Developing the Nanokick Bioreactor for Commercialisation and Cell Therapy
Lead Research Organisation:
University of Glasgow
Department Name: College of Medical, Veterinary, Life Sci
Abstract
There is a >£1B market emerging for engineered bone graft, including products containing mesenchymal stem cells (MSCs). However, MSCs don't produce bone, osteoblasts do. Previous BBSRC funding has helped develop our Nanokick bioreactor for chemical-free supply of osteogenic, bone forming, cells. Here, we will address technical, regulatory and commercial objectives towards manufacture of a genuinely scalable allogeneic cell therapy for bone grafting. We have already secured funding for a first-in-man study in 2021. However, this project will address the regulatory and process specific technological challenges to supplying clinical grade cells for large trials and, ultimately, as a marketed therapeutic product. This same challenge of scalable manufacture has slowed or ceased progress of many cellular therapies, therefore the processes being developed here are expected to have wider impact in the cell therapy sector.
Organisations
- University of Glasgow (Lead Research Organisation)
- Bone Cancer Research Trust (Collaboration)
- University of Navarra (Collaboration)
- University of Sydney (Collaboration)
- UNIVERSITY OF STRATHCLYDE (Collaboration)
- Royal College of Surgeons in Ireland (Collaboration)
- Trinity College Dublin (Collaboration)
- Atelerix (Collaboration)
- Histocell (Collaboration)
- Max Planck Society (Collaboration)
- UNIVERSITY OF GLASGOW (Collaboration)
- University of Valencia (Collaboration)
- Eindhoven University of Technology (Collaboration)
- UNIVERSITY OF EDINBURGH (Collaboration)
- Instituto de Ciencia de Materiales de Madrid (Collaboration)
- KING'S COLLEGE LONDON (Collaboration)
Publications
Childs PG
(2020)
Hurdles to uptake of mesenchymal stem cells and their progenitors in therapeutic products.
in The Biochemical journal
Hodgkinson T
(2021)
The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells.
in Science advances
Kennedy JW
(2021)
Nanovibrational stimulation inhibits osteoclastogenesis and enhances osteogenesis in co-cultures.
in Scientific reports
Robertson SN
(2020)
Reduction of Pseudomonas aeruginosa biofilm formation through the application of nanoscale vibration.
in Journal of bioscience and bioengineering
| Description | This project is ongoing. Currently, it has been shown that nanovibrational stimulation can be applied to stem cells en-mass using commercial cell stacks with osteogenesis being observed. We have also shown nanovibration is possible in hollow fibre bioreactors, this is important for manufacturing scale-up. We have successfully transferred the process to GMP facilities, this allows us to start to manufacture our cell therapy. We are in discussion with MHRA to achieve clinical trials licence and have been talking to Cell and Gene Therapy Catapult to do health economics. We are also exploring IP space, |
| Exploitation Route | The results will demonstrate a path to vibrate stem cells at commercial scales and the next step will involve establishing commercial GMP manufacturing of cells. The bioreactor is now in our GMP partners lab and we are working through maximising cell expansion and fully GMPising there processes. |
| Sectors | Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| Description | Impacts are at an early stage, however initial public engagement activities have taken place and discussion with investors regarding commercialising the cell therapy. It is notable that this project runs alongside a clinical trial of the cells that we plan to commercialise and so the impact will go on to be significant. |
| First Year Of Impact | 2000 |
| Sector | Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Societal,Economic |
| Description | GMP manufacture of nanovibrated mesenchymal stem cells |
| Geographic Reach | Europe |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Glasgow Orthopaedic Research Initiative |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Healickick (EU grant) translational day |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Preparing surgeons for the technologies and getting advice how to best present the technologies in product form |
| Description | Organisation of industry focussed stakeholder day |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Research Together - Patient and Public Involvement and Engagement Day 2023 |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Patients have fed back very positively about the day and about what they had learnt about emerging science in the area they are interested in and also future technologies. |
| Description | 'EPSRC and SFI Centre for Doctoral Training in Engineered Tissues for Discovery, Industry and Medicine |
| Amount | £7,013,578 (GBP) |
| Funding ID | EP/S02347X/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2019 |
| End | 12/2027 |
| Description | (HEALIKICK) - A modular strategy for the repair of critical sized bone fractures |
| Amount | € 5,243,536 (EUR) |
| Funding ID | 874889 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 06/2020 |
| End | 05/2025 |
| Description | Doctoral Training Partnership 2020-2021 University of Strathclyde |
| Amount | £41,886 (GBP) |
| Funding ID | EP/T517938/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2022 |
| End | 04/2026 |
| Description | Doctoral Training Partnership 2020-2021 University of Strathclyde, Johnson-Love, Olivia |
| Amount | £40,345 (GBP) |
| Funding ID | EP/T517938/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2020 |
| End | 04/2024 |
| Description | Early diagnosis and intervention of osteoporosis using nanovibrational stimulation |
| Amount | £48,807 (GBP) |
| Funding ID | ST/S000852/1 |
| Organisation | Science and Technologies Facilities Council (STFC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2018 |
| End | 10/2020 |
| Description | Mechanobiology-based medicine |
| Amount | £302,859 (GBP) |
| Funding ID | EP/W004623/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 12/2022 |
| Title | Nanovibrational Stimulation of Mesenchymal Stem Cells Induces Therapeutic Reactive Oxygen Species and Inflammation for Three- Dimensional Bone Tissue Engineering |
| Description | |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | http://researchdata.gla.ac.uk/id/eprint/1037 |
| Title | Nanovibrational stimulation inhibits osteoclastogenesis and enhances osteogenesis in co-cultures |
| Description | Models of bone homeostasis could be useful in drug discovery, particularly if the model is one that replicates bone regeneration with reduction in osteoclast activity. Here we use nanovibrational stimulation to achieve this in a 3D co-culture of primary human osteoprogenitor and osteoclast progenitor cells. We show that 1000 Hz frequency, 40 nm amplitude vibration reduces osteoclast formation and activity in human mononuclear CD14+ve blood cells and enhances osteogenesis/reduces osteoclastogenesis in a co-culture of primary human bone marrow stromal cells and bone marrow hematopoietic cells. Further, we use metabolomics to identify Akt (protein kinase C) as a potential mediator. Akt is known to be involved in bone differentiation via transforming growth factor beta 1 (TGF?1) and bone morphogenetic protein 2 (BMP2) and it has been implicated in reduced osteoclast activity via Guanine nucleotide-binding protein subunit a13 (Ga13). With further validation, our nanovibrational bioreactor could be used to help provide humanised 3D models for drug screening. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | New information on bone homeostasis and potential developmentof 3D bone models for drug screening |
| URL | http://researchdata.gla.ac.uk/id/eprint/1230 |
| Description | COllaboration with Atelerix |
| Organisation | Atelerix |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Thi sis a joint PhD project in which we are designing in vitro stem cell niches |
| Collaborator Contribution | Provision and tailoring of hydrogel materials |
| Impact | Early collaboration |
| Start Year | 2021 |
| Description | Collaboration with Bone Cancer Research Trust |
| Organisation | Bone Cancer Research Trust |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | We are developing models of sarcoma that are useful for bone cancer research |
| Collaborator Contribution | They are supporting us with training placements, access to patients and advice. |
| Impact | Development of better tissue models and enhanced training. |
| Start Year | 2020 |
| Description | Collaboration with Dr Ciro Chiappini, King's College London |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of a Nanokick bioreactor |
| Collaborator Contribution | Testing of the device and experience with biological assays |
| Impact | Disciplines: cell engineering, physics. |
| Start Year | 2021 |
| Description | Collaboration with Dr David Hoey, Trinity College Dublin |
| Organisation | Trinity College Dublin |
| Country | Ireland |
| Sector | Academic/University |
| PI Contribution | Provision of a Nanokick bioreactor |
| Collaborator Contribution | Testing of the device and experience with new cellular assays |
| Impact | Disciplines: cell engineering, physics. |
| Start Year | 2021 |
| Description | Collaboration with Dr Jennifer Paxton, University of Edinburgh |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of bioreactor devices |
| Collaborator Contribution | Cell culture and analysis |
| Impact | Data still being collected |
| Start Year | 2020 |
| Description | Collaboration with Dr Melanie Jimenez, University of Strathclyde) |
| Organisation | University of Strathclyde |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Bioreactor and cell culture |
| Collaborator Contribution | Cell deformability analysis |
| Impact | EPSRC PhD student |
| Start Year | 2022 |
| Description | Collaboration with Dr Tom Hodgkinson, Royal College of Surgeons in Ireland |
| Organisation | Royal College of Surgeons in Ireland |
| Country | Ireland |
| Sector | Academic/University |
| PI Contribution | Provision of a Nanokick bioreactor |
| Collaborator Contribution | Testing of the device and experience with chondrocyte culture. |
| Impact | Disciplines: cell engineering, physics. |
| Start Year | 2020 |
| Description | Collaboration with Histocell |
| Organisation | Histocell |
| Country | Spain |
| Sector | Private |
| PI Contribution | Provision of nanovibration protocols and devices. |
| Collaborator Contribution | GMP manufacturing of cellular therapies. |
| Impact | Disciplines: Cell engineering, physics, GMP manufacturing. |
| Start Year | 2019 |
| Description | Collaboration with Histocell |
| Organisation | Histocell |
| Country | Spain |
| Sector | Private |
| PI Contribution | We are working with Histocell to implement bone cell therapies and novel bone-related materials |
| Collaborator Contribution | Implementation of our technologies in GMP labs and guidance on manufacture, regulation and ethics. |
| Impact | Working towards cell therapies and novel scaffold technologies. |
| Start Year | 2018 |
| Description | Collaboration with Max Planck Institute of Colloids and Interfaces |
| Organisation | Max Planck Society |
| Department | Max Planck Institute of Colloids and Interfaces |
| Country | Germany |
| Sector | Charity/Non Profit |
| PI Contribution | We are providing cells and materials |
| Collaborator Contribution | They are testing our cells and materials |
| Impact | Development of novel cell therapies and biomaterials for bone regeneration |
| Start Year | 2020 |
| Description | Collaboration with Prof Jan De Boer, Technische Universiteit Eindhoven |
| Organisation | Eindhoven University of Technology |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Provision of a Nanokick bioreactor |
| Collaborator Contribution | Testing of the device and experience with new cell types |
| Impact | Disciplines: cell engineering, physics. |
| Start Year | 2020 |
| Description | Collaboration with Prof Ricardo Garcia, University of Madrid |
| Organisation | Instituto de Ciencia de Materiales de Madrid |
| Country | Spain |
| Sector | Public |
| PI Contribution | Bioreactor and cell culture experiments |
| Collaborator Contribution | AFM analysis and training |
| Impact | None yet |
| Start Year | 2022 |
| Description | Collaboration with Prof Wojciech Chrzanowski, University of Sydney |
| Organisation | University of Sydney |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Provision of a Nanokick bioreactor |
| Collaborator Contribution | Testing of the device and experience with new cell types |
| Impact | Disciplines: cell engineering, physics. |
| Start Year | 2021 |
| Description | Collaboration with Prof. Manuel Salmeron-Sanchez, University of Glasgow |
| Organisation | University of Glasgow |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | This is a long standing collaboration in which members of both laboratories work on projects together. Project team members within our research team focus on the cellular contribution and outputs of the system, as departmentally being situated in the UofG school of Molecular, Veterinary and Life Sciences. Although this definitions is not all encompassing. |
| Collaborator Contribution | This is a long standing collaboration in which members of both laboratories work on projects together. Project team members within the partners research team focus on biomedical aspects of the system, including materials as this lab is within the school of Science and Engineering at UofG. Although this definitions is not all encompassing |
| Impact | Within the scope of this project no outputs have resulted so far. This collaboration is multi-disciplinary as Prof. Salmeron-Sanchez's group is within the engineering department of UofG. This collaboration is in conjuncture with the Sir Bobby Charlton Foundation project ( previously Find a Better Way project). |
| Start Year | 2011 |
| Description | Collaboration with Prof. Stuart Reid, University of Strathclyde |
| Organisation | University of Strathclyde |
| Department | Department of Biomedical Engineering |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | As a joint project between institutes we collaborate in the characterisation and development of the Nanokick bioreactor and associated consumables for commercialisation. |
| Collaborator Contribution | They design and build the bioreactors. |
| Impact | This is a long standing collaboration in which we designed and build the nanovibrational bioreactor (Nanokick). We have worked together, produced patents and publications as well as securing further funding. This collaboration is multi-disciplinary as Prof. Reid's group is within the engineering department of University of Strathclyde and specialises in Physics and applications in biomedical engineering. This collaboration is in conjuncture with the Sir Bobby Charlton Foundation project ( previously Find a Better Way project). |
| Start Year | 2011 |
| Description | Collaboration with University of Navarra |
| Organisation | University of Navarra |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Provision of cells and materials |
| Collaborator Contribution | testing of cells and materials |
| Impact | Developing bone technologies together |
| Start Year | 2020 |
| Description | Collaboration with University of Valencia |
| Organisation | University of Valencia |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | We are providing cellular analysis |
| Collaborator Contribution | They are providing the bioreactor and know-how |
| Impact | Development of a new magnetic bioreactor for use in bone cell differentiation |
| Start Year | 2022 |
| Title | Nanovibrated mesenchymal stem cells for orthopaedic regeneration |
| Description | Bone primed cells for orthopaedic regeneration |
| Type | Therapeutic Intervention - Cellular and gene therapies |
| Current Stage Of Development | Refinement. Non-clinical |
| Year Development Stage Completed | 2022 |
| Development Status | Actively seeking support |
| Impact | Change in working of GMP cell manufacturer |
| Description | A talk at Future Investigators of Regenerative Medicine (FIRM) symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Research talk at a national conference |
| Year(s) Of Engagement Activity | 2022 |
| Description | ARCADIA public engagement |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | ARCadia, was a festival of public events that celebrated the public opening of the ARC from 16-30 September 2022 that attracted almost 7000 people. The general aims were: Collaboration between the university and non-academic groups A mix of disciplines, from the arts to social, physical and life sciences Engaging traditionally marginalised groups, or groups who experience barriers to accessing the university Engaging communities local to the ARC (postcodes G11, G3, G12) 75 free events for all ages were held day and night in the ARC, from schools workshops to cinema screenings, exhibitions, comedy, gaming, talks and even an outdoor ceilidh with dancing dinosaurs. Over 63% of events involved working in partnership with non-academic groups. An astonishing number of people helped organise and run ARCadia events (and our group CeMi was central in this) , including 326 UofG colleagues, 147 students, 239 partner staff, 30 volunteers and for student interns. The event attracted public visitor of all ages throughout the 2 weeks and everyone provided good comments and they would like to be able to experience an event like that in the future. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.gla.ac.uk/myglasgow/news/newsarchive/2022/8november2022/headline_893700_en.html |
| Description | CeMi external seminars |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | We have invited external speakers from the UK to to speak and encourage discussion at our seminar series. This is opened up to an online audience so that our colleagues in Strathclyde can contribute. |
| Year(s) Of Engagement Activity | 2022,2023 |
| Description | Cell block science |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Presented at prisoner outreach day at HMP Shotts |
| Year(s) Of Engagement Activity | 2019 |
| Description | Centre for Doctoral Training Retreat |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Retreat to The Burn for formal PGR student training in entrepreneurship |
| Year(s) Of Engagement Activity | 2021 |
| Description | Centre for the Cellular Microenvironment symposium |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | We organised an open symposium with expert speakers from the UK, EU and US - and from academic and industry |
| Year(s) Of Engagement Activity | 2019 |
| Description | Centre for the Cellular Microenvironment GLORI mini symposium 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | We organised an open symposium with expert speakers from the UK, EU and US - and from academic and industry |
| Year(s) Of Engagement Activity | 2019,2020,2021 |
| Description | Centre for the Cellular Microenvironment seminar by Dr Monica P. Tsimbouri |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | We organise seminar series that a variety of people have access to them and attendance ranges from local to international as they are online. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Change Champion helping to organise and interface with academics regarding the Advanced Research Centre at UofG |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | In the role of a Change Champion deputy my role was to assist in the organisation and planning of the building of a new centre for advanced research within Glasgow. This centre would consist of a large inter disciplinary cohort, to encourage collaboration, and would therefore require a wide degree of specialisations. At these events i was required to interface with companies, academics and univeristy professionals to exchange information and then disseminate this to my own colleagues. |
| Year(s) Of Engagement Activity | 2020,2021 |
| Description | Conference - GLORI |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | ~ 50-60 undergraduate, postgraduate, lecturers, professors alongside surgical practitioners and industrial sponsors attended the Glasgow Orthopaedic Research Initiative (GLORI) conferences. At these conferences MS presented posters and further discussed the research presented with a selection of each of these demographics. |
| Year(s) Of Engagement Activity | 2015,2018,2020 |
| Description | Conference Presentation - WBC 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Have been accepted for presentation at the 2020 World Biomaterials Congress, Glasgow. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Conference Presentation - World Biomaterials Congress 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Was accepted to present an oral presentation at the World Biomaterials Congress, hosted virtually. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Conference organisation CCE-GLORI 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | The local CCE-GLORI workshop is organised by Dr Monica P. Tsimbouri every year. It is a workshop where postgraduate students present their work to their peers and supervisors and discussion then follows the talks. This is highly beneficial to students and promotes collaboration. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Conference organisation-GLORI2020 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Monica P. Tsimbouri organises GLORI bi-annually. This conference encourages collaboration between the basic sciences, applied sciences, engineering and clinic. This has the aim of bringing the latest ideas in basic materials research into use to deliver the next-generation of orthopaedic care. It combines expertise from orthopaedic surgeons, plastic surgeons, biologists, engineers and chemists. The conference is free for attendance and involves oral and poster presentations from professionals, scientists, clinicians and postgraduate students. It is always well attended. It is sponsored by industry who are also involved in the conference. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Discussion with potential industrial partners |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Approached and opened dialogue with several industrial businesses to present data and techniques developed within these grants in aid of developing a working business relationship and partnership. These companies include, Ceramysis, Histocell, FibreCell Systems. These discussions were conducted with researched within this grant and associated professional practitioners, such as surgeons with corresponding industrial representatives. |
| Year(s) Of Engagement Activity | 2020,2021,2022 |
| Description | Dr Monica Tsimbouri, Change Champion helping to organise and interface with academics regarding the Advanced Research Centre at UofG |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | In the role of a Change Champion deputy my role was to assist in the organisation and planning of the building of a new centre for advanced research within Glasgow university. This centre consists of a large inter disciplinary cohort, to encourage collaboration, and would therefore require a wide degree of specialisations. At these events i was required to interface with companies, academics and univeristy professionals to exchange information and then disseminate this to my own colleagues. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Dr P. Tsimbouri helped organise the: Joint symposium with UCL: Mind & Body Healing October 2020 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Dr P. Tsimbouri helped organise, chaired and also delivered an oral presentation to the: Joint symposium with UCL: Mind & Body Healing October 2020. The symposium was open to the scientific community and the general public. Talk presentations were delivered from members of the UofG and UCL research teams on their research work. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.gla.ac.uk/explore/avenue/noticeboard/headline_744729_en.html |
| Description | European Society for Biomaterials Keynote (Dalby) Talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote conference talk |
| Year(s) Of Engagement Activity | 2021 |
| Description | European Society for Biomaterials Talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk at the ESB conference for Dr Hussain Jaffery |
| Year(s) Of Engagement Activity | 2022 |
| Description | Explorathon Nov 2020: Fantastic Proteins & Where to Find Them |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Short video clips on our fantastic proteins collagen, fibronectin, laminin, & piezo posted throughout the day on the Explorathon 2020 Facebook live event. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.explorathon.co.uk/events/fantastic-proteins/ |
| Description | Glasgow Science Festival: Regenerate |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | The Glasgow Science Festival runs for a few weeks and we did a full day focusing on Stem Cell activities, talking to the general public (mainly children). The aim was teach them how stem cells differentiate. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Healickick (EU grant) translation day |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussion between academics and surgeons around technologies we have developed. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Institute seminar presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | An institute and school hosted seminar series, highlighting and discussing work from within MCSB at Glasgow University. The presentation was to other post doctoral researchers and students within primarily MVLS. |
| Year(s) Of Engagement Activity | 2021,2022 |
| Description | Invited talk at British Orthopaedic Research Society |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussed research training of junior surgeons |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited talk for SULSA/Rheinland-Pfalz Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | ECR talk at the First Scottish - Rheinland-Pfalz Life Sciences and Biotechnology Conference in the "Development of Advanced Therapies and Vaccines" symposium. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Joint TCES/CDT conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Joint Tissue and Cell Engineering conference with the lifETIME CDT. Over 100 academics (PhD's to professor level) were in the audience focussing on research developments of like-minded EPSRC CDTs |
| Year(s) Of Engagement Activity | 2022 |
| Description | Joint conference of the Centres for Doctoral Training - Future Leaders in Regenerative Medicine |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | A joint meeting, hosted by the UK Society for Biomaterials, focussing on research developments of like-minded EPSRC CDTs |
| Year(s) Of Engagement Activity | 2021 |
| Description | Joint symposium with UCL: Mind & Body Healing October 2020 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Open to the public and scientific community. Presentations from UofG and UCL on research work. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.gla.ac.uk/explore/avenue/noticeboard/headline_744729_en.html |
| Description | Keynote talk (Dalby) at Tissue Engineerign and Regenerative medicien International Society |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote talk at a major conference |
| Year(s) Of Engagement Activity | 2021 |
| Description | Media interest BBC (nanokicking) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Talk sparked public interest Many interested enquirers. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Media interest BBC (orthopaedic materials) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Sparked public interest Enquieries from the public |
| Year(s) Of Engagement Activity | 2013 |
| Description | Media interest BBC (stem cell growth) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Talk sparked public interest Enquieries from the public |
| Year(s) Of Engagement Activity | 2011 |
| Description | Online lecture produced for Henry Stewart talks |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Online talk: Preclinical translation of mesenchymal stem cell therapies |
| Year(s) Of Engagement Activity | 2021 |
| Description | Poster Presentation - BBSRC open day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Supporters |
| Results and Impact | Was invited to present a poster regarding the work supprorted by the BBSRC at an instiute wide event attended by fellow BBSRC grant holders and BBSRC represenatatives, including executive chair. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Poster Session - BBSRC |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | ~30 researchers funded by the BBSRC presented posters to fellow post doctoral researchers, principle investigators and BBSRC staff, including Professor Melanie Welham (BBSRC Executive Chair). This poster session involved presenting current research funded within this project and subsequent questions and discussion following. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Presentation and Lab session for Stem Cell Engineering for Regenerative Medicine MSC course |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | A presentation and discussion regarding the work performed within the research group and within this project followed by a lab session, with experiments planned around work from within this project. The students performed 2 weeks of experiments within the lab. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Presentation at Wold Biomaterials Congress 2020 - Online |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | A conference presentation: Therapeutic refinement of tissue engineered cellular implants for non-union fracture repair |
| Year(s) Of Engagement Activity | 2020 |
| Description | Public engagement-#Run2Jordan |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | University of Glasgow and Strathclyde came together, and took part in the biggest CeMi fitness challenge to date! The aim was to raise as much as possible, a team from the CeMi run, walked and cycled the distance from Glasgow to the Sir Bobby Charlton Rehabilitation Centre in Amman, Jordan, that is 5436k! #RunToJordan We managed to raise £1,719! |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://glasgow.thecemi.org/2020/08/04/runtojordan/ |
| Description | Research Presentation for Departmental Seminars |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | PostGraduate researchers within the Institute of Molecular, Cell and Systems Biology and other related institutes from around UofG are invited to present and discuss current research with questions afterwards. The audience includes primarily postgraduates but also includes technicians and other associated lab members and external researchers relevant to the field. |
| Year(s) Of Engagement Activity | 2019,2020 |
| Description | Research Presentation for internal Biomaterials seminars |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Researchers from biomedical engineering and other related subjects from around UofG are invited to present and discuss current research with discussion afterwards. The audience includes undergraduates, postgraduates, lecturers, professors, other associated lab members and external researchers relevant to the field. |
| Year(s) Of Engagement Activity | 2015,2016,2017,2018,2019,2020 |
| Description | Research Presentation for internal departmental seminars |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Presenatation at the Institute of Molecular Cell and Systems Biology PDRA seminar series outlining current research and future work. |
| Year(s) Of Engagement Activity | 2020,2021 |
| Description | ResearchTogether: Patients Guiding the Future of Science |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | The event focused on Patient and Public Involvement and Engagement (PPIE) bringing together patients, researchers, industry, and charities to discuss recent research advancements as well as how to improve research targeting healthcare improvement in the future. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Social Media management for the CeMi |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | This social media platform, Instagram has 102 followers (at time of writing), ranging from members of the general public to professional organisations relevant to the groups field. This output aims to highlight and engage this audience with current ongoing work and researchers at the institute. |
| Year(s) Of Engagement Activity | 2018,2019,2020 |
| Description | Strategic Board Meetings - SBCF |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | Presentation or research within poster presentation and subsequent follow-up discussions and questions to board members of related charitable foundation (Sir Bobby Charlton Foundation) in conjuncture with collaborative orthogonal project (formally Find a Better Way). |
| Year(s) Of Engagement Activity | 2020,2021,2022 |
| Description | Strategic Board Meetings - SBCF |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Supporters |
| Results and Impact | Poster presentation and subsequent follow-up discussions with board members of related charitable foundation the Sir Bobby Charlton Foundation (formally Find a Better Way). |
| Year(s) Of Engagement Activity | 2019,2020 |
| Description | Strategic collaborative meetings - Sir Bobby Charlton Foundation |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Study participants or study members |
| Results and Impact | These regular focused strategy meetings involve presentations and discussions of current work from two projects related to the Sir Bobby Charlton Foundation (SBCF, previously Find A Better Way) funded project. These meetings include in-depth knowledge exchange with industrial partners and service providers we are collaborating with to bring the system to market. The outcomes of these discussions usually lead to new areas for development and possibilities of new collaborations. |
| Year(s) Of Engagement Activity | 2019,2020 |
| Description | Strategic collaborative meetings - SBCF |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Study participants or study members |
| Results and Impact | Participation in focused strategy meetings regarding the Sir Bobby Charlton Foundation (previously Find A Better Way) project presenting and discussing current work from both projects. Meetings include in-depth knowledge exchange with industrial partners and service providers we are working with to bring the system to market. These discussions have highlighted further areas of examination for projects and garnered enhanced collaboration. |
| Year(s) Of Engagement Activity | 2019,2020,2021,2022 |
| Description | Strategic collaborative meetings - Sir Bobby Charlton Foundation |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | These regular focused strategy meetings involve presentations and discussions of current work from two projects related to the Sir Bobby Charlton Foundation (SBCF, previously Find A Better Way) funded project. These meetings include in-depth knowledge exchange with industrial partners and service providers we are collaborating with to bring the system to market. The outcomes of these discussions usually lead to new areas for development and possibilities of new collaborations. |
| Year(s) Of Engagement Activity | 2019,2020,2021 |
| Description | Studentship Interviews and Assistance - CDT |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Assistance in the introduction and selection of students for PhD positions within a the LifeTimeCDT programme to be held throughout the UK. Students were shown around the institute and guided through training activities, additionally MS participated in part of the group interview process. |
| Year(s) Of Engagement Activity | 2019,2020 |
| Description | TCES 2010 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | paper presentation |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr Monica P Tsimbouri. exiting discussion after talk Interested parties continued discussion |
| Year(s) Of Engagement Activity | 2010 |
| Description | TCES 2012 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | paper presentation |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr P Tsimbouri. talk sparked questions and discussion afterwards Engagement with company Reps and received very good discount on equipment. |
| Year(s) Of Engagement Activity | 2012 |
| Description | TERMIS EU 2011 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | paper presentation |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr Monica P Tsimbouri. Talk sparked questions and discussion afterwards There was further discussion during a later session about my talk |
| Year(s) Of Engagement Activity | 2011 |
| Description | Talk in Portugal |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk for Dalby at University of Aviero |
| Year(s) Of Engagement Activity | 2022 |
| Description | TheGlasgowCeMi Instagram social media page |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The Glasgow CeMi Instagram page (formally Mimeresearch) has been set up to improve public engagement and improve the visibility of teh researchers and science being performed at the centre. This social media page has been contacted by external reserarchers, industrial companies and prospective students. It currently has at the time of writing 123 followers. |
| Year(s) Of Engagement Activity | 2019,2020,2021,2022 |
| URL | https://www.instagram.com/theglasgowcemi/ |
| Description | UKSB |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | paper presentation |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr M. P. Tsimbouri. Interesting discussion following presentation Discussion lead to problem solving for a fellow scientist |
| Year(s) Of Engagement Activity | 2010 |
| Description | lifETIME CDT student day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Stakeholders in the Centre for Doctoral Training engage with CDT students to enhance student training and careers. This is followed by discussion with the CDT advisory board. |
| Year(s) Of Engagement Activity | 2021,2022 |