How the gut reacts to stress: changes in intestinal stem cell behaviour in response to perturbation of the enteric nervous system.
Lead Research Organisation:
Quadram Institute
Department Name: Gut Health and Food Safety
Abstract
France
People |
ORCID iD |
| Maria Pin Arias (Principal Investigator) |
| Description | We have discovered that proliferation of small intestinal cells is enhanced in situations of chronic stress |
| Exploitation Route | By elucidating the mechanisms of interaction between the enteric nervous system and the epithelium, new strategies could be developed to reduce the impact of nervous stress on inflammatory bowel disease patients |
| Sectors | Healthcare,Pharmaceuticals and Medical Biotechnology |
| Description | Michel Neunlist |
| Organisation | National Institute of Health and Medical Research (INSERM) |
| Department | DR2 INSERM |
| Country | France |
| Sector | Public |
| PI Contribution | Mathematical modelling of epithelial stem cell proliferation and differentiation during acute and chronic stress |
| Collaborator Contribution | Technology to experimentally evaluate the enteric nervous system and confocal microscopy |
| Impact | N/A |
| Start Year | 2015 |