Type-II NADH dehydrogenase from the food pathogen Liseria and other microbes as "druggable" target.
Lead Research Organisation:
University of Leeds
Department Name: Sch of Biomedical Sciences
Abstract
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Publications
Hards K
(2021)
Bacterial respiration keeps amazing us in the 21st century
in The Biochemist
Nakatani Y
(2020)
Unprecedented Properties of Phenothiazines Unraveled by a NDH-2 Bioelectrochemical Assay Platform.
in Journal of the American Chemical Society
Jeuken LJC
(2020)
Extracellular Electron Transfer: Respiratory or Nutrient Homeostasis?
in Journal of bacteriology
| Description | New antibiotics are required to tackle the increasing problem of "antimicrobial resistance". However, in some cases the mode of action of candidate antibiotics are not well understood or different researchers propose different mode of actions. In a collaborations with the University of Otago, New Zealand, we studied the proposed mode of action of a group of possible antibiotic agents, known as phenothiazines, and found that these do NOT work in the way that some groups have proposed. Instead, we have proposed a a different mode of action.This knowledge is important for the further development of phenothiazines and other agents with proposed antimicrobial activity. |
| Exploitation Route | The outcomes of this collaboration are important for the further development of phenothiazines and other agents as potential antimicrobial agents. |
| Sectors | Pharmaceuticals and Medical Biotechnology |
| Description | category 4 funding for 'Access to specialised international facilities and training' |
| Amount | $9,970 (NZD) |
| Organisation | Maurice Wilkins Centre |
| Sector | Public |
| Country | New Zealand |
| Start | 02/2019 |
| End | 03/2019 |
| Description | University of Otago |
| Organisation | University of Otago |
| Department | Department of Microbiology & Immunology |
| Country | New Zealand |
| Sector | Academic/University |
| PI Contribution | We provided a research tool/methodology. The partner will visit the University of Leeds to use this research method. |
| Collaborator Contribution | The partner will contribute a purified enzyme that will be studied as part of this collaboration. |
| Impact | At the time of writing, experiments are still to be performed, so no outputs or outcomes have resulted yet. An BBSRC partnership award was applied for and funded (this information is provided under 'grants'). |
| Start Year | 2018 |