annual Meeting, 13-15 April 2015, Mar del Plata, Argentina |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on Programming by maternal diet-induced obesity: mechanistic insights and intervention strategies. |
| Year(s) Of Engagement Activity | 2015 |
| Description | VIIth Islet Society Meeting Jointly with VIIIth Islet Study Group, 19-21 July 2015, Sydney, Australia |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on Mechanisms underlying the developmental programming of type 2 diabetes. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Wellcome Trust Scientific Conference on Healthy Ageing: from Molecules to Organisms, Wellcome Trust Genome campus, Hinxton, UK 18-20 May 2015 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk on Mechanisms underlying the developmental programming of metabolic health. |
| Year(s) Of Engagement Activity | 2015 |
| Description | You are what your mother ate |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | Regional |
| Primary Audience | Other audiences |
| Results and Impact | Talk given at Metabolic Discussion Group, London UK no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2011 |