The Systems Biology of Exercise
Lead Research Organisation:
University of Leeds
Department Name: Institute of Membrane & Systems Biology
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
- University of Leeds (Lead Research Organisation, Project Partner)
- University of Tokyo (Collaboration)
- Kobe Design University (Collaboration, Project Partner)
- Kobe University (Project Partner)
- University of Tsukuba (Project Partner)
- University of Liverpool (Project Partner)
- Prefectural University of Hiroshima (Project Partner)
People |
ORCID iD |
| Harry Rossiter (Principal Investigator) | |
| Graham Kemp (Co-Investigator) |
Publications
Adami A
(2017)
Reproducibility of NIRS assessment of muscle oxidative capacity in smokers with and without COPD.
in Respiratory physiology & neurobiology
Adami A
(2014)
Relationships Among Muscle Deoxygenation, Total Heme Concentration by TRS-NIRS, and Blood Flow During Head-up Tilt 2775 Board #61 May 30, 3
in Medicine & Science in Sports & Exercise
Adami A
(2015)
Changes in whole tissue heme concentration dissociates muscle deoxygenation from muscle oxygen extraction during passive head-up tilt
in Journal of Applied Physiology
Benson A
(2014)
Optimising Oxygen Uptake Kinetic Fitting Methods in Healthy Humans Ranging in Anatomical and Physiological Characteristics 366 Board #204 May 28, 11
in Medicine & Science in Sports & Exercise
Benson AP
(2013)
An algorithm to optimise fitting of phase 2 pulmonary oxygen uptake kinetics from breath-by-breath measurements
in Medicine and Science in Sport and Exercise
Benson AP
(2013)
A validated model of oxygen uptake and circulatory dynamic interactions at exercise onset in humans.
in Journal of applied physiology (Bethesda, Md. : 1985)
Benson AP
(2012)
A validated and optimised model linking muscle and pulmonary oxygen uptake kinetics
in Virtual Physiological Human Annual Conference
Benson AP
(2012)
Optimising and validating a computational model of the influence of circulatory dynamics on VO2 kinetics.
in Medicine and Science in Sport and Exercise
Bowen TS
(2013)
Slowed oxygen uptake kinetics in hypoxia correlate with the transient peak and reduced spatial distribution of absolute skeletal muscle deoxygenation.
in Experimental physiology
Bowen TS
(2012)
A dynamic overshoot in skeletal muscle deoxygenation is not evidence of a VO2 kinetic limitation
in Medicine and Science in Sport and Exercise
| Description | This project was to support a partnership between Researchers in the UK (Leeds, Liverpool) and Japan (Kobe, Hiroshima, Tskuba) to bring together international expertise in regular meetings to progress the computational modelling of systems (cardiovascular, neuromuscular, pulmonary) interactions during exercise. The team aimed to access immobile regional resources (e.g. multi-channel, time-resolved, near-infrared spectroscopy and chemical shift magnetic resonance spectroscopy) through collaboration. This aim has been very successful and has led to multiple publications, particularly using time-resolved, near-infrared spectroscopy (TRS NIRS). We have shown that TRS NIRS can be used to assess the matching of oxygen delivery to utilization in muscle at different depths and that O2 delivery limitations can lead to slowed rate of oxidative phosphorylation in muscle. Applications of this technology after the award finished have included in healthy subjects for academic research and clinical populations (in intensive care and sickle cell anaemia) The team also build sustainable long term links through exchange of young researchers (post-doctoral and post-graduate) between partner laboratories. This aim has been successful with the exchange of several UK and Japanese students between the host labs. Three of these students went on to get personal post-doctoral fellowship fuding to continue their research in other universities. The group also met an additional aim of hosted an international conference on the Systems Biology of Exercise at the University of Leeds in 2012. |
| Exploitation Route | These findings have been used to help develop projects investigating the utility of quantitative time-resolved near-infrared spectroscopy in healthy subjects, as clinical tool to monitor adequacy or perfusion in patients in intensive care, and in academic research of exercise in healthy children and in pediatric patients with sickle cell anaemia. Papers associated with this project have been cited 102 times (Scopus, accessed Feb 19, 2017). |
| Sectors | Healthcare,Leisure Activities, including Sports, Recreation and Tourism,Pharmaceuticals and Medical Biotechnology |
| Description | Collaboration with Universities of Kobe and Tokyo |
| Organisation | Kobe Design University |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | Through the international Partnering Award, the PDRA employed on this grant was able to travel to Japan for 10 days to collaborate with Kobe University and Tokyo University. The outcome of this travel and collaborative work is a new manuscript focusing on the biochemical control of muscle contraction (currently under preparation). |
| Start Year | 2012 |
| Description | Collaboration with Universities of Kobe and Tokyo |
| Organisation | University of Tokyo |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | Through the international Partnering Award, the PDRA employed on this grant was able to travel to Japan for 10 days to collaborate with Kobe University and Tokyo University. The outcome of this travel and collaborative work is a new manuscript focusing on the biochemical control of muscle contraction (currently under preparation). |
| Start Year | 2012 |
| Description | American College of Sports Medicine, South Western Chapter, Newport Beach CA, USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Undergraduate students |
| Results and Impact | Talk sparked questions and discussion None known to date |
| Year(s) Of Engagement Activity | 2014 |
| Description | American Health Journal interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | 2016, Mar 27 TV Interview with "American Health Journal" Aired on KVCR and PBS TV in Los Angeles http://www.thedoctorshow.com |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://vimeo.com/160808833 |
| Description | Mind over muscle: what limits human performance? |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | BBSRC Press release: Mind over muscle: what limits human performance? |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://bbsrc.tumblr.com/post/148686657371/mind-over-muscle-what-limits-human-performance |
| Description | National Heart & Lung Institute, Imperial College London, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Stimulated discussion and questions None to date |
| Year(s) Of Engagement Activity | 2013 |
| Description | Research visit for HBR and GJK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | HBR and GJK visited Japan for a research project and give presentations at special symposia at the Institute of Health and Sports Science, University of Tsukuba, Tsukuba, and the Faculty of Human Development, Kobe University. No actual impacts realised to date |
| Year(s) Of Engagement Activity | 2013 |
| Description | School of Gerontology, University of Southern California, Los Angeles CA, USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Sparked questions and discussion None to date |
| Year(s) Of Engagement Activity | 2013 |