Validation of genome edited disease resistant pigs
Lead Research Organisation:
University of Edinburgh
Department Name: The Roslin Institute
Abstract
Infectious disease is the biggest threat to animal protein food security in the 21st century. As production intensifies the livestock industry becomes more vulnerable to devastating disease outbreaks potentially affecting millions of animals. In this project, we target porcine viral diseases for which no effective vaccination or other mitigating strategy is available. We are using state-of-the-art genome editing technology in pigs to produce various alleles of an important immune modulator (RELA) which we hypothesise could improve the resistance/resilience of such pigs to three specific viruses - ASFV, SIV and PRRSV. This project will enable us to validate if any of these alleles confer improved viral resistance/resilience through disease challenge experiments.
Technical Summary
Infectious disease is the biggest threat to animal protein food security in the 21st century. As production intensifies the livestock industry becomes more vulnerable to devastating disease outbreaks potentially affecting millions of animals. In this project, we target porcine viral diseases for which no effective vaccination or other mitigating strategy is available.
Our previous research has identified genetic variation in RELA as potentially underlying the dramatic difference in host response to ASFV that is seen in pigs. RELA encodes the p65 component of the NFkB immune regulatory transcription factor. Using state-of-the-art genome editing technology we are producing various RELA alleles which we hypothesise could improve the resistance/resilience of such pigs to ASFV. Given the role of NFkB we further hypothesise that these RELA alleles may alter how pigs respond to other viruses, e.g. SIV and PRRSV. All three viruses were selected given the impact they pose to the pig breeding and the zoonotic nature of SIV.
Genome edited RELA pigs will be breed to produce test cohorts of animals that comprise non-edited, heterozygous for a given test alleles and homozygous for this allele. These cohorts will be genotyped prior to challenge with the viruses. This project will enable us to validate if any of these novel alleles confer improved viral resistance/resilience through disease challenge experiments.
Our previous research has identified genetic variation in RELA as potentially underlying the dramatic difference in host response to ASFV that is seen in pigs. RELA encodes the p65 component of the NFkB immune regulatory transcription factor. Using state-of-the-art genome editing technology we are producing various RELA alleles which we hypothesise could improve the resistance/resilience of such pigs to ASFV. Given the role of NFkB we further hypothesise that these RELA alleles may alter how pigs respond to other viruses, e.g. SIV and PRRSV. All three viruses were selected given the impact they pose to the pig breeding and the zoonotic nature of SIV.
Genome edited RELA pigs will be breed to produce test cohorts of animals that comprise non-edited, heterozygous for a given test alleles and homozygous for this allele. These cohorts will be genotyped prior to challenge with the viruses. This project will enable us to validate if any of these novel alleles confer improved viral resistance/resilience through disease challenge experiments.
Planned Impact
Who will benefit from this research?
The potential non-academic beneficiaries of this research include pig breeding companies, pig producers and ultimately the entire chain of users of pig products, including meat packers, processors, retailers and consumers. There are also potential benefits to the animal biotechnology sector.
How will they benefit from this research?
ASFV, PRRSV and influenza are a high profile disease of pigs. In addition influenza is perhaps the most important zoonotic disease of our time. Vaccines are either not available or limited to virus strains and cannot be applied to wild animal populations. Thus, the development of novel and/or more effective strategies to control these viruses are needed and will improve the sustainability of the pig industry and potentially reduce the cost of pig products.
In the pig breeding sector the research outputs will have the potential to inform future breeding programmes. The pig breeding industry has already incorporated selection for desirable disease resistance genes into breeding programmes. To date selection for disease resistance has been limited to diseases for which susceptibility is determined by a single major gene. Moreover, breeding for disease resistance is constrained by the nature of any genetic variation in susceptibility to infection. With increasing capabilities to genetically modify farmed animals there are opportunities to engineer resistance. It is now timely to explore the opportunities for engineering pigs for enhanced resilience infection. The interaction between host (pig) and pathogen (ASFV, PRRSV, influenza) are now better understood and new genome editing technologies facilitate the necessary engineering.
In the long term this work aims to contribute to the science-based evidence relating to the use of genetically engineered animals in the food chain. As such it will contribute to the debate and practices surrounding our food chain. Public acceptance of genetically modified animals remains uncertain, especially in Europe. However, the development of non-transgenic pigs engineered for enhanced disease resistance using genome editing technology, which introduces no exogenous DNA, has the potential to re-shape the debate. Moreover, beneficial impacts could be delivered to the pig industry within 3-5 years of project completion.
The potential non-academic beneficiaries of this research include pig breeding companies, pig producers and ultimately the entire chain of users of pig products, including meat packers, processors, retailers and consumers. There are also potential benefits to the animal biotechnology sector.
How will they benefit from this research?
ASFV, PRRSV and influenza are a high profile disease of pigs. In addition influenza is perhaps the most important zoonotic disease of our time. Vaccines are either not available or limited to virus strains and cannot be applied to wild animal populations. Thus, the development of novel and/or more effective strategies to control these viruses are needed and will improve the sustainability of the pig industry and potentially reduce the cost of pig products.
In the pig breeding sector the research outputs will have the potential to inform future breeding programmes. The pig breeding industry has already incorporated selection for desirable disease resistance genes into breeding programmes. To date selection for disease resistance has been limited to diseases for which susceptibility is determined by a single major gene. Moreover, breeding for disease resistance is constrained by the nature of any genetic variation in susceptibility to infection. With increasing capabilities to genetically modify farmed animals there are opportunities to engineer resistance. It is now timely to explore the opportunities for engineering pigs for enhanced resilience infection. The interaction between host (pig) and pathogen (ASFV, PRRSV, influenza) are now better understood and new genome editing technologies facilitate the necessary engineering.
In the long term this work aims to contribute to the science-based evidence relating to the use of genetically engineered animals in the food chain. As such it will contribute to the debate and practices surrounding our food chain. Public acceptance of genetically modified animals remains uncertain, especially in Europe. However, the development of non-transgenic pigs engineered for enhanced disease resistance using genome editing technology, which introduces no exogenous DNA, has the potential to re-shape the debate. Moreover, beneficial impacts could be delivered to the pig industry within 3-5 years of project completion.
People |
ORCID iD |
| Christopher Whitelaw (Principal Investigator) |
Publications
Burkard C
(2018)
Pigs Lacking the Scavenger Receptor Cysteine-Rich Domain 5 of CD163 Are Resistant to Porcine Reproductive and Respiratory Syndrome Virus 1 Infection.
in Journal of virology
Ciccarelli M
(2020)
Donor-derived spermatogenesis following stem cell transplantation in sterile NANOS2 knockout males.
in Proceedings of the National Academy of Sciences of the United States of America
Gonen S
(2017)
Potential of gene drives with genome editing to increase genetic gain in livestock breeding programs.
in Genetics, selection, evolution : GSE
Gottardo P
(2019)
A Strategy To Exploit Surrogate Sire Technology in Livestock Breeding Programs.
in G3 (Bethesda, Md.)
He Z
(2016)
Comparison of CRISPR/Cas9 and TALENs on editing an integrated EGFP gene in the genome of HEK293FT cells.
in SpringerPlus
He Z
(2016)
Comparison of surrogate reporter systems for enrichment of cells with mutations induced by genome editors.
in Journal of biotechnology
He Z
(2015)
Highly efficient targeted chromosome deletions using CRISPR/Cas9.
in Biotechnology and bioengineering
Hickey JM
(2016)
Promotion of alleles by genome editing in livestock breeding programmes.
in Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie
Hoyos-Flight M
(2017)
Genome Editing and the Future of Farming meeting report.
in Transgenic research
Jenko J
(2015)
Potential of promotion of alleles by genome editing to improve quantitative traits in livestock breeding programs.
in Genetics, selection, evolution : GSE
Johnsson M
(2019)
Removal of alleles by genome editing (RAGE) against deleterious load.
in Genetics, selection, evolution : GSE
LILLICO S
(2020)
Livestock breeding for the 21st century: the promise of the editing revolution
in Frontiers of Agricultural Science and Engineering
Lillico SG
(2016)
Mammalian interspecies substitution of immune modulatory alleles by genome editing.
in Scientific reports
McCleary S
(2020)
Substitution of warthog NF-?B motifs into RELA of domestic pigs is not sufficient to confer resilience to African swine fever virus.
in Scientific reports
Menchaca A
(2016)
New insights and current tools for genetically engineered (GE) sheep and goats.
in Theriogenology
Montoliu L
(2018)
Unexpected mutations were expected and unrelated to CRISPR-Cas9 activity.
in Transgenic research
Park KE
(2017)
Generation of germline ablated male pigs by CRISPR/Cas9 editing of the NANOS2 gene.
in Scientific reports
Peacock TP
(2020)
Swine ANP32A Supports Avian Influenza Virus Polymerase.
in Journal of virology
Pridans C
(2016)
A Csf1r-EGFP Transgene Provides a Novel Marker for Monocyte Subsets in Sheep.
in Journal of immunology (Baltimore, Md. : 1950)
Proudfoot C
(2019)
Genome editing for disease resistance in pigs and chickens.
in Animal frontiers : the review magazine of animal agriculture
Proudfoot C
(2015)
Genome edited sheep and cattle.
in Transgenic research
Tait-Burkard C
(2018)
Livestock 2.0 - genome editing for fitter, healthier, and more productive farmed animals.
in Genome biology
Tan W
(2016)
Gene targeting, genome editing: from Dolly to editors.
in Transgenic research
Whitelaw B
(2019)
We have entered the era of genome-edited farmed animals.
in Emerging topics in life sciences
| Description | we used genome editing technology to produce pigs resistant to viral disease. |
| Exploitation Route | Driver for commercial development of genome editing in livestock |
| Sectors | Agriculture, Food and Drink |
| Description | Considerable global media interest in this project which aims to reduce the impact of virus disease in pigs. Driver for application of genome editing technology in livestock. |
| First Year Of Impact | 2013 |
| Sector | Agriculture, Food and Drink |
| Impact Types | Societal,Economic |
| Description | A strategic approach to identifying and combating porcine reproductive and respiratory syndrome virus outbreaks and other porcine viral diseases |
| Amount | £787,016 (GBP) |
| Funding ID | BB/R013187/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 03/2021 |
| Description | General Scheme - Bruce Whitelaw - Editing RELA S531P |
| Amount | £30,000 (GBP) |
| Organisation | Genus plc |
| Sector | Private |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 12/2019 |
| Description | General Scheme - Christine Tait-Burkard - PRRSV study at Moredun to evaluate CD163 edited pigs |
| Amount | £48,812 (GBP) |
| Organisation | Genus plc |
| Sector | Private |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 09/2017 |
| Description | Research Grant - Christine Tait-Burkard - Nanobodies as antiviral PRRSV agents |
| Amount | £59,802 (GBP) |
| Organisation | Eco Animal Health Ltd |
| Sector | Private |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2019 |
| Description | Responsive Mode - Christine Tait-Burkard - Understanding the CD163 - PRRS virus interaction to improve genetic engineering for resistance |
| Amount | £674,353 (GBP) |
| Funding ID | BB/R004463/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2017 |
| End | 11/2020 |
| Description | Pig breeding with Genus |
| Organisation | Genus plc |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Developed and demonstrated gene editing in pig zygotes. |
| Collaborator Contribution | Supply of animal resources and funds. |
| Impact | Several publications, presentations at scientific meetings, media opportunities and joint research grants. |
| Start Year | 2010 |
| Title | DOMAIN 5 OF CD163 FOR USE IN ANTIVIRAL COMPOSITIONS AGAINST PRRS, AND TRANSGENIC ANIMALS |
| Description | The present invention relates to methods and compositions useful for the prevention and/or treatment of PRRS in animals, typically domestic pigs. The invention relates to proteins which comprise fragments of CD163, nucleic acid constructs encoding such proteins, and methods of modifying expression or activity of CD163 in vivo. |
| IP Reference | WO2015011483 |
| Protection | Patent application published |
| Year Protection Granted | 2015 |
| Licensed | Commercial In Confidence |
| Impact | scientific publications |
| Title | GENETICALLY MODIFIED ANIMALS AND METHODS FOR MAKING THE SAME |
| Description | Compositions and methods for use of TALENs to make genetically modified livestock are set forth. The methods may include reporters for selecting cells or embryos that have been modified by TALENs for use as progenitor cells to make founder animals. |
| IP Reference | WO2012116274 |
| Protection | Patent application published |
| Year Protection Granted | 2012 |
| Licensed | Commercial In Confidence |
| Impact | scientific publications and research funding - media coverage |
| Title | Gene edited pigs with altered RelA activity |
| Description | production of pigs with altered NFkB activity |
| IP Reference | EP1216564.3 |
| Protection | Patent application published |
| Year Protection Granted | 2012 |
| Licensed | Commercial In Confidence |
| Impact | scientific publications and research funds |
| Description | "Curious Minds" lecture series for the Perthshire Society of Natural Science. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Participation in the "Curious Minds" lecture series for the Perthshire Society of Natural Science. The Society runs this public lecture series in collaboration with Culture Perth and Kinross. |
| Year(s) Of Engagement Activity | 2019 |
| Description | 9th International Sheep Veterinary Congress, Harrogate |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Presentation for 300 scientists on the benefits of animal biotechnology to the sheep industry |
| Year(s) Of Engagement Activity | 2017 |
| Description | Academic Wine and Cheese Lecture, University of Edinburgh |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Presented to University students on GM technology and implications for research |
| Year(s) Of Engagement Activity | 2017 |
| Description | Animal Biotechnology Workshop, Charlottesville |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Other audiences denotes scientists. Attended an international workshop on animal biotechnology regulations where plans for international harmonisation of regulations was proposed. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Article in the Times: "Help on the Way for Squirrel Nutkin as Scientists gun for Grey's Anatomy |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Entry in the Times Newspaper, with research contribution for the Roslin Institute. Grey squirrels could be wiped out in the UK by 2050 under plans to protect trees and the red squirrel population by editing the genes of the invasive species to stop the production of females. |
| Year(s) Of Engagement Activity | 2021 |
| Description | BBC Country File interview |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | TV interview on genetically engineered pigs on mainstream BBC Country File programme |
| Year(s) Of Engagement Activity | 2013 |
| Description | BBC Radio 4 Interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Interviewed by BBC radio on topic of genetic engineering of animals. |
| Year(s) Of Engagement Activity | 2017 |
| Description | BBSRC Conclave, New Delhi |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Other audiences denotes scientists. UK scientific delegation to India to identify roadmap for "smart farms" |
| Year(s) Of Engagement Activity | 2017 |
| Description | CP Life Sciences, Scottish Parliament |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Attended Parliament event |
| Year(s) Of Engagement Activity | 2017 |
| Description | Centre for Tropical Livestock and Genetic Health Visit, Gates Foundation |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Supporters |
| Results and Impact | Invited to Bill Gates visit to Easter Bush Campus |
| Year(s) Of Engagement Activity | 2017 |
| Description | Chair of Session 3A: Large Animal Transgenesis, TT2020 Conference, Israel |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Chair of the above online conference which sparked questions and discussion. Chance also to join in other sessions online. Most of the audience were fellow scientists |
| Year(s) Of Engagement Activity | 2020 |
| Description | Collaborators' meeting, India |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Indian partnerships in industry and science meeting |
| Year(s) Of Engagement Activity | 2019 |
| Description | Continuing Professional Development Talk on Animal Genetics, Glasgow |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Continuing Professional Development Talk on Animal Genetics, Glasgow to scientists and post graduate students. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Costing the Earth |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | BBC radio interview on genetically engineered livestock for BBC Radio 4 Costing the Earcth |
| Year(s) Of Engagement Activity | 2013 |
| Description | Cutting edge Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk on genome edited livestock at international science festival |
| Year(s) Of Engagement Activity | 2016 |
| Description | DBT Indian visit to Roslin |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Delegated visit to discuss joint development of research programmes in livestock sector for enhancing health and productivity of farm animals. |
| Year(s) Of Engagement Activity | 2020 |
| Description | DBT workshop |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Indian Department of Biotechnology workshop on GM Livestock in Bangalore |
| Year(s) Of Engagement Activity | 2016 |
| Description | Department of International Development Scientific Meeting, Nairobi |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | International event involving 100 stakeholders of the DFID and the Bill and Melinda Gates Foundation to take forward the Centre for Tropical Livestock and Genetic Health initiative |
| Year(s) Of Engagement Activity | 2017 |
| Description | EuroScience Open Forum Meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Genome editing involves altering some of the individual letters that make up an organism's genetic code at precise points. The technology can be used to introduce beneficial characteristics into plants and animals, such as resistance to a specific disease or improved adaptation to different environments. The changes introduced are the same as those that could occur spontaneously in nature. In this session, we will showcase how genome editing is being researched in institutions across Europe for treatment or prevention of animal diseases. The goal of the research presented here is to improve the health and welfare of farmed animals around the world, and to improve the security of food supplies in low and middle-income countries. We will start by introducing the technology and how it works, and explore how it is being used to manage a range of diseases in salmon, pigs, and cattle. A representative from a company specialised in providing genetic solutions to the farm industry will speak about how the sector is looking at the problem. Presentations will be followed by a panel discussion and Q&A session in which the audience will be asked to consider the perspective of different groups (e.g. farmers, consumers, policy makers, researchers, low and middle income countries) and will have the opportunity to put questions to the speakers. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Food Evolution Film |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Participated in academic film on food biotechnology |
| Year(s) Of Engagement Activity | 2017 |
| Description | Garth Vet Group, National Association, Yorkshire |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Talk given to scientists, vets and others at the Garth Vet Group, Yorkshire on animal biotechnology |
| Year(s) Of Engagement Activity | 2019 |
| Description | Gene Editing in Livestock, Washington DC |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Attendance and participation in the above event talk on Genome Editing Livestock |
| Year(s) Of Engagement Activity | 2019 |
| Description | Hendrix Genetcic workshop |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Closed industry workshop on application of genetic engineering technology |
| Year(s) Of Engagement Activity | 2016 |
| Description | Hendrix Genetics Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Invited participant at a closed industry meeting with Hendrix Genetics |
| Year(s) Of Engagement Activity | 2016 |
| Description | International Society for Animal Genetics Conference, Lleida, Spain |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Other audiences denotes scientists. Scientific symposium of 400 academic and students |
| Year(s) Of Engagement Activity | 2019 |
| Description | International Sympoisum on Animal Geneticw, Dublin |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Other audiences denotes scientists. Presented at scientific symposium to 400 students and students. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Interview with CB Films Research |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Discussion on how soon could we expect GM on our supermarket shelves if the government were happy to proceed with legislation now. Discussion on resistant pigs at Roslin |
| Year(s) Of Engagement Activity | 2020 |
| Description | MSc Lecture on Genome Modification of Livestock |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | MSc lecture fo 100 students on Genome Modificatio of Livestock |
| Year(s) Of Engagement Activity | 2019 |
| Description | National Academy of Science Colloquium Workshop, LA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | National Academy of Scinces Colloquium Life 2.0, The Promise and Challenge of a CRISPR Path to a Sustainable Plant, Attended conference and gave talk on genome editing which I agreed could be made public |
| Year(s) Of Engagement Activity | 2019 |
| Description | Nuffield Council Meeting on Bioethics |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Member of the Nuffield Council of Bioethics. Acting in an advisory capacity |
| Year(s) Of Engagement Activity | 2019 |
| Description | Nuffield Council bioethics workshop |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Workshop exploring bioethics of genome editing technology and applications |
| Year(s) Of Engagement Activity | 2015,2016 |
| Description | Our Changing World Series |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | University of Edinburgh showcase lecture on genome editing animals for food security |
| Year(s) Of Engagement Activity | 2016 |
| Description | Plant and Animal Genomics Workshop, USA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Workshop Lead in the above workshop/conference, leading on Animal Genetics. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Progressional Education Trust Workshop |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited to give a presentation and take part in a debate to the public on genetic engineering. PET advances public understanding of science, law and ethics in the fields of human genetics, assisted reproduction, embryology and stem cell research. Its vision is to improve the choices for people affected by infertility or genetic conditions. Its mission is to educate and debate the responsible application of reproductive and genetic science. |
| Year(s) Of Engagement Activity | 2016 |
| Description | RSB Teachers Annual Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Talk on genome editing to teachers conference |
| Year(s) Of Engagement Activity | 2016 |
| Description | Royal Dick School of Veterinary Studies and Roslin Insitute Away Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Colleagues strategic away day to take forward and enhance the working of the Campus |
| Year(s) Of Engagement Activity | 2020 |
| Description | Royal Society Genome Editing Public Consultation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Participated in Royal Society consultation of genome editing technology |
| Year(s) Of Engagement Activity | 2017 |
| Description | SUSS |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Talk on impact of genome editing technology on society at annual Scottish universities science school. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Scientific Conference, Utrecht |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Scientific event to identify with other scientists a road map for animal biotechnology in Europe |
| Year(s) Of Engagement Activity | 2017 |
| Description | The Food Chain |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | BBC World Service radio interview on genetically engineered livestock for The Food Chain |
| Year(s) Of Engagement Activity | 2018 |
| Description | Transgenic Animal Research Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Attendance at above conference as an invited speaker on Genome Modification of Livestock. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Transgenic Animal Research Conference, Tahoe, US |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Other audiences denotes scientist. Presented at scientific symposium for 100 students and scientists |
| Year(s) Of Engagement Activity | 2017 |
| Description | U3A Talk - Rewriting Livestock, Biggar Library |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited talk to general public on genome editing of livestock |
| Year(s) Of Engagement Activity | 2019 |
| Description | University Delegation to Bangalore India |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | University delegation to visit scientists in India to establish collaborative activities |
| Year(s) Of Engagement Activity | 2017 |
| Description | University of Edinburgh filming |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with University on the legacy of Dolly the Sheep |
| Year(s) Of Engagement Activity | 2020 |
| Description | University of Kent, invited speaker |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker on animal biotechnology |
| Year(s) Of Engagement Activity | 2019 |
| Description | named biotechnology speaker on US Ste |Department Economic Bureau Outreach Fund |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | International workshop top engage stakeholders in genetic engineering technology and applications |
| Year(s) Of Engagement Activity | 2015 |