Developing a network model of caloric restriction in the mouse
Lead Research Organisation:
University of Aberdeen
Department Name: Inst of Biological and Environmental Sci
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Lusseau D
(2015)
The effects of graded levels of calorie restriction: IV. Non-linear change in behavioural phenotype of mice in response to short-term calorie restriction.
in Scientific reports
Speakman JR
(2016)
Calories or protein? The effect of dietary restriction on lifespan in rodents is explained by calories alone.
in Experimental gerontology
Vaanholt LM
(2016)
Partitioning the variance in calorie restriction-induced weight and fat loss in outbred mice.
in Obesity (Silver Spring, Md.)
Speakman JR
(2016)
Using doubly-labelled water to measure free-living energy expenditure: Some old things to remember and some new things to consider.
in Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
| Description | This work is ongoing. The aim is to integrate large datasets to develop a network model of the impact of caloric restriction. |
| Exploitation Route | Once the model is developed it will be valuable to evaluate the efficacy of CR mimetic pharmaceuticals |
| Sectors | Healthcare,Pharmaceuticals and Medical Biotechnology |
| Description | Do hunger neuropeptides mediate the link between caloric restriction and lifespan extension? |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | China partnering workshop, Beijing, China, Sept 2012 no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2012 |
| Description | John Speakman Calorie restriction Society Conference (Tuscan, Arizona) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | presentation entitled "Is the Effect of Dietary Restriction Due to Calorie Restriction or Protein Restriction?". The meeting was organised by CR Society members. The key aim was to interact directly with scientists and fellow practitioners about how to optimise the practice of calorie restriction. A number of key researchers in the fields of CR, metabolism, and the retardation of aging presented. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.crsociety.org/conferences/cr_009a |
| Description | John Speakman Participation in workshop organised by Royal Society of Edinburgh |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Participation in workshop organised by Royal society of Edinburgh 9th Feb 2018, held at Royal Botanic Gardens. Scoping out the Future of UK Science activity. |
| Year(s) Of Engagement Activity | 2018 |
| Description | John Speakman Talk at the University of Wageningen, Netherlands "Calorie Restriction: does eating fewer calories lead to a longer life?" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Undergraduate students |
| Results and Impact | Invited talk at the University of Wageningen, Netherlands on Calorie Restriction: does eating fewer calories lead to a longer life? |
| Year(s) Of Engagement Activity | 2011,2018 |
| Description | John Speakman ACSM Conference on Integrative Physiology of Exercise |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | John Speakman gave an invited talk on the " Interactions between calorie restriction and physical activity" to the American College of Sports Medicine (ACSM) Conference on Integrative Physiology of Exercise, San Diego, Sept 2018 |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.emedevents.com/c/medical-conferences-2018/acsm-conference-on-integrative-physiology-of-e... |
| Description | John Speakman Chaired and spoke at World Economic Forum, Tianjin, People's Republic of China |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | John Speakman attended the World Economic forum summer meeting in Tianjin, China as a representative of the Royal Society. Chaired and spoke at a workshop meeting on Ethics of Research, Sept 2018 |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.weforum.org/events/annual-meeting-of-the-new-champions/programme |
| Description | John Speakman IAEA Dec 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | John Speakman invited talk "Physical activity and weight regulation". International Symposium on Understanding the Double Burden of Malnutrition for Effective Interventions, international Atomic Energy Agency, Vienna Dec 2018 |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.iaea.org/newscenter/news/toward-a-healthier-future-iaea-symposium-on-the-double-burden-o... |
| Description | John Speakman Invited lenary address at LipidALL meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The LipidALL International Conference on Lipid Metabolism was founded by the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and the Lipid Metabolism Conference organized by the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences. It is currently a major influence in the field of lipid metabolism science in China. John Speakman was invited to give a plenary address " Metabolomics signatures of caloric restriction: a multi-tissue perspective" Beijing Nov 2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | John Speakman Invited presentation on energy balance. Amway company, Shanghai, China |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | John Speakman invited to give a presentation on energy balance to Amway company, Shanghai, China, Nov 2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | John Speakman Invited talk University of Leeds, Feb 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | John Speakman Invited seminar presentation "Why do we get fat?" University of Leeds UK, Feb 2018 |
| Year(s) Of Engagement Activity | 2019 |
| Description | John Speakman Invited talk University of Reading. UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | John Speakman invited talk to evolutionary medicine students, University of Aberdeen, "The evolution of Obesity" Feb 2019 |
| Year(s) Of Engagement Activity | 2019 |
| Description | John Speakman Royal Academy of the Netherlands conference on Energy Balance |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | John Speakman inited to talk on Calorie Restriction at the Royal Academy of the Netherlands conference on Energy Balance, Oct 2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | John Speakman School of Biological Sciences Research Seminar Series 2019 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | John Speakman invited speaker at School of Biological Sciences Research Seminar Series 2019. "Pandas and Pikas- Studies of Energy Balance in some Enigmatic Chinese Mammals" Feb 2019 |
| Year(s) Of Engagement Activity | 2019 |
| Description | John Speakman Talk European Congress of Obesity, Vienna |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk given "Macronutrients, fast food and regulation of body weight" EASO Vienna, May 2018 |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://eco2018.easo.org/ |
| Description | John Speakman Talk at International Conference on Obesity and Cardiovascular Diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk on Body weight regulation at the International Conference on Obesity and Cardiovascular Diseases, Copenhagen June 2019 |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://waset.org/conference/2018/06/copenhagen/ICOCD |
| Description | John Speakman Talk at keystone meeting in Hannover, Germany - Pushing the Limits of Healthspan and Longevity |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | This conference addresses factors that may contribute to healthier lifestyles and outcomes, thereby delaying the onset of age-associated diseases and extending longevity. The focus is to highlight cutting-edge advances in aging research, novel technologies and potential therapeutic interventions. The conference will focus on topics not covered at previous Keystone Symposia meetings on aging biology and will specifically examine both the fundamental mechanisms involved in the aging process as well as interventions and potential therapeutics that may delay aging and the onset of age-associated diseases to forge a deeper understanding of the complex, multifactorial aging process. The discussions of novel interventions and/or therapeutics that appear to slow aging processes will, in turn, guide the field toward facilitating extended periods of good health and prolonging lifespan in humans |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.keystonesymposia.org/18D3 |
| Description | John Speakman invited presentation at Novo-Nordisk forum meeting, Copenhagen 2018 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | John Speakman "invited presentation on 'The Regulation of Body Weight' at the Novo-Nordisk forum meeting, Copenhagen 6th Dec 2018. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Jojn Speakman Invited talk at the General Assembly of the Alliance of International Science organisations (ANSO) Belt and Road conference |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | The General Assembly of the Alliance of International Science organisations (ANSO) Belt and Road conference, Beijing, China 4th Nov 2018. John Speakman invited to talk, International liaison with the University of Aberdeen The Declaration is committed to establish an official governing body with legal independence to promote cooperation of science, technology and innovation in the Belt and Road regions. Policy makers, scientist, public health experts will share their knowledge and experience in cutting-edge research and innovation, in working with local authorities to implement policies and promoting education and training. |
| Year(s) Of Engagement Activity | 2018 |