Harnessing Clay Gels for Cell, Growth Factor and Protein delivery for Regenerative Medicine
Lead Research Organisation:
University of Southampton
Department Name: Human Development and Health
Abstract
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People |
ORCID iD |
| Richard Oreffo (Principal Investigator) |
Publications
Ahlfeld T
(2017)
Development of a clay based bioink for 3D cell printing for skeletal application.
in Biofabrication
Mousa M
(2018)
Clay nanoparticles for regenerative medicine and biomaterial design: A review of clay bioactivity.
in Biomaterials
| Description | The work allowed market research into Clay materials for Regenerative Medicine and proof of concept studies for clay growth factor release. - the additional findings indicate Clays offer a unique material for growth factor retention and delivery as previously shown by us and have added to portfolio of data for a new spin out company Renovos Biologics Limited. |
| Exploitation Route | The new company Renovos is looking to translate and commercialise the findings from our pioneering research on nanoclays |
| Sectors | Healthcare,Pharmaceuticals and Medical Biotechnology |
| Description | Aided development of research data has supported a patent that has now been added to a SPIN OUT company, Renovos Biologics Limited. |
| First Year Of Impact | 2017 |
| Sector | Healthcare,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Economic |
| Description | Angiogeneisis - Vasculature development- collaboration |
| Organisation | Ludwig Boltzmann Society |
| Department | Ludwig Boltzmann Institute for Experimental and Clinical Traumatology |
| Country | Austria |
| Sector | Academic/University |
| PI Contribution | Development of new ex vivo approaches to angiogenesis and vascular development - specifically chorioallantoic membrane models - Development in partnership of a new decellularised scaffold matrix approach evaluation for skeletal tissue engineering. |
| Collaborator Contribution | Innovative vascular scaffolds - using placental tissue (Human) |
| Impact | Publications and joint grant applications |
| Start Year | 2015 |
| Title | Clay nanoparticle gels for localisation of BMP2 |
| Description | Under active development/distribution Bone Morphogenic Protein 2 (BMP2) can induce ectopic bone. This ability, which first motivated the widespread application of BMP2 in fracture healing and spinal arthrodesis has, more recently, been indicated as one of several serious adverse effects associated with the supra-physiological doses of BMP2 relied upon for clinical efficacy. Key to harnessing BMPs and other agents safely and effectively will be the ability to localize activity at a target site at substantially reduced doses. Clay (Laponite) nanoparticles can self assemble into gels under physiological conditions and bind growth factors for enhanced and localized efficacy. We have shown the ability to localize and enhance the activity of BMP2 to achieve ectopic bone formation at doses within the sub-microgram per ml range of concentrations sufficient to induce differentiation of responsive cell populations in vitro and at approximately 3000 fold lower than those employed in clinical practice. We are currently pursuing 2 strands of development towards the clinical translation of this device. 1) Large animal pre-clinical studies in direct comparison with the current gold standard approach (InductOs TM) 2) Refinement in clay mineral production in collaboration with BYK, Altana and pursuit of regulatory approval. |
| Type | Therapeutic Intervention - Drug |
| Current Stage Of Development | Refinement. Non-clinical |
| Year Development Stage Completed | 2016 |
| Development Status | Under active development/distribution |
| Impact | Nothing additional to report at this stage |
| Company Name | Renovos Biologics Limited |
| Description | Business Summary Renovos is a new company based in Southampton capitalising on decades of orthopaedic research. The company aims to be a leader in bone repair technologies. Business Description Renovos will offer: • products (stem cells for research) • services (low-cost, high-value in vivo screening assay) • therapeutics (patent-pending nanoclay preparations for drug delivery and tissue repair) |
| Year Established | 2017 |
| Impact | Formed only 3 months ago- yet to reach potential |
| Website | http://renovos.co.uk/ |
| Description | Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | 6-11 June - The Stem Cell featured at the festival and the team interacted with an estimated 1800 visitors - led to student interest in visiting our group. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited Speaker - Cancer Sciences Seminar Series - Southampton |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | 17th January 2018: Invited speaker at the Cancer Sciences Seminar series, University of Southampton. Gave seminar on "New approaches to skeletal cell based bone regeneration: repair, restore and recreate" |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited Speaker: Hungarian Academy of Sciences, Budapest |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave talk on "Harnessing Clay for Growth Factor, BMP-2, Delivery for Orthopaedics" |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited speaker - 2018 Croucher Program, The Chinese University of Hong Kong, Shatin, Hong Kong. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker - 2018 Croucher Program - Stem Cells Biology and Regenerative Medicine -Location (Site): Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong. Lecture 1: New approaches to skeletal cell based bone regeneration: repair, restore and recreate Lecture 2: Harnessing ex vivo and in vivo models to interrogate and validate bone formation strategies Lecture 3: Understanding anabolic and catabolic gene regulation in osteoarthritis |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.ort.cuhk.edu.hk/csc2018/index.html |
| Description | Invited speaker - British Limb Reconstruction Society at the Ageas Bowl |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A 20 minute talk on "Harnessing Skeletal Stem Cells and new approaches in Orthobiologics" |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited speaker - China Medical University |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | March 2018: Invited speaker at China Medical University to give the talk "Interdisciplinary microfluidic, imaging and fabrication platforms for skeletal stem cell based bone repair: isolation, characterisation and 3D bio-fabrication" |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited speaker 3D Global Biotech Limited - Taipei - Taiwan |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker - Renovos: Innovative Technologies for bone repair 3D Global Biotech Limited - Taipei - Taiwan |
| Year(s) Of Engagement Activity | 2018 |
| Description | Keynote Speaker - CDT Regenerative Medicine Conference, Manchester 12th July 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | This conference brings together the graduate students affiliated to the three CDTs in Regenerative Medicine (Leeds, Loughborough/Keele/Nottingham, Manchester) and represents one of the largest UK-based annual conferences in the area of Tissue Engineering and Regenerative Medicine. The conference is broad ranging, encapsulating the scope of cutting edge research in regenerative medicine, with research themes including biomaterials, stem cell biology, tissue engineering, extracellular matrix and inflammation, gene and cell therapy and nanomedicine. Invited as a plenary speaker to give a 30 minute talk to share work on bone development and regeneration. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Keynote speaker at LBG (Ludwig Boltzmann Gesellschaft) Meeting for Health Sciences 2018, Vienna, Austria |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Gave Keynote speech "Bridging the gap: Skeletal cell based strategies for bone repair" in Session III: Regenerative Medicine Research and Artificial Organs. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Keynote speaker at symposium in Spain |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Keynote talk "New approaches to skeletal cell based bone regeneration: repair, restore and recreate" to an audience of people working in Biomedical Institutes in Coruña and Santiago and students (Biology, Medicine and Masters students). |
| Year(s) Of Engagement Activity | 2019 |
| Description | Scientific Committee & Invited Speaker at European Orthopaedic Research Society (EORS) 2018 in Galway, Ireland |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Gave talk on "Skeletal Cell Based Strategies for Bone Repair - Opportunities and Challenges" |
| Year(s) Of Engagement Activity | 2018 |
| Description | Southampton Science and Engineering Festival |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | 18 March 2017 - Stem Cell Mountain at the Southampton Science and Engineering Festival for 1 day. regional general public. predominantly families. Interest in students to visit our laboratories |
| Year(s) Of Engagement Activity | 2017 |
| Description | Stem Cell Outreach Programme ( New Forest Country Show) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | 25 - 27 July 2017 - Stem Cell Mountain outreach programme at the New Forest Country Show (general public, farmers, agricultural community) - led ot interest by students to visit our laboratories |
| Year(s) Of Engagement Activity | 2017 |
| Description | Talk at ICORs workshop, Montreal |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk on "Regenerative Medicine Approaches and Technologies for Bone Augmentation" at ICORS Workshop: BORS Regenerative Medicine - Coming to a Clinic Near you Soon? |
| Year(s) Of Engagement Activity | 2019 |
| Description | Winchester Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | 29 - 30 July 2017 - Stem Cell Mountain at a three day festival. Engaged largely with family audience and science festival talk attendees - led ot gernerla interest in our basic research programmes |
| Year(s) Of Engagement Activity | 2017 |