China Partnering Award: Imperial College London - China collaboration on Actinobacillus pleuropneumoniae vaccines, diagnostics, and pathogenesis
Lead Research Organisation:
Imperial College London
Department Name: Infectious Disease
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
- Imperial College London (Lead Research Organisation)
- Jilin University (Collaboration)
- Huazhong Agricultural University (Collaboration, Project Partner)
- Chinese Academy of Agricultural Sciences (Collaboration)
- Chinese Academy of Agricultural Sciences (Project Partner)
- Sichuan Agricultural University (Project Partner)
- Jilin University, China (Project Partner)
People |
ORCID iD |
| Paul Langford (Principal Investigator) |
Publications
Wang S
(2019)
Overexpression of AmpC Promotes Bacteriophage Lysis of Ampicillin-Resistant Escherichia coli.
in Frontiers in microbiology
Li G
(2020)
Basal-Level Effects of (p)ppGpp in the Absence of Branched-Chain Amino Acids in Actinobacillus pleuropneumoniae.
in Journal of bacteriology
Stringer OW
(2021)
Proposal of Actinobacillus pleuropneumoniae serovar 19, and reformulation of previous multiplex PCRs for capsule-specific typing of all known serovars.
in Veterinary microbiology
Langford PR
(2021)
Application of the MISTEACHING(S) disease susceptibility framework to Actinobacillus pleuropneumoniae to identify research gaps: an exemplar of a veterinary pathogen.
in Animal health research reviews
Bao C
(2021)
IFN-?-/- Mice Resist Actinobacillus pleuropneumoniae Infection by Promoting Early Lung IL-18 Release and PMN-I Accumulation.
in Infection and immunity
Stringer O
(2021)
Rapid Detection and Typing of Actinobacillus pleuropneumoniae Serovars Directly From Clinical Samples: Combining FTA® Card Technology With Multiplex PCR
in Frontiers in Veterinary Science
Zhang Q
(2022)
The Metabolic Adaptation in Response to Nitrate Is Critical for Actinobacillus pleuropneumoniae Growth and Pathogenicity under the Regulation of NarQ/P.
in Infection and immunity
Tang H
(2022)
Identification of FtpA, a Dps-Like Protein Involved in Anti-Oxidative Stress and Virulence in Actinobacillus pleuropneumoniae.
in Journal of bacteriology
| Description | Because of covid, we have not managed to visit the four groups in China who are world leading with the pig pathogen Actinobacillus pleuropneumoniae (APP) which causes lung disease in pigs since November 2019. In the UK we have an active research programme with APP aimed at diagnostics and vaccines. China has over half of the world's pigs, and is the biggest market for any vaccines and diagnostics. However, we have maintained the links and managed to publish a number of joint papers with APP, and other bacteria, arising from previously discussed work. These include the description of a new type of APP which had diagnostic implications, and also showing that a particular strain of APP that is available in bacterial collections all over the world is the same - some doubt had been expressed in the literature it was not. We have also initaiated collaborations with another pig pathogen - Streptococcus suis. Now that China has opened up, the plan is to go to China in 2023 to ensure that the links are maintained further, and identify new areas of common interest and, in particluar, try and arrange testing of the PERP-ID diagnostic for lung dideases of pigs that we have developed with ProtonDx with Innovate funding. |
| Exploitation Route | Still ongoing. However, I am the named International Expert on major grants in the area with 2/4 of the centres named in the grant. |
| Sectors | Agriculture, Food and Drink |
| Description | Outreach activities in Chines schools (14 year olds). |
| First Year Of Impact | 2020 |
| Sector | Agriculture, Food and Drink |
| Impact Types | Cultural |
| Description | Huazhong Agricultural University Wuhan |
| Organisation | Huazhong Agricultural University |
| Country | China |
| Sector | Academic/University |
| PI Contribution | Expertise in the the bacterial pig pathogen Actinobacillus pleuropneumoniae (APP) |
| Collaborator Contribution | Expertise in the host response and genetics as applied to APP |
| Impact | Only visited once so far (Nov 2020). Discussions held about possibility of PL to undertake courses next summer and/or sabbatical in the area of transcriptional regulators of APP and virulence. Also discussions about visit of one Wuhan student to Imperial regarding mutant construction. Discussions will resume once the Covid-19 epidemic has resolved. |
| Start Year | 2020 |
| Description | Jilin |
| Organisation | Jilin University |
| Country | China |
| Sector | Academic/University |
| PI Contribution | Expertise in the biology of the pig pathogens Actinobacillus pleuropneumoniae, Haemophilus parasuis, and Streptococcus suis. In particular, in the areas of population biology, vaccines and diagnostics. |
| Collaborator Contribution | Expertise in the host response to the pig pathogens Actinobacillus pleuropneumoniae, Haemophilus parasuis, and Streptococcus suis. |
| Impact | We have visited once under the award (Nov 2020) and identified areas of interest. In particular, Jilin have agreed to help us with getting a diagnostic PCR into China. We are talking to Imperial Innovations about the faesibility of doing this as proposed by Jilin. |
| Start Year | 2020 |
| Description | State Key Laboratory of Veterinary Biotechnology Harbin |
| Organisation | Chinese Academy of Agricultural Sciences |
| Department | Harbin Veterinary Research Institute (HVRI) |
| Country | China |
| Sector | Public |
| PI Contribution | Expertise in the pig pathogen Actinobacillus pleuropneumoniae (APP) diagnostics, vaccines and pathogenesis. |
| Collaborator Contribution | Complementary expertise in the pig pathogen Actinobacillus pleuropneumoniae (APP)vaccines and pathogenesis. |
| Impact | One meeting so far (Nov 2020). Discussions were held on potential sabbatical vist for PL in the area of APP vaccines. |
| Start Year | 2020 |
| Description | State School visit |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | I was asked to talk to the son's class of our host in Harbin. There were 48 13 year olds. I was asked to talk about a day in the life of a 13 year old in the UK, life at University in the UK, and why we were in China. I asked a school teacher friend for advice on what to say, and also involved the Imperial International Office for slides and advice. I had learnt some rudimentary Mandarin - courtesy of my Mongolian born postdoc who was in the room - with the expectation that he would have to translate. Turned out this was not required as their English was excellent. The session was interactive involving small groups (which they were not used to) and prizes (e.g. who could name most landmarks in London etc.). The sports and school days were compared and there was question and answer sessions both ways.All students got postcards of London, winning groups got UK sweets, and the smallest boy and girl in the class London underground mugs. We found the killer stat for Chinese students to study at UK Universities - they would have their own room - instead of being in dorms of 10-12. The most enjoyable outreach session I have done in my career. I followed up with thank you and Chinese Happy New Year cards. Unqualified success for both sides. As they were in the final year at a middle school, the class will break up next year which is a shame. However, would be happy to do something similar again. Very rewarding. |
| Year(s) Of Engagement Activity | 2019 |