Combing biophysical and 'omics methods for understanding the basis of blood clotting and haemostasis, and how to modify it
Lead Research Organisation:
University of Manchester
Department Name: Chemistry
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Kell DB
(2016)
A Dormant Microbial Component in the Development of Preeclampsia.
in Frontiers in medicine
Kell DB
(2018)
No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases.
in Biological reviews of the Cambridge Philosophical Society
Kell DB
(2022)
A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications.
in The Biochemical journal
Kenny LC
(2017)
Immunological Tolerance, Pregnancy, and Preeclampsia: The Roles of Semen Microbes and the Father.
in Frontiers in medicine
Koperdanova M
(2015)
Interpreting raised serum ferritin levels.
in BMJ (Clinical research ed.)
Laubscher GJ
(2021)
TEG®, Microclot and Platelet Mapping for Guiding Early Management of Severe COVID-19 Coagulopathy.
in Journal of clinical medicine
Nunes JM
(2022)
The Occurrence of Hyperactivated Platelets and Fibrinaloid Microclots in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).
in Pharmaceuticals (Basel, Switzerland)
Olsen I
(2020)
Is Porphyromonas gingivalis involved in Parkinson's disease?
in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Page MJ
(2019)
Serum amyloid A binds to fibrin(ogen), promoting fibrin amyloid formation.
in Scientific reports
Description | Discovery of amyloid formation by clotting blood. Absolutely humungous discovery. Novel methods for analysing blood in control and unhealthy individuals. In particular, we discovered that blood clots into an unusual form, known as an amyloid form, and this has huge implications. |
Exploitation Route | Novel diagnostics. |
Sectors | Digital/Communication/Information Technologies (including Software),Education,Healthcare,Pharmaceuticals and Medical Biotechnology |
Description | Stellenbosch |
Organisation | University of Stellenbosch |
Country | South Africa |
Sector | Academic/University |
PI Contribution | Prof Douglas Kell appointed Extraordinary (Honorary) Professor, Department of Physiological Science, Stellenbosch University. Collaborative research in the areas of anti-microbial resistance, membrane transporters, dormant microbes as elements of supposedly non-communicable diseases, iron dysregulation, and enzyme improvement. |
Collaborator Contribution | Sharing of knowledge and analytical facilities at Stellenbosch and Liverpool. |
Impact | See publications. |
Start Year | 2017 |