China Partnering Award: Nutrition, the ageing lipidome and mitochondrial dysfunction
Lead Research Organisation:
University of Surrey
Department Name: Faculty of Health and Medical Sciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
| Helen Griffiths (Principal Investigator) |
Publications
Gao D
(2020)
SOD3 Is Secreted by Adipocytes and Mitigates High-Fat Diet-Induced Obesity, Inflammation, and Insulin Resistance.
in Antioxidants & redox signaling
Borah K
(2020)
A quantitative LC-MS/MS method for analysis of mitochondrial -specific oxysterol metabolism.
in Redox biology
Griffiths HR
(2017)
Redox regulation in metabolic programming and inflammation.
in Redox biology
Ampong I
(2022)
Odd chain fatty acid metabolism in mice after a high fat diet.
in The international journal of biochemistry & cell biology
| Description | please see version 1 of this grant. We aimed to understand how the way that cells use fat when dietary nutrient intake is not balanced. We focused our attention on how liver and adipose tissue fat metabolism changes. We identified that both organs change their secretory behaviour to exert distant effects on other organs. We found for the first time that adipose tissue secretes an enzymes known as superoxide dismutase 3 after a high fat diet and that liver cell reduce the secretion of beneficial fats. Finally, we showed that when dietary nutrient intake is not balanced, the gut microbiome becomes less diverse. The gut microbiota are less able to produce metabolically protective fats after a high fat diet. |
| Exploitation Route | please see version 1 of this grant there are two new angles to this work. the first lies in the targeting of gut microbiota to improve hepatic mitochondrial function and a paper is in preparation to describe our findings. we anticipate that a future intervention study may be developed to investigate this hypothesis. the second outcome has been realised into new funding through Neutrocure which involves targeting mitochondrial reactive oxygen species metabolism to generate oxylipids and modulate inflammation. |
| Sectors | Agriculture, Food and Drink,Healthcare,Pharmaceuticals and Medical Biotechnology |
| Description | please see version 1 of this grant report on research fish Through the InClusilver project, I have been in close contact with SMEs and in January 2020, I presented to 30 SMEs in Aarhuus on nutrient imbalance in older adults on health outcomes and the the impact of dietary nutrient imbalance on gut microbiota. In 2020, I was invited to present the findings in a workshop for dietitians and nurses. |
| First Year Of Impact | 2020 |
| Sector | Agriculture, Food and Drink |
| Impact Types | Societal,Economic |
| Description | Neutrocure |
| Amount | £420,000 (GBP) |
| Funding ID | FETOPEN-01-2018-2019-2020 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 01/2020 |
| End | 12/2024 |
| Description | Visiting position, Xi'an Jao Tong University |
| Organisation | Xi'an Jiaotong University |
| Country | China |
| Sector | Academic/University |
| PI Contribution | Several outgoing visits were made by me and my team to XJTU. During visits, we contributed to research programme development, gave lectures/seminars and supported sample collection. We have collaborated on one primary publication and one review article to date. One further primary publication and another review are in preparation. One PhD student who was involved in the collaboration has submitted his PhD and has been appointed as a post-doctoral researcher in Wake Forest, USA. |
| Collaborator Contribution | Dr Gao has been exploring the effect of lipids on metabolism in vivo and contributes preclinical and molecular expertise to the partnership. She actively supported the training of a PhD student who as now completed his PhD successfully. |
| Impact | 1: Gao D, Hu S, Zheng X, Lin W, Gao J, Chang K, Zhao D, Wang X, Zhou J, Lu S, Griffiths HR, Liu J. SOD3 Is Secreted by Adipocytes and Mitigates High-Fat Diet-Induced Obesity, Inflammation, and Insulin Resistance. Antioxid Redox Signal. 2020 Jan 20;32(3):193-212. doi: 10.1089/ars.2018.7628. PubMed PMID: 31680537. 2: Griffiths HR, Gao D, Pararasa C. Redox regulation in metabolic programming and inflammation. Redox Biol. 2017 Aug;12:50-57. doi: 10.1016/j.redox.2017.01.023. Epub 2017 Feb 12. Review. PubMed PMID: 28212523; PubMed Central PMCID: PMC5312548. 3: Russell WR, Baka A, Björck I, Delzenne N, Gao D, Griffiths HR, Hadjilucas E, Juvonen K, Lahtinen S, Lansink M, Loon LV, Mykkänen H, Östman E, Riccardi G, Vinoy S, Weickert MO. Impact of Diet Composition on Blood Glucose Regulation. Crit Rev Food Sci Nutr. 2016;56(4):541-90. doi: 10.1080/10408398.2013.792772. Review. PubMed PMID: 24219323. |
| Start Year | 2016 |
| Description | A talk at the InClusilver final event, hosted by the Danish Food Cluster |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | The INCluSilver final event - a showcase of innovative start-ups and SMEs from all over Europe with presentations by leading keynote speakers was held in Aarhus, Denmark on January 21-23. At the conference the participants got keen insights into the nutritional challenges for older adults and how companies and knowledge institutions are working together to find solutions. At the conference, the participants were also introduced to new opportunities from the EU's Horizon Europe program. This event was aimed at startups, SMEs and large corporates from all over Europe with an interest in nutrition for the growing silver economy. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.inclusilver.eu/innovation-conference-2020/ |
| Description | Dissemination Event on New knowledge for improving elderly nutrition |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | This presentation request followed on from the Inclusilver symposium in Aarhus on "New knowledge and emerging opportunities for improving elderly nutrition". I was invited to give a lecture for a dedicated group of Health Care Professionals working within the area of disease related malnutrition (primarily dietitians and nurses). the original plan was for an in person symposium but this was instead delivered over zoom. This sparked questions and discussion after and the organisers ran the session again. |
| Year(s) Of Engagement Activity | 2020 |
| Description | GRC Il Ciocca - Gordon conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | the purpose of this debate was to discuss career development, particularly for women in science. |
| Year(s) Of Engagement Activity | 2017 |