Novel anti-malarial compounds and assay targeting chloroquine resistance
Lead Research Organisation:
Cardiff University
Department Name: School of Biosciences
Abstract
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Organisations
People |
ORCID iD |
| James Murray (Principal Investigator) |
Publications
Maughan SC
(2010)
Plant homologs of the Plasmodium falciparum chloroquine-resistance transporter, PfCRT, are required for glutathione homeostasis and stress responses.
in Proceedings of the National Academy of Sciences of the United States of America
Patzewitz EM
(2013)
Glutathione transport: a new role for PfCRT in chloroquine resistance.
in Antioxidants & redox signaling
| Description | We discovered that the malaria gene conferring resistance to the frontline drug chloroquine is closely related to plant antioxidant transporters and investigated the function of these genes using yeast. |
| Exploitation Route | Has been used as the basis for further research by others. |
| Sectors | Healthcare |
| Description | Extensive press coverage around the discovery that the chloroquine resistance gene of malaria is closely related to a class of plant specific transporters that are involved in antioxidant transport. |
| First Year Of Impact | 2010 |
| Sector | Healthcare |
| Impact Types | Societal |