HDHL Biomarkers: Fatty Acid Metabolism - Interlinking Diet with Cardiometabolic Health (FAME)
Lead Research Organisation:
University of Reading
Department Name: Food and Nutritional Sciences
Abstract
Dietary fatty acid composition is an important determinant of cardiometabolic health and risk of cardiometabolic diseases such as cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM), but mechanisms underlying this relationship are still not entirely clear. This proposal will use existing biobanked samples and dietary and phenotype data from cohort studies and randomized controlled trials to a) identify novel lipidomics biomarkers of cardiometabolic health which could replace or be used in addition to fatty acid profiles as more sensitive biomarkers of status and of future cardiometabolic clinical events, b) establish relationships between whole diets and specific foods with tissue status of fatty acids as explanatory factors for diet relationships with cardiometabolic health, and c) to investigate genetic determinants of fatty acid status and metabolism which modify the physiological effects of dietary intake. The results from this multidisciplinary project will contribute to the evidence base for the refinement of current food and nutrient based dietary guidelines (in particular with regard to the intake of milk and dairy products, polyunsaturated fatty acids and plant-based diets), and the targeting of intervention strategies aimed at improved cardiometabolic health towards those most at risk of disease and/or be most responsive.
Technical Summary
The overall objective is to use existing biobanked samples and dietary and phenotype data from cohort studies and randomized controlled trials to:
a) identify novel lipidomics biomarkers of cardiometabolic health which could replace or be used in addition to fatty acid profiles as more sensitive biomarkers of status and of future cardiometabolic clinical events,
b) establish relationships between whole diets and specific foods with tissue status of fatty acids as explanatory factors for diet relationships with cardiometabolic health, and
c) investigate genetic determinants of fatty acid status and metabolism which modify the physiological effects of dietary intake.
WORKPLAN
WP1. Lipid metabolites from lipidomics as novel biomarkers of cardiometabolic health will be identified based on follow-up of prospective studies on type 2 diabetes with exploration and cross-validation (EPIC-Potsdam cohort and CORDIOPREV trial). Potential for dietary modification of identified biomarkers will be tested in well-controlled trials involving FA modification (DIVAS, LIPGENE, RESET, SATGENE).
WP2. Specific SFA and trans-FA and novel lipid biomarkers will be tested as biomarkers of dairy fat intake in a well-controlled trial (RESET) and subsequently evaluated as markers of cardiometabolic health (DIVAS, SATGENE, RESET) and long-term cardiometabolic risk (EPIC-Potsdam, CORDIOPREV, PREDIMED [n=7447])
WP3. Polyphenols and candidate genes as determinants of response to FA intake will be evaluated in the PREDIMED trial and EPIC-Potsdam cohort and subsequently validated in well-controlled trials on FA (LIPGENE, SATGENE) and polyphenol (FLAVURS) modification.
EXPECTED RESULTS Results of the project may contribute to the refinement of current food and nutrients based dietary guidelines, e.g. with regard to dairy intake, PUFA intake and plant-based diets and the targeting of intervention strategies aimed at improved cardiometabolic health to those most likely to benefit
a) identify novel lipidomics biomarkers of cardiometabolic health which could replace or be used in addition to fatty acid profiles as more sensitive biomarkers of status and of future cardiometabolic clinical events,
b) establish relationships between whole diets and specific foods with tissue status of fatty acids as explanatory factors for diet relationships with cardiometabolic health, and
c) investigate genetic determinants of fatty acid status and metabolism which modify the physiological effects of dietary intake.
WORKPLAN
WP1. Lipid metabolites from lipidomics as novel biomarkers of cardiometabolic health will be identified based on follow-up of prospective studies on type 2 diabetes with exploration and cross-validation (EPIC-Potsdam cohort and CORDIOPREV trial). Potential for dietary modification of identified biomarkers will be tested in well-controlled trials involving FA modification (DIVAS, LIPGENE, RESET, SATGENE).
WP2. Specific SFA and trans-FA and novel lipid biomarkers will be tested as biomarkers of dairy fat intake in a well-controlled trial (RESET) and subsequently evaluated as markers of cardiometabolic health (DIVAS, SATGENE, RESET) and long-term cardiometabolic risk (EPIC-Potsdam, CORDIOPREV, PREDIMED [n=7447])
WP3. Polyphenols and candidate genes as determinants of response to FA intake will be evaluated in the PREDIMED trial and EPIC-Potsdam cohort and subsequently validated in well-controlled trials on FA (LIPGENE, SATGENE) and polyphenol (FLAVURS) modification.
EXPECTED RESULTS Results of the project may contribute to the refinement of current food and nutrients based dietary guidelines, e.g. with regard to dairy intake, PUFA intake and plant-based diets and the targeting of intervention strategies aimed at improved cardiometabolic health to those most likely to benefit
Planned Impact
Results of the project will help refine, current dietary guidelines and the targeting of interventions aimed at
improved cardiometabolic health towards those most likely to be at risk of disease and/or be most responsive.
a) The identification of novel biomarkers of cardiometabolic health and future risk of T2DM has strong
potential for prediction of T2DM beyond classical risk factors (Floegel et al. 2013) and could therefore
be incorporated into existing prediction models, e.g. the German Diabetes Risk Score developed at
project partner DIfE (Mühlenbruch et al. 2014). More precise prediction algorithms allow the better
targeting of monitoring programs and prevention interventions to those at risk. Given that the project
also aims to evaluate the potential for modification of these novel markers by dietary interventions, the
project will also provide the knowledge base to modify risk through dietary intervention with the aim to
achieve long-term cardiometabolic health.
b) In Europe between 17-41% of dietary SFA is derived from dairy products (Eilander et al. 2015). Given
that the effect of high SFA intake on cardiometabolic intermediate biomarkers (lipids, blood pressure
and insulin resistance) and cardiometabolic risk (T2DM, CVD) may be differential by distinct subgroups
of SFA or their main food sources (dairy SFA associated with reduced cardiometabolic outcomes), it is
a priority to establish the impact of dairy SFA on cardiometabolic health.
c) Common gene variants which determine the response to PUFA intake and thus intake-health end-point
associations may in the future be used to stratify dietary FA recommendations to individuals more
likely to be responsive.
d) Information on other dietary determinants of PUFA metabolism beyond FAs will be informative as it
may provide, a) novel approaches to optimize tissue PUFA status, b) extent current knowledge
regarding the molecular and physiological mechanisms underlying the cardio-metabolic benefits of a
plant based diet, and c) contribute to the refinement of the current rather generic dietary
recommendations for the intakes of plant based foods such as fruit and vegetables.
improved cardiometabolic health towards those most likely to be at risk of disease and/or be most responsive.
a) The identification of novel biomarkers of cardiometabolic health and future risk of T2DM has strong
potential for prediction of T2DM beyond classical risk factors (Floegel et al. 2013) and could therefore
be incorporated into existing prediction models, e.g. the German Diabetes Risk Score developed at
project partner DIfE (Mühlenbruch et al. 2014). More precise prediction algorithms allow the better
targeting of monitoring programs and prevention interventions to those at risk. Given that the project
also aims to evaluate the potential for modification of these novel markers by dietary interventions, the
project will also provide the knowledge base to modify risk through dietary intervention with the aim to
achieve long-term cardiometabolic health.
b) In Europe between 17-41% of dietary SFA is derived from dairy products (Eilander et al. 2015). Given
that the effect of high SFA intake on cardiometabolic intermediate biomarkers (lipids, blood pressure
and insulin resistance) and cardiometabolic risk (T2DM, CVD) may be differential by distinct subgroups
of SFA or their main food sources (dairy SFA associated with reduced cardiometabolic outcomes), it is
a priority to establish the impact of dairy SFA on cardiometabolic health.
c) Common gene variants which determine the response to PUFA intake and thus intake-health end-point
associations may in the future be used to stratify dietary FA recommendations to individuals more
likely to be responsive.
d) Information on other dietary determinants of PUFA metabolism beyond FAs will be informative as it
may provide, a) novel approaches to optimize tissue PUFA status, b) extent current knowledge
regarding the molecular and physiological mechanisms underlying the cardio-metabolic benefits of a
plant based diet, and c) contribute to the refinement of the current rather generic dietary
recommendations for the intakes of plant based foods such as fruit and vegetables.
Organisations
- University of Reading (Lead Research Organisation)
- University of Navarra (Collaboration)
- Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Sorbonne-Paris-Cité, UMR Inserm, Paris, France (Collaboration)
- Leibniz Association (Collaboration)
- University of Cordoba (Collaboration)
- University of East Anglia (Collaboration)
Publications
Sellem L
(2023)
Replacement of dietary saturated with unsaturated fatty acids is associated with beneficial effects on lipidome metabolites: a secondary analysis of a randomized trial.
in The American journal of clinical nutrition
Sellem L
(2022)
Consumption of dairy products and CVD risk: results from the French prospective cohort NutriNet-Santé.
in The British journal of nutrition
Sellem L
(2022)
The impact of dietary saturated fat replacement with unsaturated fat on the plasma lipidome and cardiometabolic disease risk
in Proceedings of the Nutrition Society
Sellem L
(2022)
Can individual fatty acids be used as functional biomarkers of dairy fat consumption in relation to cardiometabolic health? A narrative review.
in The British journal of nutrition
Eichelmann F
(2022)
Deep Lipidomics in Human Plasma: Cardiometabolic Disease Risk and Effect of Dietary Fat Modulation.
in Circulation
Sellem L
(2022)
Can individual fatty acids be used as functional biomarkers of dairy fat consumption in relation to cardiometabolic health? A narrative review-CORRIGENDUM.
in The British journal of nutrition
Sellem L
(2022)
Impact of Replacement of Individual Dietary SFAs on Circulating Lipids and Other Biomarkers of Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials in Humans.
in Advances in nutrition (Bethesda, Md.)
| Description | In France, dairy products contribute to dietary saturated fat intake, of which reduced consumption is often recommended for CVD prevention. Epidemiological evidence on the association between dairy consumption and CVD risk remains unclear, suggesting either null or inverse associations. This study aimed to investigate the associations between dairy consumption (overall and specific foods) and CVD risk in a large cohort of French adults. This prospective analysis included participants aged =18 years from the NutriNet-Santé cohort (2009-2019). Daily dietary intakes were collected using 24-h dietary records. Total dairy, milk, cheese, yogurts, fermented and reduced-fat dairy intakes were investigated. CVD cases (n 1952) included cerebrovascular disease (n 878 cases) and CHD (n 1219 cases). Multivariable Cox models were performed to investigate associations. This analysis included 104 805 French adults (mean age at baseline 42·8 (sd 14·6) years, mean follow-up 5·5 (sd 3·0) years, i.e. 579 155 person-years). There were no significant associations between dairy intakes and total CVD or CHD risks. However, the consumption of at least 160 g/d of fermented dairy (e.g. cheese and yogurts) was associated with a reduced risk of cerebrovascular diseases compared with intakes below 57 g/d (hazard ratio = 0·81 (95 % CI 0·66, 0·98), Ptrend = 0·01). Despite being a major dietary source of saturated fats, dairy consumption was not associated with CVD or CHD risks in this study. However, fermented dairy was associated with a lower cerebrovascular disease risk. Robust randomised controlled trials are needed to further assess the impact of consuming different dairy foods on CVD risk and potential underlying mechanisms. |
| Exploitation Route | Help to inform dietary policy on dietary fat intake and increase evidence base on impact of dietary fats on cardiovascular disease risk |
| Sectors | Agriculture, Food and Drink,Healthcare |
| Description | Collaboration with Professor Mattilde Touvier, Sorbonne Paris Nord University, Inserm, INRAE, Cnam, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center, University of Paris (CRESS), 93017 Bobigny, Bobigny, France. |
| Organisation | Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Sorbonne-Paris-Cité, UMR Inserm, Paris, France |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Laury Sellem travelled to Professor Touvier's lab and analysed data from the NutriNet-Santé survey led by Professor Touvier. A paper has been published |
| Collaborator Contribution | Professor Touvier shared the data from NutriNet-Santé survey and trained Laury Sellem in the statistical analysis. |
| Impact | Sellem L, Srour B, Guéraud F, Pierre F, Kesse-Guyot E, Fiolet T, Lavalette C, Egnell M, Latino-Martel P, Fassier P, Hercberg S, Galan P, Deschasaux M, Touvier M. Saturated, mono- and polyunsaturated fatty acid intake and cancer risk: results from the French prospective cohort NutriNet-Santé Eur J Nutr. 2019 Jun;58(4):1515-1527. doi: 10.1007/s00394-018-1682-5. |
| Start Year | 2019 |
| Description | Collaboration with co-applicant (Professor Anne-Marie Minihane) within the Nutrigenetics Group at Norwich Medical School, University of East Anglia (UEA) |
| Organisation | University of East Anglia |
| Department | Norwich Medical School |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Dietary intervention studies from the Hugh Sinclair Unit of Human Nutrition (RESET, DIVAS, LIPGENE, SATgene, FLAVURS) will be used for detailed plasma phospholipid fatty acid and lipidomics analyses, along with genotyping. |
| Collaborator Contribution | The research focus is investigating the independent and interactive impact of select dietary components (in particular n-3 FAs and flavonoids) and common gene variants on cardiometabolic health, including insulin sensitivity, vascular health and liver fat. Much of the research (including SATgene, FLAVURS and CIRCLES) uses human intervention trial methodologies, but a variety of wild-type and transgenic rodent models and cell and molecular techniques to investigate underlying physiological and molecular mechanisms inform the foci of our RCTs. Genotyping approaches include targeted SNP analysis along with whole gene or exon sequencing. |
| Impact | no outcome yet. |
| Start Year | 2017 |
| Description | Collaboration with the Department of Internal Medicine at the Reina Sofia University Hospital, University of Cordoba (UoC), Spain (Dr Antonio Camargo & Prof. López-Miranda) |
| Organisation | University of Cordoba |
| Department | Department of Internal Medicine |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Dietary intervention studies from the Hugh Sinclair Unit of Human Nutrition (RESET, DIVAS, LIPGENE, SATgene, FLAVURS) will be used for detailed plasma phospholipid fatty acid and lipidomics analyses, along with genotyping. |
| Collaborator Contribution | Prof. López-Miranda is Principal Investigator of CORDIOPREV study, which will be used for detailed plasma phospholipid fatty acid and lipidomics analyses. |
| Impact | no outcomes yet. |
| Start Year | 2017 |
| Description | Collaboration with the Department of Molecular Epidemiology at the German Institute of Human Nutrition (DIfE) (Professor Matthias Schultze) |
| Organisation | Leibniz Association |
| Department | German Institute of Human Nutrition (DIfE) |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Dietary intervention studies from the Hugh Sinclair Unit of Human Nutrition (RESET, DIVAS, LIPGENE, SATgene, FLAVURS) will be used for detailed plasma phospholipid fatty acid and lipidomics analyses, along with genotyping. |
| Collaborator Contribution | The Department of Molecular Epidemiology at the German Institute of Human Nutrition (DIfE), led by Matthias Schulze, has long-standing experience in epidemiologic research on dietary determinants of T2DM risk based on large-scale population-based studies, in particular the EPICPotsdam cohort study. The research has specifically focused on FA biomarkers of intake and metabolism (phospholipid composition, lipidomics) and their relation to T2DM, also in the context of genetic interactions. The group has substantial experience in complex statistical modelling, e.g. with regard to biomarker mediation effects and dietary pattern analysis. Also, FA profiling of PREDIMED, FLAVURS and CIRCLES samples will be carried out by the group as part of the FAME project. |
| Impact | no output yet. |
| Start Year | 2017 |
| Description | Collaboration with the Department of Preventive Medicine & Public Health at the University of Navarra (UoN)-Professor Miguel Martinez-Gonzales & Dr Cristina Razquin Burillo) |
| Organisation | University of Navarra |
| Department | Department of Preventive Medicine and Public Health |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Dietary intervention studies from the Hugh Sinclair Unit of Human Nutrition (RESET, DIVAS, LIPGENE, SATgene, FLAVURS) will be used for detailed plasma phospholipid fatty acid and lipidomics analyses, along with genotyping. |
| Collaborator Contribution | In the frame of PREDIMED trial, we are studying lipidomics profilings and their relationship with CVD and the potential effect of the MedDiet in changing these profiles as a mediator for changing CVD risk (NIH funded project). FA profiling and potential genetic interactions will be determined to give a better understanding of the biological mechanisms involved in the beneficial effects observed with the MedDiet and CVD. |
| Impact | no output yet. |
| Start Year | 2017 |
| Description | A talk or presentation - Hugh Sinclair Nutrition Research Symposium 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Laury Sellem, PhD student, presented the protocol for the FAME project in University of Reading. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Conference keynote presentation by Julie Lovegrove |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Conference entitled "Dietary supplements 'functional' and 'super' foods: Science, regulations and roles in the diet". I was invited to give a keynote presentation on "The potential role of food supplements in public health and restrictive diets" at Royal Society of Medicine, London. A paper was published on the activity. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Conference presentation by Julie Lovegrove |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | "Dispelling the myths of dietary fats and cardiovascular disease" Leuven, Belgium |
| Year(s) Of Engagement Activity | 2022 |
| Description | Consortium Meeting: Update on dairy fatty acids as biomarkers of cardiometabolic health |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | This presentation aimed to share our preliminary findings to the members of the FAME Consortium based in Spain and Germany, and led to further collaborations on method and data analyses. |
| Year(s) Of Engagement Activity | 2020 |
| Description | FAME Consortium Meeting in Cordoba, Spain "Progress to date on WP2 - FAME" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | This presentation aimed to discuss the progress of the FAME Consortium with all collaborators and to define the next steps and schedule. |
| Year(s) Of Engagement Activity | 2018 |
| Description | FAME Consortium meeting in Cordoba, Spain "Progress of Fatty Acid Determination for WP2 - FAME" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | This presentation aimed to discuss the progress of the FAME Consortium with all collaborators and to define the next steps and schedule. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Final Symposium of the ERA-HDHL cofunded call on Biomarkers for Nutrition and Health |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Overall presentation of the findings from the consortium collaborators from Spain, Germany and England. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Invited Keynote presentations at International conference on Chronic Diseases and Lifestyle. Presentation entitled 'Diet and Cardiovascular Disease Risk'. Lahore, Pakistan. Professor Julie Lovegrove |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Keynote presentations at International conference on Chronic Diseases and Lifestyle. Presentation entitled 'Diet and Cardiovascular Disease Risk'. Lahore, Pakistan. The audience was mixed, predominantly scientists and included the President of Pakistan. Numbers were 300+. The presentation raised may questions and discussion with further invitations to present and also collaborate |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited Keynote presentations at the 30th Anniversary of National Dairy Council Ireland symposium. Presentation entitled 'Dairy and cardiovascular risk'. Coleraine, Northern Ireland. Professor Julie Lovegrove. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited presentations (Symposium) KEYNOTE at 30th Anniversary of National Dairy Council Ireland symposium 'Dairy and cardiovascular risk'. Coleraine, Northern Ireland. There were 200+ in the audience with many questions and discussion. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited presentation at International conference. 13th Federation European Nutrition Societies (FENS) meeting. 'Impact of Dairy on Human health: Biomarkers of intake and CVD risk'. Julie Lovegrove. Dublin, Ireland |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentations entitled 'Impact of Dairy on Human health: Biomarkers of intake and CVD risk'. 13th Federation European Nutrition Societies (FENS) meeting.Dublin, Ireland. Julie Lovegrove. 100+ scientists, students, industry members, policy makers attended. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited presentation at a workshop entitled "Inter-esterified fats in the food chain". British Nutrition Foundation. Professor Julie Lovegrove |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited presentation at a workshop entitled "Inter-esterified fats in the food chain". organised by British Nutrition Foundation for a BBSRC project. 20 attendees. Discussion and decisions made with a paper published form the workshop |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited presentation at scientific workshop for the 2nd Anniversary of the Institute of Food, Nutrition and Health. Entitled "Hugh Sinclair Unit: History, Achievements and Future. Reading, UK. Professor Julie Lovegrove |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited presentation on the research performed at the Hugh Sinclair Unit of Human Nutrition . The audience was mixed and was approximately 90 scientists, those from industry, policy makers. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited presentation by Professor Julie Lovegrove with a title "Dietary Fats and CVD risk. Dispelling the Myths' for the Korean Annual Nutrition Conference (virtual). 13th Nov 2020. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | An annual Conference by the Korean Nutrition Society |
| Year(s) Of Engagement Activity | 2020 |
| Description | Keynote presentation by Julie Lovegrove |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Congress on Obesity. ZoomForward22. Keynote presentation on "Dietary fats and cardiovascular disease - Dispelling the myths" Maastricht, Netherlands |
| Year(s) Of Engagement Activity | 2022 |
| Description | Keynote presentation at the Nutrition Society Irish Post-graduate meeting by Julie Lovegrove entitled "Julie Lovegrove - My career". Coleraine, Northern Ireland. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Presentation on my career in nutrition to highlighted opportunities, challenges and successes in nutrition science for postgraduate students. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Keynote presentation by Julie Lovegrove |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | International conference entitled In Food Excellent Medicine can be found. Keynote presentation given on "Dietary fats and cardiovascular risk" in Tibilisi Georgia. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Keynote presentation for IUNS 2022, Tokyo Japan by Julie Lovegrove |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "Dietary fats and cardiovascular disease - Dispelling the myths". presentation and dissemination of research activities in this area at the International IUNS 2022 conference in Tokyo |
| Year(s) Of Engagement Activity | 2022 |
| Description | Keynote presentation given by Julie Lovegrove |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Monash Conference "Dietary Dilemma - Fat and cardiovascular Disease" Malaysia, virtually. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Meeting on the analysis of lipidomics data from the DIVAS study and the EPIC-Potsdam cohort |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | FAME consortium members frrom Germany and University of Reading met to interpret the results from the lipidomics analyses performed in the EPIC-Potsdam cohort. New methods and collaborations were agreed in order to combine these results in a collaborative manuscript for consideration for publication in a high-impact peer-reviewed journal. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Plenary presentation at Nutrition Conference in Italy by Julie Lovegrove entitled . "Dispelling the myths of Dietary Fats and Cardiovascular Disease" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Plenary presentation at a conference organised for postgraduate and researchers in Italy for dissemination and discussion |
| Year(s) Of Engagement Activity | 2021 |
| Description | Presentation (poster) at Nutrition Society Winter Meeting December 2021 by Laury Sellem entitled "The impact of dietary saturated fat replacement with unsaturated fat on the plasma lipidome and cardiometabolic disease risk" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster presentation of research work. Engagement and discussion of study results and future collaborations |
| Year(s) Of Engagement Activity | 2021 |
| Description | Presentation at STEM for Britain awards ceremony by Julie Lovegrove entitled "Importance of nutritional science today" in Parliament, London, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited presentation at STEM for Britain award ceremony in Parliament, London UK for scientist, public and Parliamentarians |
| Year(s) Of Engagement Activity | 2021 |
| Description | Presentation at STEM for Britain awards ceremony by Julie Lovegrove entitled "Nutritional science and our future" in Parliament, London, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited presentation at STEM for Britain award ceremony in Parliament, London UK for scientist, public and Parliamentarians |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation at an International Nutrition Society Summer Conference in the PostGraduate Competition by Laury Sellem entitled "Evaluation of the role of individual dietary fatty acids and food matrix on cardiometabolic disease risk" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Presentation for research dissemination the the annual prestigious Post Graduate Competition. Laury Sellem is invited to publish a full paper in the Proceedings of the Nutrition Society |
| Year(s) Of Engagement Activity | 2021 |
| Description | Presentation at an MRC NRP Best Practice in Human Nutrition workshop by Julie Lovegrove entitled "Design, Conduct and Reporting of Clinical Trial in Nutrition" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | A presentation given at a workshop for debate and discussion and for further collaboration |
| Year(s) Of Engagement Activity | 2021 |
| Description | Presentation for Sir Richard Doll Epidemiological and Public Health Seminar by Julie Lovegrove entitled . "Dietary Fats and Health: Dispelling the Myths" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited sole presenter at the Sir Richard Dole Epidemiological and Public Health Seminar in University of Oxford which was open to the public, researchers from the University of Oxford UK and University of Harvard USA. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Presentation in UK Parliament for STEM for Britain by Julie Lovegrove |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Presentation at STEM for Britain.entitled "Nutritional science and our future". Aitlee Suite Parliament, London, UK |
| Year(s) Of Engagement Activity | 2022 |
| Description | Webinar for Team Satchel by Julie Lovegrove entitled "My career in Nutrition Science" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Webinar for Team Satchel that are engaged with school nationwide to highlight opportunities for different subjects and careers. |
| Year(s) Of Engagement Activity | 2022 |