FLIP: A Flexible Interchange to Explore the Regulatory Role of Heme in the Cell

Lead Research Organisation: University of Leicester
Department Name: Chemistry

Abstract

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Technical Summary

This was not requested on FLIP application form.

Planned Impact

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Publications

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Basran J (2016) Analysis of Reaction Intermediates in Tryptophan 2,3-Dioxygenase: A Comparison with Indoleamine 2,3-Dioxygenase. in Biochemistry

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Booth ES (2015) Substrate Oxidation by Indoleamine 2,3-Dioxygenase: EVIDENCE FOR A COMMON REACTION MECHANISM. in The Journal of biological chemistry

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Burton MJ (2016) A heme-binding domain controls regulation of ATP-dependent potassium channels. in Proceedings of the National Academy of Sciences of the United States of America

 
Description We carried out extensive bioinformatics work, some of which we have published (Burton et al, PNAS, 2016, 113, 3785).
Exploitation Route Understanding ion channels
Sectors Pharmaceuticals and Medical Biotechnology
URL http://www.pnas.org/content/113/14/3785.abstract