Skeletal stem cell based tissue engineering
Lead Research Organisation:
University of Southampton
Department Name: Development Origin of Health and Disease
Abstract
AUSTRALIA
People |
ORCID iD |
| Richard Oreffo (Principal Investigator) |
Publications
Black CR
(2015)
Bone Tissue Engineering.
in Current molecular biology reports
Vaezi M
(2016)
Characterization of New PEEK/HA Composites with 3D HA Network Fabricated by Extrusion Freeforming.
in Molecules (Basel, Switzerland)
| Title | Augmented Reality Apps on Smartphone |
| Description | Augmented Reality apps for smartphone showing internal bone structure of mouse and bone defect models |
| Type Of Art | Artwork |
| Year Produced | 2018 |
| Impact | The apps enable participants to move around the objects in real time and get a 3D visualisation of the object. |
| Description | Developed an appreciation of requirements for translation and limitations in translation of large anima regenerative medicine orthopaedic translational research in Regenerative Medicine |
| Exploitation Route | Development of strategies to evaluate developments in Regenerative Medicine |
| Sectors | Healthcare,Pharmaceuticals and Medical Biotechnology |
| Description | New approaches to disseminate research approaches in orthopaedics to audiences from school children to ECRs to scientific colleagues. Work has informed Speaker 4 Schools activity over the last eight years. |
| First Year Of Impact | 2015 |
| Sector | Healthcare |
| Impact Types | Societal |
| Description | Angiogeneisis - Vasculature development- collaboration |
| Organisation | Ludwig Boltzmann Society |
| Department | Ludwig Boltzmann Institute for Experimental and Clinical Traumatology |
| Country | Austria |
| Sector | Academic/University |
| PI Contribution | Development of new ex vivo approaches to angiogenesis and vascular development - specifically chorioallantoic membrane models - Development in partnership of a new decellularised scaffold matrix approach evaluation for skeletal tissue engineering. |
| Collaborator Contribution | Innovative vascular scaffolds - using placental tissue (Human) |
| Impact | Publications and joint grant applications |
| Start Year | 2015 |
| Description | QUT Collaboration |
| Organisation | Queensland University of Technology (QUT) |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Development of skeletal cell biology culture in sheep and development of orthopaedic large animal bone research |
| Collaborator Contribution | Training of PhD candidate Dr Cameron Black, over 12 months, in 2 separate visits to develop skills in orthopaedic large animal bone research together with a full research study programme using a segmental and condyle in vivo models |
| Impact | Joint research is currently being written up for publication |
| Start Year | 2014 |
| Description | Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | 6-11 June - The Stem Cell featured at the festival and the team interacted with an estimated 1800 visitors - led to student interest in visiting our group. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Cheltenham Science Festival - Central Exhibit in Discover Zone |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | The Stem Cell Mountain featured in 'Doc Brown's Lab' (in keeping with the 2015 Back to the Future Theme) at the famous Cheltenham Science Festival Discover Zone. The team interacted with an estimated 1800 visitors over 6 days. Received feedback such as the following: "Great explanation from volunteers about the stem cell model. My Year 6 pupils could then explain the purpose of the model - great" and "That's how you teach science!" |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.cheltenhamfestivals.com/science/ |
| Description | Invited Presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Over 125 people attended a workshop on "Safety and Stem Cell-Derived Cell Replacement Therapies' on 7th/8th October 2019 in Edinburgh, which raised a number of issues and approaches aorund the safety and application of stem cell derived cell therapies. The workshop provided a forum to discuss the safety around cell therapies. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Keynote speaker at symposium in Spain |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Keynote talk "New approaches to skeletal cell based bone regeneration: repair, restore and recreate" to an audience of people working in Biomedical Institutes in Coruña and Santiago and students (Biology, Medicine and Masters students). |
| Year(s) Of Engagement Activity | 2019 |
| Description | Open Conference "Stem cells for bone regeneration: state-of-the-art research and solutions" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Speaker - Bonebank Conference, Odense, Denmark. "Skeletal stem cells for bone tissue regeneration.". The audience were peer scientists, clinicians and industrialist to inform, educate and debate developments in translational bone research. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Scaffolds and cells - making replacement body parts in the lab - Exhibit at the BBSRC Great British Bioscience Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Engaged over 6500 visitors from across the UK as part of the BBSRC run GBBF. EPSRC grant generated the centre piece of our exhibit - the Stem cell mountain - a large interactive pinball machine built in collaboration with Winchester Science Centre to communicate the concept of Stem Cell Potential. In response to the feedback question 'Tell us something from your visit that you found particularly interesting' the answer 'Stem Cells' was one of the most frequently given. Through a conversation at this exhibition a talented international MSc student from Queen Mary's was inspired to commence a PhD project (self-funded) in my group. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Speaker at UKRMP Conference UK |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Speaker - Inaugural UK Regenerative Medicine Conference, London. "Size matters - Harnessing biomimetic materials for skeletal tissue engineering." The audience were peer scientists, clinicians and industrialist to inform, educate and debate developments in translational bone research. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Speaker for Schools talk at Testwood College |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | 19th October 2017: Talk to Year 9 and 10 students at Testwood Sports College |
| Year(s) Of Engagement Activity | 2017 |
| Description | Stem Cell Mountain at Bestival Music Festival Science Tent |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Stem Cell Mountain at the Bestival Music Festival Science Tent (4 days) - exhibit in shared Science Tent, mixed Festival audience (mainly general public and especially young people 17-25) Measure 1: visitors passing stand; 1400 per day = 5600 Measure 2: visitors interacting with researchers on stand; 500 per day = 2000 Particularly notable was the impact of this activity on the researchers themselves and how they viewed the importance of their own research. For example one researcher reported: "This festival was great to see how amazed people are about the potential of stem cells" |
| Year(s) Of Engagement Activity | 2015 |
| Description | Stem Cell Mountain at the Glastonbury Music Festival Science Tent |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Stem Cell Mountain exhibit in shared Science Tent, mixed Festival audience (academics, post-docs, science specialists, general public, families and young people) Measure 1: visitors passing stand; 1100 per day = 5500 Measure 2: visitors interacting with researchers on stand; 500 per day = 2500 Engaged classically hard to reached audience. Quote: "I was considering doing a PhD at one point - I didn't think I'd reconsider it here" |
| Year(s) Of Engagement Activity | 2015 |
| Description | Stem Cell Mountain on Tour - Overview |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The EPSRC funded Stem Cell Mountain Roadshow Exhibit combines the fun of a pin ball machine with a profound metaphor for a key biological concept. The stem cell mountain was designed in collaboration with Winchester Science Centre to bring to life the complex idea of stem cell potential. The exhibit has engaged festival goers at Glastonbury and Bestival, science aficionados at the UK's top Science Festivals, as well as the 100000 visitors per year that visit the Winchester Science Centre where a replica is full time resident (see individual entries for numbers at each event) Qualitative feedback on Stem Cell Mountain from the public: "This model illustrates stem cell science brilliantly, and it's fun too" "The stem cell machine was so brilliant - it really helped to explain how the body works in such an interactive and easy way" "Helpful, informative team of staff on hand" "Interesting to learn why stem cell research is so controversial" "Great explanation from volunteers about the stem cell model. My Year 6 pupils could then explain the purpose of the model - great" "That's how you teach science!" "It's great to see this activity is in the busiest tent in the field" "I'm glad we saw this - it makes a difference" "That's amazing - a really great way to show stem cell analysis" "I was considering doing a PhD at one point - I didn't think I'd reconsider it here" "The stem cell mountain - thank you for having this idea. It's such a clever way to explain the concept" "Such a simple way to represent a very complicated thing" "We need science like this in school. It's so much more interesting" Qualitative feedback from the Stem Cell Mountain team of researchers: "One of the amazing perks that come with researching! Great day, talked to many interesting people from various backgrounds and ages (from 5yr olds to 70 year old ex-specialists in the area). Very good and helpful for both the people that we talk to and for us as researchers" "It made me think my research matters" "It helps you to step back and see the amazing things you get to study in university with fresh eyes" "People were really interested in what are doing in our research" "It is a great opportunity to leave the academic bubble and a useful and interesting attempt to explain science research to a wide audience. The best thing is seeing people's reactions when everything clicks and makes sense to them!" "The stem cell mountain is very impressive. Proud to represent" "This festival was great to see how amazed people are about the potential of stem cells" " A brilliant way to inform the public about the work we do" " A pleasure to meet and collaborate with the range and depth of skills and knowledge in our roving science tent" "I was blown away by the strength, diversity and great nature of the team" "I've really enjoyed manning the stem cell volcano - my first experience of the exhibit. I'd quite like one in my living room!" "It's good to see so many people interested in stem cell research" |
| Year(s) Of Engagement Activity | 2014,2015,2016 |
| Description | Stem Cell Outreach Programme ( New Forest Country Show) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | 25 - 27 July 2017 - Stem Cell Mountain outreach programme at the New Forest Country Show (general public, farmers, agricultural community) - led ot interest by students to visit our laboratories |
| Year(s) Of Engagement Activity | 2017 |
| Description | Thomas Hardye School Science Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | A Dorset secondary school open day engaging 300 students with translational stem cell medicine. First experience of public engagement for several colleagues who reported great satisfaction with the experience. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.southampton.ac.uk/per/university/roadshow.page |
| Description | Winchester Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | 29 - 30 July 2017 - Stem Cell Mountain at a three day festival. Engaged largely with family audience and science festival talk attendees - led ot gernerla interest in our basic research programmes |
| Year(s) Of Engagement Activity | 2017 |