Regulation of the fatty acid lipidome in ageing skin: a route towards novel anti-inflammatory products
Lead Research Organisation:
Aston University
Department Name: Sch of Life and Health Sciences
Abstract
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Technical Summary
N/A
Planned Impact
N/A
People |
ORCID iD |
| Helen Griffiths (Principal Investigator) |
Publications
Griffiths HR
(2017)
Redox regulation in metabolic programming and inflammation.
in Redox biology
Pararasa C
(2022)
Lower polyunsaturated fatty acid levels and FADS2 expression in adult compared to neonatal keratinocytes are associated with FADS2 promotor hypermethylation.
in Biochemical and biophysical research communications
| Description | We have developed methods that are sufficiently sensitive to characterise the regulation of the fat composition (lipid-ome) in skin cells.We have identified that a unique epigenetic signature, i.e. a mark on the DNA, is more prevalent in skin cells from older donors and can regulate the genes that control skin lipids. We have shown that the altered lipid profile in adult compared to neonatal skin cells (lower levels of n-7, n-9 and n-10 polyunsaturated fatty acids) is driving inflammatory responses from skin cells. Our discovery sheds new light onto the difference in normal skin barrier function, which depends on lipid content and secretion, between neonatal and adult skin. Further work is needed to understand whether DNA marking is reversible in adult skin cells. If the marks can be removed, this may increase the production of anti-inflammatory lipids in adult skin and improve older skin function and healing. |
| Exploitation Route | The future findings may support improved skin health care during ageing. |
| Sectors | Agriculture, Food and Drink,Healthcare,Pharmaceuticals and Medical Biotechnology |
| Description | Ageing skin |
| Organisation | Unilever |
| Department | Unilever Research and Development Vlaardingen B.V. |
| Country | Netherlands |
| Sector | Private |
| PI Contribution | Aston has contributed methods on fatty acid analysis |
| Collaborator Contribution | Unilever has contributed methods on skin culture |
| Impact | C. Pararasa, D.J. Messenger, K.E. Barrett, D. Hyliands, D. Talbot, M.I. Fowler, T. Kawatra, D.A. Gunn, F.L. Lim, L.J. Wainwright, G. Jenkins, H.R. Griffiths, Lower polyunsaturated fatty acid levels and FADS2 expression in adult compared to neonatal keratinocytes are associated with FADS2 promotor hypermethylation, Biochemical and Biophysical Research Communications, Volume 601, 2022, Pages 9-15, ISSN 0006-291X, https://doi.org/10.1016/j.bbrc.2022.02.055. |
| Start Year | 2014 |
| Description | Heartlands Foundation Trust presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | 20 staff attended to continuing professional development about lipids during ageing. The visit sparked additional conversations about a new NIHR research grant.The stakeholders were also able to provide new contacts into primary care. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Talk and poster presentations |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Poster presentation prize winner, British Society for REsearch on Ageing, Chathyan Pararsa Prize winner 2015, UCL London, UK |
| Year(s) Of Engagement Activity | 2015 |
| URL | https://www.ucl.ac.uk/iha/iha-news/iha_hosts_bsra_annual_meeting |