Modelling hormonal crosstalk - commonalities between bacterial and fungal resistance and susceptibility networks.
Lead Research Organisation:
University of Exeter
Department Name: Biosciences
Abstract
Australia
Publications
Thatcher LF
(2016)
Characterization of a JAZ7 activation-tagged Arabidopsis mutant with increased susceptibility to the fungal pathogen Fusarium oxysporum.
in Journal of experimental botany
Grant MR
(2013)
Exploiting pathogens' tricks of the trade for engineering of plant disease resistance: challenges and opportunities.
in Microbial biotechnology
Perkins LE
(2013)
Generalist insects behave in a jasmonate-dependent manner on their host plants, leaving induced areas quickly and staying longer on distant parts.
in Proceedings. Biological sciences
| Description | A role for a jasmonic acid repressor, JAZ7, in resistance to the wheat patohgen Fusarium. |
| Exploitation Route | CSIRO are following up the JAZ7 story to understand the underlying mechanisms. New publication now out - added above |
| Sectors | Agriculture, Food and Drink |
| Description | Understanding the mechanism of chloroplast immunity |
| Amount | £510,096 (GBP) |
| Funding ID | BB/P002560/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 03/2020 |
| Title | JAZ mRNAseq data |
| Description | mRNA-seq of JAZ5/10 mutant plants responding to Pseudomonas infection |
| Type Of Material | Database/Collection of data |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | First mRNA-seq of a double jaz mutant. First molecular insight into a virulence phenotype of jaz mutants. |
| URL | http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE72461 |
| Title | Pseudomonas- Arabidopsis time series microarray data |
| Description | Large scale time series microarray data capturing the plant defence response and the pathogen virulence strategy over 13 time-points using two-colour microarrays. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | Strong interest from the wider community - resulted in a number of imvitations to speak. However, most importantly was the basis for two key pieces of work. The disucovery that jasmonate signalling, contrary to the current dogma that it functioned early in plant-bacterial interactions, was a late response and the pathogenic outcome was dictated by ABA, with the JAZ repressors protecting the plant during early infection. Secondly, analyses of these data led to the discovery of chloroplast immunity. |
| URL | http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE56094 |
| Description | Structural elucidation |
| Organisation | University of Queensland |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | The travel award enabled the PI to meet ad initiate a collaboration with one of the world leading structural biologists in plant defence responses - Bostjan Kobe, who is an expert in on TIR domains |
| Collaborator Contribution | We identified a novel set of effector activated genes containing TIR domains. This counter-intuitive finding led to development of a new hypothesis we have asked Prof. Kobe to collaborate on |
| Impact | While not directly related to the work undertaken on the grant, the ability to work in an environment where Prof. Kobe was, meant I was familiar with his work and was able to meet more recently to discuss the possibilities of collaboration (March 2017). The project is multidisciplinary - we are currently in the process of developing the constructs to pursue this. This collaboration would not have happened had the PI not been at CSIRO in Brisbane on BBSRC travel monies. |
| Start Year | 2017 |