Development of new analytical tools to study the physiology/pharmacology of the ageing gastrointestinal tract.
Lead Research Organisation:
University of Brighton
Department Name: Sch of Pharmacy & Biomolecular Sciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Patel N
(2017)
3D Printed Molds Encompassing Carbon Composite Electrodes To Conduct Multisite Monitoring in the Entire Colon.
in Analytical chemistry
Patel N
(2018)
Correction to 3D Printed Molds Encompassing Carbon Composite Electrodes to Conduct Multisite Monitoring in the Entire Colon.
in Analytical chemistry
Brown IA
(2016)
Enteric glia mediate neuron death in colitis through purinergic pathways that require connexin-43 and nitric oxide.
in Cellular and molecular gastroenterology and hepatology
| Description | The multi-site sensor has the ability to be used to explore the functioning of serotonin containing enterochromaffin cells along the lower bowel. Currently these methods are limited to recordings at one or two distinct sites. The ability to record from multiple sites has allowed us to map the spatial and temporal release of 5-HT from the enterochromaffin cells during studies in which muscle contractions are being simultaneously recorded, allowing the precise relationship between 5-HT release and motility can be studied in exquisite detail. |
| Exploitation Route | The multi-site sensor has the ability to be used to explore the functioning of serotonin containing enterochromaffin cells along the lower bowel. This could be used by academics or members of the pharmaceutical industry or healthcare professions to explore how drug treatment is able to modulate 5-HT release and how these changes impact on lower bowel motility. |
| Sectors | Healthcare,Pharmaceuticals and Medical Biotechnology |
| URL | https://www.brighton.ac.uk/strand/what-we-do/research-projects/effects-of-age-on-signalling-and-function-in-the-lower-bowel.aspx |
| Title | Enterochromaffin isolation from murine colon |
| Description | Isolation and characterization of murine enterochromaffin cells from the colon |
| Type Of Material | Biological samples |
| Provided To Others? | No |
| Impact | None currently |
| Title | Multi-sensor array for monitoring 5-HT release from colonic mucosa |
| Description | Multi-sensor array for monitoring 5-HT release from colonic mucosa |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | None currently |
| Description | Development of novel tools to study the physiology and pharmacology of the ageing gastrointestinal tract |
| Organisation | Michigan State University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | BBSRC ISIS award (BB/IO25409/1) |
| Start Year | 2011 |
| Description | STEM Sussex event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | We have a stand booked at STEM Sussex, Crawley for the 6th July to disseminate some of our findings on the ageing bowel to an audience of school, children aged 7-11 years old. This is a one day event designed to familiarise school children with the workings of the GI tract and the effects that age has on the function of the GI tract Large model of GI tract that school children can walk though and examine. Lab test to look at taste and how taste regulates physiological functions. No recordable impacts |
| Year(s) Of Engagement Activity | 2012 |
| Description | STEM Sussex event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Workshop highlighting the role played by the senses in nutrition and the function of the gastrointestinal tract and how it changes with age |
| Year(s) Of Engagement Activity | 2014 |
| Description | STEM Sussex event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Stimulated thought and increased knowledge in a group of school children aged 11-19 years ol Stand was one of the most highly rated by the students in the show. Interactive and engaging. |
| Year(s) Of Engagement Activity | 2013 |
| Description | STEM Sussex event at the South of England show ground |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Demonstration and participation in events stimulated lots of talk with the school children about their aims and aspirations and potential future ewmployment Stand was voted the best in show and we have been asked to return next year, with a bigger interactive stand |
| Year(s) Of Engagement Activity | 2014 |