In vivo proof of efficacy - Fhepatica sub-unit vaccines
Lead Research Organisation:
University of Liverpool
Department Name: Institute of Infection and Global Health
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
| Robin Flynn (Principal Investigator) |
Publications
Beesley NJ
(2018)
Fasciola and fasciolosis in ruminants in Europe: Identifying research needs.
in Transboundary and emerging diseases
Sachdev D
(2017)
The Chronic Stages of Bovine Fasciola hepatica Are Dominated by CD4 T-Cell Exhaustion.
in Frontiers in immunology
| Description | The original objectives of the award have been met successfully and we are currently pursuing methods of fundings larger trials to with a view to developing novel IP. |
| Exploitation Route | Similar approaches to vaccine design could be applied to other infectious agents. |
| Sectors | Agriculture, Food and Drink |
| Description | As part of this study we have used anaemia as an indicator of clinical disease to monitor vaccine success. We have been able to disseminate this, as good practice for experimental purposes to the wider research community and collaborators. |
| First Year Of Impact | 2018 |
| Sector | Agriculture, Food and Drink |
| Impact Types | Societal |
| Description | I contributed to an updated expert review of Fasciola as an entire disease area for the EU Discontools Project. |
| Geographic Reach | Europe |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| URL | http://www.discontools.eu/database.html |
| Description | Enterprise Fund Award |
| Amount | £94,000 (GBP) |
| Organisation | University of Liverpool |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 04/2019 |
| End | 03/2020 |
| Description | University of Liverpool WT ISSF |
| Amount | £29,660 (GBP) |
| Organisation | University of Liverpool |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 02/2019 |
| End | 03/2020 |
| Description | University of Liverpool: - PhD Studentship awarded through the Liverpool/newcastle/durham BBSRC DTP program. |
| Amount | £0 (GBP) |
| Organisation | University of Liverpool |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2019 |
| End | 09/2023 |
| Description | Formulation CPI -NR |
| Organisation | Centre for Process Innovation (CPI) |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We have been involved in round table discussion with the UoL and CPI in terms of vaccine production etc... This has led to a series of interactions centred around developing new formulation approaches for vaccine development. This has in turn led to refinements in funding applications to further this grant. |
| Collaborator Contribution | Has a wide range of expertise in formulation technology but also in scale-up and mass production. |
| Impact | Pending application with BBSRC for FoF funding directly related to this award. |
| Start Year | 2018 |
| Description | SiSaf |
| Organisation | SiSaf Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | In colla |
| Collaborator Contribution | Our partners, SiSaf, have offered support and advice in terms of how best to formulate antigens/vaccine preparations for in vivo delivery this has fed directly into the work undertaken as part of this award. They have provided intellectual input. |
| Impact | N/A |
| Start Year | 2017 |
| Description | Parasitology/Immunology CPD |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Was asked to speak at the British Cattle Veterinary Association annual meeting as a sponsored session by Boehringer Ingelheim. Presented on mucosal immunology in the context of infection. Main audience was practising vets and some industry members. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Edinburgh Invited Talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited seminar at the University of Edinburgh Immunology Group to speak on the role of anergy in developing protective immunity/vaccination against Fasciola hepatica. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Moredun Research Institute Invited Seminar - RF |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | RF was invited to give a talk at the Moredun Research Institute (Edin.) in 2017 to present findings on current vaccine based control approaches to Fasciola hepatica. There was discussion afterwards which in turn has led to a new research collaboration being initiated. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Public Involvement Panel - Speaking Engagement at University of Liverpool |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | A 20 min overview of research in the fasciola area was presented and potential problems and future directions were explained. There was discussion afterwards specific to the topic and more generally around public perception of disease control, government involvement and animal experimentation. |
| Year(s) Of Engagement Activity | 2017 |