International exploitation of new reagents and assays for antibiotic discovery
Lead Research Organisation:
University of Warwick
Department Name: School of Life Sciences
Abstract
USA
Organisations
Publications
Vajs J
(2017)
Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis.
in European journal of medicinal chemistry
Tran AT
(2017)
Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis.
in Nature communications
| Description | Lobbying policy makers and funders to support multidisciplinary research in support of AMR discovery |
| Exploitation Route | Future strategy for AMR development and funding |
| Sectors | Aerospace, Defence and Marine,Government, Democracy and Justice,Pharmaceuticals and Medical Biotechnology |
| Description | Enabled further international engagement with industry, defence agencies and government |
| First Year Of Impact | 2015 |
| Sector | Aerospace, Defence and Marine,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology,Security and Diplomacy |
| Impact Types | Economic,Policy & public services |
| Description | ASIA-EUROPE Foundation Universal Health Coverage in an era of antimicrobial resistance (AMR) and pandemics |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| URL | https://asef.org/projects/2023-uhc-in-an-era-of-amr-and-pandemics-conference/ |
| Description | Chair of Scientific Committee Antibiotic Research Uk |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Impact | Patient focussed dialogue regarding antibiotic effectiveness and patient informed research |
| URL | https://www.antibioticresearch.org.uk |
| Description | Accelerate CHNUK AMR discovery: Establishing joint China/UK training and research platforms enabling highthroughput fragment based inhibitor discovery |
| Amount | £1,000,000 (GBP) |
| Funding ID | MR/P007503/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2016 |
| End | 05/2019 |
| Description | Coventry General Charities |
| Amount | £157,000 (GBP) |
| Organisation | General Charity of the City of Coventry |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 09/2022 |
| Description | MRC AMR theme 1 collaboration award |
| Amount | £3,200,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2015 |
| End | 03/2021 |
| Description | Newton UK china ANMR hubs |
| Amount | £3,000,000 (GBP) |
| Funding ID | MR/S014934/1 |
| Organisation | University of Warwick |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2019 |
| End | 12/2021 |
| Description | Wellcome Trust Innovation Award |
| Amount | £100,000 (GBP) |
| Funding ID | 109676/Z/15/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2016 |
| End | 06/2017 |
| Description | Entasis collaboration |
| Organisation | Entasis Therapeutics |
| Country | United States |
| Sector | Private |
| PI Contribution | Biochemistry and assay development |
| Collaborator Contribution | Assay validation and hit characterisation insight |
| Impact | Successful award of Wellcome Trust Pathfinder award |
| Start Year | 2015 |
| Description | H3D drug discovery University of Cape Town |
| Organisation | University of Cape Town |
| Country | South Africa |
| Sector | Academic/University |
| PI Contribution | Input of reagents assays and protein structures |
| Collaborator Contribution | Input of medicinal chemistry know-how and chemical matter |
| Impact | Interpersonal exchange of postdocs and to be PhD students |
| Start Year | 2017 |
| Company Name | Antimicrobial Discovery Solutions Ltd |
| Description | Reagents, assay development and services |
| Year Established | 2015 |
| Impact | N/A |
| Description | 10 Downing Street 2018 Chinese New Year Celebrations |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Invitation from the PM to attend event to showcase UK China collaborative AMR research |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.gov.uk/government/news/pm-hosts-chinese-new-year-reception-at-downing-street |
| Description | ANTRUK Antibiotic Research UK |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Establishment of new charity and new fundraising campaign regional and national media interest |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.antibioticresearch.org.uk |
| Description | Establishment of Medicines discovery Catapult Facility |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | World-class technology and expertise are now available to UK drug discovery companies as a result of new laboratory facilities developed by the Medicines Discovery Catapult - launched on Wednesday 29th March at the University of Warwick. Catapult open for business with £1m investment in cutting-edge lab capacity to support UK drug discovery https://warwick.ac.uk/newsandevents/pressreleases/catapult_open_for/ |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://vimeo.com/211376977 |
| Description | MRC Milennium Medal Showcase of AMR research Palace of Westminster |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Presentation of MRC and RCUK funded AMR research to Peers and Politicians at the Palace of Westminster as part of the 2018 MRC Millennium Medal Award event |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.youtube.com/watch?v=n2Z6Xxs8aA0 |
| Description | O'Neil AMR review |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | In December we published our first report1 showing that infections caused by drug-resistant pathogens are one of the biggest health problems the world faces today. Bacteria and other pathogens have always evolved to resist the new drugs that modern medicine uses to combat them. But in recent years the rise in drug resistance has been a particular worry, especially the emergence of antibioticresistant superbugs. Unless action is taken to address this huge global issue, our conservative estimate is that it will cost the world an additional 10 million lives a year by 2050, more than the number of people currently dying from cancer annually. It will also have a cumulative cost of 100 trillion USD, more than one and a half times annual world GDP today, or roughly the equivalent to losing the UK economy from global output every year. We now turn our attention to how this problem can be tackled. This paper is the first in a series that works towards global and sustainable solutions. There are many angles to the problem that we will need more time to consider. In particular, the focus of our next paper, due to be published in the spring, will be how to stimulate the market for companies to invest in and develop new antimicrobials and diagnostics, which is not fully addressed here. There we will assess potential 'push' and 'pull' incentives to encourage the development of new antimicrobial drugs, and set out our proposals for action by policy makers. In later papers we will also focus on important issues such as the use of antibiotics in agriculture and potential alternatives to antimicrobials |
| Year(s) Of Engagement Activity | 2015 |
| URL | https://amr-review.org/sites/default/files/Report-52.15.pdf |
| Description | Pew Road Map for Antibiotic Discovery |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | The Pew Charitable Trusts convened a multidisciplinary group of leading industry and academic experts to identify the key scientific roadblocks to antibiotic discovery and consulted with numerous other public and private sector stakeholders to develop a Scientific Roadmap for Antibiotic Discovery. The roadmap outlines a concrete approach-both a scientific plan and organizational structure to support this research-that would lay a foundation for the sustained and diversified discovery and development of new antibiotics and therapies over the coming decades.The report's key findings show a need for: • A targeted approach to tackle the basic scientific barriers impeding antibiotic discovery and development. • A better understanding of how to overcome the cellular defenses of drug-resistant Gram-negative bacteria, which cause some of the most difficult-to-treat infections. • Generation of new chemical matter designed for antibiotic discovery. • Tools and methodologies to evaluate promising alternatives to traditional antibiotic use. • A framework for sharing information, expertise, and materials across the research community to foster innovative science and spur the discovery of novel antibacterial therapies. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.pewtrusts.org/~/media/assets/2016/05/ascientificroadmapforantibioticdiscovery.pdf |
| Description | Radio 4 3 part drama production |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Radio drama highlighting factors driving antibiotic resistance and global consequences - raising public awareness at the National level |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.bbc.co.uk/programmes/b08g7y1l |
| Description | UK CHINA: CHNUK virtual workshops and research seminar series |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Presentation/ discussion with Brazilian microbiology groups as to how develop and work effectively as national and international consortia in AMR discovery |
| Year(s) Of Engagement Activity | 2020 |
| Description | United Nations General Assembley |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Invited to attended AMR working group presentations |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.un.org/pga/71/event-latest/high-level-meeting-on-antimicrobial-resistance/ |