China partnering: exploiting actinobacteria from extreme environments
Lead Research Organisation:
Swansea University
Department Name: Institute of Life Science Medical School
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Chen X
(2022)
A new bacterial tRNA enhances antibiotic production in Streptomyces by circumventing inefficient wobble base-pairing.
in Nucleic acids research
Zhang B
(2020)
Microbial mercury methylation profile in terminus of a high-elevation glacier on the northern boundary of the Tibetan Plateau.
in The Science of the total environment
Zhang B
(2019)
Variation in Actinobacterial Community Composition and Potential Function in Different Soil Ecosystems Belonging to the Arid Heihe River Basin of Northwest China.
in Frontiers in microbiology
Zhang B
(2019)
Streptomyces dangxiongensis sp. nov., isolated from soil of Qinghai-Tibet Plateau.
in International journal of systematic and evolutionary microbiology
Zhang B
(2018)
Streptomyces qaidamensis sp. nov., isolated from sand in the Qaidam Basin, China
in The Journal of Antibiotics
Chen X
(2017)
A trehalose biosynthetic enzyme doubles as an osmotic stress sensor to regulate bacterial morphogenesis.
in PLoS genetics
Zhang B
(2016)
Diversity and Succession of Actinobacteria in the Forelands of the Tianshan Glacier, China
in Geomicrobiology Journal
Zhang H
(2016)
Complete genome sequence of a psychotrophic Pseudarthrobacter sulfonivorans strain Ar51 (CGMCC 4.7316), a novel crude oil and multi benzene compounds degradation strain.
in Journal of biotechnology
Zhang B
(2016)
Streptomyces lacrimifluminis sp. nov., a novel actinobacterium that produces antibacterial compounds, isolated from soil.
in International journal of systematic and evolutionary microbiology
| Description | Several new antibiotic-producing soil bacteria have been isolated from extreme environments in NW China. Antibiotics are currently being purified for structural and activity analyses. |
| Exploitation Route | Any novel antibiotics with promising activities could be taken further by the pharmaceutical industry for eventual medical use. |
| Sectors | Pharmaceuticals and Medical Biotechnology |
| Description | Swansea-Lanzhou research collaboration |
| Organisation | Chinese Academy of Sciences |
| Department | Northwest Institute of Eco-Environment and Resources |
| Country | China |
| Sector | Academic/University |
| PI Contribution | Following the end of the China partnering award, the research collaboration has continued. Prof Dyson visited Lanzhou in spring 2017 to write a paper that was submitted and accepted for publication by PLoS Genetics. Additional collaborative research is currently underway. |
| Collaborator Contribution | They contributed the lab-based research and funding. |
| Impact | See list of publications. |
| Start Year | 2014 |
| Description | Antimicrobial resistance sandpit event, Cardiff |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk: Isolation of new antibiotic producing Streptomyces species & genetic manipulation for expression |
| Year(s) Of Engagement Activity | 2017 |