Integrated Microfluidic Process for the Production of Chiral Amines: Scaling-up
Lead Research Organisation:
University College London
Department Name: Biochemical Engineering
Abstract
Slovenia
Publications
Marques MP
(2017)
Bioprocess microfluidics: applying microfluidic devices for bioprocessing.
in Current opinion in chemical engineering
Gruber P
(2018)
Enzymatic synthesis of chiral amino-alcohols by coupling transketolase and transaminase-catalyzed reactions in a cascading continuous-flow microreactor system.
in Biotechnology and bioengineering
| Description | This is a travel grant. The comparison of performance of the UCL LLE device with the Corning Reactor system could not be completed. We learned that an intermediate step for the scale-up between our microfluidic device and the large Corning reactor is needed. We reported on them in more details in the section "Other Outputs & Knowledge/Future Steps" |
| Exploitation Route | The partner at the Univ of Ljubljana are continuing the work over a Master thesis student. |
| Sectors | Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| Description | Lectures at UCL |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | A professor from the U of Osijek in Croatia has been giving two lectures in two modules, one for each module. For Biochemical Reaction Engineering, she spoke of biodiesel, and for Bio-microfluidics/Microsystems Engineering of enzmatic microreactors. Attendance depends on yearly cohort size between 15 and 40 students. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Lectures at UCL |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Two professors from UL, Slovenia, Prof Znidarsic-Plazl and Prof Plazl, held lectures to UG students in Biochemical Engineering on Biocatalysis in Non-Conventional Media, and Modeling Biocatalytic Reactions, respectively. Additionally, both professors held a seminar on their research in microfluidic enzyme reactors. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Presentation at the University Ljubljana |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Presentation on Microfluidics Tools for biocatalytical processes, in particular, results of the BBSRC funded project MicroTools. Postgraduate student (approx. 12) as well as senior researchers and Professors of the University of Ljubljana attended the presentation. Future collaborations in place. |
| Year(s) Of Engagement Activity | 2016 |