Exploiting microbial genomics and synthetic biology for discovery of novel antibiotics
Lead Research Organisation:
University of Warwick
Department Name: Chemistry
Abstract
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Publications
Sidda J
(2016)
Overproduction and identification of butyrolactones SCB1-8 in the antibiotic production superhost Streptomyces M1152
in Organic & Biomolecular Chemistry
Rutledge P
(2015)
Discovery of microbial natural products by activation of silent biosynthetic gene clusters
in Nature Reviews Microbiology
Wang W
(2016)
Development of a Synthetic Oxytetracycline-Inducible Expression System for Streptomycetes Using de Novo Characterized Genetic Parts.
in ACS synthetic biology
| Description | We have discovered novel natural products from Streptomyces species and developed novel synthetic biology tools for use in this genus |
| Exploitation Route | The novel natural products can be screened for biological activity. This may result in the discovery of novel leads for antibiotics, anticancer agents or agrochemicals. The novel synthetic biology tools can be used by others to refactor biosynthetic pathways and create novel gene expression systems. |
| Sectors | Agriculture, Food and Drink,Chemicals,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| Description | We have sent some of the compounds we have discovered to Syngenta for biological testing |
| First Year Of Impact | 2015 |
| Sector | Agriculture, Food and Drink |