Japan Partnering Award: The Generation of Eye Tissues from Human Induced Pluripotent Stem (iPS) Cells.
Lead Research Organisation:
Cardiff University
Department Name: Optometry and Vision Sciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Nomi K
(2021)
Generation of functional conjunctival epithelium, including goblet cells, from human iPSCs.
in Cell reports
Shibata S
(2018)
Selective Laminin-Directed Differentiation of Human Induced Pluripotent Stem Cells into Distinct Ocular Lineages
in Cell Reports
Matsushita K
(2023)
Barium-induced toxic anterior segment syndrome.
in European journal of ophthalmology
Wang K
(2020)
Cell compaction is not required for the development of gradient refractive index profiles in the embryonic chick lens.
in Experimental eye research
Ashworth S
(2020)
Chondroitin Sulfate as a Potential Modulator of the Stem Cell Niche in Cornea.
in Frontiers in cell and developmental biology
Hashida N
(2022)
Mitochondrial DNA as a Biomarker for Acute Central Serous Chorioretinopathy: A Case-Control Study
in Frontiers in Medicine
Bains KK
(2023)
Chondroitin Sulphate/Dermatan Sulphate Proteoglycans: Potential Regulators of Corneal Stem/Progenitor Cell Phenotype In Vitro.
in International journal of molecular sciences
Baba K
(2021)
The generation of fluorometholone nanocrystal eye drops, their metabolization to dihydrofluorometholone and penetration into rabbit eyes.
in International journal of pharmaceutics
Watanabe S
(2021)
Human iPS cells engender corneal epithelial stem cells with holoclone-forming capabilities.
in iScience
Hayashi R
(2022)
Generation of 3D lacrimal gland organoids from human pluripotent stem cells
in Nature
| Description | Initial meetings have taken place between vision researchers in Cardiff, Newcastle, Nottingham, UCL, Osaka, Kyoto and Kobe and three of proposed six ECR PDRA placements have taken place. |
| Exploitation Route | UK-Japan collaborations in the vision sciences will be established. |
| Sectors | Healthcare |
| Description | Dr Yixin Wang research in Osaka University |
| Organisation | Osaka University |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | My PhD student, Dr Yixin Wang, conducted experiments in Osaka University on human induced pluripotent stem cells and extracellular matrix molecules that is advancing our knowledge and will lead to publications in the next year or so |
| Collaborator Contribution | Professor Ryuhei Hayashi hosted Dr Wang and provided training and mentorship |
| Impact | None yet |
| Start Year | 2014 |
| Description | JPA collaboration |
| Organisation | Newcastle University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Research collaboration between Cardiff Newcastle and Osaka |
| Collaborator Contribution | Research collaboration between Cardiff Newcastle and Osaka |
| Impact | None yet |
| Start Year | 2018 |
| Description | JPA link Nottingham Trent |
| Organisation | Nottingham Trent University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | New research in lens development and beamtime at the Japan synchrotron |
| Collaborator Contribution | New research in lens development and beamtime at the Japan synchrotron |
| Impact | Data being written up |
| Start Year | 2018 |
| Description | Nishida SEAM collaboration |
| Organisation | Osaka University |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | The joint ongoing study of iPS cell derived eye-like cells |
| Collaborator Contribution | The joint ongoing study of iPS cell derived eye-like cells |
| Impact | Preliminary, unpublished data as part of this new collaborative project with long-standing partners |