ProxiMAX 2: Investigating the market for multiple, unnatural amino acids in saturation mutagenesis.
Lead Research Organisation:
Aston University
Department Name: Sch of Life and Health Sciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
People |
ORCID iD |
| Anna Hine (Principal Investigator) |
Publications
Ferreira Amaral MM
(2017)
Beyond the Natural Proteome: Nondegenerate Saturation Mutagenesis-Methodologies and Advantages.
in Methods in enzymology
Amaral Marta M. Ferreira
(2018)
Aminoacyl-Trna Synthetases: Investigations of Specificity for Application in Proximax/Synthetic Biology
in PROTEIN SCIENCE
| Description | The award primarily covered market research, which has successfully established that there is a definite market for the science that we wish to develop. The award also provided minor funding towards key scientific milestones. 3 out of the 4 such objectives were achieved within the award and the 4th firstly via my innovator of the year award and more recently as part of the PhD research conducted by Dr Marta Ferreira Amaral. Unfortunately, a robust solution to objective 4 remains elusive, despite many approaches both from literature precedent and our own novel approaches. |
| Exploitation Route | SInce we have been unable to create a robust and straightforward method to analyse synthetic aminoacylation, it is unlikely that we will be pursuing the award further. Findings have been distributed for use by others via conference posters and Dr Ferreira Amaral's PhD thesis, which will be published via the British Library EThOS system in due course. |
| Sectors | Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| Description | I was invited to speak in non-confidential terms about my work at the BBSRC headquarters at the BBSRC quarterly meeting. We will need development funding before more substantive impact can be achieved. Current work on the related studentship is promising. Likewise the feedback on commercial interest from the current study was promising. I anticipate application for further funding (possibly follow-on-fund) towards the end of the studentship. Update: The studentship was completed recently and although an excellent thesis, unfortunately the work therein confirmed that this process is currently far too complex for scale-up / commercial viability. |
| First Year Of Impact | 2015 |
| Sector | Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| Description | Multiple poster presentations (France, UK, USA) on engineering aminoacyl synthetases |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Presentation of results in the field of this grant. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Service on multiple BBSRC panels concerning impact and innovation. |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Third sector organisations |
| Results and Impact | I serve / have served on the BBSRC Follow-on-fund panel, the BBSRC Excellence with Impact panel and the BBSRC Impact Acceleration Account panel. |
| Year(s) Of Engagement Activity | 2016,2017,2018 |